HUP0303731A2 - Szulfonil-guanidinek és felhasználásuk gyógyszerkészítmények előállítására - Google Patents

Szulfonil-guanidinek és felhasználásuk gyógyszerkészítmények előállítására

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Publication number
HUP0303731A2
HUP0303731A2 HU0303731A HUP0303731A HUP0303731A2 HU P0303731 A2 HUP0303731 A2 HU P0303731A2 HU 0303731 A HU0303731 A HU 0303731A HU P0303731 A HUP0303731 A HU P0303731A HU P0303731 A2 HUP0303731 A2 HU P0303731A2
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HU
Hungary
Prior art keywords
aryl
cycloalkyl
alkyl
group
carbon atom
Prior art date
Application number
HU0303731A
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English (en)
Inventor
Boris Chizh
Matthias Gerlach
Michael Haurand
Corinna Maul
Claudia Katharina Pütz
Heinz Uragg
Original Assignee
Grünenthal GmbH.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10048716A external-priority patent/DE10048716A1/de
Priority claimed from DE10112068A external-priority patent/DE10112068A1/de
Application filed by Grünenthal GmbH. filed Critical Grünenthal GmbH.
Publication of HUP0303731A2 publication Critical patent/HUP0303731A2/hu
Publication of HUP0303731A3 publication Critical patent/HUP0303731A3/hu

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  • Organic Chemistry (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Quinoline Compounds (AREA)
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  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
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Abstract

A találmány tárgyát képezi az (I) és (Ia) általános képletű tautomerszulfonil-guanidinek - a képletben R1 1-10 szénatomos alkil-, 3-8szénatomos cikloalkil- vagy biciklusos alkilén-, aril- vagyheteroaril-csoportot vagy a molekula többi részéhez 1-3 szénatomosalkilcsoporton keresztül kapcsolódó aril-, 3-9 szénatomos cikloalkil-vagy heteroaril-csoportot jelent; R2 1-10 szénatomos alkil-, 3-8szénatomos cikloalkil-, aril- vagy heteroaril-csopontot, a molekulatöbbi részéhez 1-3 szénatomos alkil-, S(O)2 vagy NH csoportonkeresztül kapcsolódó aril-, 3-9 szénatomos cikloalkil- vagyheteroaril-csoportot, vagy NR4R5 vagy -SO2R6 csoportot jelent; és R3hidrogénatomot vagy 1-10 szénatomos alkil-, 3-8 szénatomoscikloalkil-, aril- vagy heteroaril-csoportot vagy a molekula többirészéhez 1-3 szénatomos alkilcsoporton keresztül kapcsolódó aril-, 3-9szénatomos cikloalkil- vagy heteroaril-csopontot jelent; vagy R2 és R3együtt -CH2(CH2)2-3CH2-, -CH2CN2OCH2CH2- vagy -CH2CH2N(R8)-CH2CH2-csoportot alkothat; és a fentiekben felsorolt szénhidrogéncsoportoktelítettek vagy telítetlenek lehetnek, és a fentiekben felsoroltalkil-, cikloalkil-, biciklusos alkilén-, aril- és heteroaril-csoportokhoz adott esetben egy vagy több szubsztituens kapcsolódhatfelhasználása gyógyászati célokra, elsősorban fájdalomcsillapítóhatású gyógyszerkészítmények gyártásához. A találmány tárgyát képeziktovábbá az új (I) és (Ia) általános képletű vegyületeket tartalmazógyógyszerkészítmények is. Ó
HU0303731A 2000-09-30 2001-10-01 Sulfonylguanidines and their use for preparation of pharmaceutical compositions HUP0303731A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10048716A DE10048716A1 (de) 2000-09-30 2000-09-30 Sulfonylguanidine
DE10112068A DE10112068A1 (de) 2001-03-12 2001-03-12 Sulfonylguanidine
PCT/EP2001/011245 WO2002030881A1 (de) 2000-09-30 2001-10-01 Sulfonylguanidine

Publications (2)

Publication Number Publication Date
HUP0303731A2 true HUP0303731A2 (hu) 2004-03-01
HUP0303731A3 HUP0303731A3 (en) 2006-02-28

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Application Number Title Priority Date Filing Date
HU0303731A HUP0303731A3 (en) 2000-09-30 2001-10-01 Sulfonylguanidines and their use for preparation of pharmaceutical compositions

Country Status (13)

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US (2) US20030225084A1 (hu)
EP (1) EP1320520B1 (hu)
JP (1) JP4034651B2 (hu)
AR (1) AR034160A1 (hu)
AT (1) ATE509008T1 (hu)
AU (2) AU2001293852B8 (hu)
CA (1) CA2424107A1 (hu)
HU (1) HUP0303731A3 (hu)
MX (1) MXPA03002668A (hu)
NZ (1) NZ525252A (hu)
PE (1) PE20021046A1 (hu)
PL (1) PL207739B1 (hu)
WO (1) WO2002030881A1 (hu)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
BR0205602A (pt) * 2001-03-22 2003-07-08 Solvay Pharm Bv EnantiÈmero possuindo a configuração s na posição-4 dos seu anel pirazol de um composto, composição farmacêutica, método para a preparação de composições farmacêuticas, processo para a preparação de compostos, e, métodos de tratamento de distúrbios que envolvem neurotransmissão canabinóide
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JP2004511463A (ja) 2004-04-15
US7671074B2 (en) 2010-03-02
AU9385201A (en) 2002-04-22
EP1320520A1 (de) 2003-06-25
JP4034651B2 (ja) 2008-01-16
EP1320520B1 (de) 2011-05-11
PL362349A1 (en) 2004-10-18
NZ525252A (en) 2005-12-23
US20080085900A1 (en) 2008-04-10
AU2001293852B2 (en) 2006-11-09
HUP0303731A3 (en) 2006-02-28
CA2424107A1 (en) 2003-03-28
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AU2001293852B8 (en) 2006-11-30
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