WO2002014313A2 - Neue beta-amyloid inhibitoren, verfahren zu deren herstellung und deren verwendung als arzneimittel - Google Patents
Neue beta-amyloid inhibitoren, verfahren zu deren herstellung und deren verwendung als arzneimittel Download PDFInfo
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- WO2002014313A2 WO2002014313A2 PCT/EP2001/008456 EP0108456W WO0214313A2 WO 2002014313 A2 WO2002014313 A2 WO 2002014313A2 EP 0108456 W EP0108456 W EP 0108456W WO 0214313 A2 WO0214313 A2 WO 0214313A2
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- 0 *CCCc1c(*)nc2[n]1C=C*(*)C=C2 Chemical compound *CCCc1c(*)nc2[n]1C=C*(*)C=C2 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to compounds of the general formula (I)
- radicals A, Het, R 1 , R 2 and R 3 may have the meaning given in the description below and in the claims, processes for their preparation and the use of compounds of the general formula (I) as medicaments, in particular as Medicinal products with beta-amyloid inhibitory activity.
- Aß amyloid- ⁇ -peptide
- APP amyloid precursor protein
- the ⁇ -secretase cleaves within the Aß region of the APP and thus leads to the secretion of the soluble N-terminal region of the protein (-APPs) and, after a ⁇ -secretase cut, to the release of p3.
- the amyloidogenic pathway leads to the formation of Aß, in that two proteases generate the N-terminus (ß-secretase) and the C-terminus ( ⁇ -secretase) of Aß.
- Aß can be detected in vivo in human plasma and cerebrospinal fluid.
- Aß can also be detected in cell culture in the cell culture supernatant in various cell types which endogenously express or overexpress APP or fragments thereof in cell culture.
- the present invention is based on the further object of providing compounds which can be used effectively for the prevention or treatment of Alzheimer's disease.
- R 1 is hydrogen or halogen, preferably hydrogen
- R 2 is hydrogen, C 1 -C 4 alkyl, CF 3 or a phenyl radical which may optionally be substituted by halogen, C 1 -C 4 alkyl or C 1 -C 4 alkyloxy;
- R 3 is hydrogen, C C-4-alkyl, HO-C C 4 -alkyl, C 2 -C 4 -alkenyl or a radical selected from the group consisting of phenyl, benzyl and phenylethyl, which may be replaced by halogen, CF 3 , C 1 -C 4 -alkyl or C 1 -C 4 -alkyloxy can be substituted, or a heterocycle selected from the group consisting of morpholine, 25 piperidine, piperazine and dihydrobenzimidazolone, which can be linked directly or via a C 1 -C 4 -alkylene bridge, mean.
- Preferred compounds of the general formula (I) are those in which
- a -CH 2 -CH 2 -, -CH 2 -CH 2 -CH 2 -, -CH2-CO- or -CH CH-CO-; 0 Het piperidinyl, piperazinyl or dihydrobenzimidazolonyl;
- R 1 is hydrogen or halogen, preferably hydrogen
- R 2 is hydrogen, CrC4-alkyl, phenyl, halogen-substituted phenyl, C 1 -C 4 -
- R 1 is hydrogen or chlorine, preferably hydrogen
- R 2 is hydrogen, methyl, phenyl or 4-chlorophenyl; R 3 -CC 4 alkyl, HO -CC 4 alkyl, C 2 -C 4 alkenyl, phenyl, benzyl, halogen-substituted benzyl or a heterocycle selected from morpholine and dihydrobenzimidazolone, which is used directly or via a C ⁇ -C 4 alkylene bridge can be linked mean.
- a -CH 2 -CH 2 -, -CH 2 -CH 2 -CH 2 - or -CH CH-CO-;
- R 1 is hydrogen or chlorine, preferably hydrogen;
- R 2 is hydrogen, methyl, phenyl or 4-chlorophenyl;
- R 1 is hydrogen
- R 2 is hydrogen, methyl, phenyl or 4-chlorophenyl
- R 3 is benzyl, 4-chlorobenzyl or 1, 3-dihydrobenzimidazol-2-one-1-yl.
- the invention relates to the respective compounds, optionally in the form of the individual optical isomers, mixtures of the individual enantiomers or racemates, in the form of the tautomers and in the form of the free bases or the corresponding acid addition salts with pharmacologically acceptable acids - such as, for example, acid addition salts with hydrohalic acids - for example chlorine. or hydrobromic acid - or organic acids - such as oxalic, fumaric, diglycolic or methanesulfonic acid.
- pharmacologically acceptable acids - such as, for example, acid addition salts with hydrohalic acids - for example chlorine. or hydrobromic acid - or organic acids - such as oxalic, fumaric, diglycolic or methanesulfonic acid.
- alkyl groups with ibis 4 carbon atoms are considered as alkyl groups (also insofar as they are part of other radicals). Examples include: methyl, ethyl, propyl and butyl. Unless otherwise stated, the abovementioned names propyl and butyl encompass all of the possible isomeric forms. Accordingly, the term propyl includes the two isomeric residues n-propyl and iso-propyl and the term butyl n-butyl, iso-butyl, sec. Butyl and tert-butyl. If necessary, common abbreviations such as Me for methyl, Et for ethyl etc. are used to denote the alkyl radicals mentioned above.
- Branched and unbranched alkylene bridges with 1 to 4 carbon atoms are considered as alkyl groups.
- alkyl groups For example, the following are mentioned: methylene, ethylene, propylene and butylene Unless otherwise stated, the abovementioned names propylene and butylene encompass all of the possible isomeric forms. Accordingly, the term propylene comprises the two isomeric bridges n-propylene and dimethylmethylene and the term butylene the isomeric bridges n-butylene, 1-methylpropylene, 2-methylpropylene, 1,1-dimethylethylene and 1,2-dimethylethylene.
- alkenyl groups also insofar as they are part of other radicals
- branched and unbranched alkenyl groups with 2 to 4 carbon atoms are mentioned, provided that they have at least one double bond, such as vinyl (provided that no unstable enamines or enol ethers are formed), propenyl, isopropenyl and butenyl.
- Halogen is generally referred to as fluorine, chlorine, bromine or iodine. Unless otherwise stated, chlorine is considered preferred in the context of the present invention.
- radicals A and Het are to be regarded as double-bonded groups in accordance with the general formula (I).
- the linkage in which the carbonyl function of the abovementioned bridge members is linked directly to the group "Het" is regarded as the preferred orientation.
- the group Het can also be linked to its neighboring groups in different orientations.
- the linkage in which the group Het is linked to the bridge A by at least one nitrogen atom is regarded as the preferred orientation according to the invention.
- the piperazinyl and dihydrobenzimidazolonyl radicals defined as groups Het are also particularly preferably linked to the radical R 3 via their second N atom.
- Dihydrobenzimidazolonyl is understood to mean 1,3-dihydro-benzimidazol-2-one-1-yl.
- Another aspect of the present invention aims at the use of the compounds of the general formula (I) defined above as medicaments.
- the present invention aims at the use of the compounds of the general formula (I) for the manufacture of a medicament for the prevention and / or treatment of diseases in which by intervention (preferably inhibition) in the process of Aß formation or release from cells therapeutic benefits can be achieved.
- preference is given to the use of compounds of the general formula (I) mentioned above for the production of a medicament for the prevention and / or treatment of Alzheimer's disease.
- Synthetic access to the compounds of the general formula (I) according to the invention can be carried out using different methods, if appropriate based on or using conventional chemical synthesis methods, as described in more detail below.
- a 2H-imidazo [1, 2-a] pyridine (II) is converted into the aminomethyl-substituted compounds (III) by reaction with N, N-dimethylmethyleniminium chloride, from which compounds are obtained by alkylation with methyl iodide
- Step B the quaternary ammonium salts (IV) can be obtained. They can be converted into the nitriles (V) (stage C), the hydrolysis of which gives access to the carboxylic acid esters (VI) (stage D).
- Reduction of the compounds (VI) after step E leads to the alcohols (VII) which are converted into the halides (VIII) according to step F. From these, the compounds of the formula (I) in which A denotes -CH 2 -CH 2 - can be obtained via nucleophilic substitution (step G).
- the 2H-imidazo [1, 2-a] pyridines (II) are converted into the formylated 2H-imidazo [1, 2-a] pyridines (IX) in a Vilsmeier reaction (stage H).
- the olefins (X) can be obtained from these by means of the Wittig reaction (stage I).
- the alcohols (VII) are accessible according to stage J by hydroboration of the compounds (X).
- the ⁇ -bromocarbonyl compounds (XII) can be obtained by bromination (step K) which, after reaction with 1-aminopyridines of the formula (XIII), give access to the esters (VI) (step L).
- compounds of the formula (I) can be obtained from the esters of the formula (VI) in which A represents the bridge -CH 2 -CO-. These can in turn be converted into compounds of the formula (I) in which A is -CH 2 -CH 2 - (Scheme 4).
- a further process variant (cf. Scheme 6) allows access to the compounds of the formula (XVII) which deviates from Scheme 5 on the one hand, and access to the compounds of the formula (I) in which A for -CH 2 -CH 2 - CO- stands.
- the ⁇ -bromocarbonyl compounds (XX) can be obtained from bromination (step K) which, after reaction with 1-aminopyridines of the formula (XIII), give access to the esters (XXI) (step L).
- these can be converted into the alcohols (XVII) according to stage E, and on the other hand, after saponification (stage M) to the carboxylic acids (XXII), they can also serve as starting compounds for the preparation of the compounds of the formula (I) in which A is -CH 2 -CH 2 -CO- means.
- the latter can be reductively converted into the compounds of the general formula (I) in which A represents -CH 2 -CH 2 -CH 2 - analogously to stage O (cf. Scheme 4);
- Example 1 1 -pl - (2-imidazo ⁇ , 2-a1pyridin-3-yl-ethyl) -piperidin-4-vn-1, 3-dihvdro-5 benzimidazol-2-one
- step E a solution of 3.30 g (29.7 mmol) of anhydrous calcium chloride in 35 ml of ethanol is dissolved in a solution of 5.50 g (27.0 mmol) of the compound Example 1.4, dissolved in 50 ml of THF, added. The mixture is cooled to -10 ° C. and 2.26 g (59.7 mmol) sodium borohydride are added in portions. The mixture is allowed to warm to room temperature, stirred for 6 h and then left to stand at 4 ° C. for 16 h. The mixture is mixed with 2 N HCl and then with conc. Ammonia solution made alkaline again. The organic solvent is distilled off and the aqueous phase is adjusted to pH 11 with potassium carbonate. Extraction with ethyl acetate, concentration and drying at 40 ° C. gives 3.80 g of yellow crystals.
- the mixture is then stirred at 5 ° C. for 1 h and then heated to 100 ° C. for 6 h. Then 100 ml of water is added dropwise with ice cooling and 40 ml of conc. Ammonia solution adjusted to pH 7. The mixture is extracted exhaustively with dichloromethane, the organic phase is washed with water, dried and concentrated. After cleaning the
- step F 3- (2-bromoethyl) imidazoH, 2-alpyridine (corresponds to compound of the formula (VIII))
- Example 2 1 - [1 - [2- (2-methylimidazo [1, 2-a] pyridin-3-yl) ethyl] piperidin-4-yl] -1, 3-dihydro-benzimidazol-2 -one
- Example 4 70 mg (0.21 mmol) of Example 4 are dissolved in 2 ml of ethanol and mixed with 100 ⁇ l of ethanolic hydrochloric acid. The mixture is stirred for 3 h at room temperature, the solvent is removed and 62.4 mg of the product are obtained by crystallization from dichloromethane / ethanol. Mp: 236 ° C;
- stage M 3.50 g (12.5 mmol) of 3-ethoxycarbonylmethyl-2-phenyl-imidazo [1, 2-a] pyridine (compound of the formula (VI) obtainable from stage D) are dissolved in 200 ml of 2N Hydrochloric acid heated to 100 ° C for 5 h. The hydrochloric acid is distilled off, the residue is taken up in water and brought about by adding conc. Ammonia solution for Crystallization. This gives 2.60 g of product. Mp: dec. 243-244 ° C;
- Example 6.1 230 mg (0.99 mmol) of the compound Example 6.1 are dissolved in 15 ml of THF and 15 ml of dichloromethane, and 217 mg (0.99 mmol) of 4- (2-piperazin-1-yl-ethyl) morpholine are added. 350 mg (0.99 mmol) of TBTU and 128 mg (0.99 mmol) of DIPEA are added and the mixture is stirred at room temperature for 24 h. The solvent is removed, the residue is taken up in ethyl acetate and with 10 percent
- Example 7 1 - 1 - 2- (2 -PhenvI-imidazoH, 2-aTpyridin-3-vD-2-oxo-ethv ⁇ -piperidin-4-
- Example 8 1 - [2- (2-phenylimidazo [1, 2-a] pyridin-3-yl) -2-oxoethyl] -3- (propen-2-yl) -1,3-dihydro benzimidazole-on-2
- Example 10 1 - [2- (2 "phenyl-imidazo [1, 2 " a] pyridin-3-yl) -2-oxo-ethyl] -1, 3-dihydro-benzimidazoI-2-one
- step Q 290 mg (2.61 mmol) of calcium chloride are dissolved in 10 ml of ethanol and a solution of 500 mg (2.31 mmol) of the compound Example 11.1 in 15 ml of THF is added. The mixture is cooled to -15 ° C. and 250 mg (6.60 mmol) sodium borohydride are added in portions. The mixture is first stirred at 0 ° C. for 3 h and then left to stand at 4 ° C. for 72 h. The suspension is mixed with 2 N hydrochloric acid and then with conc. Ammonia solution made alkaline. The organic solvents are distilled off and the residue is saturated with sat. Potassium carbonate solution added.
- Example 12 1- 1-r3- (2-phenyl-imidazori, 2-alpyridin-3-yl) -propyn-piperidin-4-yl-1,3-dihydro-benzimidazol-2-one
- Example 13 1 -d -r3- (2-p-chlorophenyl-imidazo ⁇ .2-alpyridin-3-vP-propy ⁇ -
- step K 5- (4-chlorophenvD-5-oxo-4-bromopentanoic acid ethyl ester (corresponds to compound according to formula (XX))
- Process according to step K 5.00 g (19.6 mmol) 5- (4- Chlorphenyl) -5-oxo-pentanoic acid ethyl ester (corresponds Compound according to formula (XIX)) are initially dissolved in 50 ml of ether and 4.00 g (25.0 mmol) of bromine are added dropwise at -15 ° C. The mixture is boiled under reflux for 2 hours. The reaction mixture is washed with water, the organic phase is dried and concentrated. 5.90 g of the product are obtained as a light brown oil.
- Example 13 Starting from connection example 13.3. the title compound can be synthesized analogously to the procedure according to Example 11.3 (method according to stage F) and then according to Example 11.4 (method according to stage G). Mp: 236 ° C; Example 14: 3-r3- (4-Benzvl-piperazin-1 -vD-propv ⁇ -2- (4-chlorophenyl) imidazori .2- a] pyridine
- Example 19 160 mg (0.32 mmol) of the compound Example 19 are dissolved in 10 ml of THF and, while cooling with ice, 4 ml (4 mmol) of a 1 M solution of borantetrahydrofuran complex in THF are added. The mixture is stirred for 3 hours while cooling with ice and mixed with 8 ml of 1N hydrochloric acid. Then with 10 percent. Sodium bicarbonate solution adjusted to pH 8. The mixture is concentrated and the residue is extracted with ethyl acetate. Drying and flash chromatographic cleaning (dichloromethane / ethanol 95: 5) gives 10 mg of the product.
- Example 21 1-r3- (2-phenyl-imidazori, 2-a1pyridin-3-vO-1-oxo-2 (E) propenyripiperidin-4-yl .3-dihydro-benzimidazol-2-one
- Process stage H analogous to Example 11.1) in 10 ml of ethanol with 3 ml of 40%.
- Example 24 1 -r3- (6-chloro-2-methylimidazori .2-a1pyridin-3-yl) -1-oxo-2 (E) propenvn-piperidin-4-yl -1,3-dihydrobenzimidazole -2-one
- Example 25 1 - (3-r2- (4-MethoxyphenvO-imidazoH .2-a1pyridin-3-vn-1-oxo-
- Example 26 1 -r3- (2-trofluoromethyl-imidazof1, 2-alpyridin-3-v0-1 -oxo- 2 (£) propenv ⁇ -piperidin-4-yl -1,3-dihvdro-benzimidazol-2-one
- Example 28 3- (3-r4- (4-Phenv0-piperidin-1-yl-1-oxo-2 (E) -propenyl ⁇ -2-phenyl-6-chloro-imidazofl, 2-alpyridine
- the compounds according to the invention are distinguished in that they inhibit the process of Aß formation or release from cells. Said ability was tested according to the test description below.
- astroglioma cells U 373, ATCC
- Vector pRC-CMV stably transfected.
- a clone with high APP751 expression U373-K10 was selected.
- the cells are plated in 96-well plates (Falcon) in Dulbecco's Minimal Essential Medium (DMEM, Bio-Whittaker) with 10% FCS and cultured to confluence at 37 ° C / 5% CO 2 .
- DMEM Dulbecco's Minimal Essential Medium
- the substances to be tested are first dissolved in 100% DMSO and then diluted to the test concentration in culture medium so that the DMSO concentration of the test solution is always below 0.5%.
- 150 ⁇ l of the test solution are placed per well on a confluent culture plate previously washed once with DMEM and preincubated for about 16 hours. After washing once, this solution is replaced by 150 ⁇ l of fresh test solution and incubated again for 4 hours.
- the compounds according to the invention can be administered orally, transdermally, intrathecally, by inhalation or parenterally and are present as active constituents in customary dosage forms, for example in
- compositions consisting essentially of an inert pharmaceutical carrier and an effective dose of the active ingredient, such as tablets, dragees, capsules, wafers, powders, solutions, suspensions, emulsions, syrups, suppositories, transdermal systems etc.
- An effective dose of Compounds according to the invention are between 1 and 5000, preferably between 10 and 1000, particularly preferably between 10 and 100 mg / dose in the case of oral use, and between 0.001 and 100, preferably between 0.1 and 10 mg / dose in the case of intravenous or intramuscular use. Solutions which contain 0.01 to 1.0, preferably 0.1 to 0.5% active ingredient are suitable for inhalation. The use of powders is necessary for inhalation prefers. It is also possible to use the compounds according to the invention as an infusion solution, preferably in a physiological saline or nutrient solution.
- the compounds according to the invention can be used alone or in combination with other active compounds according to the invention, if appropriate also in combination with other pharmacologically active compounds. Suitable forms of use are, for example, tablets, capsules, suppositories, solutions, juices, emulsions or dispersible powders.
- Corresponding tablets can be mixed, for example, by mixing the active ingredient (s) with known auxiliaries, for example inert diluents such as calcium carbonate, calcium phosphate or milk sugar, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants such as magnesium stearate or talc, and / or agents to achieve the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate.
- auxiliaries for example inert diluents such as calcium carbonate, calcium phosphate or milk sugar, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants such as magnesium stearate or talc, and / or agents to achieve the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate.
- auxiliaries for example inert diluents
- coated tablets can be produced by coating cores produced analogously to the tablets with agents commonly used in tablet coatings, for example collidone or shellac, gum arabic, talc, titanium dioxide or sugar.
- the core can also consist of several layers in order to achieve a depot effect or to avoid incompatibilities.
- the coated tablet to achieve a depot effect can consist of several layers, wherein the auxiliaries mentioned above for the tablets can be used.
- Juices of the active substances or combinations of active substances according to the invention can additionally contain a sweetener such as saccharin, cyclamate, glycerol or sugar as well as a taste-improving agent, e.g. Flavorings, such as vanillin or orange extract, contain. They can also contain suspending aids or thickeners, such as sodium carboxymethyl cellulose, wetting agents, for example condensation products of fatty alcohols with ethylene oxide, or protective agents, such as p-hydroxybenzoates.
- a sweetener such as saccharin, cyclamate, glycerol or sugar
- a taste-improving agent e.g.
- Flavorings such as vanillin or orange extract
- suspending aids or thickeners such as sodium carboxymethyl cellulose, wetting agents, for example condensation products of fatty alcohols with ethylene oxide, or protective agents, such as p-hydroxybenzoates.
- Preservatives such as p-hydroxybenzoates, or stabilizers such as alkali metal salts of ethylenediamine tetraacetic acid, and transferred into injection bottles or ampoules filled.
- the capsules containing one or more active ingredients or combinations of active ingredients can be produced, for example, by mixing the active ingredients with inert carriers, such as lactose or sorbitol, and encapsulating them in gelatin capsules.
- Suitable suppositories can be produced, for example, by mixing them with carriers, such as neutral fats or polyethylene glycol or its derivatives.
- a therapeutically effective daily dose is between 1 and 5000 mg, preferably 100-1000 mg per adult.
- the finely ground active ingredient, milk sugar and part of the corn starch are mixed together.
- the mixture is sieved, whereupon it is moistened with a solution of polyvinylpyrrolidone in water, kneaded, wet-granulated and dried.
- the granules, the rest of the corn starch and the magnesium stearate are sieved and mixed together.
- the mixture is compressed into tablets of a suitable shape and size.
- the finely ground active ingredient, part of the corn starch, milk sugar, microcrystalline cellulose and polyvinylpyrrolidone are mixed together, the mixture is sieved and processed with the rest of the corn starch and water to form a granulate, which is dried and sieved.
- the sodium carboxymethyl starch and the magnesium stearate are added, the mixture is mixed and pressed into tablets of a suitable size.
- the active ingredient, corn starch, milk sugar and polyvinylpyrrolidone are mixed well and moistened with water.
- the moist mass is pressed through a sieve with a 1 mm mesh size, dried at approx. 45 ° C and then the granules are passed through the same sieve.
- domed dragee cores with a diameter of 6 mm are pressed on a tablet machine.
- the dragee cores thus produced are coated in a known manner with a layer consisting essentially of sugar and talc.
- the finished coated tablets are polished with wax.
- the substance and corn starch are mixed and moistened with water.
- the moist mass is sieved and dried.
- the dry granules are sieved and mixed with magnesium stearate.
- the final mixture is filled into size 1 hard gelatin capsules.
- the active ingredient is dissolved in water at its own pH or, if appropriate, at pH 5.5 to 6.5, and sodium chloride is added as the isotonic agent, the solution obtained is filtered pyrogen-free and the filtrate is filled into ampoules under aseptic conditions, which are then sterilized and sealed ,
- the ampoules contain 5 mg, 25 mg and 50 mg of active ingredient.
- the hard fat is melted.
- the milled active substance is homogeneously dispersed at 40 ° C. It is cooled to 38 ° C and poured into weakly pre-cooled suppository molds.
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Abstract
Description
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Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2417190A CA2417190C (en) | 2000-08-16 | 2001-07-21 | New beta-amyloid inhibitors, processes for preparing them and their use as pharmaceutical compositions |
MXPA03001356A MXPA03001356A (es) | 2000-08-16 | 2001-07-21 | Nuevos agentes inhibidores de beta-amiloides, procedimientos para su preparacion y su uso como medicamentos. |
DE50104557T DE50104557D1 (de) | 2000-08-16 | 2001-07-21 | Neue beta-amyloid inhibitoren, verfahren zu deren herstellung und deren verwendung als arzneimittel |
AU2002210425A AU2002210425A1 (en) | 2000-08-16 | 2001-07-21 | Novel beta-amyloid inhibitors, method for producing the same and the use thereofas medicaments |
EP01978258A EP1311508B1 (de) | 2000-08-16 | 2001-07-21 | Neue beta-amyloid inhibitoren, verfahren zu deren herstellung und deren verwendung als arzneimittel |
JP2002519453A JP5031171B2 (ja) | 2000-08-16 | 2001-07-21 | 新規β−アミロイド阻害剤、その製造方法及び医薬組成物としての使用 |
AT01978258T ATE282615T1 (de) | 2000-08-16 | 2001-07-21 | Neue beta-amyloid inhibitoren, verfahren zu deren herstellung und deren verwendung als arzneimittel |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE10040016A DE10040016A1 (de) | 2000-08-16 | 2000-08-16 | Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
DE10040016.7 | 2000-08-16 |
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WO2002014313A2 true WO2002014313A2 (de) | 2002-02-21 |
WO2002014313A3 WO2002014313A3 (de) | 2002-05-23 |
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EP (1) | EP1311508B1 (de) |
JP (1) | JP5031171B2 (de) |
AT (1) | ATE282615T1 (de) |
AU (1) | AU2002210425A1 (de) |
CA (1) | CA2417190C (de) |
DE (2) | DE10040016A1 (de) |
ES (1) | ES2232669T3 (de) |
MX (1) | MXPA03001356A (de) |
WO (1) | WO2002014313A2 (de) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004033453A1 (de) * | 2002-10-08 | 2004-04-22 | Grünenthal GmbH | Substituierte c-imidazo[1,2-a]lpyridin-3yl-methylamine |
WO2005080362A1 (en) * | 2004-02-25 | 2005-09-01 | Active Biotech Ab | Cinnamic amides, process for their preparation, and pharmaceutical compositions containing them |
US7148353B2 (en) * | 2003-10-28 | 2006-12-12 | Sepracor Inc. | Imidazo[1,2-a] pyridine anxiolytics |
EP2022792A1 (de) * | 2006-04-28 | 2009-02-11 | Nihon Medi-Physics Co., Ltd. | Neue verbindung mit affinität zu amyloid |
WO2009143156A2 (en) * | 2008-05-19 | 2009-11-26 | Sepracor Inc. | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS |
WO2012057300A1 (ja) * | 2010-10-29 | 2012-05-03 | 大日本住友製薬株式会社 | 新規ピリジン誘導体 |
WO2020029980A1 (en) * | 2018-08-06 | 2020-02-13 | Moexa Pharmaceuticals Limited | Smad3 inhibitors |
WO2024017144A1 (en) * | 2022-07-18 | 2024-01-25 | Moexa Pharmaceuticals Limited | Substituted imidazo [1, 2-a] pyridine compounds and the use thereof in the treatment and prevention of fibrosis |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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TW200808795A (en) | 2006-05-19 | 2008-02-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity for amyloid |
EP2042501B1 (de) | 2006-06-21 | 2017-04-12 | Nihon Medi-Physics Co., Ltd. | Verbindung mit affinität zu amyloid |
TW200811175A (en) * | 2006-06-21 | 2008-03-01 | Nihon Mediphysics Co Ltd | Novel compound with affinity with amyloid |
TWI406674B (zh) | 2007-02-13 | 2013-09-01 | Nihon Mediphysics Co Ltd | Method for manufacturing diagnostic radiographic diagnostic agents |
WO2010064020A1 (en) * | 2008-12-04 | 2010-06-10 | Proximagen Ltd. | Imidazopyridine compounds |
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JP2777159B2 (ja) * | 1988-12-22 | 1998-07-16 | エーザイ株式会社 | 環状アミン誘導体を含有する医薬 |
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PL343435A1 (en) * | 1998-03-06 | 2001-08-13 | Janssen Pharmaceutica Nv | Glycine transport inhibitors |
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- 2001-07-21 AU AU2002210425A patent/AU2002210425A1/en not_active Abandoned
- 2001-07-21 MX MXPA03001356A patent/MXPA03001356A/es active IP Right Grant
- 2001-07-21 AT AT01978258T patent/ATE282615T1/de active
- 2001-07-21 WO PCT/EP2001/008456 patent/WO2002014313A2/de active IP Right Grant
- 2001-07-21 ES ES01978258T patent/ES2232669T3/es not_active Expired - Lifetime
- 2001-07-21 JP JP2002519453A patent/JP5031171B2/ja not_active Expired - Lifetime
- 2001-07-21 EP EP01978258A patent/EP1311508B1/de not_active Expired - Lifetime
- 2001-07-21 DE DE50104557T patent/DE50104557D1/de not_active Expired - Lifetime
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Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004033453A1 (de) * | 2002-10-08 | 2004-04-22 | Grünenthal GmbH | Substituierte c-imidazo[1,2-a]lpyridin-3yl-methylamine |
DE10246890A1 (de) * | 2002-10-08 | 2004-04-22 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-alpyridin-3-yl-methylamine |
US7342025B2 (en) | 2002-10-08 | 2008-03-11 | Gruenenthal Gmbh | Substituted C-imidazo[1,2-a]pyridin-3-yl-methylamines |
US7148353B2 (en) * | 2003-10-28 | 2006-12-12 | Sepracor Inc. | Imidazo[1,2-a] pyridine anxiolytics |
WO2005080362A1 (en) * | 2004-02-25 | 2005-09-01 | Active Biotech Ab | Cinnamic amides, process for their preparation, and pharmaceutical compositions containing them |
EP2022792A1 (de) * | 2006-04-28 | 2009-02-11 | Nihon Medi-Physics Co., Ltd. | Neue verbindung mit affinität zu amyloid |
EP2022792A4 (de) * | 2006-04-28 | 2009-11-11 | Nihon Mediphysics Co Ltd | Neue verbindung mit affinität zu amyloid |
US8022207B2 (en) | 2006-04-28 | 2011-09-20 | Nihon Medi-Physics Co., Ltd. | Compound having affinity to amyloid |
WO2009143156A3 (en) * | 2008-05-19 | 2010-01-14 | Sepracor Inc. | Imidazo [1, 2-a] pyridine compounds as gaba-a receptor modulators |
WO2009143156A2 (en) * | 2008-05-19 | 2009-11-26 | Sepracor Inc. | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS |
US8497278B2 (en) | 2008-05-19 | 2013-07-30 | Sunovion Pharmaceuticals Inc. | Imidazo[1,2-a]pyridine compounds |
WO2012057300A1 (ja) * | 2010-10-29 | 2012-05-03 | 大日本住友製薬株式会社 | 新規ピリジン誘導体 |
WO2020029980A1 (en) * | 2018-08-06 | 2020-02-13 | Moexa Pharmaceuticals Limited | Smad3 inhibitors |
CN112689634A (zh) * | 2018-08-06 | 2021-04-20 | 莫扎制药有限公司 | Smad3抑制剂 |
EP3833664A4 (de) * | 2018-08-06 | 2022-06-08 | Moexa Pharmaceuticals Limited | Smad3-inhibitoren |
AU2019316858B2 (en) * | 2018-08-06 | 2024-03-28 | Moexa Pharmaceuticals Limited | Smad3 inhibitors |
CN112689634B (zh) * | 2018-08-06 | 2024-07-16 | 莫扎制药有限公司 | Smad3抑制剂 |
US12090149B2 (en) | 2018-08-06 | 2024-09-17 | Moexa Pharmaceuticals Limited | SMAD3 inhibitors |
WO2024017144A1 (en) * | 2022-07-18 | 2024-01-25 | Moexa Pharmaceuticals Limited | Substituted imidazo [1, 2-a] pyridine compounds and the use thereof in the treatment and prevention of fibrosis |
Also Published As
Publication number | Publication date |
---|---|
JP2004506633A (ja) | 2004-03-04 |
CA2417190C (en) | 2010-10-26 |
ATE282615T1 (de) | 2004-12-15 |
JP5031171B2 (ja) | 2012-09-19 |
EP1311508A2 (de) | 2003-05-21 |
AU2002210425A1 (en) | 2002-02-25 |
MXPA03001356A (es) | 2004-04-05 |
DE50104557D1 (de) | 2004-12-23 |
CA2417190A1 (en) | 2003-01-24 |
ES2232669T3 (es) | 2005-06-01 |
WO2002014313A3 (de) | 2002-05-23 |
DE10040016A1 (de) | 2002-02-28 |
EP1311508B1 (de) | 2004-11-17 |
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