WO2000050349A2 - Biodegradable ceramic fibres from silica sols - Google Patents

Biodegradable ceramic fibres from silica sols Download PDF

Info

Publication number
WO2000050349A2
WO2000050349A2 PCT/FI2000/000131 FI0000131W WO0050349A2 WO 2000050349 A2 WO2000050349 A2 WO 2000050349A2 FI 0000131 W FI0000131 W FI 0000131W WO 0050349 A2 WO0050349 A2 WO 0050349A2
Authority
WO
WIPO (PCT)
Prior art keywords
viscosity
spinning
silica
sol
fibre
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FI2000/000131
Other languages
English (en)
French (fr)
Other versions
WO2000050349A3 (en
Inventor
Mika Jokinen
Timo Peltola
Sinikka Veittola
Manja Ahola
Pirjo Kortesuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioxid Oy
Original Assignee
Bioxid Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ513013A priority Critical patent/NZ513013A/xx
Priority to SK1061-2001A priority patent/SK10612001A3/sk
Priority to PL350576A priority patent/PL204627B1/pl
Priority to EP00906390A priority patent/EP1144323B1/en
Priority to JP2000600935A priority patent/JP4932992B2/ja
Priority to DE60035672T priority patent/DE60035672T2/de
Priority to US09/913,643 priority patent/US7897166B1/en
Priority to AU28076/00A priority patent/AU764663C/en
Application filed by Bioxid Oy filed Critical Bioxid Oy
Priority to CA002359699A priority patent/CA2359699C/en
Publication of WO2000050349A2 publication Critical patent/WO2000050349A2/en
Publication of WO2000050349A3 publication Critical patent/WO2000050349A3/en
Priority to NO20014014A priority patent/NO20014014L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B37/00—Manufacture or treatment of flakes, fibres, or filaments from softened glass, minerals, or slags
    • C03B37/01—Manufacture of glass fibres or filaments
    • C03B37/011—Manufacture of glass fibres or filaments starting from a liquid phase reaction process, e.g. through a gel phase
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C13/00—Fibre or filament compositions
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/62227—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products obtaining fibres
    • C04B35/62231—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products obtaining fibres based on oxide ceramics
    • C04B35/6224—Fibres based on silica
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
    • C03C2213/00—Glass fibres or filaments
    • C03C2213/02—Biodegradable glass fibres

Definitions

  • Figure 11 shows the SiO 2 solubility measured as saturation level of silica in SBF as a function of sol viscosity at the starting point of the spinning process for FIB3 aged for various time periods.
  • the spinning viscosity as a function of the starting point of the spinning process is presented in Figure 5.
  • the graph decribes schematically the viscosity levels of the spinning sols and ageing times for the fibres FIB 1 , FIB2 and FIB3 before the biodegradation test in the simulated body fluid.
  • the biodegradation of the samples was studied in vitro using a simulated body fluid (SBF).
  • SBF simulated body fluid
  • the simulated body fluid was prepared by dissolving the reagent chemicals of NaCl, NaHCO 3 , KC1, K 2 HPO 4 -3H 2 O, MgCl 2 -6H 2 O, CaCl 2 -2H 2 O and Na 2 SO 4 into deionised water.
  • the fluid was buffered at a physiological pH 7.40 at 37°C with tris(hydroxymethyl)aminomethane and hydrochloric acid (Ohtsuki, C, et al.,

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Ceramic Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Structural Engineering (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Inorganic Fibers (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Compounds (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Artificial Filaments (AREA)
  • Colloid Chemistry (AREA)
PCT/FI2000/000131 1999-02-22 2000-02-21 Biodegradable ceramic fibres from silica sols Ceased WO2000050349A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US09/913,643 US7897166B1 (en) 1999-02-22 2000-02-21 Biodegradable ceramic fibres from silica sols
PL350576A PL204627B1 (pl) 1999-02-22 2000-02-21 Sposób regulowania stopnia biologicznej degradacji przędzonego z zolu krzemionkowego włókna krzemionkowego, włókno krzemionkowe i jego zastosowanie
EP00906390A EP1144323B1 (en) 1999-02-22 2000-02-21 Biodegradable ceramic fibres from silica sols
JP2000600935A JP4932992B2 (ja) 1999-02-22 2000-02-21 シリカゾルからの生分解性セラミック繊維
DE60035672T DE60035672T2 (de) 1999-02-22 2000-02-21 Biologisch abbaubare silicafasern aus einem silicasol
NZ513013A NZ513013A (en) 1999-02-22 2000-02-21 Biodegradable ceramic fibres from silica sols useful in delivery devices for biologically active agents
SK1061-2001A SK10612001A3 (sk) 1999-02-22 2000-02-21 Spôsob výroby riadene biodegradovateľných keramických vlákien z hydrosólu oxidu kremičitého
AU28076/00A AU764663C (en) 1999-02-22 2000-02-21 Biodegradable ceramic fibres from silica sols
CA002359699A CA2359699C (en) 1999-02-22 2000-02-21 Biodegradable ceramic fibres from silica sols
NO20014014A NO20014014L (no) 1999-02-22 2001-08-17 Bionedbrytbare keramiske fibrer fremstilt fra silikasoler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12118099P 1999-02-22 1999-02-22
US60/121,180 1999-02-22

Publications (2)

Publication Number Publication Date
WO2000050349A2 true WO2000050349A2 (en) 2000-08-31
WO2000050349A3 WO2000050349A3 (en) 2001-08-02

Family

ID=22395079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2000/000131 Ceased WO2000050349A2 (en) 1999-02-22 2000-02-21 Biodegradable ceramic fibres from silica sols

Country Status (15)

Country Link
US (1) US7897166B1 (enExample)
EP (1) EP1144323B1 (enExample)
JP (1) JP4932992B2 (enExample)
AT (1) ATE368011T1 (enExample)
AU (1) AU764663C (enExample)
CA (1) CA2359699C (enExample)
CZ (1) CZ20012748A3 (enExample)
DE (1) DE60035672T2 (enExample)
ES (1) ES2290013T3 (enExample)
HU (1) HUP0200277A3 (enExample)
NO (1) NO20014014L (enExample)
NZ (1) NZ513013A (enExample)
PL (1) PL204627B1 (enExample)
SK (1) SK10612001A3 (enExample)
WO (1) WO2000050349A2 (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001013924A1 (en) * 1999-08-25 2001-03-01 Bioxid Oy Novel compositions for controlled release of a biologically active agent, and the preparation thereof
WO2001062232A1 (en) * 2000-02-21 2001-08-30 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
WO2007117296A2 (en) 2005-12-23 2007-10-18 Boston Scientific, Limited Spun nanofiber, medical devices, and methods
WO2007135224A2 (en) 2006-05-23 2007-11-29 Delsitech Oy Method for storing silica-based material, package produced with the method and use of package for packaging of silica-based products
WO2008086970A1 (de) * 2007-01-15 2008-07-24 Bayer Innovation Gmbh Kieselsol-material zur herstellung von biologisch degradierbaren und/oder resorbierbaren kieselgel-materialien, dessen herstellung und verwendung
WO2009077104A1 (de) * 2007-12-19 2009-06-25 Bayer Innovation Gmbh Nicht-toxisches polysiloxan-material zur herstellung von biologisch resorbierbaren und/oder bioaktiven polysiloxan-material enthaltenden artikeln, dessen herstellung und verwendung
US20110123596A1 (en) * 2008-07-16 2011-05-26 Bayer Innovation Gmbh Silica sol material having at least one therapeutically active substance for producing biologically degradable and/or resorbable silica gel materials for human medicine and/or medical technology
WO2012058715A1 (en) 2010-11-01 2012-05-10 University Of Technology, Sydney Immune-modulating agents and uses therefor
US10149825B2 (en) 2004-02-27 2018-12-11 Delsitech Oy Method for preparing adjustably bioresorbable sol-gel derived SiO2
EP3590503A1 (en) 2006-10-12 2020-01-08 The University of Queensland Compositions and methods for modulating immune responses
US10835495B2 (en) 2012-11-14 2020-11-17 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide material and methods of making and using the same

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2427546C2 (ru) * 2005-11-10 2011-08-27 ДЗЕ МОРГАН КРАСИБЛ КОМПАНИ ПиЭлСи Жаростойкие волокна
DE102007026043B4 (de) * 2007-06-04 2018-08-16 Jiangsu Synecoun Medical Technology Co., Ltd. Nicht-toxisches Polyethoxysiloxan-Material zur Herstellung von biologisch resorbierbares und/oder bioaktives Polyethoxysiloxan-Material enthaltenden Artikeln, dessen Herstellung und Verwendung
DE102015101282A1 (de) 2015-01-29 2016-08-04 Rwth Aachen Verfahren und Vorrichtung zur Herstellung anorganischer Aerogel-Fasern
FI20155779A7 (fi) 2015-10-30 2017-05-01 Solani Therapeutics Ltd Ei-steroidaalisen anti-inflammatorisen lääkkeen hidastetusti vapautuva annostelu
CN111989089B (zh) * 2018-04-02 2024-11-08 美国纳米有限责任公司 掺入二氧化硅纤维的局部组合物

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NL8401912A (nl) 1984-06-15 1986-01-02 Tno Met aktieve stof beladen biodegradeerbare polymeersubstraten, geschikt voor het gecontroleerd afgeven van de aktieve stof door middel van een membraan.
US4895709A (en) 1985-04-26 1990-01-23 Sri International Method of preparing metal carbides, nitrides, and the like
EP0253554A3 (en) 1986-07-15 1988-07-20 Pfizer Inc. Controlled release drug-containing fibers
IT1216570B (it) * 1988-04-08 1990-03-08 Vectorpharma Int Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione.
JPH02124734A (ja) * 1988-10-31 1990-05-14 Nippon Sheet Glass Co Ltd 無機繊維の製造方法
US4919871A (en) * 1989-01-04 1990-04-24 Ppg Industries, Inc. Forming glass fibers from sol-gel compositions
JPH02221417A (ja) * 1989-01-04 1990-09-04 Ppg Ind Inc ゾル・ゲル組成物からの無機酸化物繊維の製造方法及びその装置
WO1991013830A1 (fr) 1990-03-07 1991-09-19 Joseph Davidovits Procede d'obtention d'un geopolymere alumino-silicate et produits realises par ce procede
JPH09511666A (ja) 1994-04-08 1997-11-25 アトリックス・ラボラトリーズ・インコーポレイテッド 医療装置で使用する付随的ポリマー系
PL181150B1 (pl) * 1994-11-08 2001-06-29 Rockwool Int Sztuczne włókna szkliste
DE19609551C1 (de) 1996-03-12 1997-07-17 Fraunhofer Ges Forschung Biologisch degradierbare und/oder biologisch resorbierbare (Endlos)Fasern, Verfahren zu deren Herstellung und deren Verwendung als Verstärkungsfasern
RU2208582C2 (ru) * 1996-05-29 2003-07-20 Биоксид Ой Средство для доставки, обеспечивающее непрерывное и/или регулируемое высвобождение биологически активных агентов
US6632412B2 (en) * 1999-12-01 2003-10-14 Timo Peltola Bioactive sol-gel derived silica fibers and methods for their preparation

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112339B1 (en) 1999-08-25 2006-09-26 Delsitech Oy Compositions for controlled release of a biologically active agent, and the preparation thereof
WO2001013924A1 (en) * 1999-08-25 2001-03-01 Bioxid Oy Novel compositions for controlled release of a biologically active agent, and the preparation thereof
US7585521B2 (en) 2000-02-21 2009-09-08 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
US7258874B2 (en) 2000-02-21 2007-08-21 Australian Nuclear Sciences & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
WO2001062232A1 (en) * 2000-02-21 2001-08-30 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
US7357948B2 (en) 2000-02-21 2008-04-15 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
US7354603B2 (en) 2000-02-21 2008-04-08 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
US7354602B2 (en) 2000-02-21 2008-04-08 Australian Nuclear Science & Technology Organisation Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use
US10149825B2 (en) 2004-02-27 2018-12-11 Delsitech Oy Method for preparing adjustably bioresorbable sol-gel derived SiO2
WO2007117296A3 (en) * 2005-12-23 2008-04-17 Boston Scient Ltd Spun nanofiber, medical devices, and methods
WO2007117296A2 (en) 2005-12-23 2007-10-18 Boston Scientific, Limited Spun nanofiber, medical devices, and methods
WO2007135224A2 (en) 2006-05-23 2007-11-29 Delsitech Oy Method for storing silica-based material, package produced with the method and use of package for packaging of silica-based products
US9226893B2 (en) 2006-05-23 2016-01-05 Delsitech Oy Method for storing silica-based material, package produced with the method and use of package for packaging of silica-based products
EP3590503A1 (en) 2006-10-12 2020-01-08 The University of Queensland Compositions and methods for modulating immune responses
WO2008086970A1 (de) * 2007-01-15 2008-07-24 Bayer Innovation Gmbh Kieselsol-material zur herstellung von biologisch degradierbaren und/oder resorbierbaren kieselgel-materialien, dessen herstellung und verwendung
AU2008207129B2 (en) * 2007-01-15 2014-02-20 Bayer Innovation Gmbh Silica sol material for producing biologically degradable and/or resorbable silica gel materials, the production and use thereof
US9862940B2 (en) 2007-01-15 2018-01-09 Bayer Intellectual Property Gmbh Silica sol material for producing bilogically degradable and/or resorbable silica gel materials, the production and use thereof
US9051204B2 (en) 2007-12-19 2015-06-09 Bayer Innovation Gmbh Nontoxic polysiloxane material for producing biologically resorbable and/or bioactive articles containing polysiloxane material, its production and use
RU2496804C2 (ru) * 2007-12-19 2013-10-27 Байер Инновейшн Гмбх Нетоксичный полисилоксановый материал для изготовления изделий, содержащих биорассасывающийся и/или биоактивный полисилоксановый материал, его получение и применение
CN101903298B (zh) * 2007-12-19 2013-09-18 拜尔创新有限责任公司 用于生产包含聚硅氧烷材料的可生物吸收和/或生物活性的制品的无毒聚硅氧烷材料及其生产方法和用途
WO2009077104A1 (de) * 2007-12-19 2009-06-25 Bayer Innovation Gmbh Nicht-toxisches polysiloxan-material zur herstellung von biologisch resorbierbaren und/oder bioaktiven polysiloxan-material enthaltenden artikeln, dessen herstellung und verwendung
US20110123596A1 (en) * 2008-07-16 2011-05-26 Bayer Innovation Gmbh Silica sol material having at least one therapeutically active substance for producing biologically degradable and/or resorbable silica gel materials for human medicine and/or medical technology
WO2012058715A1 (en) 2010-11-01 2012-05-10 University Of Technology, Sydney Immune-modulating agents and uses therefor
US10835495B2 (en) 2012-11-14 2020-11-17 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide material and methods of making and using the same

Also Published As

Publication number Publication date
PL350576A1 (en) 2002-12-30
HUP0200277A2 (hu) 2002-05-29
JP2002537502A (ja) 2002-11-05
ES2290013T3 (es) 2008-02-16
ATE368011T1 (de) 2007-08-15
CA2359699C (en) 2009-08-11
CA2359699A1 (en) 2000-08-31
NZ513013A (en) 2002-11-26
HUP0200277A3 (en) 2004-03-29
EP1144323A2 (en) 2001-10-17
WO2000050349A3 (en) 2001-08-02
AU764663C (en) 2005-02-03
AU2807600A (en) 2000-09-14
US7897166B1 (en) 2011-03-01
NO20014014D0 (no) 2001-08-17
JP4932992B2 (ja) 2012-05-16
EP1144323B1 (en) 2007-07-25
DE60035672T2 (de) 2008-04-30
NO20014014L (no) 2001-08-17
PL204627B1 (pl) 2010-01-29
CZ20012748A3 (cs) 2002-03-13
AU764663B2 (en) 2003-08-28
SK10612001A3 (sk) 2002-02-05
DE60035672D1 (de) 2007-09-06

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