WO2000003980A1 - DERIVES DE PHENYL-POSTAGLANDINE E 5-THIA-φ-SUBSTITUES, PROCEDE DE PRODUCTION DESDITS DERIVES ET MEDICAMENTS CONTENANT LESDITS DERIVES EN TANT QUE PRINCIPE ACTIF - Google Patents

DERIVES DE PHENYL-POSTAGLANDINE E 5-THIA-φ-SUBSTITUES, PROCEDE DE PRODUCTION DESDITS DERIVES ET MEDICAMENTS CONTENANT LESDITS DERIVES EN TANT QUE PRINCIPE ACTIF Download PDF

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Publication number
WO2000003980A1
WO2000003980A1 PCT/JP1999/003798 JP9903798W WO0003980A1 WO 2000003980 A1 WO2000003980 A1 WO 2000003980A1 JP 9903798 W JP9903798 W JP 9903798W WO 0003980 A1 WO0003980 A1 WO 0003980A1
Authority
WO
WIPO (PCT)
Prior art keywords
same
thia
prostaglandin
substituted phenyl
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1999/003798
Other languages
English (en)
French (fr)
Inventor
Toru Maruyama
Shuichi Ohuchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU46518/99A priority Critical patent/AU763668B2/en
Priority to NZ509293A priority patent/NZ509293A/en
Priority to DE69924258T priority patent/DE69924258T2/de
Priority to AT99929831T priority patent/ATE291013T1/de
Priority to CA002336952A priority patent/CA2336952C/en
Priority to BRPI9912813-6A priority patent/BR9912813B1/pt
Priority to EP99929831A priority patent/EP1097922B1/en
Priority to DK99929831T priority patent/DK1097922T3/da
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to HU0204170A priority patent/HUP0204170A3/hu
Priority to JP2000560089A priority patent/JP3174563B2/ja
Priority to US09/720,675 priority patent/US6462081B1/en
Publication of WO2000003980A1 publication Critical patent/WO2000003980A1/ja
Priority to NO20010213A priority patent/NO327781B1/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
PCT/JP1999/003798 1998-07-15 1999-07-14 DERIVES DE PHENYL-POSTAGLANDINE E 5-THIA-φ-SUBSTITUES, PROCEDE DE PRODUCTION DESDITS DERIVES ET MEDICAMENTS CONTENANT LESDITS DERIVES EN TANT QUE PRINCIPE ACTIF Ceased WO2000003980A1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP99929831A EP1097922B1 (en) 1998-07-15 1999-07-14 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient
DE69924258T DE69924258T2 (de) 1998-07-15 1999-07-14 Durch einen omega-thiarest substituierte phenyl-prostaglandin-e-derivate, verfahren zu ihrer herstellung und medikamente die diese als aktiven inhaltsstoff enthalten
AT99929831T ATE291013T1 (de) 1998-07-15 1999-07-14 Durch einen omega-thiarest substituierte phenyl- prostaglandin-e-derivate, verfahren zu ihrer herstellung und medikamente die diese als aktiven inhaltsstoff enthalten
CA002336952A CA2336952C (en) 1998-07-15 1999-07-14 5-thia-.omega.-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient
BRPI9912813-6A BR9912813B1 (pt) 1998-07-15 1999-07-14 derivados de fenil-prostaglandina e 5-tia-omega-substituìdos, processo para a produção dos mesmos, bem como composição e uso dos referidos derivados.
DK99929831T DK1097922T3 (da) 1998-07-15 1999-07-14 5-Thia-omega-substituerede phenyl-prostaglandin E derivater, fremgangsmåde til fremstilling deraf samt lægemidler indeholdende forbindelsen som aktiv bestanddel
HU0204170A HUP0204170A3 (en) 1998-07-15 1999-07-14 5-thia-omega-substituted phenyl-prostaglandin e derivatives, process for producing the same and drugs containing the same as the active ingredient
AU46518/99A AU763668B2 (en) 1998-07-15 1999-07-14 5-Thia-omega-substituted phenyl-prostaglandin E derivatives, process for producing the same and drugs containing the same as the active ingredient
NZ509293A NZ509293A (en) 1998-07-15 1999-07-14 5-Thia-omega-substituted phenyl-prostaglandin E derivatives
JP2000560089A JP3174563B2 (ja) 1998-07-15 1999-07-14 ５−チア−ω−置換フェニル−プロスタグランジンＥ誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤
US09/720,675 US6462081B1 (en) 1998-07-15 1999-07-14 5-thia-ω-substituted phenyl-prostaglandin E derivatives, process for producing the same and drugs containing the same as the active ingredient
NO20010213A NO327781B1 (no) 1998-07-15 2001-01-12 5-tia-ω-substituerte fenyl-prostaglandin E-derivater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20075298 1998-07-15
JP10/200752 1998-07-15

Publications (1)

Publication Number Publication Date
WO2000003980A1 true WO2000003980A1 (fr) 2000-01-27

Family

ID=16429595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/003798 Ceased WO2000003980A1 (fr) 1998-07-15 1999-07-14 DERIVES DE PHENYL-POSTAGLANDINE E 5-THIA-φ-SUBSTITUES, PROCEDE DE PRODUCTION DESDITS DERIVES ET MEDICAMENTS CONTENANT LESDITS DERIVES EN TANT QUE PRINCIPE ACTIF

Country Status (21)

Country Link
US (1) US6462081B1 (ja)
EP (1) EP1097922B1 (ja)
JP (1) JP3174563B2 (ja)
KR (1) KR100598660B1 (ja)
CN (1) CN1173945C (ja)
AT (1) ATE291013T1 (ja)
AU (1) AU763668B2 (ja)
BR (1) BR9912813B1 (ja)
CA (1) CA2336952C (ja)
DE (1) DE69924258T2 (ja)
DK (1) DK1097922T3 (ja)
ES (1) ES2239448T3 (ja)
HU (1) HUP0204170A3 (ja)
NO (1) NO327781B1 (ja)
NZ (1) NZ509293A (ja)
PT (1) PT1097922E (ja)
RU (1) RU2220135C2 (ja)
TR (1) TR200100623T2 (ja)
TW (1) TWI249520B (ja)
WO (1) WO2000003980A1 (ja)
ZA (1) ZA200100295B (ja)

Cited By (44)

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WO2001024800A1 (en) * 1999-10-07 2001-04-12 Ono Pharmaceutical Co., Ltd. Erection insufficiency remedies
WO2001037877A1 (en) * 1999-11-24 2001-05-31 Ono Pharmaceutical Co., Ltd. Remedies for diseases in association with decrease in bone mass
WO2002047669A1 (en) * 2000-12-14 2002-06-20 Glaxo Group Limited Use of ep4 receptor agonists for treating neuropathic pain
WO2003009872A1 (fr) * 2001-07-23 2003-02-06 Ono Pharmaceutical Co., Ltd. Medicaments contenant un agoniste de ep4 en tant que principe actif destines aux maladies associees a une perte de la masse osseuse
WO2003016254A1 (en) * 2001-08-09 2003-02-27 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
WO2003041717A1 (fr) * 2001-11-12 2003-05-22 Ono Pharmaceutical Co., Ltd. Preparation pelliculaire persistante pour administration localisee contenant un derive de prostaglandine
WO2004032965A1 (ja) * 2002-10-10 2004-04-22 Ono Pharmaceutical Co., Ltd. 内因性修復因子産生促進剤
RU2259830C2 (ru) * 1999-11-24 2005-09-10 Оно Фармасьютикал Ко., Лтд. Фармацевтическая композиция для лечения заболеваний, связанных с потерей костной массы
JP2005537235A (ja) * 2002-06-06 2005-12-08 メルク フロスト カナダ アンド カンパニー Ｅｐ４受容体作動薬、組成物及びその方法
JP2005537225A (ja) * 2002-04-17 2005-12-08 メディカル リサーチ カウンシル 子宮の病態治療のためのＦＰレセプターアンタゴニスト又はＰＧＦ２αアンタゴニスト
WO2006016695A1 (ja) * 2004-08-10 2006-02-16 Ono Pharmaceutical Co., Ltd. Ｅｐ４アゴニストを含有してなる高カリウム血症の予防および／または治療剤
WO2006016689A1 (ja) * 2004-08-10 2006-02-16 Ono Pharmaceutical Co., Ltd. Ｅｐ４アゴニストを含有してなる下部尿路系疾患の予防および／または治療剤
EP1132086B1 (en) * 2000-01-31 2006-05-31 Pfizer Products Inc. Use of prostaglandin (PGE2) receptor 4 (EP4) selective agonists for the treatment of acute and chronic renal failure
US7074942B2 (en) 1999-08-04 2006-07-11 The Procter & Gamble Company 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
WO2006075690A1 (ja) * 2005-01-14 2006-07-20 Ono Pharmaceutical Co., Ltd. 安定な医薬組成物
WO2006118173A1 (ja) 2005-04-28 2006-11-09 Ono Pharmaceutical Co., Ltd. 経皮吸収製剤
US7166631B2 (en) 2001-02-09 2007-01-23 Glaxo Group Limited Benzo[f]isoindole derivatives with affinity to the EP4 receptor
WO2007088190A1 (en) 2006-02-03 2007-08-09 Glaxo Group Limited Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as ep4 receptor agonists
US7276531B2 (en) 2003-03-03 2007-10-02 Applied Research Systems Ars Holding N.V. G-lactam derivatives as prostaglandin agonists
WO2008050848A1 (en) 2006-10-26 2008-05-02 Ono Pharmaceutical Co., Ltd. Adhesive preparation
US7388029B2 (en) 2000-03-31 2008-06-17 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
WO2008071736A1 (en) 2006-12-15 2008-06-19 Glaxo Group Limited Benzamide derivatives as ep4 receptor agonists
US7407987B2 (en) 2000-03-31 2008-08-05 Duke University Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
JP2008533158A (ja) * 2005-03-17 2008-08-21 アラーガン、インコーポレイテッド 炎症性腸疾患の処置
WO2008136519A1 (ja) 2007-05-08 2008-11-13 National University Corporation, Hamamatsu University School Of Medicine Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤
US7465755B2 (en) 2003-07-18 2008-12-16 Laboratoires Serono Sa Hydrazide derivatives as prostaglandin receptors modulators
WO2009056582A1 (en) 2007-11-02 2009-05-07 Glaxo Group Limited Novel compounds
WO2010096123A2 (en) 2008-10-29 2010-08-26 Aerie Pharmaceuticals, Inc. Amino acid salts of prostaglandins
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US20120136011A1 (en) * 2010-07-30 2012-05-31 Allergan, Inc. Compounds and methods for skin repair
US20120142684A1 (en) * 2010-12-02 2012-06-07 Allergan, Inc. Compounds and methods for skin repair
CN1893977B (zh) * 2001-07-23 2012-12-05 小野药品工业株式会社 以ep4激动剂为活性成分的治疗与骨质损失有关的疾病的药物
WO2013167582A1 (en) 2012-05-09 2013-11-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease
WO2014069401A1 (ja) 2012-10-29 2014-05-08 株式会社カルディオ 肺疾患特異的治療剤
WO2014144781A1 (en) 2013-03-15 2014-09-18 Aerie Pharmaceuticals, Inc. Combination therapy
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US9968716B2 (en) 2013-10-15 2018-05-15 Ono Pharmaceutical Co., Ltd. Drug-eluting stent graft
US10112920B2 (en) 2008-07-25 2018-10-30 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US10174017B2 (en) 2009-05-01 2019-01-08 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
US10472327B2 (en) 2007-01-10 2019-11-12 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US10858339B2 (en) 2017-03-31 2020-12-08 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
US11389441B2 (en) 2016-08-31 2022-07-19 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
US11427563B2 (en) 2018-09-14 2022-08-30 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

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CA2303060A1 (en) * 1999-04-14 2000-10-14 United States Gear Corporation Towed vehicle brake controller
KR20020067594A (ko) * 2000-01-05 2002-08-22 오노 야꾸힝 고교 가부시키가이샤 5-티아-ω-치환 페닐-프로스타글란딘 Ｅ-알콜, 이들의제조 방법 및 이들을 유효 성분으로서 함유하는 약제
US6586462B2 (en) * 2000-10-20 2003-07-01 Allergan, Inc. ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
EP1408961B1 (en) * 2001-07-16 2007-07-11 F. Hoffmann-La Roche Ag 2 pyrrolidone derivatives as prostanoid agonists
JP2003078830A (ja) * 2001-09-03 2003-03-14 Sony Corp デジタル放送受信装置および通信情報伝送方法
EP1467738A1 (en) * 2001-10-08 2004-10-20 Medical Research Council Use of prostaglandin e synthase inhibitors, or ep2 or ep4 receptor antagonists, in the treatment of a pathological condition of the uterus
DE60222168T2 (de) * 2001-10-31 2008-05-15 Medical Research Council Antagonisten der prostaglandin ep2 und/oder ep4 rezeptoren zur behandlung von menorrhagie
WO2003037373A1 (en) * 2001-10-31 2003-05-08 Medical Research Council Use of an ep2 or ep4 receptor antagonist and/or a cox-1 inhibitor for treating cervical cancer
AU2003209571A1 (en) * 2002-03-18 2003-09-29 Pfizer Products Inc. Use of selective ep4 receptor agonists for the treatment of liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension
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JP4477504B2 (ja) * 2002-11-13 2010-06-09 大正製薬株式会社 鎮痒剤
NZ541603A (en) * 2003-02-07 2008-03-28 Ono Pharmaceutical Co Carbonyl phenyl propanoic acid derivative compounds
CN1946391A (zh) * 2004-04-20 2007-04-11 辉瑞产品公司 包含α－2－δ配体的组合
JP2008518013A (ja) * 2004-10-26 2008-05-29 アラーガン、インコーポレイテッド プロスタグランジンｅｐ４アゴニストによる処置方法およびデリバリー方法
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KR101172638B1 (ko) 2008-12-30 2012-08-08 조선대학교산학협력단 신규한 티아졸리딘디온 유도체 및 그의 용도
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
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WO2013123272A1 (en) 2012-02-16 2013-08-22 Allergan, Inc. Compositions and improved soft tissue replacement methods
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EP2814526B1 (en) 2012-02-16 2016-11-02 Allergan, Inc. Compositions and improved soft tissue replacement methods
HUE031885T2 (en) 2012-07-19 2017-08-28 Cayman Chemical Co Inc Difluoro lactam preparations for EP4-mediated osteo-related diseases and conditions
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USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US7115659B2 (en) 1999-08-04 2006-10-03 The Procter & Gamble Company Method of treating a condition by administering a prostaglandin derivative
US7074942B2 (en) 1999-08-04 2006-07-11 The Procter & Gamble Company 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US6710081B1 (en) 1999-10-07 2004-03-23 Ono Pharmaceutical Co., Ltd. Erection insufficiency remedies
WO2001024800A1 (en) * 1999-10-07 2001-04-12 Ono Pharmaceutical Co., Ltd. Erection insufficiency remedies
RU2259830C2 (ru) * 1999-11-24 2005-09-10 Оно Фармасьютикал Ко., Лтд. Фармацевтическая композиция для лечения заболеваний, связанных с потерей костной массы
WO2001037877A1 (en) * 1999-11-24 2001-05-31 Ono Pharmaceutical Co., Ltd. Remedies for diseases in association with decrease in bone mass
EP1132086B1 (en) * 2000-01-31 2006-05-31 Pfizer Products Inc. Use of prostaglandin (PGE2) receptor 4 (EP4) selective agonists for the treatment of acute and chronic renal failure
US7388029B2 (en) 2000-03-31 2008-06-17 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US7407987B2 (en) 2000-03-31 2008-08-05 Duke University Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US9675539B2 (en) 2000-03-31 2017-06-13 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US8906962B2 (en) 2000-03-31 2014-12-09 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9579270B2 (en) 2000-03-31 2017-02-28 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
WO2002047669A1 (en) * 2000-12-14 2002-06-20 Glaxo Group Limited Use of ep4 receptor agonists for treating neuropathic pain
US7732622B2 (en) 2001-02-09 2010-06-08 Glaxo Group Limited Naphthalene derivatives
US7166631B2 (en) 2001-02-09 2007-01-23 Glaxo Group Limited Benzo[f]isoindole derivatives with affinity to the EP4 receptor
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ATE291013T1 (de) 2005-04-15
NO327781B1 (no) 2009-09-21
BR9912813A (pt) 2001-05-02
CN1312796A (zh) 2001-09-12
US6462081B1 (en) 2002-10-08
EP1097922A4 (en) 2003-02-12
TR200100623T2 (tr) 2001-06-21
CN1173945C (zh) 2004-11-03
RU2220135C2 (ru) 2003-12-27
KR100598660B1 (ko) 2006-07-13
CA2336952C (en) 2009-09-15
TWI249520B (en) 2006-02-21
EP1097922B1 (en) 2005-03-16
ZA200100295B (en) 2002-07-10
AU4651899A (en) 2000-02-07
DK1097922T3 (da) 2005-05-30
KR20010053386A (ko) 2001-06-25
DE69924258D1 (de) 2005-04-21
NO20010213L (no) 2001-03-15
NO20010213D0 (no) 2001-01-12
CA2336952A1 (en) 2000-01-27
NZ509293A (en) 2003-05-30
BR9912813B1 (pt) 2010-11-30
DE69924258T2 (de) 2006-01-26
ES2239448T3 (es) 2005-09-16
HUP0204170A2 (hu) 2003-04-28
EP1097922A1 (en) 2001-05-09
HUP0204170A3 (en) 2005-03-29
AU763668B2 (en) 2003-07-31
PT1097922E (pt) 2005-06-30

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