WO2002030881A1 - Sulfonylguanidine - Google Patents
Sulfonylguanidine Download PDFInfo
- Publication number
- WO2002030881A1 WO2002030881A1 PCT/EP2001/011245 EP0111245W WO0230881A1 WO 2002030881 A1 WO2002030881 A1 WO 2002030881A1 EP 0111245 W EP0111245 W EP 0111245W WO 0230881 A1 WO0230881 A1 WO 0230881A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amino
- methylene
- ylmethyl
- unsubstituted
- pyridin
- Prior art date
Links
- 0 *N(*)C(N)=NS(*)(=O)=O Chemical compound *N(*)C(N)=NS(*)(=O)=O 0.000 description 2
- VPFZFPSDOPDULK-UHFFFAOYSA-N Cc(cc1)ccc1S(/N=C(/N)\NCc1ccc[s]1)(=O)=O Chemical compound Cc(cc1)ccc1S(/N=C(/N)\NCc1ccc[s]1)(=O)=O VPFZFPSDOPDULK-UHFFFAOYSA-N 0.000 description 1
- FMGRWYAXBNDENR-UHFFFAOYSA-N Cc(cc1)ccc1S(/N=C(\N)/N1CCCC1)(=O)=O Chemical compound Cc(cc1)ccc1S(/N=C(\N)/N1CCCC1)(=O)=O FMGRWYAXBNDENR-UHFFFAOYSA-N 0.000 description 1
- CEABXENINFHKSN-UHFFFAOYSA-N Cc(cc1)ccc1S(/N=C(\N)/NNc1ccccn1)(=O)=O Chemical compound Cc(cc1)ccc1S(/N=C(\N)/NNc1ccccn1)(=O)=O CEABXENINFHKSN-UHFFFAOYSA-N 0.000 description 1
- VEBSWLZELPUIAV-UHFFFAOYSA-N Cc(cc1)ccc1S(/N=C(\N)/Nc1ccccc1)(=O)=O Chemical compound Cc(cc1)ccc1S(/N=C(\N)/Nc1ccccc1)(=O)=O VEBSWLZELPUIAV-UHFFFAOYSA-N 0.000 description 1
- IAUKKJXCFFZYSP-UHFFFAOYSA-N Cc1cccc(S(/N=C(\N)/NCc2ncccc2)(=O)=O)c1 Chemical compound Cc1cccc(S(/N=C(\N)/NCc2ncccc2)(=O)=O)c1 IAUKKJXCFFZYSP-UHFFFAOYSA-N 0.000 description 1
- OKMLDWDXLMSLFB-UHFFFAOYSA-N N/C(/N1CCCC1)=N\S(c1ccccc1)(=O)=O Chemical compound N/C(/N1CCCC1)=N\S(c1ccccc1)(=O)=O OKMLDWDXLMSLFB-UHFFFAOYSA-N 0.000 description 1
- IAGVVMWNCYZRDA-UHFFFAOYSA-N N/C(/NCc1ccccn1)=N\S(c(cc1)ccc1F)(=O)=O Chemical compound N/C(/NCc1ccccn1)=N\S(c(cc1)ccc1F)(=O)=O IAGVVMWNCYZRDA-UHFFFAOYSA-N 0.000 description 1
- PQSQSNJKKVTMFV-UHFFFAOYSA-N N/C(/NN1CCOCC1)=N\S(c1c(cccc2)c2ccc1)(=O)=O Chemical compound N/C(/NN1CCOCC1)=N\S(c1c(cccc2)c2ccc1)(=O)=O PQSQSNJKKVTMFV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/64—X and Y being nitrogen atoms, e.g. N-sulfonylguanidine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
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- C07—ORGANIC CHEMISTRY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002534269A JP4034651B2 (ja) | 2000-09-30 | 2001-10-01 | スルホニルグアニジン |
EP01974309A EP1320520B1 (de) | 2000-09-30 | 2001-10-01 | Sulfonylguanidine |
AT01974309T ATE509008T1 (de) | 2000-09-30 | 2001-10-01 | Sulfonylguanidine |
MXPA03002668A MXPA03002668A (es) | 2000-09-30 | 2001-10-01 | Guanidinas de sulfonilo. |
NZ525252A NZ525252A (en) | 2000-09-30 | 2001-10-01 | Sulfonylguanidines for use in treating pain |
HU0303731A HUP0303731A3 (en) | 2000-09-30 | 2001-10-01 | Sulfonylguanidines and their use for preparation of pharmaceutical compositions |
CA002424107A CA2424107A1 (en) | 2000-09-30 | 2001-10-01 | Sulfonylguanidines |
PL362349A PL207739B1 (pl) | 2000-09-30 | 2001-10-01 | Sulfonyloguanidyny, ich zastosowanie oraz środki lecznicze |
AU9385201A AU9385201A (en) | 2000-09-30 | 2001-10-01 | Sulfonylguanidine |
AU2001293852A AU2001293852B8 (en) | 2000-09-30 | 2001-10-01 | Sulfonylguanidine |
US10/402,382 US20030225084A1 (en) | 2000-09-30 | 2003-03-31 | Sulfonylguanidine compounds and pharmaceutical uses thereof |
US11/742,946 US7671074B2 (en) | 2000-09-30 | 2007-05-01 | Sulfonylguanidine compounds and pharmaceutical uses thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10048716A DE10048716A1 (de) | 2000-09-30 | 2000-09-30 | Sulfonylguanidine |
DE10048716.5 | 2000-09-30 | ||
DE10112068A DE10112068A1 (de) | 2001-03-12 | 2001-03-12 | Sulfonylguanidine |
DE10112068.0 | 2001-03-12 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/402,382 Continuation US20030225084A1 (en) | 2000-09-30 | 2003-03-31 | Sulfonylguanidine compounds and pharmaceutical uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002030881A1 true WO2002030881A1 (de) | 2002-04-18 |
Family
ID=26007237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/011245 WO2002030881A1 (de) | 2000-09-30 | 2001-10-01 | Sulfonylguanidine |
Country Status (13)
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004518763A (ja) * | 2001-03-22 | 2004-06-24 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | Cb1−拮抗活性を有する4,5−ジヒドロ−1h−ピラゾール誘導体 |
WO2007095611A2 (en) * | 2006-02-15 | 2007-08-23 | Janssen Pharmaceutica N.V. | Use of benzo-fused heteroaryl sulfamide derivatives for the treatment of migraine |
WO2008034863A2 (en) | 2006-09-22 | 2008-03-27 | Solvay Pharmaceuticals B.V. | Sulfonylpyrazoline carboxamidine derivatives as 5-ht6 antagonists |
WO2008077599A1 (en) | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | COMBINATION THERAPY OF LOWER URINARY TRACT DISORDERS WITH α2δ LIGANDS AND NSAIDS |
US7432299B2 (en) | 2002-12-13 | 2008-10-07 | Pfizer Inc. | Method of treatment for sexual dysfunction |
EP2156863A2 (en) | 2003-09-12 | 2010-02-24 | Pfizer Limited | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline reuptake inhibitors |
EP2196201A2 (en) | 2002-12-13 | 2010-06-16 | Warner-Lambert Company LLC | Combination of an alpha-2-delta ligand with a pdev inhibitor or a muscarinic antagonist to treat lower urinary tract symptoms |
EP2366392A1 (de) * | 2004-02-19 | 2011-09-21 | Abbott GmbH & Co. KG | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
US8853263B2 (en) | 2006-05-19 | 2014-10-07 | Janssen Pharmaceutica Nv | Co-therapy for the treatment of epilepsy and related disorders |
US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
US9296697B2 (en) | 2005-08-24 | 2016-03-29 | Abbott Laboratories | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors |
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US20050090548A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of epilepsy |
US20050090549A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of pain |
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- 2001-10-01 WO PCT/EP2001/011245 patent/WO2002030881A1/de active Application Filing
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US8431604B2 (en) | 2004-02-19 | 2013-04-30 | Abbott Gmbh & Co. Kg | Guanidine compounds, and use thereof as binding partners for 5-HT5 receptors |
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Also Published As
Publication number | Publication date |
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PE20021046A1 (es) | 2002-12-14 |
PL362349A1 (en) | 2004-10-18 |
EP1320520A1 (de) | 2003-06-25 |
US7671074B2 (en) | 2010-03-02 |
CA2424107A1 (en) | 2003-03-28 |
EP1320520B1 (de) | 2011-05-11 |
AU9385201A (en) | 2002-04-22 |
AR034160A1 (es) | 2004-02-04 |
JP4034651B2 (ja) | 2008-01-16 |
US20080085900A1 (en) | 2008-04-10 |
AU2001293852B2 (en) | 2006-11-09 |
JP2004511463A (ja) | 2004-04-15 |
HUP0303731A2 (hu) | 2004-03-01 |
US20030225084A1 (en) | 2003-12-04 |
HUP0303731A3 (en) | 2006-02-28 |
NZ525252A (en) | 2005-12-23 |
MXPA03002668A (es) | 2003-08-20 |
PL207739B1 (pl) | 2011-01-31 |
AU2001293852B8 (en) | 2006-11-30 |
ATE509008T1 (de) | 2011-05-15 |
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