WO1999065864A3 - Amines substituees de maniere geminee - Google Patents
Amines substituees de maniere geminee Download PDFInfo
- Publication number
- WO1999065864A3 WO1999065864A3 PCT/EP1999/004258 EP9904258W WO9965864A3 WO 1999065864 A3 WO1999065864 A3 WO 1999065864A3 EP 9904258 W EP9904258 W EP 9904258W WO 9965864 A3 WO9965864 A3 WO 9965864A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substituted
- aryl
- cycloalkyl
- alkinyl
- cycloalkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/023—Preparation; Separation; Stabilisation; Use of additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0201—Oxygen-containing compounds
- B01J31/0211—Oxygen-containing compounds with a metal-oxygen link
- B01J31/0212—Alkoxylates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0237—Amines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0272—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing elements other than those covered by B01J31/0201 - B01J31/0255
- B01J31/0274—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing elements other than those covered by B01J31/0201 - B01J31/0255 containing silicon
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/66—Preparation of compounds containing amino groups bound to a carbon skeleton from or via metallo-organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
L'invention concerne une amine de la formule générale (I), où R1 et R2 peuvent être identiques ou différents et désignent chacun indépendamment l'un de l'autre alkyle substitué ou non substitué, cycloalkyle, alkényle, cycloalkényle, alkinyle, aryle ou trialkylsilyle ou R1 et R2 peuvent former conjointement avec l'atome d'azote auquel ils sont liés, un composé cyclique cycloalkyle substitué ou non substitué qui, outre l'atome d'azote, peut contenir un autre hétéroatome, sélectionné dans le groupe comprenant azote, oxygène ou soufre. R3 est sélectionné parmi hydrogène et méthyle pouvant éventuellement être substitué par 1 à 3 atomes de fluor. R4 et R5 peuvent être identiques ou différents et désignent chacun indépendamment l'un de l'autre alkyle, cycloalkyle, alkényle, cycloalkényle, alkinyle, aryle substitué ou non substitué ou un alkyle substitué par aryle substitué ou non substitué, cycloalkyle, alkényle, cycloalkényle ou alkinyle, sous réserve qu'au moins un reste R4 ou R5 contienne un groupe aryle ou un de ses sels.
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19827166A DE19827166A1 (de) | 1998-06-18 | 1998-06-18 | Verfahren zur katalytischen Disubstitution von Carbonsäureamiden mit wenigstens einem Grignardreagenz |
DE19827165A DE19827165A1 (de) | 1998-06-18 | 1998-06-18 | Katalytisch Titan(IV)-oxid-vermittelte geminale unsymmetrische Dialkylierung von Carbonsäureamiden |
DE19827164A DE19827164A1 (de) | 1998-06-18 | 1998-06-18 | Katalytisch Titan(IV)-oxid vermittelte geminale symmetrische Dialkylierung von Carbonsäureamiden |
DE19827167 | 1998-06-18 | ||
DE19827161A DE19827161A1 (de) | 1998-06-18 | 1998-06-18 | Verfahren zur katalytischen, symmetrischen Disubstitution von Carbonsäureamiden mit Grignardreagenzien |
DE19827165.4 | 1998-06-18 | ||
DE19827164.6 | 1998-06-18 | ||
DE19827166.2 | 1998-06-18 | ||
DE19827163A DE19827163A1 (de) | 1998-06-18 | 1998-06-18 | Verfahren zur katalytischen, unsymmetrischen Disubstitution von Carbonsäureamiden mit 2 unterschiedlichen Grignardreagenzien |
DE19827163.8 | 1998-06-18 | ||
DE19827161.1 | 1998-06-18 | ||
DE19827167.0 | 1998-06-18 | ||
DE19844194A DE19844194A1 (de) | 1998-06-18 | 1998-09-26 | Verfahren zur symmetrischen oder unsymmetrischen Disubstitution von Carbonsäureamiden mit Organotitanaten und Grignardreagenzien |
DE19844194.0 | 1998-09-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999065864A2 WO1999065864A2 (fr) | 1999-12-23 |
WO1999065864A3 true WO1999065864A3 (fr) | 2003-05-22 |
Family
ID=27561759
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/004256 WO1999065318A2 (fr) | 1998-06-18 | 1999-06-18 | Amines substituees de maniere geminee |
PCT/EP1999/004258 WO1999065864A2 (fr) | 1998-06-18 | 1999-06-18 | Amines substituees de maniere geminee |
PCT/EP1999/004257 WO1999065863A1 (fr) | 1998-06-18 | 1999-06-18 | Procede pour preparer des bibliotheques combinatoires d'amines |
PCT/EP1999/004255 WO1999065855A2 (fr) | 1998-06-18 | 1999-06-18 | Bibliotheques combinatoires d'amines substituees de maniere geminee |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/004256 WO1999065318A2 (fr) | 1998-06-18 | 1999-06-18 | Amines substituees de maniere geminee |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/004257 WO1999065863A1 (fr) | 1998-06-18 | 1999-06-18 | Procede pour preparer des bibliotheques combinatoires d'amines |
PCT/EP1999/004255 WO1999065855A2 (fr) | 1998-06-18 | 1999-06-18 | Bibliotheques combinatoires d'amines substituees de maniere geminee |
Country Status (3)
Country | Link |
---|---|
EP (2) | EP1087929A1 (fr) |
JP (2) | JP2002518366A (fr) |
WO (4) | WO1999065318A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19960377A1 (de) * | 1999-12-14 | 2001-06-21 | Merck Patent Gmbh | Verfahren zur Herstellung kombinatorischer Aminbibliotheken |
DE19961372A1 (de) * | 1999-12-17 | 2001-06-21 | Merck Patent Gmbh | Verfahren zur Herstellung kombinatorischer Bibliotheken arylsubstituierter Amine |
BR112013004585B1 (pt) * | 2010-09-20 | 2021-09-08 | Merck Sharp & Dohme Corp | Lipídeo catiônico, composição de lnp, e, uso de um lipídeo catiônico |
GB201208775D0 (en) | 2012-05-18 | 2012-07-04 | Uni I Oslo | Chemical compounds |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB807835A (en) * | 1955-07-01 | 1959-01-21 | Thomae Gmbh Dr K | New tertiary amines and their salts and process for their preparation |
GB921943A (en) * | 1959-11-25 | 1963-03-27 | Lilly Co Eli | Anti-hypertensive compositions |
US4020059A (en) * | 1975-06-02 | 1977-04-26 | Nippon Shokubai Kagaku Kogyo Co., Ltd. | Process for preparing tertiary amines |
DE2725245A1 (de) * | 1976-06-03 | 1977-12-15 | Labaz | Methylaminderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische oder veterinaermedizinische zusammensetzungen |
DE2657476A1 (de) * | 1976-12-18 | 1978-06-22 | Basf Ag | Morpholinderivate |
WO1998000398A1 (fr) * | 1996-06-28 | 1998-01-08 | University Of Southern California | Methode de synthese d'amines et d'acides amines avec des derives organobores |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2207137A1 (fr) * | 1996-06-14 | 1997-12-14 | James Erwin Fritz | Procede combinatoire a l'aide d'agent d'elimination pour la preparation de banques d'amine secondaire |
-
1999
- 1999-06-18 EP EP99929282A patent/EP1087929A1/fr not_active Withdrawn
- 1999-06-18 WO PCT/EP1999/004256 patent/WO1999065318A2/fr not_active Application Discontinuation
- 1999-06-18 JP JP2000554690A patent/JP2002518366A/ja active Pending
- 1999-06-18 WO PCT/EP1999/004258 patent/WO1999065864A2/fr active Application Filing
- 1999-06-18 JP JP2000554208A patent/JP2003524588A/ja active Pending
- 1999-06-18 WO PCT/EP1999/004257 patent/WO1999065863A1/fr not_active Application Discontinuation
- 1999-06-18 EP EP99932703A patent/EP1088029A1/fr not_active Ceased
- 1999-06-18 WO PCT/EP1999/004255 patent/WO1999065855A2/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB807835A (en) * | 1955-07-01 | 1959-01-21 | Thomae Gmbh Dr K | New tertiary amines and their salts and process for their preparation |
GB921943A (en) * | 1959-11-25 | 1963-03-27 | Lilly Co Eli | Anti-hypertensive compositions |
US4020059A (en) * | 1975-06-02 | 1977-04-26 | Nippon Shokubai Kagaku Kogyo Co., Ltd. | Process for preparing tertiary amines |
DE2725245A1 (de) * | 1976-06-03 | 1977-12-15 | Labaz | Methylaminderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische oder veterinaermedizinische zusammensetzungen |
DE2657476A1 (de) * | 1976-12-18 | 1978-06-22 | Basf Ag | Morpholinderivate |
WO1998000398A1 (fr) * | 1996-06-28 | 1998-01-08 | University Of Southern California | Methode de synthese d'amines et d'acides amines avec des derives organobores |
Non-Patent Citations (15)
Title |
---|
"BEILSTEINS HANDBUCH DER ORGANISCHEN CHEMIE, vierte Auflage, drittes Ergänzungswerk, Band IV, erster Teil, S. 308, 428", 1962, SPRINGER-VERLAG, BERLIN . GÖTTINGEN . HEIDELBERG, XP002118210 * |
"BEILSTEINS HANDBUCH DER ORGANISCHEN CHEMIE, vierte Auflage, drittes Ergänzungswerk, Band XII, vierter Teil, S. 2223-2224", 1972, SPRINGER-VERLAG, BERLIN . HEIDELBERG . NEW YORK, XP002118212 * |
"BEILSTEINS HANDBUCH DER ORGANISCHEN CHEMIE, vierte Auflage, drittes und viertes Ergänzungswerk, Bd 20, erster Teil, S. 316", 1977, SPRINGER-VERLAG, BERLIN . HEIDELBERG . NEW YORK, XP002117681 * |
"BEILSTEINS HANDBUCH DER ORGANISCHEN CHEMIE, vierte Auflage, viertes Ergänzungswerk, Band IV, erster Teil, S. 689, 745", 1977, SPRINGER-VERLAG, BERLIN . HEIDELBERG . NEW YORK, XP002118211 * |
"BEILSTEINS HANDBUCH DER ORGANISCHEN CHEMIE, vierte Auflage, viertes Ergänzungswerk, Band XII, vierter Teil, S. 2182", 1984, SPRINGER-VERLAG, BERLIN . HEIDELBERG . NEW YORK . TOKYO, XP002118213 * |
"HOUBEN-WEYL, METHODEN DER ORGANISCHEN CHEMIE, vol. XI/1, S. 820-823", 1957, GEORG THIEME VERLAG, STUTTGART, DE, XP002117680 * |
AN. QUIM., vol. 69, no. 9-10, 1973, pages 1047 - 1054 * |
CHEMICAL ABSTRACTS, vol. 80, no. 21, 27 May 1974, Columbus, Ohio, US; abstract no. 120423p, IBANEZ-PANIELLO: "Synthesis of dibenzylamine derivatives..." page 394; column 1; XP002118214 * |
FRANK G. RIDDELL ET AL.: "Intramolecular motions.....", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2., 1996, LETCHWORTH GB, pages 493 - 504, XP002118208 * |
KUFFNER ET AL.: "Über hochverzeigte aliphatische Verbindungen.", MONATSHEFTE FÜR CHEMIE, vol. 82, 1951, pages 330 - 335, XP002117674 * |
KUFFNER F. ET AL.: "Über hochverzweigte aliphatische Verbindungen", MONATSHEFTE FÜR CHEMIE, vol. 93, 1962, pages 499 - 475, XP002117676 * |
MICHAEL B. SMITH ET AL.: "Reaction of amines with cyclopropylcarbinyl halides", JOURNAL OF ORGANIC CHEMISTRY., vol. 50, no. 24, 1985, EASTON US, pages 4815 - 4821, XP002118209 * |
N. MAXIM ET AL.: "Sur la méthode de Bouveault ....", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE., vol. 5, no. 3, 1936, SOCIETE FRANCAISE DE CHIMIE. PARIS., FR, pages 1084 - 1093, XP002117677, ISSN: 0037-8968 * |
R. LUKÈS ET AL.: "Die Spaltung verzweigter, optisch aktiver tertiärer basen", COLLECTION CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 24, 1959, pages 110 - 115, XP002117675 * |
R. LUKÈS ET AL.: "Über die Spaltung verzweigter tertiärer Basen II.", COLLECTION CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 25, 1960, pages 461 - 464, XP002117678 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999065864A2 (fr) | 1999-12-23 |
JP2002518366A (ja) | 2002-06-25 |
WO1999065855A2 (fr) | 1999-12-23 |
WO1999065318A2 (fr) | 1999-12-23 |
WO1999065863A1 (fr) | 1999-12-23 |
JP2003524588A (ja) | 2003-08-19 |
EP1087929A1 (fr) | 2001-04-04 |
WO1999065855A3 (fr) | 2003-12-11 |
EP1088029A1 (fr) | 2001-04-04 |
WO1999065318A3 (fr) | 2003-04-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2086404A1 (fr) | Derives triazolopyrimidine | |
DE69532245D1 (en) | Imidazolderivat | |
TR199701427T1 (xx) | �nsektisidler olarak kullan�lan bisiklik aminler. | |
DK0613900T3 (da) | Triazolopyrimidinderivater med fungiced virkning | |
IT1283588B1 (it) | Miscela sinergica di agenti stabilizzanti | |
MY109737A (en) | Treatment and compounds. | |
CA2161499A1 (fr) | Melange de stabilisation synergique | |
AP9600855A0 (en) | Insecticidal n-(substituted phenyl) methyl) piperidines | |
EP0945439A4 (fr) | Nouveaux derives d'aminopyrazole | |
ZA847274B (en) | Oxopyramidine derivatives and pharmaceutical compositions containing them | |
KR850003719A (ko) | 시아노피라졸 제초제에 대한 개량 | |
DE60322565D1 (de) | Antistatika und davon abgeleitete polymerzusammensetzungen | |
WO1999065864A3 (fr) | Amines substituees de maniere geminee | |
EP0721945A4 (fr) | Derive de benzolactame | |
WO1997028122A3 (fr) | Procede de preparation de composes dicetoniques | |
TW259785B (en) | Chemical compounds | |
KR970069989A (ko) | 피리딘-2,3-디카르복실산 디아미드 유도체 및 유효성분으로 상기 유도체를 함유하는 제초제 | |
EP0680960A4 (fr) | Compose d'imidazole. | |
DE69219124T2 (de) | Fungizide verbindungen | |
MX9804861A (es) | Mezclas fungicidas. | |
KR930023031A (ko) | 아졸 유도체를 함유하는 항아로마타제제 | |
EP0579836A4 (fr) | ||
WO2001044160A3 (fr) | Procede d'elaboration de bibliotheques combinatoires d'amines | |
NO154228C (no) | Metylenkloridblanding inneholdende et tertiaert amin som stabilisator mot spalting paa grunn av vann. | |
WO2000020399A3 (fr) | Utilisation de 5-hydroxypyrazoles substitues, nouveaux 5-hydroxypyrazoles, procedes permettant de les preparer et agents les contenant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): JP KR US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
122 | Ep: pct application non-entry in european phase |