WO2008126918A1 - １２員環マクロラクタム誘導体 - Google Patents

１２員環マクロラクタム誘導体 Download PDF

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Publication number
WO2008126918A1
WO2008126918A1 PCT/JP2008/057173 JP2008057173W WO2008126918A1 WO 2008126918 A1 WO2008126918 A1 WO 2008126918A1 JP 2008057173 W JP2008057173 W JP 2008057173W WO 2008126918 A1 WO2008126918 A1 WO 2008126918A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogen atom
group
cyclomacrolactam
twelve
membered
Prior art date
Application number
PCT/JP2008/057173
Other languages
English (en)
French (fr)
Inventor
Masayuki Miyano
Daisuke Ito
Norio Murai
Original Assignee
Eisai R & D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R & D Management Co., Ltd. filed Critical Eisai R & D Management Co., Ltd.
Priority to EP08740270A priority Critical patent/EP2145886A1/en
Priority to JP2009509381A priority patent/JPWO2008126918A1/ja
Publication of WO2008126918A1 publication Critical patent/WO2008126918A1/ja
Priority to IL200237A priority patent/IL200237A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Abstract

　　抗腫瘍活性を有する１２員環マクロラクタム誘導体の提供。式（１）で表される化合物またはその塩。式中、Ｒ１は水素原子、Ｃ１－６アルキル基、Ｃ１－６アルキルカルボニル基またはＣ６－１４アリールカルボニル基を表す；Ｒ２は水素原子またはＣ１－６アルキル基を表す；Ｒ３は水素原子または水酸基を表す；Ｒ４は水素原子または水酸基を表す；Ｒ５は水素原子またはＣ１－６アルキル基を表す；Ｒ６は水素原子または水酸基を表す；Ｒ７はアセチル基等を表す。
PCT/JP2008/057173 2007-04-12 2008-04-11 １２員環マクロラクタム誘導体 WO2008126918A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08740270A EP2145886A1 (en) 2007-04-12 2008-04-11 Twelve-membered cyclomacrolactam derivative
JP2009509381A JPWO2008126918A1 (ja) 2007-04-12 2008-04-11 １２員環マクロラクタム誘導体
IL200237A IL200237A0 (en) 2007-04-12 2009-08-04 12-membered-ring macrolactam derivatives and pharmaceutical compositions containing the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91141007P 2007-04-12 2007-04-12
US60/911,410 2007-04-12
JP2007321169 2007-12-12
JP2007-321169 2007-12-12

Publications (1)

Publication Number Publication Date
WO2008126918A1 true WO2008126918A1 (ja) 2008-10-23

Family

ID=39864013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057173 WO2008126918A1 (ja) 2007-04-12 2008-04-11 １２員環マクロラクタム誘導体

Country Status (4)

Country Link
US (2) US20080312317A1 (ja)
EP (1) EP2145886A1 (ja)
JP (1) JPWO2008126918A1 (ja)
WO (1) WO2008126918A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015175594A1 (en) 2014-05-15 2015-11-19 Eisai R&D Management Co., Ltd. Pladienolide pyridine compounds and methods of use
WO2017040526A2 (en) 2015-09-01 2017-03-09 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic sf3b1 mutants
WO2017087667A1 (en) 2015-11-18 2017-05-26 Eisai R&D Management Co., Ltd. A solid state form of pladienolide pyridine compounds and methods of use
WO2018170129A1 (en) 2017-03-15 2018-09-20 Eisai Co., Ltd Spliceosome mutations and uses thereof
WO2019089641A1 (en) 2017-10-31 2019-05-09 Eisai R&D Management Co., Ltd. Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from bcl2 inhibitors, bcl2/bclxl inhibitors, and bclxl inhibitors and methods of use
WO2019200100A1 (en) 2018-04-12 2019-10-17 Andrew Cook Pladienolide derivatives as spliceosome targeting agents for treating cancer
WO2019199667A2 (en) 2018-04-09 2019-10-17 Keaney Gregg F Certain pladienolide compounds and methods of use
WO2019232433A2 (en) 2018-06-01 2019-12-05 Eisai R&D Management Co., Ltd. Methods of using splicing modulators
WO2022098712A1 (en) 2020-11-04 2022-05-12 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
WO2023131866A1 (en) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04352783A (ja) 1991-05-27 1992-12-07 Taisho Pharmaceut Co Ltd １２員環マクロライド系化合物
JP2002060890A (ja) 2000-08-09 2002-02-28 Nippon Steel Corp 応力除去焼鈍後の溶接部靱性に優れたＮｉ含有鋼
WO2002060890A1 (fr) * 2001-02-01 2002-08-08 Mercian Corporation Nouvelles substances physiologiquement actives
JP2003099813A (ja) 2001-09-20 2003-04-04 Toshiba Corp 券発行装置
JP2004011661A (ja) 2002-06-03 2004-01-15 Nsk Ltd 複列円筒ころ軸受
JP2004011459A (ja) 2002-06-04 2004-01-15 Ishikawajima Harima Heavy Ind Co Ltd 舶用２軸型ガスタービンの過回転防止装置とその方法
WO2006001967A2 (en) * 2004-05-25 2006-01-05 Sloan-Kettering Institute For Cancer Research Migrastatin analogs in the treatment of cancer
JP2007043621A (ja) 2005-08-05 2007-02-15 Matsushita Electric Ind Co Ltd アンテナ装置およびアンテナ装置の製造方法
WO2007043621A1 (ja) 2005-10-13 2007-04-19 Eisai R & D Management Co., Ltd. プラジエノライド ｂ及びプラジエノライド ｄの全合成方法
JP2007110705A (ja) 2005-09-24 2007-04-26 Internatl Business Mach Corp <Ibm> Ｓｉｐシグナリングの暗号化を検証するための方法および装置
JP2007110704A (ja) 2005-10-11 2007-04-26 Lg Electronics Inc モバイルデジタル放送の受信機及びデジタル放送の処理方法
WO2007110705A2 (en) * 2005-09-28 2007-10-04 Novimmune Sa Macrolide as inhibitors of mhc class ii

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI334866B (en) * 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
US7576204B2 (en) * 2002-07-31 2009-08-18 Mercian Corporation Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same
WO2004011661A1 (ja) * 2002-07-31 2004-02-05 Mercian Corporation 新規生理活性物質
US7353605B2 (en) * 2004-07-30 2008-04-08 Eastman Kodak Company Method for producing a metallic core for use in cylinder sleeves for an electrophotographic process

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04352783A (ja) 1991-05-27 1992-12-07 Taisho Pharmaceut Co Ltd １２員環マクロライド系化合物
JP2002060890A (ja) 2000-08-09 2002-02-28 Nippon Steel Corp 応力除去焼鈍後の溶接部靱性に優れたＮｉ含有鋼
WO2002060890A1 (fr) * 2001-02-01 2002-08-08 Mercian Corporation Nouvelles substances physiologiquement actives
JP2003099813A (ja) 2001-09-20 2003-04-04 Toshiba Corp 券発行装置
JP2004011661A (ja) 2002-06-03 2004-01-15 Nsk Ltd 複列円筒ころ軸受
JP2004011459A (ja) 2002-06-04 2004-01-15 Ishikawajima Harima Heavy Ind Co Ltd 舶用２軸型ガスタービンの過回転防止装置とその方法
WO2006001967A2 (en) * 2004-05-25 2006-01-05 Sloan-Kettering Institute For Cancer Research Migrastatin analogs in the treatment of cancer
JP2007043621A (ja) 2005-08-05 2007-02-15 Matsushita Electric Ind Co Ltd アンテナ装置およびアンテナ装置の製造方法
JP2007110705A (ja) 2005-09-24 2007-04-26 Internatl Business Mach Corp <Ibm> Ｓｉｐシグナリングの暗号化を検証するための方法および装置
WO2007110705A2 (en) * 2005-09-28 2007-10-04 Novimmune Sa Macrolide as inhibitors of mhc class ii
JP2007110704A (ja) 2005-10-11 2007-04-26 Lg Electronics Inc モバイルデジタル放送の受信機及びデジタル放送の処理方法
WO2007043621A1 (ja) 2005-10-13 2007-04-19 Eisai R & D Management Co., Ltd. プラジエノライド ｂ及びプラジエノライド ｄの全合成方法

Non-Patent Citations (29)

* Cited by examiner, † Cited by third party
Title
ALEXANDER, J., SYNTHETIC COMMUNICATIONS, vol. 25, no. 23, 1995, pages 3875 - 3881
BLAKEMORE, P. R., SYNLETT, 1998, pages 26 - 28
BLAKEMORE, P.R., SYNLETT, 1998, pages 26 - 28
FUJII, N., JOURNAL OF THE CHEMICAL SOCIETY PERKIN TRANSACTIONS, vol. 1, 1996, pages 865 - 866
FURSTNER ET AL., CHEMICAL REVIEW, vol. 99, 1999, pages 991 - 1045
FURSTNER, A., CHEMICAL REVIEWS, vol. 99, 1999, pages 991 - 1045
GAO, Y., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 109, 1987, pages 5765 - 5780
GREEN, T. W.: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE
GRUBBS, R. H.: "Handbook of metathesis", vol. 2, 2003, WILEY-VCH, pages: 246 - 292
GRUBBS, R.H.: "Handbook of metathesis", vol. 1-3, 2003, WILEY-VCH
GRUBBS, R.H.: "Handbook of Metathesis", vol. 2, 2003, WILEY-VCH, pages: 246 - 292
IRELAND, R.E., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107, 1985, pages 3285 - 3294
KATSUKI, T, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 102, 1980, pages 5976 - 5978
KOSKINEN, A.M.P; OTSOMAA, L.A, TETRAHEDRON, vol. 53, no. 18, 1997, pages 6473 - 6484
MATSUBARA, S, SYNLETT, vol. 97, 1998, pages 313 - 315
MITSUMORI, S., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 128, 2006, pages 1040 - 1041
MITSUNOBU, O., SYNTHESIS, 1981, pages 1 - 28
ORGANIC SYNTHESIS, vol. 9, 1992, pages 300
PILLI ET AL., THE JOURNAL OF ORGANIC CHEMISTRY, vol. 63, 1998, pages 7811 - 7819
PILLI, R.A., THE JOURNAL OF ORGANIC CHEMISTRY, vol. 63, 1998, pages 7811 - 7819
SARANDESES, L.A., JOURNAL OF THE CHEMICAL SOCIETY CHEMICAL COMMUNICATION, 1991, pages 818 - 820
SHULTZ, H.S., JOURNAL OF ORGANIC CHEMISTRY, vol. 28, no. 4, 1963, pages 1140 - 1140
STAMOS ET AL., TETRAHEDRON LETTER, vol. 38, no. 36, 1997, pages 6355 - 6358
STAMOS, D.P., TETRAHEDRON LETTERS, vol. 38, no. 36, 1997, pages 6355 - 6358
TAKAI, K., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 108, 1986, pages 7408 - 7410
VERKADE, J.M.M, TETRAHEDRON LETTERS, vol. 47, no. 46, 2006, pages 8109 - 8113
WANG, Z., -X., JOURNAL OF ORGANIC CHEMISTRY, vol. 62, 1997, pages 2328 - 2329
WANG, Z., -X., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 119, 1997, pages 11224 - 11235
WILLIAMS, J. M., TETRAHEDRON LETTERS, vol. 36, no. 31, 1995, pages 5461 - 5464

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9481669B2 (en) 2014-05-15 2016-11-01 Eisai R&D Management Co., Ltd. Pladienolide pyridine compounds and methods of use
WO2015175594A1 (en) 2014-05-15 2015-11-19 Eisai R&D Management Co., Ltd. Pladienolide pyridine compounds and methods of use
EP3514154A1 (en) 2014-05-15 2019-07-24 Eisai R&D Management Co., Ltd. Pladienolide pyridine compounds and methods of use
WO2017040526A2 (en) 2015-09-01 2017-03-09 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic sf3b1 mutants
US11761045B2 (en) 2015-09-01 2023-09-19 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic SF3B1 mutants
EP3910073A1 (en) 2015-09-01 2021-11-17 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic sf3b1 mutants
US10889866B2 (en) 2015-09-01 2021-01-12 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic SF3B1 mutants
US10745387B2 (en) 2015-11-18 2020-08-18 Eisai R&D Management Co., Ltd. Crystalline form of (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(piridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl-4-methylpiperazine-1-carboxylate and methods of use thereof
WO2017087667A1 (en) 2015-11-18 2017-05-26 Eisai R&D Management Co., Ltd. A solid state form of pladienolide pyridine compounds and methods of use
WO2018170129A1 (en) 2017-03-15 2018-09-20 Eisai Co., Ltd Spliceosome mutations and uses thereof
WO2019089641A1 (en) 2017-10-31 2019-05-09 Eisai R&D Management Co., Ltd. Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from bcl2 inhibitors, bcl2/bclxl inhibitors, and bclxl inhibitors and methods of use
WO2019199667A2 (en) 2018-04-09 2019-10-17 Keaney Gregg F Certain pladienolide compounds and methods of use
WO2019200100A1 (en) 2018-04-12 2019-10-17 Andrew Cook Pladienolide derivatives as spliceosome targeting agents for treating cancer
WO2019232433A2 (en) 2018-06-01 2019-12-05 Eisai R&D Management Co., Ltd. Methods of using splicing modulators
WO2022098712A1 (en) 2020-11-04 2022-05-12 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
WO2023131866A1 (en) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same

Also Published As

Publication number Publication date
US20080312317A1 (en) 2008-12-18
JPWO2008126918A1 (ja) 2010-07-22
US20110136902A1 (en) 2011-06-09
EP2145886A1 (en) 2010-01-20

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