WO2002063961A1 - Composition and methods for modulation of vascular structure and/or function - Google Patents
Composition and methods for modulation of vascular structure and/or function Download PDFInfo
- Publication number
- WO2002063961A1 WO2002063961A1 PCT/US2002/003792 US0203792W WO02063961A1 WO 2002063961 A1 WO2002063961 A1 WO 2002063961A1 US 0203792 W US0203792 W US 0203792W WO 02063961 A1 WO02063961 A1 WO 02063961A1
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- Prior art keywords
- glcnac
- acetylglucosamine
- semi
- daltons
- endothelin
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Classifications
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K9/7007—Drug-containing films, membranes or sheets
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
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- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
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- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
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- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (12)
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AU2002306455A AU2002306455B2 (en) | 2001-02-12 | 2002-02-08 | Composition and methods for modulation of vascular structure and/or function |
ES02740104T ES2456695T3 (es) | 2001-02-12 | 2002-02-08 | Composiciones y procedimientos para la modulación de la estructura y/o función vascular |
CA 2437812 CA2437812C (en) | 2001-02-12 | 2002-02-08 | Compositions and methods for modulation of vascular structure and/or function |
NZ527872A NZ527872A (en) | 2001-02-12 | 2002-02-08 | Composition and methods for modulation of vascular structure and/or function with a material comprising semi- crystalline poly-beta-1-4 N-acetylglucosasmine (p-GlcNac) polymers |
JP2002563772A JP5303088B2 (ja) | 2001-02-12 | 2002-02-08 | 血管構造及び/または機能のモジュレーションのための組成物及び方法 |
MXPA03007176A MXPA03007176A (es) | 2001-02-12 | 2002-02-08 | Composicion y metodos para la modulacion de la estructura y/o funcion vascular. |
DK02740104T DK1365651T3 (da) | 2001-02-12 | 2002-02-08 | Sammensætning og fremgangsmåder til modulation af vaskulær struktur og/eller funktion |
EP20020740104 EP1365651B1 (en) | 2001-02-12 | 2002-02-08 | Composition and methods for modulation of vascular structure and/or function |
IL15732702A IL157327A0 (en) | 2001-02-12 | 2002-02-08 | Composition and methods for modulation of vascular structure and/or function |
IL15732703A IL157327A (en) | 2001-02-12 | 2003-08-11 | Use of n-acetylglucosamine polymers for the preparation of medicaments for modulation of vascular structure and/or function |
AU2007251899A AU2007251899B2 (en) | 2001-02-12 | 2007-12-20 | Compositions and methods for modulation of vascular structure and/or function |
AU2011200400A AU2011200400B2 (en) | 2001-02-12 | 2011-01-31 | Compositions and methods for modulation of vascular structure and/or function |
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US09/781,182 US7041657B2 (en) | 2001-02-12 | 2001-02-12 | Compositions and methods for modulation of vascular structure and/or function |
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WO2002063961B1 WO2002063961B1 (en) | 2003-03-06 |
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PCT/US2002/003792 WO2002063961A1 (en) | 2001-02-12 | 2002-02-08 | Composition and methods for modulation of vascular structure and/or function |
Country Status (12)
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2007504918A (ja) * | 2003-09-12 | 2007-03-08 | マリン ポリマー テクノロジーズ,インコーポレーテッド | 血液透析患者における血管アクセスの保存 |
US7285266B2 (en) | 2003-02-24 | 2007-10-23 | Marine Polymer Technologies, Inc. | Cell-polymer fiber compositions and uses thereof |
US7931637B2 (en) | 2002-12-31 | 2011-04-26 | Marine Polymer Technologies, Inc. | Hemostatic compositions and uses therefor |
US8481512B2 (en) | 2001-02-12 | 2013-07-09 | Marine Polymer Technologies, Inc. | Compositions and methods for modulation of vascular structure and/or function |
US9642871B2 (en) | 2010-04-15 | 2017-05-09 | Marine Polymer Technologies, Inc. | Anti-bacterial applications of poly-N-acetylglucosamine nanofibers |
US10383971B2 (en) | 2007-02-19 | 2019-08-20 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
US10765698B2 (en) | 2011-04-15 | 2020-09-08 | Marine Polymer Technologies, Inc. | Treatment of disease with poly-N-acetylglucosamine nanofibers |
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US6743783B1 (en) * | 1993-12-01 | 2004-06-01 | Marine Polymer Technologies, Inc. | Pharmaceutical compositions comprising poly-β-1→4-N-acetylglucosamine |
US5858350A (en) | 1993-12-01 | 1999-01-12 | Marine Polymer Technologies | Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system |
US8613772B2 (en) * | 2003-04-21 | 2013-12-24 | Rsb Spine Llc | Lateral mount implant device |
US7803182B2 (en) * | 2004-05-28 | 2010-09-28 | Cordis Corporation | Biodegradable vascular device with buffering agent |
US7785615B2 (en) * | 2004-05-28 | 2010-08-31 | Cordis Corporation | Biodegradable medical implant with encapsulated buffering agent |
US20070031468A1 (en) * | 2005-08-04 | 2007-02-08 | Endomedix, Inc. | Modified chitosan for vascular embolization |
US20070031467A1 (en) * | 2005-08-04 | 2007-02-08 | Abrahams John M | Composition and method for vascular embolization |
US7854923B2 (en) * | 2006-04-18 | 2010-12-21 | Endomedix, Inc. | Biopolymer system for tissue sealing |
US20080075657A1 (en) * | 2006-04-18 | 2008-03-27 | Abrahams John M | Biopolymer system for tissue sealing |
US20070243130A1 (en) * | 2006-04-18 | 2007-10-18 | Weiliam Chen | Biopolymer system for tissue sealing |
US20090010982A1 (en) * | 2006-04-18 | 2009-01-08 | Endomedix, Inc. | Biocompatible adherent sheet for tissue sealing |
US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
NZ599338A (en) | 2007-06-27 | 2013-11-29 | Marinepolymer Tech Inc | Complexes of il-15 and il-15ralpha and uses thereof |
US8486033B2 (en) | 2007-07-18 | 2013-07-16 | Marine Polymer Technologies, Inc. | Application of polymeric materials to screens to facilitate hemostasis and wound healing |
US20130096518A1 (en) | 2007-12-06 | 2013-04-18 | Smith & Nephew Plc | Wound filling apparatuses and methods |
US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
US9566256B2 (en) | 2008-09-22 | 2017-02-14 | Biochemics, Inc. | Transdermal drug delivery using an osmolyte and vasoactive agent |
EP2352543B1 (en) | 2008-12-04 | 2019-04-03 | BioChemics, Inc. | Methods and compositions for tattoo removal |
CA2780898A1 (en) | 2009-11-13 | 2011-05-19 | University Of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
WO2014160136A1 (en) | 2013-03-13 | 2014-10-02 | University Of Maryland, Office Of Technology Commercialization | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
NZ729181A (en) | 2013-03-14 | 2018-11-30 | Marine Polymer Tech Inc | Treatment of disease with poly-n-acetylglucosamine nanofibers |
US10517988B1 (en) | 2018-11-19 | 2019-12-31 | Endomedix, Inc. | Methods and compositions for achieving hemostasis and stable blood clot formation |
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