WO2000025792A1 - Preparation adhesive contenant de l'oestradiol - Google Patents

Preparation adhesive contenant de l'oestradiol Download PDF

Info

Publication number
WO2000025792A1
WO2000025792A1 PCT/JP1999/005920 JP9905920W WO0025792A1 WO 2000025792 A1 WO2000025792 A1 WO 2000025792A1 JP 9905920 W JP9905920 W JP 9905920W WO 0025792 A1 WO0025792 A1 WO 0025792A1
Authority
WO
WIPO (PCT)
Prior art keywords
estradiol
patch
hours
weight
polyisobutylene
Prior art date
Application number
PCT/JP1999/005920
Other languages
English (en)
Japanese (ja)
Inventor
Miyuki Shinmura
Yasuhiro Ikeura
Original Assignee
Hisamitsu Pharmaceutical Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co., Inc. filed Critical Hisamitsu Pharmaceutical Co., Inc.
Priority to AU62307/99A priority Critical patent/AU6230799A/en
Publication of WO2000025792A1 publication Critical patent/WO2000025792A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Abstract

L'invention se rapporte à une préparation adhésive contenant de l'oestradiol, qui se caractérise en ce que 10 à 32 % de l'oestradiol est libéré en trois heures après immersion dans de l'eau à une température de 32±0,5 °C. De préférence, la préparation contient un élastomère thermoplastique, un agent donnant du collant et un plastifiant et/ou un accélérateur d'absorption. Ledit élastomère comporte de préférence un copolymère séquencé styrène/isoprène/styrène et du polyisobutylène. La préparation comporte de préférence 0,5 à 3 % en poids d'oestradiol, 15 à 24 % en poids du copolymère séquencé styrène/isoprène/styrène, 5,1 à 25 % en poids du polyisobutylène, 26 à 40 % en poids de l'agent donnant du collant et 15 à 30 % en poids du plastifiant et/ou 0,5 à 8 % en poids de l'accélérateur d'absorption.
PCT/JP1999/005920 1998-10-29 1999-10-26 Preparation adhesive contenant de l'oestradiol WO2000025792A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62307/99A AU6230799A (en) 1998-10-29 1999-10-26 Estradiol-containing adhesive preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10308119A JP2000136128A (ja) 1998-10-29 1998-10-29 エストラジオール含有貼付剤
JP10/308119 1998-10-29

Publications (1)

Publication Number Publication Date
WO2000025792A1 true WO2000025792A1 (fr) 2000-05-11

Family

ID=17977114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/005920 WO2000025792A1 (fr) 1998-10-29 1999-10-26 Preparation adhesive contenant de l'oestradiol

Country Status (3)

Country Link
JP (1) JP2000136128A (fr)
AU (1) AU6230799A (fr)
WO (1) WO2000025792A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096434A1 (fr) * 2001-05-29 2002-12-05 Tokuhon Corporation Composition de platre
WO2004014395A1 (fr) * 2002-08-09 2004-02-19 Teikoku Seiyaku Co.,Ltd. Timbre adhesif contenant une hormone femelle
JP2004075537A (ja) * 2002-08-09 2004-03-11 Teikoku Seiyaku Co Ltd エストラジオール含有貼付剤
WO2004024155A1 (fr) * 2002-09-13 2004-03-25 Hisamitsu Pharmaceutical Co., Inc. Pastille adhesive

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1929827A (zh) * 2004-01-14 2007-03-14 拉维法姆实验室股份有限公司 包含至少一种脂肪酸的用于二氢吡啶类钙拮抗剂的经皮递送装置
DE102006050558B4 (de) 2006-10-26 2009-03-26 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System enthaltend Norelgestromin zur Kontrazeption und Hormonsubstitution

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271056A (ja) * 1992-03-27 1993-10-19 Hisamitsu Pharmaceut Co Inc 微粉体制御型経皮投与製剤
JPH08113532A (ja) * 1994-10-17 1996-05-07 Daikyo Yakuhin Kogyo Kk 硬膏剤及びその製造法
WO1996015776A1 (fr) * 1994-11-18 1996-05-30 Hisamitsu Pharmaceutical Co., Inc. Timbre absorbable par voie percutanee
JPH09315957A (ja) * 1996-05-28 1997-12-09 Hisamitsu Pharmaceut Co Inc 経皮治療用装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05271056A (ja) * 1992-03-27 1993-10-19 Hisamitsu Pharmaceut Co Inc 微粉体制御型経皮投与製剤
JPH08113532A (ja) * 1994-10-17 1996-05-07 Daikyo Yakuhin Kogyo Kk 硬膏剤及びその製造法
WO1996015776A1 (fr) * 1994-11-18 1996-05-30 Hisamitsu Pharmaceutical Co., Inc. Timbre absorbable par voie percutanee
JPH09315957A (ja) * 1996-05-28 1997-12-09 Hisamitsu Pharmaceut Co Inc 経皮治療用装置

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096434A1 (fr) * 2001-05-29 2002-12-05 Tokuhon Corporation Composition de platre
WO2004014395A1 (fr) * 2002-08-09 2004-02-19 Teikoku Seiyaku Co.,Ltd. Timbre adhesif contenant une hormone femelle
JP2004075537A (ja) * 2002-08-09 2004-03-11 Teikoku Seiyaku Co Ltd エストラジオール含有貼付剤
US8124122B2 (en) 2002-08-09 2012-02-28 Teikoku Seiyaku Co., Ltd. Female hormone-containing patch
WO2004024155A1 (fr) * 2002-09-13 2004-03-25 Hisamitsu Pharmaceutical Co., Inc. Pastille adhesive
US7785622B2 (en) 2002-09-13 2010-08-31 Hisamitsu Pharmaceutical Co., Inc. Adhesive patch for fentanyl administration

Also Published As

Publication number Publication date
AU6230799A (en) 2000-05-22
JP2000136128A (ja) 2000-05-16

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