WO2000040569A8 - 2-oxy-4h-3,1-benzoxazine-4-ones destinees au traitement de l'obesite - Google Patents

2-oxy-4h-3,1-benzoxazine-4-ones destinees au traitement de l'obesite

Info

Publication number
WO2000040569A8
WO2000040569A8 PCT/GB2000/000031 GB0000031W WO0040569A8 WO 2000040569 A8 WO2000040569 A8 WO 2000040569A8 GB 0000031 W GB0000031 W GB 0000031W WO 0040569 A8 WO0040569 A8 WO 0040569A8
Authority
WO
WIPO (PCT)
Prior art keywords
reduced
formula
obesity
treatment
inhibition
Prior art date
Application number
PCT/GB2000/000031
Other languages
English (en)
Other versions
WO2000040569A1 (fr
WO2000040569A9 (fr
Inventor
Harold Francis Hodson
Robert Downham
Timothy John Mitchell
Beverley Jane Carr
Christopher Robert Dunk
Richard Michael John Palmer
Original Assignee
Alizyme Therapeutics Ltd
Harold Francis Hodson
Robert Downham
Timothy John Mitchell
Beverley Jane Carr
Christopher Robert Dunk
Richard Michael John Palmer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2000592277A priority Critical patent/JP2002534419A/ja
Priority to DK00900081T priority patent/DK1144395T3/da
Application filed by Alizyme Therapeutics Ltd, Harold Francis Hodson, Robert Downham, Timothy John Mitchell, Beverley Jane Carr, Christopher Robert Dunk, Richard Michael John Palmer filed Critical Alizyme Therapeutics Ltd
Priority to CA002359987A priority patent/CA2359987C/fr
Priority to AT00900081T priority patent/ATE293610T1/de
Priority to SI200030674T priority patent/SI1144395T1/xx
Priority to HU0104909A priority patent/HUP0104909A3/hu
Priority to EP00900081A priority patent/EP1144395B1/fr
Priority to DE60019556T priority patent/DE60019556T2/de
Priority to AU18845/00A priority patent/AU770342B2/en
Priority to PL00350412A priority patent/PL350412A1/xx
Priority to NZ512739A priority patent/NZ512739A/en
Publication of WO2000040569A1 publication Critical patent/WO2000040569A1/fr
Publication of WO2000040569A8 publication Critical patent/WO2000040569A8/fr
Priority to NO20013380A priority patent/NO321058B1/no
Priority to US09/901,868 priority patent/US6656934B2/en
Publication of WO2000040569A9 publication Critical patent/WO2000040569A9/fr
Priority to US10/306,375 priority patent/US7776853B2/en
Priority to HK02109007.0A priority patent/HK1047284A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne l'utilisation d'un composé de formule (I) ou d'un sel, d'un ester, d'un amide ou d'un promédicament dudit composé, pour inhiber une enzyme dont le mode d'action préféré est de catalyser l'hydrolyse d'une fonctionnalité ester, par exemple pour la régulation et l'inhibition des enzymes indésirables dans les produits et les processus. Ces composés sont également utiles en médecine, par exemple pour le traitement de l'obésité et des pathologies voisines. L'invention concerne également des composés de formule (I), des procédés permettant de les préparer et des compositions pharmaceutiques les contenant. Dans la formule (I), A est un noyau aromatique ou hétéro-aromatique à 6 éléments; et R1 est alkyle ramifié ou non ramifié (éventuellement interrompu par un ou plusieurs atomes d'oxygène), alcényle, alcinyle, cycloalkyle, cycloalcényle, aryle, arylalkyle, arylalkyle réduit, arylalcényle, hétéroaryle, hétéro-arylalkyle, hétéro-arylalcényle, aryle réduit, hétéro-aryle réduit, hétéro-arylalkyle réduit, ou un dérivé substitué de l'un des groupes ci-dessus.
PCT/GB2000/000031 1999-01-08 2000-01-06 2-oxy-4h-3,1-benzoxazine-4-ones destinees au traitement de l'obesite WO2000040569A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
EP00900081A EP1144395B1 (fr) 1999-01-08 2000-01-06 2-amino-benzoxazinones destinees au traitement de l'obesite
DE60019556T DE60019556T2 (de) 1999-01-08 2000-01-06 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit
CA002359987A CA2359987C (fr) 1999-01-08 2000-01-06 2-oxy-4h-3,1-benzoxazine-4-ones destinees au traitement de l'obesite
AT00900081T ATE293610T1 (de) 1999-01-08 2000-01-06 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit
SI200030674T SI1144395T1 (fr) 1999-01-08 2000-01-06
HU0104909A HUP0104909A3 (en) 1999-01-08 2000-01-06 2-amino-benzoxazinone derivatives for the treatment of obesity, process for their preparation and medicaments containing them
DK00900081T DK1144395T3 (da) 1999-01-08 2000-01-06 2-amino-benzoxazinon-derivater til behandling af fedme
JP2000592277A JP2002534419A (ja) 1999-01-08 2000-01-06 肥満治療用２−アミノ−４ｈ−３，１−ベンゾオキサジン−４−オン誘導体
AU18845/00A AU770342B2 (en) 1999-01-08 2000-01-06 2-amino-4H-3,1-Benzoxazin-4-one derivatives for the treatment of obesity
NZ512739A NZ512739A (en) 1999-01-08 2000-01-06 2-amino-benzoxazinone derivatives for the treatment of obesity
PL00350412A PL350412A1 (en) 1999-01-08 2000-01-06 2−amino−benzoxazinone derivatives for the treatment of obesity
US09/901,868 US6656934B2 (en) 1999-01-08 2001-07-06 2-amino-benzoxazinone derivatives for the treatment of obesity
NO20013380A NO321058B1 (no) 1999-01-08 2001-07-06 Anvendelse av 2-aminobenzoksazinonderivater ved fremstilling av et medikament for profylakse eller behandling av overvekt eller en overvektsrelatert forstyrrelse, 2-aminobenzoksazinonderivater, fremgangsmate for fremstilling derav, farmasoytiske preparater og matprodukter som inneholder derivatene, anvendelser av derivatene samt kosmetisk fremgangsmate ved administrering derav.
US10/306,375 US7776853B2 (en) 1999-01-08 2002-11-27 2-amino-benzoxazinone derivatives for the treatment of obesity
HK02109007.0A HK1047284A1 (en) 1999-01-08 2002-12-12 2-amino-benzoxazinone derivatives for the treatment of obesity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9900416.0A GB9900416D0 (en) 1999-01-08 1999-01-08 Inhibitors
GB9900416.0 1999-01-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/901,868 Continuation US6656934B2 (en) 1999-01-08 2001-07-06 2-amino-benzoxazinone derivatives for the treatment of obesity

Publications (3)

Publication Number Publication Date
WO2000040569A1 WO2000040569A1 (fr) 2000-07-13
WO2000040569A8 true WO2000040569A8 (fr) 2001-03-15
WO2000040569A9 WO2000040569A9 (fr) 2002-02-28

Family

ID=10845777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/000031 WO2000040569A1 (fr) 1999-01-08 2000-01-06 2-oxy-4h-3,1-benzoxazine-4-ones destinees au traitement de l'obesite

Country Status (22)

Country Link
US (2) US6656934B2 (fr)
EP (1) EP1144395B1 (fr)
JP (1) JP2002534419A (fr)
KR (1) KR100615914B1 (fr)
CN (1) CN100480245C (fr)
AR (1) AR022203A1 (fr)
AT (1) ATE293610T1 (fr)
AU (1) AU770342B2 (fr)
CA (1) CA2359987C (fr)
DE (1) DE60019556T2 (fr)
DK (1) DK1144395T3 (fr)
ES (1) ES2240051T3 (fr)
GB (1) GB9900416D0 (fr)
HK (1) HK1047284A1 (fr)
HU (1) HUP0104909A3 (fr)
MY (1) MY129247A (fr)
NO (1) NO321058B1 (fr)
NZ (1) NZ512739A (fr)
PL (1) PL350412A1 (fr)
PT (1) PT1144395E (fr)
RU (1) RU2244711C2 (fr)
WO (1) WO2000040569A1 (fr)

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ATE293477T1 (de) 2000-07-28 2005-05-15 Hoffmann La Roche Neue verwendung von lipase-inhibitoren
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RU2244711C2 (ru) 2005-01-20
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NO20013380D0 (no) 2001-07-06
JP2002534419A (ja) 2002-10-15
GB9900416D0 (en) 1999-02-24
US7776853B2 (en) 2010-08-17
AU770342B2 (en) 2004-02-19
PT1144395E (pt) 2005-08-31
DE60019556D1 (de) 2005-05-25
HUP0104909A2 (hu) 2002-04-29
AU1884500A (en) 2000-07-24
DK1144395T3 (da) 2005-08-15
US20030013707A1 (en) 2003-01-16
EP1144395A1 (fr) 2001-10-17
US6656934B2 (en) 2003-12-02
ES2240051T3 (es) 2005-10-16
HK1047284A1 (en) 2003-02-14
CA2359987A1 (fr) 2000-07-13
CN1354747A (zh) 2002-06-19
NO321058B1 (no) 2006-03-06
KR20010108073A (ko) 2001-12-07
KR100615914B1 (ko) 2006-08-28
WO2000040569A9 (fr) 2002-02-28
EP1144395B1 (fr) 2005-04-20
PL350412A1 (en) 2002-12-02
CA2359987C (fr) 2008-03-25
HUP0104909A3 (en) 2004-11-29
NZ512739A (en) 2003-10-31
US20030191123A1 (en) 2003-10-09
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AR022203A1 (es) 2002-09-04
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ATE293610T1 (de) 2005-05-15
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