WO2003024467A1 - Compositions comprenant des plantes determinees et medicaments et aliments de sante comprenant ces compositions en tant qu'ingredients actifs - Google Patents

Compositions comprenant des plantes determinees et medicaments et aliments de sante comprenant ces compositions en tant qu'ingredients actifs Download PDF

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Publication number
WO2003024467A1
WO2003024467A1 PCT/JP2002/009484 JP0209484W WO03024467A1 WO 2003024467 A1 WO2003024467 A1 WO 2003024467A1 JP 0209484 W JP0209484 W JP 0209484W WO 03024467 A1 WO03024467 A1 WO 03024467A1
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Prior art keywords
compositions
foods
hachimi
jio
gan
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Application number
PCT/JP2002/009484
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English (en)
Japanese (ja)
Inventor
Torao Ishida
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School Juridical Person, Suzuka Univesity Of Medical Science
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Publication of WO2003024467A1 publication Critical patent/WO2003024467A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention vise des compositions dont l'effet médicamenteux est supérieur à celui de Hachimi-jio-gan (formule chinoise ancienne à base d'herbes médicinales) et des médicaments préventifs et thérapeutiques dirigés contre l'ostéoporose, l'hyperlipémie ou le diabète ainsi que des aliments de santé qui ont un effet médicamenteux supérieur à celui de Hachimi-jio-gan. A cet effet, nous avons développé des compositions comprenant des plantes fraîches, des plantes séchées ou des extraits d'au moins une plante sélectionnée dans le groupe comprenant Rehmannia de Scrophulariaceae, Cornus de Cornaceae, Diosorea de Discoreaceae, Alisma de Alismataceae, Poria de Poyporaceae, Paeonia de Paeoniaceae, Cinnamomum de Lauraceae et Aconitum de Ranunculaceae, et au moins une plante sélectionnée dans le groupe comprenant Angerica, Lingusticum et Levisticum d'Apiaceae, Salvia de Lamiacea, Panax d'Araliaceae, Codonopsis de Capanulaceae et Atractylodes d'Asteraceae ainsi que des médicaments préventifs et thérapeutiques dirigés contre l'ostéoporose, l'hyperlipémie ou le diabète ainsi que des aliments de santé qui comprennent ces compositions en tant qu'ingrédients actifs. Il a été confirmé que ces compositions inhibent de façon remarquable la baisse de la densité osseuse dans la région lombaire et augmentent de façon remarquable la densité osseuse réduite dans la région lombaire, qu'elles inhibent une augmentation globale du taux de cholestérol dans le plasma et diminuent le taux de cholestérol accru dans le plasma ou qu'elles inhibent une augmentation du taux de glucose dans le sang et abaissent le taux de glucose accru dans le sang, le tout comparé à Hachimi-jio-gan.
PCT/JP2002/009484 2001-09-17 2002-09-17 Compositions comprenant des plantes determinees et medicaments et aliments de sante comprenant ces compositions en tant qu'ingredients actifs WO2003024467A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001/281161 2001-09-17
JP2001281161 2001-09-17
JP2001293336 2001-09-26
JP2001/293361 2001-09-26
JP2001/293336 2001-09-26
JP2001293361 2001-09-26

Publications (1)

Publication Number Publication Date
WO2003024467A1 true WO2003024467A1 (fr) 2003-03-27

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091030A1 (fr) * 2005-02-23 2006-08-31 Oscotec Inc. Extrait de melange de plantes medicinales de rehmanniae radix preparata et d'acanthopanacis cortex et composition en comportant pour la prevention et le traitement de l'osteoporose
CN102512505A (zh) * 2011-11-29 2012-06-27 郑星有 一种治疗骨刺的中成药
CN102552468A (zh) * 2011-12-28 2012-07-11 蚌埠丰原涂山制药有限公司 一种治疗高血脂的中药组合物
CN108403883A (zh) * 2018-05-29 2018-08-17 李豫杰 用于治疗风湿、类风湿病的中药熏蒸组合物及其制备方法
CN108434276A (zh) * 2018-05-23 2018-08-24 尹璐 一种具有降血脂功能的中药组合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06321795A (ja) * 1993-05-07 1994-11-22 Kuga Takaaki アトピー性皮膚炎等の皮膚疾患治療薬
JPH07109225A (ja) * 1992-09-09 1995-04-25 Maruho Kk 骨強度増強及び骨石灰化作用剤
JPH0892069A (ja) * 1994-07-22 1996-04-09 Shizuoka Pref Gov Bussan Koeki Kk 蜜 丸
JPH0923851A (ja) * 1995-07-14 1997-01-28 Moritani Kenko Shokuhin Kk 安眠用健康食品
JPH10109931A (ja) * 1996-10-07 1998-04-28 Taisho Pharmaceut Co Ltd 生薬類配合固形組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07109225A (ja) * 1992-09-09 1995-04-25 Maruho Kk 骨強度増強及び骨石灰化作用剤
JPH06321795A (ja) * 1993-05-07 1994-11-22 Kuga Takaaki アトピー性皮膚炎等の皮膚疾患治療薬
JPH0892069A (ja) * 1994-07-22 1996-04-09 Shizuoka Pref Gov Bussan Koeki Kk 蜜 丸
JPH0923851A (ja) * 1995-07-14 1997-01-28 Moritani Kenko Shokuhin Kk 安眠用健康食品
JPH10109931A (ja) * 1996-10-07 1998-04-28 Taisho Pharmaceut Co Ltd 生薬類配合固形組成物

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KANEKO HITOSHI ET AL.: "Studies on improving effect on unidentified complaints by combined therapy using hachimijiougan and red ginseng", WAKAN YAKU GAKKAISHI, vol. 6, no. 3, 1989, pages 542 - 543, XP002966828 *
NISHINA FUMIO ET AL.: "The effects of hachimijiogan and on lumbar osteoporosis", KANPO SHINRYO, vol. 6, no. 5, 1987, pages 36 - 39, XP002966825 *
TANI TADATO: "Current medical treatment and Chinese medicines. 25. Crude drugs for control of diabetes mellitus", IYAKU JANARU, vol. 23, no. 6, 1987, pages 1247 - 1253, XP002966829 *
TOHARA S. ET AL.: "Trial with kanpo cure for osteoporosis", PHARMA. MED., vol. 14, no. 10, 1996, pages 168 - 169, XP002966826 *
YAMAMOTO MASAHIRO ET AL.: "Multicenter clinical trials on the improving effect of Panax ginsengin addution to 3 traditional formulae as hachimijio-gan, touki-shakuyaku-san or keishi-bukuryou-gan in patients with various complaints", THERAPEUTIC RESEARCH, vol. 21, no. 3, 2000, pages 657 - 667, XP002966827 *
YAMAMOTO MASAHIRO: "Hypolipidemic drugs. Drug therapy from metabolism and pathological features. Hypolipidemic druge", J. ORIENTAL DRUG, CHIRYOGAKU, vol. 18, no. 5, 1987, pages 657 - 660, XP002966830 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006091030A1 (fr) * 2005-02-23 2006-08-31 Oscotec Inc. Extrait de melange de plantes medicinales de rehmanniae radix preparata et d'acanthopanacis cortex et composition en comportant pour la prevention et le traitement de l'osteoporose
US8053001B2 (en) 2005-02-23 2011-11-08 Oscotec Inc. Herbal mixture extract of Rehmanniae radix preparata and Acanthopanacis cortex and a composition comprising the same for prevention and treatment of osteoporosis
CN102512505A (zh) * 2011-11-29 2012-06-27 郑星有 一种治疗骨刺的中成药
CN102552468A (zh) * 2011-12-28 2012-07-11 蚌埠丰原涂山制药有限公司 一种治疗高血脂的中药组合物
CN108434276A (zh) * 2018-05-23 2018-08-24 尹璐 一种具有降血脂功能的中药组合物
CN108403883A (zh) * 2018-05-29 2018-08-17 李豫杰 用于治疗风湿、类风湿病的中药熏蒸组合物及其制备方法

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