WO2001089426A1 - Dispositif pour retrecir et/ou renforcer les orifices valvulaires du coeur - Google Patents

Dispositif pour retrecir et/ou renforcer les orifices valvulaires du coeur Download PDF

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Publication number
WO2001089426A1
WO2001089426A1 PCT/IB2000/001605 IB0001605W WO0189426A1 WO 2001089426 A1 WO2001089426 A1 WO 2001089426A1 IB 0001605 W IB0001605 W IB 0001605W WO 0189426 A1 WO0189426 A1 WO 0189426A1
Authority
WO
WIPO (PCT)
Prior art keywords
link
endomyocardium
needle
valve
absorbable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2000/001605
Other languages
English (en)
French (fr)
Inventor
Afksendiyos Kalangos
Raymond Andrieu
Philippe Le Goff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIORING SA
Original Assignee
BIORING SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MXPA02011590A priority Critical patent/MXPA02011590A/es
Priority to DE60023566T priority patent/DE60023566T2/de
Priority to AU1407501A priority patent/AU1407501A/xx
Priority to NZ522752A priority patent/NZ522752A/en
Priority to US10/296,449 priority patent/US7347870B1/en
Priority to RU2002135083/14A priority patent/RU2254830C2/ru
Priority to DK00976200T priority patent/DK1284688T3/da
Priority to AU2001214075A priority patent/AU2001214075B2/en
Priority to SI200030785T priority patent/SI1284688T1/sl
Application filed by BIORING SA filed Critical BIORING SA
Priority to JP2001585672A priority patent/JP2003534045A/ja
Priority to CA002413847A priority patent/CA2413847C/en
Priority to EP00976200A priority patent/EP1284688B1/fr
Priority to AT00976200T priority patent/ATE307541T1/de
Publication of WO2001089426A1 publication Critical patent/WO2001089426A1/fr
Anticipated expiration legal-status Critical
Priority to CY20061100056T priority patent/CY1105350T1/el
Priority to US11/934,095 priority patent/US20080288062A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00778—Operations on blood vessels
    • A61B2017/00783—Valvuloplasty
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B2017/06057—Double-armed sutures, i.e. sutures having a needle attached to each end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable

Definitions

  • the lesions of the valvular orifices of the heart whether it is the sigmoid valves of the aorta or the pulmonary artery or whether it is the mitral or tricuspid valves arise in 80 to 90% of cases of a prolapse or a restriction which induce a dilation of the ring by widening the cardiac cavities concerned and in practically all the rest of the cases of a dilation of the ring without associated valve damage.
  • the subject of the present invention is a device for narrowing and / or strengthening the valvular orifices of the heart which prevents any predisposition to infection and which allows normal growth of the valve ring in children, thus avoiding stenosis or successive interventions.
  • the device for narrowing and / or strengthening the valve orifices of the heart is distinguished by the characteristics listed in claim 1.
  • Figure 1 is a schematic representation of the human heart.
  • Figures 2, 3 and 4 are simplified diagrams respectively illustrating the mitral valve, the tricuspid valve and the sigmoid valves.
  • Figure 5 illustrates schematically or simplified a first embodiment of the device according to the invention.
  • Figure 6 illustrates schematically or simplified a second embodiment of the device according to the invention.
  • Figure 7 illustrates schematically or simplified a third embodiment of the device according to the invention.
  • Figure 8 illustrates schematically or simplified a fourth embodiment of the device according to the invention.
  • FIG. 9 schematically or simplified illustrates a variant of the device illustrated in FIG. 7.
  • the present technique consists in placing a flexible link on the along all or part of the periphery of the valve orifice inside the endocardium, i.e. the layer of tissue located on the internal side of the myocardial muscle, to define the dimension of the valve opening by a defined length of the link , to fix it in one or two points of the endocardium for example by stitches.
  • an absorbable link biodegradable or bioabsorbable
  • biodegradable or bioabsorbable is used, that is to say biodegradable and not causing an immune response on the part of the organism.
  • absorbable is used to define in an undifferentiated manner bioabsorbable or biodegradable and absorbable suture threads or not. Initially after the operation, the link maintains the valve ring at its normal or desired size thus preventing its expansion.
  • the organism creates by reaction a scar along the link characterized by fibrous tissue having greater resistance to stretching.
  • the link has been absorbed by the organism, the maintenance of the valve orifice at the desired size is effected by the rigidity of this fibrous tissue of the scar.
  • the residual scar consists of biological tissue specific to the patient, there can be no predisposition to infection, but above all this scar can grow normally during the growth process of the child, which avoids the problems of stenosis late.
  • this new technique is made possible by the device for repairing lesions, narrowing and / or strengthening the valve orifices of the heart according to the present invention.
  • this device comprises a link 1, made of a material absorbable by the body, terminated at one of its ends by a loop 2 or a stop and fixing member which may or may not be absorbed, by example a hook or hook allowing the attachment of this end to the endomyocardium.
  • the other end of the link 1 is integral, generally coming from a workpiece, with a very flexible thin wire 3, such as suture wire.
  • This thin wire 3 is preferably also absorbable and generally formed of the same material as the link 1.
  • This wire 3 is fixed at its free end to a needle 4 allowing the establishment of the link 1 of the device. It is obvious that the present device is produced in several sizes because for easy installation it is preferable that the curvature and the length of the needle 4 correspond to the curvature of the ring of the valve orifice and to the length of the perimeter portion of the orifice to be fitted with link 1 of the device.
  • the link 1 has a length and if possible a curvature corresponding to the portion of the periphery of the valve orifice to be fitted with the link.
  • the surgeon can, in the case of the valves illustrated in FIGS. 2 and 3, introduce the needle 4 at X into the endomyocardium of the valvular ring A, make the needle pass inside this layer of tissue up to point Y of the valve ring A since the curvature of the needle 4 and its length are adapted to the valve to be fitted.
  • the surgeon pulls out the needle 4 at point Y and pulls the wire 3 to drive the link 1 into the position for which the fixing member 2 is located near the insertion point X and the junction between the link 1 and the wire thin 3 is it located at the exit point Y.
  • the surgeon fixes by making some stitches and possibly using a stop, for example a button, the link 1 at the exit point Y with the wire 3, then cuts this wire 3
  • the surgeon fixes and buries in the endomyocardium by a few stitches the loop 2 or the stop provided at the free end of the link 1.
  • the link 1 has a curvature corresponding approximately to that of the ring of the orifice of the valve and the amount of absorbable material depends on the mass of fibrous tissue which it is desired to induce by resorption to obtain the desired rigidity of this natural scar which will in the long term alone ensure the maintenance of the ring of the valve orifice and prevent any expansion of the latter.
  • the link 1 and the needle 4 depend on this diameter and on the X - Y portion of the periphery of the orifice. valve to be equipped.
  • several types are provided with different thicknesses of the link 1.
  • the link 1 made of absorbable material is coated with a layer of a second material more quickly absorbable than that used to make the internal part of the tie.
  • a rapid initial resorption for example of a few days to a few weeks, and therefore the faster formation of a fibrous tissue allowing an almost immediate reinforcement of the orifice. valvular.
  • This rapid initial healing is followed by slow healing, six to twelve months, due to the resorption of the central part of the link 1.
  • the surgeon has testers, templates of the shape of the valve orifices, but of different sections.
  • a tester corresponding to the size of the surface of the anterior sheet of the mitral or tricuspid valve to be repaired or to the diameter of the sinotubular junction where the three sigmoid valves coaptate.
  • the surgeon determines the size of the device to be used.
  • the choice of the type of device within the determined size is assessed according to the patient's age, his body surface, and the condition of the lesion. The greater the amount of absorbable material of the link 1, the greater the scar and the stronger the strengthening of the ring of the valve orifice.
  • the link has a succession of bulges 5 and thinning 6.
  • This type of device generates slight or weak scarring at the level of the thinning 6 and strong at the level of the bulges 5. This is particularly interesting in young children or infants because during growth the parts with poor healing, corresponding to thinning 6, can easily stretch depending on the growth of the subject.
  • the curvature of the needle 4 and that of the absorbable link 5, 6 correspond substantially to that of the valve orifice to be fitted.
  • the absorbable link 5, 6 can be covered with a layer of material more quickly absorbable than that used to make the interior of the link so as to create a resorption in two stages.
  • the third embodiment of the device illustrated in FIG. 7 is more particularly, but not exclusively, intended for the case of repair, narrowing or reinforcement of valve orifices in which it is necessary to reinforce the entire periphery of the valve orifice, by example in the case of the mitral, tricuspid and sigmoid valve.
  • This device comprises a thick and absorbable link 1 and the ends of which both include thin wires 3 each provided with a needle 4.
  • the surgeon introduces the absorbable link 1 in the endomyocardium so as to form a loop, then it ties the two thin wires 3, also absorbable, of the device so as to keep the link 1 closed on itself.
  • the rest of the wires are cut (see Figure 9).
  • the curvature of the needles 4 and the link 1 of the device preferably correspond to the normal curvature of the valve orifice to be fitted.
  • the link 1 may include, as illustrated in Figure 6, bulges and thinning.
  • this link 1 may comprise a layer or covering made of a material which is more quickly absorbable than that forming the inside of the link 1 of the device so as to obtain resorption in two stages.
  • the fourth embodiment of the device according to the invention illustrated in FIG. 8 is more particularly intended for the repair of sigmoid valves formed from three lobes L.
  • the link consists of several, here three, parts 7, 8, 9.
  • the central part 8 is connected to the lateral parts 7, 9 of this central portion and these lateral parts each have a thread 3 terminated by a needle 4.
  • the curvature of the needles 4 and of the parts 7, 8, 9 of the link corresponds to the curvature free edges B of lobes L of the sigmoid valve.
  • the wires 3 are then knotted together and cut.
  • the link and possibly the wires 3 are made of an absorbable material, possibly in two stages as described above.
  • This link can have a diameter of the order of 0.2 mm to a few millimeters depending on the conditions of use. Its section can be circular, oval, polygonal and in particular rectangular to give it greater resistance to deformation. This link is generally flexible, but resumes by its own elasticity its curved shape corresponding approximately to the valve orifice.
  • One of the innovative features of the invention consists in using one or more absorbable materials for the embodiments of the link 1 and of the wires 3.
  • the absorbable materials have several applications in the field of medical devices, for example as that suture, or as a prosthesis, or even as a device for the controlled release of medicinal substances in the body, there is no application in which the material has to ensure, in addition to its primary function d repairing element, a function of induction of a curative and evolutionary action coming from the organism itself.
  • the absorbable materials finding applications in the health fields are obtained from tissues or proteins originating from the animal kingdom, such as collagen or catgut, or from polymers produced by synthesis.
  • the chemical natures of the main polymers known to be absorbable include polyesters, polyorthoesters, polyanhydrides, poly (ether) esters, polyamino acids and polydepsipeptides (see for example: B. Buchholz; J. Mater. Sci. Mater: Med 4 (1993) 381-388).
  • the absorbable polymers can be described by a pattern corresponding to the general formula:
  • X1 denote an oxygen atom or an NH group
  • Y1 denotes an oxygen atom, or an NH group, or a chemical bond directly linking R1 to R3 (respectively R2 to R4)
  • R1; R2; R3; R4 denote linear or branched carbon chains, saturated or partially unsaturated, carrying or not heteroatoms and containing from 0 to 10 carbon atoms.
  • X1 is equal to X2 and Y1 is equal to Y2 and R1 is equal to R3 and R2 is equal to R4, the polymer obtained is called homopolymer. Otherwise, the polymer obtained is called a copolymer.
  • X2 denote an oxygen atom
  • Y1 denotes an oxygen atom or a chemical bond directly connecting R1 to R3 (respectively R2 to R4)
  • R1; R2; R3; R4 denote linear or branched carbon chains containing 0 to 5 carbon atoms and preferably 0 to 3 atoms.
  • polymers include, for example, polylactides, polyglycolides, polydioxanones, polyalkylenecarbonates and polylactones. To these homopolymers are added the copolymers obtained by combinations of the different monomers. These polymers are known for their ability to resorb in vivo according to known and predictable modes of resorption.
  • polydioxanones are known to resorb more slowly than polylactides, or polyglycolides , or that catgut or collagen.
  • the flexibility of the material obtained also depends on the nature of the polymer used.
  • the mechanical characteristics of the material obtained will vary, for example, with the chemical nature of the motif, the molecular weight, the polymerization process, the technique for using the material, etc.
  • the link 1 is formed from two different materials
  • the external coating causes a first fibrous reaction during its early resorption while protecting the polydioxanone which will only start its slow resorption when the external coating is absorbed. A later resorption is thus obtained which induces a more consolidating fibrous reaction.
  • the thick main segments 5 would comprise the two materials while the thin connecting parts 6 could comprise only one of the two aforementioned materials.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Prostheses (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Paper (AREA)
  • Valves And Accessory Devices For Braking Systems (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Self-Closing Valves And Venting Or Aerating Valves (AREA)
  • Golf Clubs (AREA)
  • Chair Legs, Seat Parts, And Backrests (AREA)
PCT/IB2000/001605 2000-05-25 2000-11-07 Dispositif pour retrecir et/ou renforcer les orifices valvulaires du coeur Ceased WO2001089426A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SI200030785T SI1284688T1 (sl) 2000-05-25 2000-11-07 Priprava za zozitev in/ali ojacitev odprtin in srcnih zaklopk
AU1407501A AU1407501A (en) 2000-05-25 2000-11-07 Device for shrinking or reinforcing the heart valvular orifices
JP2001585672A JP2003534045A (ja) 2000-05-25 2000-11-07 心臓弁の開口を狭めおよび／または補強する装置
US10/296,449 US7347870B1 (en) 2000-05-25 2000-11-07 Device for shrinking or reinforcing the heart valvular orifices
RU2002135083/14A RU2254830C2 (ru) 2000-05-25 2000-11-07 Устройство для стягивания и/или подкрепления отверстий клапанов сердца (варианты) и способ коррекции размеров и/или подкрепления отверстий клапанов сердца
DK00976200T DK1284688T3 (da) 2000-05-25 2000-11-07 Indretning til indsnævring og/eller forstærkning af hjerteklapåbningerne
AU2001214075A AU2001214075B2 (en) 2000-05-25 2000-11-07 Device for shrinking or reinforcing the heart valvular orifices
MXPA02011590A MXPA02011590A (es) 2000-05-25 2000-11-07 Dispositivo para estrechar y/o reforzar los orificios valvulares del corazon.
NZ522752A NZ522752A (en) 2000-05-25 2000-11-07 Device for shrinking or reinforcing the heart valvular orifices
DE60023566T DE60023566T2 (de) 2000-05-25 2000-11-07 Vorrichtung zur reduzierung und/oder verstärkung der herzklappenöffnungen
CA002413847A CA2413847C (en) 2000-05-25 2000-11-07 Device for shrinking or reinforcing the heart valvular orifices
EP00976200A EP1284688B1 (fr) 2000-05-25 2000-11-07 Dispositif pour retrecir et/ou renforcer les orifices valvulaires du coeur
AT00976200T ATE307541T1 (de) 2000-05-25 2000-11-07 Vorrichtung zur reduzierung und/oder verstärkung der herzklappenöffnungen
CY20061100056T CY1105350T1 (el) 2000-05-25 2006-01-17 Μηχανισμος για στενεψη και/ή ενισχυση των στομιων καρδιακων βαλβιδων
US11/934,095 US20080288062A1 (en) 2000-05-25 2007-11-02 Device for shrinking or reinforcing the valvular orifices of the heart

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB0000707 2000-05-25
IBPCT/IB00/00707 2000-05-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/934,095 Division US20080288062A1 (en) 2000-05-25 2007-11-02 Device for shrinking or reinforcing the valvular orifices of the heart

Publications (1)

Publication Number Publication Date
WO2001089426A1 true WO2001089426A1 (fr) 2001-11-29

Family

ID=11003923

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/001605 Ceased WO2001089426A1 (fr) 2000-05-25 2000-11-07 Dispositif pour retrecir et/ou renforcer les orifices valvulaires du coeur

Country Status (17)

Country Link
US (2) US7347870B1 (enExample)
EP (1) EP1284688B1 (enExample)
JP (1) JP2003534045A (enExample)
AT (1) ATE307541T1 (enExample)
AU (2) AU1407501A (enExample)
CA (1) CA2413847C (enExample)
CY (1) CY1105350T1 (enExample)
CZ (1) CZ20023821A3 (enExample)
DE (1) DE60023566T2 (enExample)
DK (1) DK1284688T3 (enExample)
ES (1) ES2251408T3 (enExample)
MX (1) MXPA02011590A (enExample)
NZ (1) NZ522752A (enExample)
RU (1) RU2254830C2 (enExample)
SI (1) SI1284688T1 (enExample)
WO (1) WO2001089426A1 (enExample)
ZA (1) ZA200209517B (enExample)

Cited By (25)

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WO2003055417A1 (en) * 2001-12-28 2003-07-10 Edwards Lifesciences Ag Delayed memory device
US6989028B2 (en) 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6997951B2 (en) 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US7004176B2 (en) 2003-10-17 2006-02-28 Edwards Lifesciences Ag Heart valve leaflet locator
US7011682B2 (en) 2000-01-31 2006-03-14 Edwards Lifesciences Ag Methods and apparatus for remodeling an extravascular tissue structure
US7044967B1 (en) 1999-06-29 2006-05-16 Edwards Lifesciences Ag Device and method for treatment of mitral insufficiency
US7090695B2 (en) 1999-06-30 2006-08-15 Edwards Lifesciences Ag Method for treatment of mitral insufficiency
US7192443B2 (en) 2002-01-11 2007-03-20 Edwards Lifesciences Ag Delayed memory device
US7211110B2 (en) 2004-12-09 2007-05-01 Edwards Lifesciences Corporation Diagnostic kit to assist with heart valve annulus adjustment
US7500989B2 (en) 2005-06-03 2009-03-10 Edwards Lifesciences Corp. Devices and methods for percutaneous repair of the mitral valve via the coronary sinus
US7510576B2 (en) 2001-01-30 2009-03-31 Edwards Lifesciences Ag Transluminal mitral annuloplasty
WO2008152465A3 (fr) * 2007-06-12 2009-12-10 Bioring Sa Dispositif biodégradable pour angioplastie temporaire et induction réparatrice des conduits vasculaires en général et des artères coronaires en particulier
US7637946B2 (en) 2006-02-09 2009-12-29 Edwards Lifesciences Corporation Coiled implant for mitral valve repair
US7695512B2 (en) 2000-01-31 2010-04-13 Edwards Lifesciences Ag Remotely activated mitral annuloplasty system and methods
US7935146B2 (en) 2000-01-31 2011-05-03 Edwards Lifesciences Ag Percutaneous mitral annuloplasty with hemodynamic monitoring
US7993397B2 (en) 2004-04-05 2011-08-09 Edwards Lifesciences Ag Remotely adjustable coronary sinus implant
US8100820B2 (en) 2007-08-22 2012-01-24 Edwards Lifesciences Corporation Implantable device for treatment of ventricular dilation
US8167787B2 (en) 2008-01-03 2012-05-01 Revent Medical, Inc. Partially erodable systems for treatment of obstructive sleep apnea
US8327854B2 (en) 2008-05-12 2012-12-11 Revent Medical, Inc. Partially erodable systems for treatment of obstructive sleep apnea
US8733363B2 (en) 2010-03-19 2014-05-27 Revent Medical, Inc. Systems and methods for treatment of sleep apnea
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AU1407501A (en) 2001-12-03
RU2254830C2 (ru) 2005-06-27
ATE307541T1 (de) 2005-11-15
SI1284688T1 (sl) 2006-04-30
ES2251408T3 (es) 2006-05-01
MXPA02011590A (es) 2004-07-30
DE60023566T2 (de) 2006-07-27
DE60023566D1 (de) 2005-12-01
ZA200209517B (en) 2003-12-04
NZ522752A (en) 2004-08-27
US20080288062A1 (en) 2008-11-20
AU2001214075B2 (en) 2004-12-09
CZ20023821A3 (cs) 2003-04-16
EP1284688A1 (fr) 2003-02-26
US7347870B1 (en) 2008-03-25
CA2413847C (en) 2008-07-08
CY1105350T1 (el) 2010-03-03
DK1284688T3 (da) 2006-03-06
JP2003534045A (ja) 2003-11-18
EP1284688B1 (fr) 2005-10-26
CA2413847A1 (en) 2001-11-29

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