WO2003025553A3 - Analysegerät zur bestimmung der chemischen struktur und/oder zusammensetzung einer vielzahl von proben und träger zur aufnahme der proben - Google Patents

Analysegerät zur bestimmung der chemischen struktur und/oder zusammensetzung einer vielzahl von proben und träger zur aufnahme der proben Download PDF

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Publication number
WO2003025553A3
WO2003025553A3 PCT/DE2002/003424 DE0203424W WO03025553A3 WO 2003025553 A3 WO2003025553 A3 WO 2003025553A3 DE 0203424 W DE0203424 W DE 0203424W WO 03025553 A3 WO03025553 A3 WO 03025553A3
Authority
WO
WIPO (PCT)
Prior art keywords
layer
detector
samples
holder
analytical equipment
Prior art date
Application number
PCT/DE2002/003424
Other languages
English (en)
French (fr)
Other versions
WO2003025553A2 (de
Inventor
Michael Sander
Benjamin Wicks
Elisabeth Katherine Hill
Original Assignee
Leybold Optics Gmbh
Michael Sander
Benjamin Wicks
Elisabeth Katherine Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leybold Optics Gmbh, Michael Sander, Benjamin Wicks, Elisabeth Katherine Hill filed Critical Leybold Optics Gmbh
Priority to US10/489,368 priority Critical patent/US20050019217A1/en
Priority to DE20280249U priority patent/DE20280249U1/de
Priority to JP2003529132A priority patent/JP2005502896A/ja
Priority to DE10297670T priority patent/DE10297670D2/de
Priority to EP02769951A priority patent/EP1425569A2/de
Priority to AU2002336064A priority patent/AU2002336064A1/en
Publication of WO2003025553A2 publication Critical patent/WO2003025553A2/de
Publication of WO2003025553A3 publication Critical patent/WO2003025553A3/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Die Erfindung beruht auf dem Problem, ein effektiv arbeitendes Analysegerät für Reihenuntersuchungen z.B. an genetischem Material zu schaffen. Eine bevorzugt eingesetzte Methode sind Fluoreszenz- oder Luminiszenz-Verfahren. Damit ein guter Signal-Rausch-Abstand vorliegt, ist es notwendig, das Anregungslicht vom Detektor fernzuhalten und das Emissionslicht möglichst auf diesen zu bündeln. Die Erfindung sieht dazu einen Träger für die zu untersuchenden Proben vor, der mit einer optisch aktiven Schicht versehen ist, wobei diese Schicht für das Emissionslicht reflektierend und für das Anregungslicht transparent ist. Wenn z.B. der Probenaufnahmenschacht eines Probenträgers mit einer solchen Schicht ausgekeidet ist, wird das Emissionslicht an den Wänden und dem Boden des Schachtes reflektiert und auf einen Detektor gerichtet. Das Anregungslicht tritt, soweit es nicht zur Molekülanregung beiträgt, durch die Schicht hindurch und wird im Träger absorbiert.
PCT/DE2002/003424 2001-09-14 2002-09-16 Analysegerät zur bestimmung der chemischen struktur und/oder zusammensetzung einer vielzahl von proben und träger zur aufnahme der proben WO2003025553A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/489,368 US20050019217A1 (en) 2001-09-14 2002-09-16 Analytical equipment for determining the chemical structure and/or composition of a plurality of samples and sample holder
DE20280249U DE20280249U1 (de) 2001-09-14 2002-09-16 Analysegerät zur Bestimmung der chemischen Struktur und/oder Zusammensetzung einer Vielzahl von Proben und Träger zur Aufnahme der Proben
JP2003529132A JP2005502896A (ja) 2001-09-14 2002-09-16 複数のサンプルの化学的な構造および／または組成を求める方法およびサンプルホルダ
DE10297670T DE10297670D2 (de) 2001-09-14 2002-09-16 Analysegerät zur Bestimmung der chemischen Struktur und/oder Zusammensetzung einer Vielzahl von Proben und Träger zur Aufnahme der Proben
EP02769951A EP1425569A2 (de) 2001-09-14 2002-09-16 Analysegerät zur bestimmung der chemischen struktur und/oder zusammensetzung einer vielzahl von proben und träger zur aufnahme der proben
AU2002336064A AU2002336064A1 (en) 2001-09-14 2002-09-16 Analytical equipment for determining the chemical structure and/or composition of a plurality of samples and sample holder

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0122286.8A GB0122286D0 (en) 2001-09-14 2001-09-14 Optical coatings for high-throughput laboratory consumables
GB0122286.8 2001-09-14

Publications (2)

Publication Number Publication Date
WO2003025553A2 WO2003025553A2 (de) 2003-03-27
WO2003025553A3 true WO2003025553A3 (de) 2003-10-16

Family

ID=9922127

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/003424 WO2003025553A2 (de) 2001-09-14 2002-09-16 Analysegerät zur bestimmung der chemischen struktur und/oder zusammensetzung einer vielzahl von proben und träger zur aufnahme der proben

Country Status (8)

Country Link
US (1) US20050019217A1 (de)
EP (1) EP1425569A2 (de)
JP (1) JP2005502896A (de)
CN (1) CN1555485A (de)
AU (1) AU2002336064A1 (de)
DE (2) DE20280249U1 (de)
GB (1) GB0122286D0 (de)
WO (1) WO2003025553A2 (de)

Families Citing this family (12)

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TWI329208B (en) 2003-06-03 2010-08-21 Oerlikon Trading Ag Optical substrate for enhanced detectability of fluorescence
US7285789B2 (en) 2003-06-06 2007-10-23 Oc Oerlikon Balzers Ag Optical device for surface-generated fluorescence
JP3978153B2 (ja) * 2003-06-12 2007-09-19 富士フイルム株式会社 光干渉基材、標的検出用基材、並びに、標的検出装置及び標的検出方法
EP1529567A3 (de) * 2003-11-07 2005-05-25 Herbener, Heinz-Gerd Probenträger mit einer Reaktionskammer
US7682816B2 (en) * 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
US20080260586A1 (en) * 2005-11-07 2008-10-23 Koninklijke Philips Electronics, N.V. Pillar Based Biosensor and Method of Making the Same
FR2893415A1 (fr) * 2005-11-15 2007-05-18 Commissariat Energie Atomique Biopuce a rapport signal fluorescent/signal parasite ameliore
WO2009067513A1 (en) * 2007-11-20 2009-05-28 3M Innovative Properties Company Sample preparation container and method
JP2011038922A (ja) * 2009-08-12 2011-02-24 Sony Corp 光検出用チップおよび該光検出用チップを用いた光検出装置
DE102010001714A1 (de) * 2010-02-09 2011-08-11 Robert Bosch GmbH, 70469 Vorrichtung und Verfahren zur optischen Parallelanalyse einer Probenanordnung und entsprechendes Herstellungsverfahren
JP5487127B2 (ja) * 2011-01-14 2014-05-07 富士フイルム株式会社 測定装置およびセンサチップ
CN110218628B (zh) * 2019-06-19 2021-01-29 中国科学院半导体研究所 一种数字pcr芯片及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0266430A (ja) * 1988-09-01 1990-03-06 Agency Of Ind Science & Technol 蛍光測定用試料保持体
WO1994021379A1 (en) * 1993-03-16 1994-09-29 Westaim Technologies Inc. Enhanced microtitre plate and immunoassays conducted therein
US6171780B1 (en) * 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
WO2002016912A1 (fr) * 2000-08-21 2002-02-28 Genewave Dispositif de support d'elements chromophores
WO2002099395A1 (en) * 2001-06-02 2002-12-12 Techelan Article comprising ir-reflective multi-well plates

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US3630809A (en) * 1965-01-04 1971-12-28 Monsanto Co Pellucid laminates
US3637294A (en) * 1969-12-19 1972-01-25 Bell Telephone Labor Inc Interference filter with alternately designed pairs of dielectric layers
US3679291A (en) * 1970-04-21 1972-07-25 Optical Coating Laboratory Inc Filter with neutral transmitting multilayer coating having asymmetric reflectance
US4012119A (en) * 1975-12-12 1977-03-15 Xerox Corporation Direct current liquid crystal display with highly reflecting dielectric mirror
US5166784A (en) * 1985-10-25 1992-11-24 Canon Kabushiki Kaisha Original reading apparatus, having a filter, for reading a color original
US4924870A (en) * 1989-01-13 1990-05-15 Fiberoptic Sensor Technologies, Inc. Fiber optic sensors
US5099359A (en) * 1990-09-11 1992-03-24 Eastman Kodak Company Composite optical interference filter for use in film scanner system
FI109730B (fi) * 1998-06-18 2002-09-30 Janesko Oy Sovitelma pH:n tai muun väriaineindikaattoreilla ilmaistavissa olevan kemiallisen ominaisuuden mittauksen yhteydessä
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0266430A (ja) * 1988-09-01 1990-03-06 Agency Of Ind Science & Technol 蛍光測定用試料保持体
WO1994021379A1 (en) * 1993-03-16 1994-09-29 Westaim Technologies Inc. Enhanced microtitre plate and immunoassays conducted therein
US6171780B1 (en) * 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
WO2002016912A1 (fr) * 2000-08-21 2002-02-28 Genewave Dispositif de support d'elements chromophores
WO2002099395A1 (en) * 2001-06-02 2002-12-12 Techelan Article comprising ir-reflective multi-well plates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 014, no. 249 (P - 1053) 28 May 1990 (1990-05-28) *

Also Published As

Publication number Publication date
DE20280249U1 (de) 2004-06-09
WO2003025553A2 (de) 2003-03-27
EP1425569A2 (de) 2004-06-09
CN1555485A (zh) 2004-12-15
DE10297670D2 (de) 2005-02-10
GB0122286D0 (en) 2001-11-07
US20050019217A1 (en) 2005-01-27
JP2005502896A (ja) 2005-01-27
AU2002336064A1 (en) 2003-04-01

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