CA2392811C - Method of producing porous spherical particles - Google Patents
Method of producing porous spherical particles Download PDFInfo
- Publication number
- CA2392811C CA2392811C CA002392811A CA2392811A CA2392811C CA 2392811 C CA2392811 C CA 2392811C CA 002392811 A CA002392811 A CA 002392811A CA 2392811 A CA2392811 A CA 2392811A CA 2392811 C CA2392811 C CA 2392811C
- Authority
- CA
- Canada
- Prior art keywords
- droplets
- polysaccharide
- temperature
- particles
- humidity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 29
- 239000012798 spherical particle Substances 0.000 title claims abstract description 15
- 150000004676 glycans Chemical class 0.000 claims abstract description 30
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 30
- 239000005017 polysaccharide Substances 0.000 claims abstract description 30
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 229920000936 Agarose Polymers 0.000 claims description 11
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 229920001817 Agar Polymers 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 235000010419 agar Nutrition 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000002609 medium Substances 0.000 description 15
- 239000000463 material Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 7
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 238000004320 controlled atmosphere Methods 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000003960 organic solvent Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000013375 chromatographic separation Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000002523 gelfiltration Methods 0.000 description 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 2
- 238000004255 ion exchange chromatography Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000012501 chromatography medium Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000112 cooling gas Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000007792 gaseous phase Substances 0.000 description 1
- 239000007863 gel particle Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/285—Porous sorbents based on polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
- B01J2/08—Gelation of a colloidal solution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/12—Agar or agar-agar, i.e. mixture of agarose and agaropectin; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904344-0 | 1999-12-01 | ||
| SE9904344A SE9904344D0 (sv) | 1999-12-01 | 1999-12-01 | Method of producing porous spherical particles |
| PCT/SE2000/002358 WO2001040767A1 (en) | 1999-12-01 | 2000-11-29 | Method of producing porous spherical particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2392811A1 CA2392811A1 (en) | 2001-06-07 |
| CA2392811C true CA2392811C (en) | 2005-02-01 |
Family
ID=20417913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002392811A Expired - Lifetime CA2392811C (en) | 1999-12-01 | 2000-11-29 | Method of producing porous spherical particles |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6841097B2 (enExample) |
| EP (1) | EP1240497B1 (enExample) |
| JP (1) | JP5000059B2 (enExample) |
| AT (1) | ATE399986T1 (enExample) |
| AU (1) | AU1909901A (enExample) |
| CA (1) | CA2392811C (enExample) |
| DE (1) | DE60039368D1 (enExample) |
| ES (1) | ES2309004T3 (enExample) |
| SE (1) | SE9904344D0 (enExample) |
| WO (1) | WO2001040767A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904344D0 (sv) * | 1999-12-01 | 1999-12-01 | Ralf Goeran Andersson | Method of producing porous spherical particles |
| SE0102369D0 (sv) * | 2001-07-03 | 2001-07-03 | Monocell Ab | New method |
| SG131015A1 (en) * | 2005-09-15 | 2007-04-26 | Millipore Corp | Method and apparatus for making porous agarose beads |
| SG131016A1 (en) | 2005-09-19 | 2007-04-26 | Millipore Corp | Asymmetric porous adsorptive bead |
| GB0619869D0 (en) * | 2006-10-07 | 2006-11-15 | Regentec Ltd | Porous particles |
| US9192907B2 (en) * | 2007-12-03 | 2015-11-24 | Dpx Holdings B.V. | System and method for producing beads |
| US8372286B2 (en) * | 2008-02-05 | 2013-02-12 | Ge Healthcare Bio-Sciences Ab | Method for production of separation media |
| CN101240036B (zh) * | 2008-02-26 | 2010-06-09 | 西北师范大学 | 一种微波辅助提取沙蒿多糖的方法 |
| US8083069B2 (en) * | 2009-07-31 | 2011-12-27 | General Electric Company | High throughput magnetic isolation technique and device for biological materials |
| WO2014148966A1 (en) * | 2013-03-19 | 2014-09-25 | HB Ijorari | Process for manufacturing porous polysaccharide particles and particles thereby obtained. |
| WO2015052460A1 (en) * | 2013-10-09 | 2015-04-16 | Ucl Business Plc | Chromatography medium |
| CN106140038B (zh) * | 2015-04-08 | 2019-07-12 | 通用电气公司 | 制备聚合物微粒的方法和装置 |
| HK1257499A1 (zh) | 2015-11-12 | 2019-10-25 | Graybug Vision, Inc. | 用於治疗的聚集性微粒 |
| CN107537412B (zh) | 2016-06-27 | 2021-06-01 | 思拓凡生物工艺研发有限公司 | 制备聚合物微球的方法和系统 |
| CN110662543A (zh) | 2017-03-23 | 2020-01-07 | 灰色视觉公司 | 用于治疗眼部疾病的药物和组合物 |
| MX2019013363A (es) | 2017-05-10 | 2020-01-13 | Graybug Vision Inc | Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica. |
| CN107754767B (zh) * | 2017-10-31 | 2020-04-21 | 苏州博进生物技术有限公司 | 一种高稳定性固定化金属螯合亲和层析介质 |
| CN116640351B (zh) * | 2023-06-19 | 2024-05-07 | 浙江三赢新材料有限公司 | 一种多糖球形凝胶树脂的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61263630A (ja) * | 1985-05-15 | 1986-11-21 | Kyodo Kikaku Kk | 分子篩機能を有する寒天ビーズの製造法 |
| SE456486B (sv) * | 1987-03-27 | 1988-10-10 | Ralf Andersson | Sett och anordning for uppdelning av en smelta i droppar |
| US5053332A (en) | 1989-07-24 | 1991-10-01 | Cook Richard B | Agarose beads, preferably incorporating biological materials |
| DE4125133C2 (de) | 1991-07-30 | 1993-09-30 | Nukem Gmbh | Verfahren und Vorrichtung zur Herstellung von Alginatkugeln |
| JPH05179005A (ja) | 1991-12-26 | 1993-07-20 | Kobe Steel Ltd | 均一な球形粒子の製造方法 |
| SE9400261D0 (sv) * | 1994-01-28 | 1994-01-28 | Biodev Ab | Förfarande för framställning av sfäriska gelade partiklar |
| US5662840A (en) * | 1994-06-10 | 1997-09-02 | Fmc Corporation | Process for making gel microbeads |
| DE4424998C2 (de) * | 1994-07-15 | 1996-06-20 | Vorlop Klaus Dieter | Verfahren zur Herstellung von Teilchen aus einem flüssigen Medium |
| JP3177587B2 (ja) * | 1996-12-26 | 2001-06-18 | レンゴー株式会社 | セルロース微粒子の製造方法 |
| JP2001526733A (ja) * | 1997-12-14 | 2001-12-18 | シェリンギッシェス インスティチュート フュア テクスチル−ウント クンストストッフェ−フォルシュング エー．ブイ． | 正規粒状セルローズの製造方法と粒状セルローズおよびその使用 |
| US6248268B1 (en) * | 1998-11-16 | 2001-06-19 | Xc Corporation | Process of making microparticles of a thermally-gelled polysaccharide |
| SE9904344D0 (sv) * | 1999-12-01 | 1999-12-01 | Ralf Goeran Andersson | Method of producing porous spherical particles |
| CA2314921A1 (en) | 2000-08-03 | 2002-02-03 | Barry Partington | Apparatus and method for producing porous polymer particles |
| SE0201289D0 (sv) * | 2002-04-25 | 2002-04-25 | Amersham Biosciences Ab | Manufacture of polysaccharide beads |
-
1999
- 1999-12-01 SE SE9904344A patent/SE9904344D0/xx unknown
-
2000
- 2000-11-29 EP EP00982023A patent/EP1240497B1/en not_active Expired - Lifetime
- 2000-11-29 CA CA002392811A patent/CA2392811C/en not_active Expired - Lifetime
- 2000-11-29 AU AU19099/01A patent/AU1909901A/en not_active Abandoned
- 2000-11-29 WO PCT/SE2000/002358 patent/WO2001040767A1/en not_active Ceased
- 2000-11-29 JP JP2001542183A patent/JP5000059B2/ja not_active Expired - Lifetime
- 2000-11-29 ES ES00982023T patent/ES2309004T3/es not_active Expired - Lifetime
- 2000-11-29 AT AT00982023T patent/ATE399986T1/de not_active IP Right Cessation
- 2000-11-29 US US10/148,718 patent/US6841097B2/en not_active Expired - Lifetime
- 2000-11-29 DE DE60039368T patent/DE60039368D1/de not_active Expired - Lifetime
-
2004
- 2004-12-15 US US11/013,032 patent/US20050110176A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2309004T3 (es) | 2008-12-16 |
| DE60039368D1 (de) | 2008-08-14 |
| US6841097B2 (en) | 2005-01-11 |
| AU1909901A (en) | 2001-06-12 |
| JP5000059B2 (ja) | 2012-08-15 |
| JP2003517509A (ja) | 2003-05-27 |
| ATE399986T1 (de) | 2008-07-15 |
| US20030052426A1 (en) | 2003-03-20 |
| EP1240497A1 (en) | 2002-09-18 |
| EP1240497B1 (en) | 2008-07-02 |
| SE9904344D0 (sv) | 1999-12-01 |
| WO2001040767A1 (en) | 2001-06-07 |
| CA2392811A1 (en) | 2001-06-07 |
| US20050110176A1 (en) | 2005-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20201130 |