WO2001040767A1 - Method of producing porous spherical particles - Google Patents

Method of producing porous spherical particles Download PDF

Info

Publication number
WO2001040767A1
WO2001040767A1 PCT/SE2000/002358 SE0002358W WO0140767A1 WO 2001040767 A1 WO2001040767 A1 WO 2001040767A1 SE 0002358 W SE0002358 W SE 0002358W WO 0140767 A1 WO0140767 A1 WO 0140767A1
Authority
WO
WIPO (PCT)
Prior art keywords
polysaccharide
particles
temperature
droplets
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE2000/002358
Other languages
English (en)
French (fr)
Inventor
Ralf Göran ANDERSSON
Ingemar Jonsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AP BIOTECH AB
Original Assignee
AP BIOTECH AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AP BIOTECH AB filed Critical AP BIOTECH AB
Priority to JP2001542183A priority Critical patent/JP5000059B2/ja
Priority to AU19099/01A priority patent/AU1909901A/en
Priority to US10/148,718 priority patent/US6841097B2/en
Priority to EP00982023A priority patent/EP1240497B1/en
Priority to DE60039368T priority patent/DE60039368D1/de
Priority to CA002392811A priority patent/CA2392811C/en
Publication of WO2001040767A1 publication Critical patent/WO2001040767A1/en
Anticipated expiration legal-status Critical
Priority to US11/013,032 priority patent/US20050110176A1/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • B01J2/08—Gelation of a colloidal solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/12—Agar or agar-agar, i.e. mixture of agarose and agaropectin; Derivatives thereof

Definitions

  • the present invention refers to a method of producing porous spherical gelled particles. More precisely, the invention refers to a method of controlling the porosity of porous spherical particles produced from a polysaccharide dissolved in a solvent, in which it can be gelled, said polysaccharide solution being finely divided by mechanical means into spherical droplets which are allowed to pass through a humid atmosphere and transferred to a capturing medium.
  • Gel filtration is a commonly used chromatographic separation method in which molecules are separated with respect to their size. Small molecules diffuse into porous particles while large molecules pass on the outside thereof. Spherical particles intended for the separation of macromolecules by means of such a chromatography are produced from a gelled and/or polymerized material. Of course, a good separation does not only depend on the size and the size distribution of the particles but also on the extent of the porosity of the particles.
  • these particles are produced by means of dispersion procedures which are based on a vigorous mech- anical mixing of the generally water soluble substance which is to be dispersed in a dispersing medium usually comprising an organic solvent such as toluene.
  • a dispersing medium usually comprising an organic solvent such as toluene.
  • the processing of the spherical particles obtained from the dispersing procedure takes place in several steps accompanied by a thorough rinsing in order to remove the solvent.
  • This conventional method of producing the particle shaped material for chromatography is thus energy demanding as well as expensive and, in addition, the productivity is low and produced batchwise.
  • One way of avoiding organic solvents when producing such particles would be to use water as a solvent in the manufacturing procedure.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
PCT/SE2000/002358 1999-12-01 2000-11-29 Method of producing porous spherical particles Ceased WO2001040767A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2001542183A JP5000059B2 (ja) 1999-12-01 2000-11-29 多孔性球状粒子の製造方法
AU19099/01A AU1909901A (en) 1999-12-01 2000-11-29 Method of producing porous spherical particles
US10/148,718 US6841097B2 (en) 1999-12-01 2000-11-29 Method of producing porous spherical particles
EP00982023A EP1240497B1 (en) 1999-12-01 2000-11-29 Method of producing porous spherical particles
DE60039368T DE60039368D1 (de) 1999-12-01 2000-11-29 Verfahren zur produktion poröser sphärischer partikel
CA002392811A CA2392811C (en) 1999-12-01 2000-11-29 Method of producing porous spherical particles
US11/013,032 US20050110176A1 (en) 1999-12-01 2004-12-15 Method of producing porous spherical particles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9904344-0 1999-12-01
SE9904344A SE9904344D0 (sv) 1999-12-01 1999-12-01 Method of producing porous spherical particles

Publications (1)

Publication Number Publication Date
WO2001040767A1 true WO2001040767A1 (en) 2001-06-07

Family

ID=20417913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2000/002358 Ceased WO2001040767A1 (en) 1999-12-01 2000-11-29 Method of producing porous spherical particles

Country Status (10)

Country Link
US (2) US6841097B2 (enExample)
EP (1) EP1240497B1 (enExample)
JP (1) JP5000059B2 (enExample)
AT (1) ATE399986T1 (enExample)
AU (1) AU1909901A (enExample)
CA (1) CA2392811C (enExample)
DE (1) DE60039368D1 (enExample)
ES (1) ES2309004T3 (enExample)
SE (1) SE9904344D0 (enExample)
WO (1) WO2001040767A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004534A1 (en) * 2001-07-03 2003-01-16 Ijorari Hb Ub Cellulosic particles suitable for chiral separation
WO2008041001A1 (en) * 2006-10-07 2008-04-10 Regentec Limited Porous particles
WO2009099375A1 (en) * 2008-02-05 2009-08-13 Ge Healthcare Bio-Sciences Ab Method for production of separation media
CN101240036B (zh) * 2008-02-26 2010-06-09 西北师范大学 一种微波辅助提取沙蒿多糖的方法
CN107754767A (zh) * 2017-10-31 2018-03-06 苏州博进生物技术有限公司 一种高稳定性固定化金属螯合亲和层析介质
US10441548B2 (en) 2015-11-12 2019-10-15 Graybug Vision, Inc. Aggregating microparticles for medical therapy
US11160870B2 (en) 2017-05-10 2021-11-02 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904344D0 (sv) * 1999-12-01 1999-12-01 Ralf Goeran Andersson Method of producing porous spherical particles
SG131015A1 (en) * 2005-09-15 2007-04-26 Millipore Corp Method and apparatus for making porous agarose beads
SG131016A1 (en) 2005-09-19 2007-04-26 Millipore Corp Asymmetric porous adsorptive bead
US9192907B2 (en) * 2007-12-03 2015-11-24 Dpx Holdings B.V. System and method for producing beads
US8083069B2 (en) * 2009-07-31 2011-12-27 General Electric Company High throughput magnetic isolation technique and device for biological materials
WO2014148966A1 (en) * 2013-03-19 2014-09-25 HB Ijorari Process for manufacturing porous polysaccharide particles and particles thereby obtained.
WO2015052460A1 (en) * 2013-10-09 2015-04-16 Ucl Business Plc Chromatography medium
CN106140038B (zh) * 2015-04-08 2019-07-12 通用电气公司 制备聚合物微粒的方法和装置
CN107537412B (zh) 2016-06-27 2021-06-01 思拓凡生物工艺研发有限公司 制备聚合物微球的方法和系统
CN110662543A (zh) 2017-03-23 2020-01-07 灰色视觉公司 用于治疗眼部疾病的药物和组合物
CN116640351B (zh) * 2023-06-19 2024-05-07 浙江三赢新材料有限公司 一种多糖球形凝胶树脂的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053332A (en) * 1989-07-24 1991-10-01 Cook Richard B Agarose beads, preferably incorporating biological materials
WO1993002785A1 (de) * 1991-07-30 1993-02-18 Nukem Gmbh Verfahren und vorrichtung zur herstellung von alginatkugeln
JPH05179005A (ja) * 1991-12-26 1993-07-20 Kobe Steel Ltd 均一な球形粒子の製造方法
WO1995020620A1 (en) * 1994-01-28 1995-08-03 Bio Dev Ab Procedure for production of spherical gel particles
DE4424998A1 (de) * 1994-07-15 1996-02-01 Vorlop Klaus Dieter Verfahren und Vorrichtung zur Herstellung von Teilchen aus einem flüssigen Medium
WO1999031141A2 (de) * 1997-12-14 1999-06-24 Thüringisches Institut für Textil- und Kunststoff-Forschung e.V. Verfahren zur herstellung von regulären porösen perlcellulosen, die perlcellulosen und ihre verwendung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61263630A (ja) * 1985-05-15 1986-11-21 Kyodo Kikaku Kk 分子篩機能を有する寒天ビーズの製造法
SE456486B (sv) * 1987-03-27 1988-10-10 Ralf Andersson Sett och anordning for uppdelning av en smelta i droppar
US5662840A (en) * 1994-06-10 1997-09-02 Fmc Corporation Process for making gel microbeads
JP3177587B2 (ja) * 1996-12-26 2001-06-18 レンゴー株式会社 セルロース微粒子の製造方法
US6248268B1 (en) * 1998-11-16 2001-06-19 Xc Corporation Process of making microparticles of a thermally-gelled polysaccharide
SE9904344D0 (sv) * 1999-12-01 1999-12-01 Ralf Goeran Andersson Method of producing porous spherical particles
CA2314921A1 (en) 2000-08-03 2002-02-03 Barry Partington Apparatus and method for producing porous polymer particles
SE0201289D0 (sv) * 2002-04-25 2002-04-25 Amersham Biosciences Ab Manufacture of polysaccharide beads

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053332A (en) * 1989-07-24 1991-10-01 Cook Richard B Agarose beads, preferably incorporating biological materials
WO1993002785A1 (de) * 1991-07-30 1993-02-18 Nukem Gmbh Verfahren und vorrichtung zur herstellung von alginatkugeln
JPH05179005A (ja) * 1991-12-26 1993-07-20 Kobe Steel Ltd 均一な球形粒子の製造方法
WO1995020620A1 (en) * 1994-01-28 1995-08-03 Bio Dev Ab Procedure for production of spherical gel particles
DE4424998A1 (de) * 1994-07-15 1996-02-01 Vorlop Klaus Dieter Verfahren und Vorrichtung zur Herstellung von Teilchen aus einem flüssigen Medium
WO1999031141A2 (de) * 1997-12-14 1999-06-24 Thüringisches Institut für Textil- und Kunststoff-Forschung e.V. Verfahren zur herstellung von regulären porösen perlcellulosen, die perlcellulosen und ihre verwendung

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 199333, Derwent World Patents Index; AN 1993-261726, XP002953083 *
PATENT ABSTRACTS OF JAPAN *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004534A1 (en) * 2001-07-03 2003-01-16 Ijorari Hb Ub Cellulosic particles suitable for chiral separation
WO2008041001A1 (en) * 2006-10-07 2008-04-10 Regentec Limited Porous particles
WO2009099375A1 (en) * 2008-02-05 2009-08-13 Ge Healthcare Bio-Sciences Ab Method for production of separation media
US8372286B2 (en) 2008-02-05 2013-02-12 Ge Healthcare Bio-Sciences Ab Method for production of separation media
CN101240036B (zh) * 2008-02-26 2010-06-09 西北师范大学 一种微波辅助提取沙蒿多糖的方法
US10441548B2 (en) 2015-11-12 2019-10-15 Graybug Vision, Inc. Aggregating microparticles for medical therapy
US11331276B2 (en) 2015-11-12 2022-05-17 Graybug Vision, Inc. Aggregating microparticles for medical therapy
US11564890B2 (en) 2015-11-12 2023-01-31 Graybug Vision, Inc. Aggregating microparticles for medical therapy
US11160870B2 (en) 2017-05-10 2021-11-02 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
CN107754767A (zh) * 2017-10-31 2018-03-06 苏州博进生物技术有限公司 一种高稳定性固定化金属螯合亲和层析介质
CN107754767B (zh) * 2017-10-31 2020-04-21 苏州博进生物技术有限公司 一种高稳定性固定化金属螯合亲和层析介质

Also Published As

Publication number Publication date
ES2309004T3 (es) 2008-12-16
DE60039368D1 (de) 2008-08-14
US6841097B2 (en) 2005-01-11
AU1909901A (en) 2001-06-12
JP5000059B2 (ja) 2012-08-15
JP2003517509A (ja) 2003-05-27
ATE399986T1 (de) 2008-07-15
US20030052426A1 (en) 2003-03-20
EP1240497A1 (en) 2002-09-18
EP1240497B1 (en) 2008-07-02
SE9904344D0 (sv) 1999-12-01
CA2392811A1 (en) 2001-06-07
CA2392811C (en) 2005-02-01
US20050110176A1 (en) 2005-05-26

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