WO2003035645A1 - Novel 4-(2-furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same - Google Patents
Novel 4-(2-furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same Download PDFInfo
- Publication number
- WO2003035645A1 WO2003035645A1 PCT/JP2002/010449 JP0210449W WO03035645A1 WO 2003035645 A1 WO2003035645 A1 WO 2003035645A1 JP 0210449 W JP0210449 W JP 0210449W WO 03035645 A1 WO03035645 A1 WO 03035645A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- same
- furoyl
- aminopiperidines
- intermediates
- synthesizing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA04003330A MXPA04003330A (es) | 2001-10-09 | 2002-10-08 | 4-(2-furoil) aminopiperidinas novedosas, compuestos intermedios en la sintesis de las mismas, proceso para producirlas y su uso medicinal. |
EP02772984A EP1443046B1 (en) | 2001-10-09 | 2002-10-08 | Novel 4-(2furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same |
US10/492,065 US7375115B2 (en) | 2001-10-09 | 2002-10-08 | 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same |
CA2468529A CA2468529C (en) | 2001-10-09 | 2002-10-08 | 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same |
JP2003538161A JP4009251B2 (ja) | 2001-10-09 | 2002-10-08 | 新規な4−(2−フロイル)アミノピペリジン、その合成中間体、その製造方法および医薬としてのその用途 |
DK02772984T DK1443046T3 (da) | 2001-10-09 | 2002-10-08 | Nye 4-(2-furoyl)-amino-piperidiner, mellemprodukter til deres syntese, fremgangsmåde til deres fremstilling og deres medicinske anvendelse |
BR0213186-2A BR0213186A (pt) | 2001-10-09 | 2002-10-08 | 4-(2-furoil)aminopiperidinas, intermediários na sìntese dos mesmos, processo para produzir os mesmos e uso medicinal dos mesmos |
DE60230437T DE60230437D1 (de) | 2001-10-09 | 2002-10-08 | Neue 4-(2-furoyl)-amino-piperidine, zwischenprodukte für deren synthese, verfahren zu deren herstellung und deren medizinische verwendung |
KR1020047005180A KR100938369B1 (ko) | 2001-10-09 | 2002-10-08 | 신규 4-(2-푸로일)아미노피페리딘, 그의 합성 중간체,그의 제조방법 및 의약으로서의 그의 용도 |
US12/077,687 US20080194826A1 (en) | 2001-10-09 | 2008-03-20 | Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001311828 | 2001-10-09 | ||
JP2001/311828 | 2001-10-09 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/077,687 Division US20080194826A1 (en) | 2001-10-09 | 2008-03-20 | Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003035645A1 true WO2003035645A1 (en) | 2003-05-01 |
Family
ID=19130581
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/010449 WO2003035645A1 (en) | 2001-10-09 | 2002-10-08 | Novel 4-(2-furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same |
Country Status (14)
Country | Link |
---|---|
US (2) | US7375115B2 (ja) |
EP (1) | EP1443046B1 (ja) |
JP (1) | JP4009251B2 (ja) |
KR (1) | KR100938369B1 (ja) |
CN (1) | CN1326853C (ja) |
AT (1) | ATE417845T1 (ja) |
BR (1) | BR0213186A (ja) |
CA (1) | CA2468529C (ja) |
DE (1) | DE60230437D1 (ja) |
DK (1) | DK1443046T3 (ja) |
ES (1) | ES2319879T3 (ja) |
MX (1) | MXPA04003330A (ja) |
PT (1) | PT1443046E (ja) |
WO (1) | WO2003035645A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004099194A1 (ja) * | 2003-05-08 | 2004-11-18 | Kyorin Pharmaceutical Co. Ltd. | 掻痒治療薬として有用な4-(2-フロイル)アミノピペリジン類 |
JP2004352714A (ja) * | 2003-05-08 | 2004-12-16 | Kyorin Pharmaceut Co Ltd | 新規な4−(2−フロイル)アミノピペリジン誘導体 |
EP1622613A2 (en) * | 2003-05-14 | 2006-02-08 | Cytokinetics, Inc. | Compounds, compositions and methods |
JP2007308406A (ja) * | 2006-05-17 | 2007-11-29 | Nisshin Kyorin Pharmaceutical Co Ltd | [1−[2−[4−[n−(5−メチルピリジン−2−イル)−2−フランカルボキサミド]ピペリジン−1−イル]エチル]シクロヘキシル]アセトヒドロキサム酸の製造方法及び精製方法 |
JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのピリジン誘導体 |
WO2011030537A1 (ja) * | 2009-09-08 | 2011-03-17 | 杏林製薬株式会社 | 4-(5-メチルピリジン-2-イルアミノ)ピペリジン-1-カルボン酸誘導体の製造方法 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
MY149422A (en) * | 2005-12-01 | 2013-08-30 | Elan Pharm Inc | 5-(arylsulfonyl)-pyrazolopiperidines |
MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
EP2148879B1 (en) | 2007-04-23 | 2012-11-28 | Janssen Pharmaceutica, N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
DK2148873T3 (da) | 2007-04-23 | 2012-11-26 | Janssen Pharmaceutica Nv | 4-alkoxypyridazinderivater som hurtigt dissocierende dopamin 2- receptorantagonister |
CN102159554B (zh) | 2008-07-03 | 2014-09-24 | 詹森药业有限公司 | 作为5-ht6受体拮抗剂的取代的6-(1-哌嗪基)-哒嗪 |
EA019048B1 (ru) | 2008-07-31 | 2013-12-30 | Янссен Фармацевтика Нв | Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина |
WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
WO2012040177A1 (en) * | 2010-09-20 | 2012-03-29 | Kareus Therapeutics, Sa | Methods and compositions for treatment of diabetes and dyslipidemia |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0160422A1 (en) * | 1984-04-09 | 1985-11-06 | Anaquest, Inc. | N-Aryl-N-(4-Piperidinyl)amides and pharmaceutical compositions and methods employing such compounds |
EP0277794A2 (en) * | 1987-02-02 | 1988-08-10 | Ohmeda Pharmaceutical Products Division Inc. | N-heterocyclic-N-(4-piperidyl) amides |
WO1994027967A1 (en) * | 1993-05-26 | 1994-12-08 | Smithkline Beecham Laboratoires Pharmaceutiques | Novel compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59112984A (ja) * | 1982-12-21 | 1984-06-29 | Shionogi & Co Ltd | 1,4−ベンゾジアゼピン誘導体 |
US4912109A (en) * | 1987-02-02 | 1990-03-27 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds |
-
2002
- 2002-10-08 US US10/492,065 patent/US7375115B2/en not_active Expired - Fee Related
- 2002-10-08 DE DE60230437T patent/DE60230437D1/de not_active Expired - Lifetime
- 2002-10-08 DK DK02772984T patent/DK1443046T3/da active
- 2002-10-08 ES ES02772984T patent/ES2319879T3/es not_active Expired - Lifetime
- 2002-10-08 BR BR0213186-2A patent/BR0213186A/pt not_active IP Right Cessation
- 2002-10-08 EP EP02772984A patent/EP1443046B1/en not_active Expired - Lifetime
- 2002-10-08 KR KR1020047005180A patent/KR100938369B1/ko not_active IP Right Cessation
- 2002-10-08 WO PCT/JP2002/010449 patent/WO2003035645A1/ja active Application Filing
- 2002-10-08 CA CA2468529A patent/CA2468529C/en not_active Expired - Fee Related
- 2002-10-08 PT PT02772984T patent/PT1443046E/pt unknown
- 2002-10-08 AT AT02772984T patent/ATE417845T1/de active
- 2002-10-08 JP JP2003538161A patent/JP4009251B2/ja not_active Expired - Fee Related
- 2002-10-08 CN CNB028241568A patent/CN1326853C/zh not_active Expired - Fee Related
- 2002-10-08 MX MXPA04003330A patent/MXPA04003330A/es active IP Right Grant
-
2008
- 2008-03-20 US US12/077,687 patent/US20080194826A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0160422A1 (en) * | 1984-04-09 | 1985-11-06 | Anaquest, Inc. | N-Aryl-N-(4-Piperidinyl)amides and pharmaceutical compositions and methods employing such compounds |
EP0277794A2 (en) * | 1987-02-02 | 1988-08-10 | Ohmeda Pharmaceutical Products Division Inc. | N-heterocyclic-N-(4-piperidyl) amides |
WO1994027967A1 (en) * | 1993-05-26 | 1994-12-08 | Smithkline Beecham Laboratoires Pharmaceutiques | Novel compounds |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004099194A1 (ja) * | 2003-05-08 | 2004-11-18 | Kyorin Pharmaceutical Co. Ltd. | 掻痒治療薬として有用な4-(2-フロイル)アミノピペリジン類 |
JP2004352714A (ja) * | 2003-05-08 | 2004-12-16 | Kyorin Pharmaceut Co Ltd | 新規な4−(2−フロイル)アミノピペリジン誘導体 |
EP1621538A4 (en) * | 2003-05-08 | 2009-07-29 | Kyorin Seiyaku Kk | AMINOPIPERIDINE 4- (2-FUROYL) AMINOPIPERIDINE COMPOUND AS THERAPEUTIC AGENT AGAINST PRURITUS |
US7601843B2 (en) | 2003-05-08 | 2009-10-13 | Kyorin Pharmaceutical Co., Ltd | 4-(2-furoyl)aminopiperidine compound useful as therapeutic agent for itching |
EP2325183A1 (en) | 2003-05-08 | 2011-05-25 | Kyorin Pharmaceutical Co., Ltd. | 4-(2-Furoyl) Aminopiperidine compound useful as therapeutic agent for itching |
KR101160858B1 (ko) * | 2003-05-08 | 2012-07-02 | 가부시끼가이샤 닛신 세이훈 그룹 혼샤 | 소양 치료약으로서 유용한 4-(2-푸로일)아미노피페리딘류 |
EP1622613A2 (en) * | 2003-05-14 | 2006-02-08 | Cytokinetics, Inc. | Compounds, compositions and methods |
EP1622613A4 (en) * | 2003-05-14 | 2008-04-02 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
JP2007308406A (ja) * | 2006-05-17 | 2007-11-29 | Nisshin Kyorin Pharmaceutical Co Ltd | [1−[2−[4−[n−(5−メチルピリジン−2−イル)−2−フランカルボキサミド]ピペリジン−1−イル]エチル]シクロヘキシル]アセトヒドロキサム酸の製造方法及び精製方法 |
JP2010525013A (ja) * | 2007-04-23 | 2010-07-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのピリジン誘導体 |
WO2011030537A1 (ja) * | 2009-09-08 | 2011-03-17 | 杏林製薬株式会社 | 4-(5-メチルピリジン-2-イルアミノ)ピペリジン-1-カルボン酸誘導体の製造方法 |
CN102498108A (zh) * | 2009-09-08 | 2012-06-13 | 杏林制药株式会社 | 4-(5-甲基吡啶-2-基氨基)哌啶-1-甲酸衍生物的制造方法 |
Also Published As
Publication number | Publication date |
---|---|
PT1443046E (pt) | 2009-02-26 |
BR0213186A (pt) | 2004-08-10 |
CA2468529A1 (en) | 2003-05-01 |
ES2319879T3 (es) | 2009-05-14 |
EP1443046A1 (en) | 2004-08-04 |
EP1443046A4 (en) | 2005-11-16 |
US20050085508A1 (en) | 2005-04-21 |
CA2468529C (en) | 2011-03-01 |
JP4009251B2 (ja) | 2007-11-14 |
CN1326853C (zh) | 2007-07-18 |
EP1443046B1 (en) | 2008-12-17 |
KR20040039495A (ko) | 2004-05-10 |
KR100938369B1 (ko) | 2010-01-22 |
US20080194826A1 (en) | 2008-08-14 |
DK1443046T3 (da) | 2009-04-14 |
JPWO2003035645A1 (ja) | 2005-02-10 |
ATE417845T1 (de) | 2009-01-15 |
MXPA04003330A (es) | 2004-07-08 |
US7375115B2 (en) | 2008-05-20 |
DE60230437D1 (de) | 2009-01-29 |
CN1582286A (zh) | 2005-02-16 |
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