WO2002060890A1 - Nouvelles substances physiologiquement actives - Google Patents

Nouvelles substances physiologiquement actives Download PDF

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Publication number
WO2002060890A1
WO2002060890A1 PCT/JP2002/000848 JP0200848W WO02060890A1 WO 2002060890 A1 WO2002060890 A1 WO 2002060890A1 JP 0200848 W JP0200848 W JP 0200848W WO 02060890 A1 WO02060890 A1 WO 02060890A1
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WO
WIPO (PCT)
Prior art keywords
active substances
physiologically active
same
novel physiologically
producing
Prior art date
Application number
PCT/JP2002/000848
Other languages
English (en)
French (fr)
Inventor
Yoshiharu Mizui
Takashi Sakai
Satoshi Yamamoto
Keisuke Komeda
Masanori Fujita
Akifumi Okuda
Kumiko Kishi
Jun Niijima
Mitsuo Nagai
Kiyoshi Okamoto
Masao Iwata
Yoshihiko Kotake
Toshimitsu Uenaka
Naoki Asai
Motoko Matsufuji
Tomohiro Sameshima
Naoto Kawamura
Kazuyuki Dobashi
Takashi Nakashima
Masashi Yoshida
Toshio Tsuchida
Susumu Takeda
Tomonari Yamada
Koji Norihisa
Takao Yamori
Original Assignee
Mercian Corporation
Eisai Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercian Corporation, Eisai Co., Ltd. filed Critical Mercian Corporation
Priority to EP02711280A priority Critical patent/EP1380579A4/en
Priority to CA2436667A priority patent/CA2436667C/en
Priority to JP2002561040A priority patent/JP4439181B2/ja
Priority to KR1020037009709A priority patent/KR101115364B1/ko
Priority to US10/470,806 priority patent/US7026352B1/en
Priority to CN028041879A priority patent/CN1489583B/zh
Publication of WO2002060890A1 publication Critical patent/WO2002060890A1/ja
Priority to US11/213,962 priority patent/US7667052B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PCT/JP2002/000848 2001-02-01 2002-02-01 Nouvelles substances physiologiquement actives WO2002060890A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP02711280A EP1380579A4 (en) 2001-02-01 2002-02-01 NEW PHYSIOLOGICALLY EFFECTIVE SUBSTANCES
CA2436667A CA2436667C (en) 2001-02-01 2002-02-01 Novel bioactive substance
JP2002561040A JP4439181B2 (ja) 2001-02-01 2002-02-01 新規生理活性物質
KR1020037009709A KR101115364B1 (ko) 2001-02-01 2002-02-01 신규한 생리 활성 물질
US10/470,806 US7026352B1 (en) 2001-02-01 2002-02-01 Physiologically active substances
CN028041879A CN1489583B (zh) 2001-02-01 2002-02-01 一种生理活性物质
US11/213,962 US7667052B2 (en) 2001-02-01 2005-08-30 Bioactive substance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001025458 2001-02-01
JP2001-25458 2001-02-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/213,962 Division US7667052B2 (en) 2001-02-01 2005-08-30 Bioactive substance

Publications (1)

Publication Number Publication Date
WO2002060890A1 true WO2002060890A1 (fr) 2002-08-08

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ID=18890441

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Application Number Title Priority Date Filing Date
PCT/JP2002/000848 WO2002060890A1 (fr) 2001-02-01 2002-02-01 Nouvelles substances physiologiquement actives

Country Status (9)

Country Link
US (2) US7026352B1 (ja)
EP (3) EP2292610B1 (ja)
JP (1) JP4439181B2 (ja)
KR (2) KR101115364B1 (ja)
CN (1) CN1489583B (ja)
CA (1) CA2436667C (ja)
ES (1) ES2477240T3 (ja)
TW (2) TWI312681B (ja)
WO (1) WO2002060890A1 (ja)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003099813A1 (fr) 2002-05-29 2003-12-04 Mercian Corporation Nouvelles substances physiologiquement actives
WO2004011459A1 (ja) * 2002-07-31 2004-02-05 Mercian Corporation 新規生理活性物質
WO2004011661A1 (ja) 2002-07-31 2004-02-05 Mercian Corporation 新規生理活性物質
WO2004050890A1 (ja) * 2002-11-29 2004-06-17 Mercian Corporation マクロライド系化合物の製造方法
WO2005052152A1 (ja) * 2003-11-27 2005-06-09 Mercian Corporation マクロライド系化合物の水酸化に関与するｄｎａ
WO2005073223A1 (ja) * 2004-01-29 2005-08-11 Eisai R & D Management Co., Ltd. マクロライド系化合物の安定化方法
WO2005075681A1 (ja) * 2004-02-06 2005-08-18 Eisai R & D Management Co., Ltd. 抗癌剤に対する癌細胞の感受性を検定する方法
WO2006009276A1 (ja) * 2004-07-20 2006-01-26 Eisai R & D Management Co., Ltd. プラジエノライドの生合成に関与するポリペプチドをコードするｄｎａ
WO2006126723A1 (ja) * 2005-05-26 2006-11-30 Eisai R & D Management Co., Ltd. 遺伝子組換え微生物およびそれらの微生物を用いるマクロライド系化合物の製造方法
WO2007043621A1 (ja) 2005-10-13 2007-04-19 Eisai R & D Management Co., Ltd. プラジエノライド ｂ及びプラジエノライド ｄの全合成方法
WO2008016187A1 (fr) 2006-08-02 2008-02-07 Eisai R & D Management Co., Ltd. Molécule cible de pladiénolide, composé capable de se lier à la molécule cible et procédé de criblage pour rechercher le composé
WO2008111466A1 (ja) 2007-03-05 2008-09-18 Eisai R & D Management Co., Ltd. 遺伝子の発現量減少を指標とする抗ガン剤の作用検定方法
WO2008111464A1 (ja) 2007-03-05 2008-09-18 Eisai R & D Management Co., Ltd. スプライシング異常を指標とする抗ガン剤の作用検定方法
WO2008126918A1 (ja) * 2007-04-12 2008-10-23 Eisai R & D Management Co., Ltd. １２員環マクロラクタム誘導体
WO2009008492A1 (ja) 2007-07-06 2009-01-15 Eisai R & D Management Co., Ltd. マクロライド系化合物の製造方法およびその製造中間体
US7667052B2 (en) 2001-02-01 2010-02-23 Eisai R&D Management Co., Ltd. Bioactive substance
US7790887B2 (en) 2007-01-29 2010-09-07 Eisai R&D Management Co., Ltd. Macrolide compound in solid form, process for preparation thereof, and pharmaceutical composition containing the same
CN103145740A (zh) * 2013-02-28 2013-06-12 大连理工大学 一种亚砜生物碱类化合物及其制备方法与应用
JP2015524669A (ja) * 2012-08-14 2015-08-27 コーリア リサーチ インスティテュート オブ ケミカル テクノロジー ストレプトマイセス・スコプリリディスｋｒ−００１株またはその培養液を活性成分として含む雑草防除用組成物
WO2015175594A1 (en) 2014-05-15 2015-11-19 Eisai R&D Management Co., Ltd. Pladienolide pyridine compounds and methods of use
WO2017040526A2 (en) 2015-09-01 2017-03-09 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic sf3b1 mutants
WO2017087667A1 (en) 2015-11-18 2017-05-26 Eisai R&D Management Co., Ltd. A solid state form of pladienolide pyridine compounds and methods of use
WO2018170129A1 (en) 2017-03-15 2018-09-20 Eisai Co., Ltd Spliceosome mutations and uses thereof
WO2019089641A1 (en) 2017-10-31 2019-05-09 Eisai R&D Management Co., Ltd. Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from bcl2 inhibitors, bcl2/bclxl inhibitors, and bclxl inhibitors and methods of use
WO2019200100A1 (en) 2018-04-12 2019-10-17 Andrew Cook Pladienolide derivatives as spliceosome targeting agents for treating cancer
WO2019199667A2 (en) 2018-04-09 2019-10-17 Keaney Gregg F Certain pladienolide compounds and methods of use
WO2019232433A2 (en) 2018-06-01 2019-12-05 Eisai R&D Management Co., Ltd. Methods of using splicing modulators
JP2020147509A (ja) * 2019-03-12 2020-09-17 学校法人大阪医科薬科大学 抗がん剤
WO2022098712A1 (en) 2020-11-04 2022-05-12 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
WO2023131866A1 (en) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same

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CA2520377A1 (en) 2003-03-28 2004-10-14 Cornell Research Foundation, Inc. Migrastatin analog compositions and uses thereof
WO2006001967A2 (en) 2004-05-25 2006-01-05 Sloan-Kettering Institute For Cancer Research Migrastatin analogs in the treatment of cancer
CA2582766C (en) 2004-09-23 2014-07-22 Sloan-Kettering Institute For Cancer Research Isomigrastatin analogs in the treatment of cancer
WO2007110704A2 (en) * 2005-09-28 2007-10-04 Novimmune Sa Macrolide compositions as therapeutic agent
AU2007285215A1 (en) * 2006-08-14 2008-02-21 Eisai R & D Management Co., Ltd. Stable lyophilized preparation
GB0821540D0 (en) * 2008-11-25 2008-12-31 Merlion Pharmaceuticals Pte Ltd Lipopeptide compounds and their use
GB0821539D0 (en) * 2008-11-25 2008-12-31 Merlion Pharmaceuticals Pte Ltd Therapeutic compounds and their use
WO2013148324A1 (en) 2012-03-26 2013-10-03 The Regents Of The University Of California Anti-cancer polyketide compounds
WO2024119114A1 (en) * 2022-12-01 2024-06-06 Aspera Biomedicines, Inc. Chemoenzymatic synthesis of polyketides

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JPH04352783A (ja) * 1991-05-27 1992-12-07 Taisho Pharmaceut Co Ltd １２員環マクロライド系化合物
WO2000075126A1 (en) * 1999-06-03 2000-12-14 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Mycolactone and related compounds, compositions and methods of use
WO2002012533A2 (en) * 2000-08-03 2002-02-14 Kosan Biosciences, Inc. Fermentation and purification of mycolactones

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CN1489583B (zh) 2011-03-30
JP4439181B2 (ja) 2010-03-24
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TWI312681B (en) 2009-08-01
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KR20030070131A (ko) 2003-08-27
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