WO2003016302A1 - Derives de diamine - Google Patents

Derives de diamine Download PDF

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Publication number
WO2003016302A1
WO2003016302A1 PCT/JP2002/008119 JP0208119W WO03016302A1 WO 2003016302 A1 WO2003016302 A1 WO 2003016302A1 JP 0208119 W JP0208119 W JP 0208119W WO 03016302 A1 WO03016302 A1 WO 03016302A1
Authority
WO
WIPO (PCT)
Prior art keywords
thrombosis
following
infarction
represent
same
Prior art date
Application number
PCT/JP2002/008119
Other languages
English (en)
French (fr)
Inventor
Toshiharu Ohta
Satoshi Komoriya
Toshiharu Yoshino
Kouichi Uoto
Yumi Nakamoto
Hiroyuki Naito
Akiyoshi Mochizuki
Tsutomu Nagata
Hideyuki Kanno
Noriyasu Haginoya
Kenji Yoshikawa
Masatoshi Nagamochi
Syozo Kobayashi
Makoto Ono
Original Assignee
Daiichi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2002/002683 external-priority patent/WO2003000657A1/ja
Priority claimed from PCT/JP2002/006141 external-priority patent/WO2003000680A1/ja
Priority to IL16020402A priority Critical patent/IL160204A0/xx
Priority to ES02762760T priority patent/ES2383749T3/es
Priority to BR0211565-4A priority patent/BR0211565A/pt
Priority to AT02762760T priority patent/ATE556066T1/de
Priority to MXPA04001272A priority patent/MXPA04001272A/es
Priority to AU2002328596A priority patent/AU2002328596B2/en
Priority to RU2004106625/04A priority patent/RU2314303C2/ru
Priority to CNB02819652XA priority patent/CN100545160C/zh
Application filed by Daiichi Pharmaceutical Co., Ltd. filed Critical Daiichi Pharmaceutical Co., Ltd.
Priority to CA002456841A priority patent/CA2456841A1/en
Priority to JP2003521226A priority patent/JP4331595B2/ja
Priority to EP02762760A priority patent/EP1415992B1/en
Priority to KR1020047001827A priority patent/KR100908966B1/ko
Publication of WO2003016302A1 publication Critical patent/WO2003016302A1/ja
Priority to IL160204A priority patent/IL160204A/en
Priority to NO20040557A priority patent/NO327003B1/no
Priority to US10/773,344 priority patent/US7342014B2/en
Priority to HK07102898.2A priority patent/HK1095814A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
PCT/JP2002/008119 2001-06-20 2002-08-08 Derives de diamine WO2003016302A1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
EP02762760A EP1415992B1 (en) 2001-08-09 2002-08-08 Diamine derivatives
KR1020047001827A KR100908966B1 (ko) 2001-08-09 2002-08-08 디아민 유도체
CA002456841A CA2456841A1 (en) 2001-08-09 2002-08-08 Cyclohexyl and piperidine diamine derivatives useful as activated blood coagulation factor x inhibitors
BR0211565-4A BR0211565A (pt) 2001-08-09 2002-08-08 Derivados de diamina
AT02762760T ATE556066T1 (de) 2001-08-09 2002-08-08 Diaminderivate
MXPA04001272A MXPA04001272A (es) 2001-08-09 2002-08-08 Derivados de diamina.
AU2002328596A AU2002328596B2 (en) 2001-08-09 2002-08-08 Diamine derivatives
RU2004106625/04A RU2314303C2 (ru) 2001-08-09 2002-08-08 Производные диамина
CNB02819652XA CN100545160C (zh) 2001-08-09 2002-08-08 二胺衍生物
IL16020402A IL160204A0 (en) 2001-08-09 2002-08-08 Diamine derivatives
ES02762760T ES2383749T3 (es) 2001-08-09 2002-08-08 Derivados de diamina
JP2003521226A JP4331595B2 (ja) 2001-08-09 2002-08-08 ジアミン誘導体
IL160204A IL160204A (en) 2001-08-09 2004-02-04 DIAMINE DERIVATIVES, SALTS THEREOF AND SOLVATES AND N-OXIDES THEREOF WHICH EXIBIT POTENT FXa-INHIBITING EFFECT AND ANTICOAGULANT EFFECT
NO20040557A NO327003B1 (no) 2001-08-09 2004-02-06 Diamin-derivater, medisinsk preparat omfattende slike, slike forbindelser for anvendelse som legemiddel samt anvendelse av disse for fremstilling av middel for forebygging og behandling av sykdom.
US10/773,344 US7342014B2 (en) 2001-06-20 2004-02-09 Diamine derivatives
HK07102898.2A HK1095814A1 (en) 2001-08-09 2007-03-19 Diamine derivatives

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
JP2001-243046 2001-08-09
JP2001243046 2001-08-09
JP2001-311808 2001-10-09
JP2001311808 2001-10-09
JP2001398708 2001-12-28
JP2001-398708 2001-12-28
JPPCT/JP02/02683 2002-03-20
PCT/JP2002/002683 WO2003000657A1 (fr) 2001-06-20 2002-03-20 Derives de diamine
PCT/JP2002/006141 WO2003000680A1 (fr) 2001-06-20 2002-06-20 Derives de diamine
JPPCT/JP02/06141 2002-06-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/773,344 Continuation-In-Part US7342014B2 (en) 2001-06-20 2004-02-09 Diamine derivatives

Publications (1)

Publication Number Publication Date
WO2003016302A1 true WO2003016302A1 (fr) 2003-02-27

Family

ID=32600712

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008119 WO2003016302A1 (fr) 2001-06-20 2002-08-08 Derives de diamine

Country Status (16)

Country Link
EP (1) EP1415992B1 (ja)
JP (1) JP4331595B2 (ja)
KR (1) KR100908966B1 (ja)
CN (1) CN100545160C (ja)
AT (1) ATE556066T1 (ja)
AU (1) AU2002328596B2 (ja)
BR (1) BR0211565A (ja)
CA (1) CA2456841A1 (ja)
ES (1) ES2383749T3 (ja)
HK (1) HK1095814A1 (ja)
IL (2) IL160204A0 (ja)
MX (1) MXPA04001272A (ja)
NO (1) NO327003B1 (ja)
PL (1) PL368402A1 (ja)
RU (1) RU2314303C2 (ja)
WO (1) WO2003016302A1 (ja)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1577301A1 (en) * 2002-12-25 2005-09-21 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
US7192968B2 (en) 2000-04-05 2007-03-20 Daiichi Pharmaceutical Co., Ltd. Ethylenediamine derivatives
WO2007032498A1 (ja) * 2005-09-16 2007-03-22 Daiichi Sankyo Company, Limited 光学活性なジアミン誘導体およびその製造方法
US7291615B2 (en) 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
WO2008026563A1 (fr) 2006-08-30 2008-03-06 Shionogi & Co., Ltd. Dérivé d'hydrazine amide
US7378409B2 (en) 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
WO2008129846A1 (ja) 2007-03-29 2008-10-30 Daiichi Sankyo Company, Limited 医薬組成物
US7547786B2 (en) 2003-11-12 2009-06-16 Daiichi Sankyo Company, Limited Process for producing thiazole derivative
WO2010067824A1 (ja) 2008-12-12 2010-06-17 第一三共株式会社 光学活性カルボン酸の製造方法
WO2010071121A1 (ja) 2008-12-17 2010-06-24 第一三共株式会社 ジアミン誘導体の製造方法
WO2010082531A1 (ja) 2009-01-13 2010-07-22 第一三共株式会社 活性化血液凝固因子阻害剤
WO2010104078A1 (ja) 2009-03-10 2010-09-16 第一三共株式会社 ジアミン誘導体の製造方法
WO2010104106A1 (ja) 2009-03-13 2010-09-16 第一三共株式会社 光学活性なジアミン誘導体の製造方法
WO2010131663A1 (ja) * 2009-05-15 2010-11-18 第一三共株式会社 オキサミド誘導体
WO2010147169A1 (ja) 2009-06-18 2010-12-23 第一三共株式会社 溶出性の改善された医薬組成物
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7893098B2 (en) 2003-12-29 2011-02-22 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
WO2011059080A1 (ja) * 2009-11-16 2011-05-19 第一三共株式会社 同位体置換されたジアミン誘導体
WO2011102504A1 (ja) 2010-02-22 2011-08-25 第一三共株式会社 経口用徐放性固形製剤
WO2011102506A1 (ja) 2010-02-22 2011-08-25 第一三共株式会社 経口用徐放性固形製剤
WO2011102505A1 (ja) 2010-02-22 2011-08-25 第一三共株式会社 経口用徐放性固形製剤
WO2011115066A1 (ja) 2010-03-19 2011-09-22 第一三共株式会社 ジアミン誘導体の結晶およびその製造方法
WO2011115067A1 (ja) 2010-03-19 2011-09-22 第一三共株式会社 抗凝固剤の溶出改善方法
US8053603B2 (en) 2006-01-06 2011-11-08 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
WO2011149110A1 (en) 2010-05-28 2011-12-01 Daiichi Sankyo Company, Limited Novel composition for the prevention and/or treatment of thromboembolism
WO2012002538A1 (ja) 2010-07-02 2012-01-05 第一三共株式会社 光学活性ジアミン誘導体の塩の製造方法
US8097760B2 (en) 2006-03-31 2012-01-17 Sunovion Pharmacuticals Inc. Preparation of chiral amides and amines
WO2012017932A1 (ja) 2010-08-04 2012-02-09 第一三共株式会社 ニトロキシドラジカル化合物を反応触媒とする新規ザンドマイヤー様反応成績体の製造法
WO2013022059A1 (ja) 2011-08-10 2013-02-14 第一三共株式会社 ジアミン誘導体含有医薬組成物
US8669291B2 (en) 2007-05-31 2014-03-11 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
WO2014157612A1 (ja) 2013-03-29 2014-10-02 第一三共株式会社 （１ｓ，４ｓ，５ｓ）－４－ブロモ－６－オキサビシクロ［３．２．１］オクタン－７－オンの製造方法
WO2014157653A1 (ja) 2013-03-29 2014-10-02 第一三共株式会社 光学活性ジアミン誘導体の製造方法
US8877975B2 (en) 2006-01-06 2014-11-04 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
WO2015125710A1 (ja) * 2014-02-18 2015-08-27 第一三共株式会社 活性化血液凝固第Ｘ因子（ＦＸａ）の阻害薬の製造方法
US9827199B2 (en) 2012-09-03 2017-11-28 Daiichi Sankyo Company, Limited Hydromorphone hydrochloride-containing oral sustained-release pharmaceutical composition
JP2017210468A (ja) * 2016-05-23 2017-11-30 宇部興産株式会社 ヨードラクトン化合物の製造方法
JP2018058809A (ja) * 2016-06-24 2018-04-12 宇部興産株式会社 オキサビシクロオクタン化合物の製造方法
WO2022129535A1 (en) 2020-12-18 2022-06-23 Krka, D.D., Novo Mesto Edoxaban formulation containing no sugar alcohols

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Publication number Priority date Publication date Assignee Title
WO2003000657A1 (fr) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
WO2003000680A1 (fr) * 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
CN106467475A (zh) * 2016-08-29 2017-03-01 上海大学 邻位双叠氮化合物的制备方法
CN107573256B (zh) * 2017-09-26 2020-02-21 安徽国星生物化学有限公司 一种对氯苯肼盐酸盐连续化生产方法及其装置
CN111138357B (zh) * 2018-11-06 2022-11-04 天津药物研究院有限公司 2-氧代-1，2-二氢喹啉类衍生物、其制备方法及其在医药上的应用
CN111606827B (zh) * 2020-06-23 2022-10-25 内蒙古京东药业有限公司 一种制备依度沙班手性胺中间体的方法
CN111763222B (zh) * 2020-08-03 2021-05-25 珠海市海瑞德新材料科技有限公司 用于制备依度沙班游离碱的中间体及其制备方法和应用

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