JP2003517509A5 - - Google Patents
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- Publication number
- JP2003517509A5 JP2003517509A5 JP2001542183A JP2001542183A JP2003517509A5 JP 2003517509 A5 JP2003517509 A5 JP 2003517509A5 JP 2001542183 A JP2001542183 A JP 2001542183A JP 2001542183 A JP2001542183 A JP 2001542183A JP 2003517509 A5 JP2003517509 A5 JP 2003517509A5
- Authority
- JP
- Japan
- Prior art keywords
- particles
- polysaccharides
- temperature
- water
- atmosphere
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 description 38
- 239000007788 liquid Substances 0.000 description 28
- 239000005017 polysaccharide Substances 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- 238000000034 method Methods 0.000 description 19
- 239000002609 medium Substances 0.000 description 15
- 239000000243 solution Substances 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 13
- 239000012798 spherical particle Substances 0.000 description 11
- 238000001879 gelation Methods 0.000 description 10
- 239000000499 gel Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 8
- 229920000936 Agarose Polymers 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 5
- 238000004320 controlled atmosphere Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 239000011800 void material Substances 0.000 description 5
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 241000135164 Timea Species 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000002523 gelfiltration Methods 0.000 description 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 2
- 238000004255 ion exchange chromatography Methods 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000012501 chromatography medium Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007863 gel particle Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904344A SE9904344D0 (sv) | 1999-12-01 | 1999-12-01 | Method of producing porous spherical particles |
| SE9904344-0 | 1999-12-01 | ||
| PCT/SE2000/002358 WO2001040767A1 (en) | 1999-12-01 | 2000-11-29 | Method of producing porous spherical particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003517509A JP2003517509A (ja) | 2003-05-27 |
| JP2003517509A5 true JP2003517509A5 (enExample) | 2011-10-06 |
| JP5000059B2 JP5000059B2 (ja) | 2012-08-15 |
Family
ID=20417913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001542183A Expired - Lifetime JP5000059B2 (ja) | 1999-12-01 | 2000-11-29 | 多孔性球状粒子の製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6841097B2 (enExample) |
| EP (1) | EP1240497B1 (enExample) |
| JP (1) | JP5000059B2 (enExample) |
| AT (1) | ATE399986T1 (enExample) |
| AU (1) | AU1909901A (enExample) |
| CA (1) | CA2392811C (enExample) |
| DE (1) | DE60039368D1 (enExample) |
| ES (1) | ES2309004T3 (enExample) |
| SE (1) | SE9904344D0 (enExample) |
| WO (1) | WO2001040767A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904344D0 (sv) * | 1999-12-01 | 1999-12-01 | Ralf Goeran Andersson | Method of producing porous spherical particles |
| SE0102369D0 (sv) * | 2001-07-03 | 2001-07-03 | Monocell Ab | New method |
| SG131015A1 (en) * | 2005-09-15 | 2007-04-26 | Millipore Corp | Method and apparatus for making porous agarose beads |
| SG131016A1 (en) | 2005-09-19 | 2007-04-26 | Millipore Corp | Asymmetric porous adsorptive bead |
| GB0619869D0 (en) * | 2006-10-07 | 2006-11-15 | Regentec Ltd | Porous particles |
| KR101593247B1 (ko) | 2007-12-03 | 2016-02-11 | 디피엑스 홀딩스 비.브이. | 비드 제조 시스템 및 방법 |
| EP2237879A4 (en) * | 2008-02-05 | 2013-08-14 | Ge Healthcare Bio Sciences Ab | METHOD FOR THE PRODUCTION OF SEPARATE MEDIA |
| CN101240036B (zh) * | 2008-02-26 | 2010-06-09 | 西北师范大学 | 一种微波辅助提取沙蒿多糖的方法 |
| US8083069B2 (en) * | 2009-07-31 | 2011-12-27 | General Electric Company | High throughput magnetic isolation technique and device for biological materials |
| WO2014148966A1 (en) * | 2013-03-19 | 2014-09-25 | HB Ijorari | Process for manufacturing porous polysaccharide particles and particles thereby obtained. |
| WO2015052460A1 (en) * | 2013-10-09 | 2015-04-16 | Ucl Business Plc | Chromatography medium |
| CN106140038B (zh) * | 2015-04-08 | 2019-07-12 | 通用电气公司 | 制备聚合物微粒的方法和装置 |
| BR112018009644A2 (pt) | 2015-11-12 | 2018-11-06 | Graybug Vision Inc | micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície |
| CN107537412B (zh) | 2016-06-27 | 2021-06-01 | 思拓凡生物工艺研发有限公司 | 制备聚合物微球的方法和系统 |
| WO2018175922A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| CN111201040A (zh) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | 用于医学疗法的缓释微粒及其悬浮液 |
| CN107754767B (zh) * | 2017-10-31 | 2020-04-21 | 苏州博进生物技术有限公司 | 一种高稳定性固定化金属螯合亲和层析介质 |
| CN116640351B (zh) * | 2023-06-19 | 2024-05-07 | 浙江三赢新材料有限公司 | 一种多糖球形凝胶树脂的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61263630A (ja) * | 1985-05-15 | 1986-11-21 | Kyodo Kikaku Kk | 分子篩機能を有する寒天ビーズの製造法 |
| SE456486B (sv) * | 1987-03-27 | 1988-10-10 | Ralf Andersson | Sett och anordning for uppdelning av en smelta i droppar |
| US5053332A (en) * | 1989-07-24 | 1991-10-01 | Cook Richard B | Agarose beads, preferably incorporating biological materials |
| DE4125133C2 (de) | 1991-07-30 | 1993-09-30 | Nukem Gmbh | Verfahren und Vorrichtung zur Herstellung von Alginatkugeln |
| JPH05179005A (ja) | 1991-12-26 | 1993-07-20 | Kobe Steel Ltd | 均一な球形粒子の製造方法 |
| SE9400261D0 (sv) * | 1994-01-28 | 1994-01-28 | Biodev Ab | Förfarande för framställning av sfäriska gelade partiklar |
| US5662840A (en) * | 1994-06-10 | 1997-09-02 | Fmc Corporation | Process for making gel microbeads |
| DE4424998C2 (de) * | 1994-07-15 | 1996-06-20 | Vorlop Klaus Dieter | Verfahren zur Herstellung von Teilchen aus einem flüssigen Medium |
| JP3177587B2 (ja) * | 1996-12-26 | 2001-06-18 | レンゴー株式会社 | セルロース微粒子の製造方法 |
| US6670469B1 (en) * | 1997-12-14 | 2003-12-30 | Thuringisches Institut Fur Textil-Und Kunststoff-Forschung E.V. | Method for producing regular porous cellulose pearls, corresponding cellulose pearls and use thereof |
| US6248268B1 (en) * | 1998-11-16 | 2001-06-19 | Xc Corporation | Process of making microparticles of a thermally-gelled polysaccharide |
| SE9904344D0 (sv) * | 1999-12-01 | 1999-12-01 | Ralf Goeran Andersson | Method of producing porous spherical particles |
| CA2314921A1 (en) | 2000-08-03 | 2002-02-03 | Barry Partington | Apparatus and method for producing porous polymer particles |
| SE0201289D0 (sv) * | 2002-04-25 | 2002-04-25 | Amersham Biosciences Ab | Manufacture of polysaccharide beads |
-
1999
- 1999-12-01 SE SE9904344A patent/SE9904344D0/xx unknown
-
2000
- 2000-11-29 CA CA002392811A patent/CA2392811C/en not_active Expired - Lifetime
- 2000-11-29 US US10/148,718 patent/US6841097B2/en not_active Expired - Lifetime
- 2000-11-29 AT AT00982023T patent/ATE399986T1/de not_active IP Right Cessation
- 2000-11-29 AU AU19099/01A patent/AU1909901A/en not_active Abandoned
- 2000-11-29 ES ES00982023T patent/ES2309004T3/es not_active Expired - Lifetime
- 2000-11-29 DE DE60039368T patent/DE60039368D1/de not_active Expired - Lifetime
- 2000-11-29 JP JP2001542183A patent/JP5000059B2/ja not_active Expired - Lifetime
- 2000-11-29 WO PCT/SE2000/002358 patent/WO2001040767A1/en not_active Ceased
- 2000-11-29 EP EP00982023A patent/EP1240497B1/en not_active Expired - Lifetime
-
2004
- 2004-12-15 US US11/013,032 patent/US20050110176A1/en not_active Abandoned
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