WO1999041007A2 - Method and apparatus for chemical and biochemical reactions using photo-generated reagents - Google Patents

Method and apparatus for chemical and biochemical reactions using photo-generated reagents Download PDF

Info

Publication number
WO1999041007A2
WO1999041007A2 PCT/US1999/002945 US9902945W WO9941007A2 WO 1999041007 A2 WO1999041007 A2 WO 1999041007A2 US 9902945 W US9902945 W US 9902945W WO 9941007 A2 WO9941007 A2 WO 9941007A2
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
reactions
photo
chemical
acid
Prior art date
Application number
PCT/US1999/002945
Other languages
English (en)
French (fr)
Other versions
WO1999041007B1 (en
WO1999041007A3 (en
Inventor
Xiaolian Gao
Xiaochuan Zhou
Erdogan Gulari
Original Assignee
University Of Houston
University Of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22119182&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999041007(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University Of Houston, University Of Michigan filed Critical University Of Houston
Priority to JP2000531248A priority Critical patent/JP4503828B2/ja
Priority to AT99906913T priority patent/ATE246041T1/de
Priority to EP99906913A priority patent/EP1054726B1/en
Priority to AU26714/99A priority patent/AU755239B2/en
Priority to CA002319587A priority patent/CA2319587C/en
Priority to DE69909972T priority patent/DE69909972T2/de
Publication of WO1999041007A2 publication Critical patent/WO1999041007A2/en
Publication of WO1999041007A3 publication Critical patent/WO1999041007A3/en
Publication of WO1999041007B1 publication Critical patent/WO1999041007B1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00434—Liquid crystal masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00439—Maskless processes using micromirror arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00675—In-situ synthesis on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00731—Saccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
    • G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PCT/US1999/002945 1998-02-11 1999-02-10 Method and apparatus for chemical and biochemical reactions using photo-generated reagents WO1999041007A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2000531248A JP4503828B2 (ja) 1998-02-11 1999-02-10 光生成試薬を用いる化学反応および生化学反応のための方法および装置
AT99906913T ATE246041T1 (de) 1998-02-11 1999-02-10 Vorrichtung zur durchführung chemischer und biochemischer reaktionen unter anwendung von photoerzeugten reagenzien
EP99906913A EP1054726B1 (en) 1998-02-11 1999-02-10 Apparatus for chemical and biochemical reactions using photo-generated reagents
AU26714/99A AU755239B2 (en) 1998-02-11 1999-02-10 Method and apparatus for chemical and biochemical reactions using photo-generated reagents
CA002319587A CA2319587C (en) 1998-02-11 1999-02-10 Method and apparatus for chemical and biochemical reactions using photo-generated reagents
DE69909972T DE69909972T2 (de) 1998-02-11 1999-02-10 Vorrichtung zur durchführung chemischer und biochemischer reaktionen unter anwendung von photoerzeugten reagenzien

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7436898P 1998-02-11 1998-02-11
US60/074,368 1998-02-11

Publications (3)

Publication Number Publication Date
WO1999041007A2 true WO1999041007A2 (en) 1999-08-19
WO1999041007A3 WO1999041007A3 (en) 1999-11-11
WO1999041007B1 WO1999041007B1 (en) 2000-01-13

Family

ID=22119182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002945 WO1999041007A2 (en) 1998-02-11 1999-02-10 Method and apparatus for chemical and biochemical reactions using photo-generated reagents

Country Status (8)

Country Link
US (7) US6426184B1 (US07544638-20090609-C00025.png)
EP (2) EP2332645A1 (US07544638-20090609-C00025.png)
JP (1) JP4503828B2 (US07544638-20090609-C00025.png)
AT (1) ATE246041T1 (US07544638-20090609-C00025.png)
AU (1) AU755239B2 (US07544638-20090609-C00025.png)
CA (1) CA2319587C (US07544638-20090609-C00025.png)
DE (1) DE69909972T2 (US07544638-20090609-C00025.png)
WO (1) WO1999041007A2 (US07544638-20090609-C00025.png)

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999060156A2 (de) * 1998-05-18 1999-11-25 Epigenomics Gmbh Verfahren und vorrichtung zur photolithographischen herstellung von dna, pna und protein chips
EP0961174A2 (en) * 1998-05-29 1999-12-01 Affymetrix, Inc. (a California Corporation) Compositions and methods involving direct write optical lithography
WO2000013017A2 (de) * 1998-08-28 2000-03-09 Febit Ferrarius Biotechnology Gmbh Verfahren und vorrichtung zur herstellung und/oder analyse von biochemischen reaktionsträgern
EP1066506A1 (en) * 1998-02-23 2001-01-10 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
FR2798675A1 (fr) * 1999-09-16 2001-03-23 Centre Nat Rech Scient Procede et dispositif de fabrication d'un support porteur d'une pluralite de sequences polynucleotidiques et/ou peptidiques differentes
US6295153B1 (en) 1998-06-04 2001-09-25 Board Of Regents, The University Of Texas System Digital optical chemistry micromirror imager
EP1180111A1 (en) * 1999-02-10 2002-02-20 Macrogen Inc. Method and apparatus for compound library preparation using optical modulator
WO2002026373A1 (fr) * 2000-09-27 2002-04-04 Centre National De La Recherche Scientifique (C.N.R.S.) Procede et dispositif de fabrication d'un support porteur d'une pluralite de sequences polynucleotidiques et/ou peptidiques differentes
WO2003000644A1 (en) * 2001-06-21 2003-01-03 The Institute Of Cancer Research Photolabile esters and their uses
WO2003008088A2 (de) * 2001-07-17 2003-01-30 Frieder Breitling Verfahren und anordnung zum anbringen von in transportmitteln immobilisierten substanzen sowie monomerpartikel
WO2003064026A1 (en) 2002-01-31 2003-08-07 Nimblegen Systems Llc Pre-patterned substrate, device and method for optical synthesis of dna probes
WO2004004885A1 (de) * 2002-07-05 2004-01-15 Marcel Rogalla Verfahren und programmierbare beleuchtungsvorrichtung zur hochauflösenden, massiv parallelen, räumlichen synthese und analyse von microarrays
JP2004501665A (ja) * 2000-07-03 2004-01-22 ゼオトロン　コーポレイション 光生成試薬を用いて化学反応を行なうためのデバイスおよび方法
US6838447B2 (en) 2001-03-26 2005-01-04 Linden Technologies, Inc. Particulate compositions for chemical synthesis
EP1547678A3 (en) * 2003-12-22 2005-09-21 Affymetrix, Inc. (a Delaware Corporation) Process for high-yield synthesis of nucleic acid arrays
US6962822B2 (en) 2002-08-07 2005-11-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
WO2006117556A2 (en) * 2005-05-04 2006-11-09 The Institute Of Cancer Research: Royal Cancer Hospital Materials and methods for the photodirected synthesis of oligonucleotide arrays
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
EP1795965A2 (en) * 2005-12-08 2007-06-13 Electronics And Telecommunications Research Institute Programmable mask for fabricating biomolecule array or polymer array
US7435575B2 (en) 2000-12-28 2008-10-14 Roche Molecular Systems, Inc. Method for processing a nucleic acid sample by oscillating a cartridge, a system and a cartridge for performing such a method
US7470540B2 (en) 2000-10-17 2008-12-30 Febit Ag Method and device for the integrated synthesis and analysis of analytes on a support
US7491680B2 (en) 1998-02-11 2009-02-17 The Regents Of The University Of Michigan Device for chemical and biochemical reactions using photo-generated reagents
US7722824B2 (en) 2005-08-02 2010-05-25 Wisconsin Alumni Research Foundation Synthesis of arrays of oligonucleotides and other chain molecules
WO2010118264A2 (en) 2009-04-09 2010-10-14 California Institute Of Technology Multiplexed sites for polymer synthesis
US7862996B2 (en) 2005-12-29 2011-01-04 Affymetrix, Inc. Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
WO2013135844A1 (fr) * 2012-03-14 2013-09-19 Alveole Dispositif de greffage micro-structure de proteines sur un substrat
US8822158B2 (en) 2009-02-25 2014-09-02 Roche Molecular Systems, Inc. Miniaturized, high-throughput nucleic acid analysis
US9347092B2 (en) 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
EP2920272B1 (en) * 2012-11-14 2019-08-21 Vibrant Holdings, LLC Methods for array synthesis
RU2702559C2 (ru) * 2014-10-03 2019-10-08 Юниверсите Де Бордо Печать адгезивного шаблона на необрастающей подложке
US10450560B2 (en) 2002-09-12 2019-10-22 Gen9, Inc. Microarray synthesis and assembly of gene-length polynucleotides
US10486129B2 (en) 2012-02-07 2019-11-26 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
GB2511600B (en) * 2011-05-09 2019-12-04 Woodbury Neal Methods for performing patterned chemistry
US10577391B2 (en) 2014-02-21 2020-03-03 Vibrant Holdings, Llc Selective photoactivation of amino acids for single step peptide coupling
US10816553B2 (en) 2013-02-15 2020-10-27 Vibrant Holdings, Llc Methods and compositions for amplified electrochemiluminescence detection
US11168365B2 (en) 2017-05-26 2021-11-09 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887665B2 (en) * 1996-11-14 2005-05-03 Affymetrix, Inc. Methods of array synthesis
US20040035690A1 (en) * 1998-02-11 2004-02-26 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
WO2000066259A1 (en) * 1999-05-05 2000-11-09 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US6660479B2 (en) * 1999-06-07 2003-12-09 Samsung Electronics Co., Ltd. Process for preparing peptide nucleic acid probe using polymeric photoacid generator
US20030118486A1 (en) * 2000-07-03 2003-06-26 Xeotron Corporation Fluidic methods and devices for parallel chemical reactions
US20050181421A1 (en) * 2000-08-03 2005-08-18 Affymetrix, Inc. Methods of array synthesis
US6852524B2 (en) * 2001-04-27 2005-02-08 Canon Kabushiki Kaisha Probe carrier, probe fixing carrier and method of manufacturing the same
GB0126281D0 (en) * 2001-11-01 2002-01-02 Astrazeneca Ab A chemical reactor
US7037659B2 (en) * 2002-01-31 2006-05-02 Nimblegen Systems Inc. Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer
NL1020066C2 (nl) * 2002-02-26 2003-08-27 Dutch Space B V Inrichting voor het vervaardigen van een DNA-testarray.
CN1202266C (zh) * 2002-04-30 2005-05-18 欧姆龙株式会社 设置有光扫描装置的生物芯片和该生物芯片的读取方法
JP2004085955A (ja) * 2002-08-27 2004-03-18 Japan Science & Technology Corp 液晶式フォトマスク、それを用いたパターン露光方法、パターン露光装置及びｄｎａチップの製造方法
KR101476067B1 (ko) 2002-09-06 2014-12-23 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
AU2003277059A1 (en) * 2002-10-01 2004-04-23 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
JP2006503586A (ja) * 2002-10-28 2006-02-02 ゼオトロン コーポレイション アレイオリゴマー合成および使用
TWI255971B (en) * 2002-11-29 2006-06-01 Asml Netherlands Bv Lithographic apparatus and device manufacturing method
US20040110133A1 (en) * 2002-12-06 2004-06-10 Affymetrix, Inc. Functionated photoacid generator for biological microarray synthesis
US7053198B2 (en) * 2002-12-06 2006-05-30 Affymetrix, Inc. Functionated photoacid generator and functionated polymer system for biological microarray synthesis
AU2003296945A1 (en) * 2002-12-12 2004-07-09 Chiron Corporation Device and method for in-line blood testing using biochips
US20040115654A1 (en) * 2002-12-16 2004-06-17 Intel Corporation Laser exposure of photosensitive masks for DNA microarray fabrication
US7923550B2 (en) * 2003-04-14 2011-04-12 Xiaolian Gao Reagent compounds and methods of making and using the same
US7858387B2 (en) * 2003-04-30 2010-12-28 Perkinelmer Health Sciences, Inc. Method of scanning a sample plate surface mask in an area adjacent to a conductive area using matrix-assisted laser desorption and ionization mass spectrometry
KR100561842B1 (ko) 2003-08-25 2006-03-16 삼성전자주식회사 단량체 광산발생제 조성물, 상기 조성물로 코팅된 기판,상기 단량체 광산발생제 조성물을 이용하여 기판상에서화합물을 합성하는 방법 및 상기 방법에 의하여 제조된마이크로어레이
FR2861608B1 (fr) * 2003-10-31 2005-12-23 Commissariat Energie Atomique Dispositif de travail comportant des zones de travail bordees, laboratoire sur puce et microsysteme
US20050272059A1 (en) * 2004-02-12 2005-12-08 Xiaolian Gao Method for providing microarrays
CA2557841A1 (en) * 2004-02-27 2005-09-09 President And Fellows Of Harvard College Polony fluorescent in situ sequencing beads
WO2005089110A2 (en) * 2004-02-27 2005-09-29 President And Fellows Of Harvard College Polynucleotide synthesis
US7435074B2 (en) * 2004-03-13 2008-10-14 International Business Machines Corporation Method for fabricating dual damascence structures using photo-imprint lithography, methods for fabricating imprint lithography molds for dual damascene structures, materials for imprintable dielectrics and equipment for photo-imprint lithography used in dual damascence patterning
US20050214779A1 (en) * 2004-03-29 2005-09-29 Peck Bill J Methods for in situ generation of nucleic acid arrays
DE102004019098A1 (de) 2004-04-20 2005-11-10 Chemogenix Gmbh Photolabile Schutzgruppen
DE102004056980A1 (de) * 2004-11-25 2006-06-01 Clondiag Chip Technologies Gmbh Verfahren zur ortsspezifischen Synthese von Biopolymeren auf festen Trägern
DE102004062256A1 (de) * 2004-12-23 2006-07-13 Basf Ag Hochempfindliches Verfahren zur Detektion von Unterschieden zwischen den physikalisch messbaren Eigenschaften einer Probe und einer Referenz
KR100793962B1 (ko) * 2005-01-03 2008-01-16 삼성전자주식회사 생분자 검출 장치 및 이를 이용한 생분자 검출 방법
KR100919820B1 (ko) * 2007-11-26 2009-10-01 한국전자통신연구원 광화학 합성 장치
US20090023609A1 (en) * 2005-12-08 2009-01-22 Moon Youn Jung Programmable mask for fabricating biomolecule array or polymer array, apparatus for fabricating biomolecule array or polymer array including the programmable mask, and method of fabricating biomolecule array or polymer array using the programmable mask and photochemical synthesis apparatus
WO2007078833A2 (en) * 2005-12-16 2007-07-12 The Curators Of The University Of Missouri Reusable pcr amplification system and method
JP2007256001A (ja) * 2006-03-22 2007-10-04 Oki Electric Ind Co Ltd 有機化合物合成装置および有機化合物合成用基板
JP2007252249A (ja) * 2006-03-22 2007-10-04 Oki Electric Ind Co Ltd 有機化合物合成装置，光照射装置，有機化合物合成用基板および有機化合物の合成方法
EP1996947A1 (en) * 2006-03-24 2008-12-03 The Regents of the University of Michigan Method for forming molecular sequences on surfaces
US20070231805A1 (en) * 2006-03-31 2007-10-04 Baynes Brian M Nucleic acid assembly optimization using clamped mismatch binding proteins
KR100745990B1 (ko) * 2006-07-17 2007-08-06 삼성전자주식회사 마이크로 어레이의 제조 방법
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
US9096953B2 (en) * 2006-09-29 2015-08-04 Intel Corporation Method for high throughput, high volume manufacturing of biomolecule micro arrays
US20080161204A1 (en) * 2006-10-06 2008-07-03 Mo-Huang Li Microwell array for parallel synthesis of chain molecules
US8345241B1 (en) 2006-12-19 2013-01-01 J. A. Woollam Co., Inc. Application of digital light processor in imaging ellipsometer and the like systems
WO2008082506A1 (en) * 2006-12-19 2008-07-10 J.A. Woollam Co., Inc. Application of digital light processor in scanning spectrometer and imaging ellipsometer and the like systems
US8749782B1 (en) 2006-12-19 2014-06-10 J.A. Woollam Co., Inc. DLP base small spot investigation system
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス， インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
US20100093554A1 (en) * 2007-06-01 2010-04-15 Keting Chu Methods for identifying biomarkers, autoantibody signatures, and stratifying subject groups using peptide arrays
US8039612B2 (en) * 2007-10-15 2011-10-18 Honeywell International, Inc. Synthesis of oligonucleotides or phosphorothioate oligonucleotide with a capping agent of N-methylimidazole free of 1,3,5-trimethylhexahydro-1,3,5-triazine
US20100047876A1 (en) * 2008-08-08 2010-02-25 President And Fellows Of Harvard College Hierarchical assembly of polynucleotides
US8808986B2 (en) 2008-08-27 2014-08-19 Gen9, Inc. Methods and devices for high fidelity polynucleotide synthesis
US20100112558A1 (en) * 2008-11-03 2010-05-06 Xiaolian Gao Probe Bead Synthesis and Use
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
EP2503888A4 (en) * 2009-11-23 2015-07-29 Cerulean Pharma Inc POLYMERS ON CYCLODEXTRINBASIS FOR THERAPEUTIC ADMINISTRATION
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
WO2011066186A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Methods and apparatuses for chip-based dna error reduction
WO2011085075A2 (en) 2010-01-07 2011-07-14 Gen9, Inc. Assembly of high fidelity polynucleotides
US8716467B2 (en) 2010-03-03 2014-05-06 Gen9, Inc. Methods and devices for nucleic acid synthesis
US10240194B2 (en) 2010-05-13 2019-03-26 Gen9, Inc. Methods for nucleotide sequencing and high fidelity polynucleotide synthesis
WO2011150168A1 (en) 2010-05-28 2011-12-01 Gen9, Inc. Methods and devices for in situ nucleic acid synthesis
ES2548400T3 (es) 2010-11-12 2015-10-16 Gen9, Inc. Métodos y dispositivos para la síntesis de ácidos nucleicos
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
JP2012131718A (ja) 2010-12-20 2012-07-12 Samsung Electronics Co Ltd 化合物合成方法、マイクロアレイ、酸転写用組成物及びバイオチップ製造用組成物
US8450131B2 (en) 2011-01-11 2013-05-28 Nanohmics, Inc. Imprinted semiconductor multiplex detection array
US9828696B2 (en) 2011-03-23 2017-11-28 Nanohmics, Inc. Method for assembly of analyte filter arrays using biomolecules
US9252175B2 (en) 2011-03-23 2016-02-02 Nanohmics, Inc. Method for assembly of spectroscopic filter arrays using biomolecules
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
WO2012174337A1 (en) 2011-06-15 2012-12-20 Gen9, Inc. Methods for preparative in vitro cloning
EP2944693B1 (en) 2011-08-26 2019-04-24 Gen9, Inc. Compositions and methods for high fidelity assembly of nucleic acids
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
EP4001427A1 (en) 2012-04-24 2022-05-25 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
JP6509727B2 (ja) 2012-06-25 2019-05-15 ギンゴー バイオワークス， インコーポレイテッド 核酸アセンブリおよび高処理シークエンシングのための方法
CN104662544B (zh) 2012-07-19 2018-08-03 哈佛大学校长及研究员协会 利用核酸存储信息的方法
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
TWI721929B (zh) 2013-08-05 2021-03-11 美商扭轉生物科技有限公司 重新合成之基因庫
US9645391B2 (en) 2013-11-27 2017-05-09 Tokyo Electron Limited Substrate tuning system and method using optical projection
JP6676527B6 (ja) * 2013-11-27 2020-05-20 東京エレクトロン株式会社 光学投影を使用する基板チューニングシステム及び方法
CA2961743A1 (en) * 2014-09-17 2016-03-24 Ibis Biosciences, Inc. Sequencing by synthesis using pulse read optics
CN107532129B (zh) 2014-12-09 2022-09-13 生命技术公司 高效小体积核酸合成
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
WO2016126987A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
IL258164B (en) 2015-09-18 2022-09-01 Twist Bioscience Corp Methods to regulate the activity of proteins and cells and a method for the production of nucleic acids
WO2017053450A1 (en) 2015-09-22 2017-03-30 Twist Bioscience Corporation Flexible substrates for nucleic acid synthesis
CN108603307A (zh) 2015-12-01 2018-09-28 特韦斯特生物科学公司 功能化表面及其制备
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
KR102632268B1 (ko) * 2016-01-11 2024-01-31 삼성전자주식회사 포토 레지스트 조성물 및 이를 이용한 반도체 장치의 제조 방법
WO2018038772A1 (en) 2016-08-22 2018-03-01 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
JP6871364B2 (ja) 2016-09-21 2021-05-12 ツイスト バイオサイエンス コーポレーション 核酸に基づくデータ保存
EA201991262A1 (ru) 2016-12-16 2020-04-07 Твист Байосайенс Корпорейшн Библиотеки вариантов иммунологического синапса и их синтез
SG11201907713WA (en) 2017-02-22 2019-09-27 Twist Bioscience Corp Nucleic acid based data storage
EP3595674A4 (en) 2017-03-15 2020-12-16 Twist Bioscience Corporation BANKS OF VARIANTS OF IMMUNOLOGICAL SYNAPSE AND THEIR SYNTHESIS
CN111566209A (zh) 2017-06-12 2020-08-21 特韦斯特生物科学公司 无缝核酸装配方法
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
US20190009240A1 (en) * 2017-07-10 2019-01-10 The Charles Stark Draper Laboratory, Inc. Apparatus Enabling High Density Information Storage in Molecular Chains
US11407837B2 (en) 2017-09-11 2022-08-09 Twist Bioscience Corporation GPCR binding proteins and synthesis thereof
KR20240024357A (ko) 2017-10-20 2024-02-23 트위스트 바이오사이언스 코포레이션 폴리뉴클레오타이드 합성을 위한 가열된 나노웰
US10936953B2 (en) 2018-01-04 2021-03-02 Twist Bioscience Corporation DNA-based digital information storage with sidewall electrodes
US20200384436A1 (en) * 2018-01-05 2020-12-10 Centrillion Technologies, Inc. Methods for fabricating high resolution dna array and its application in sequencing
KR20210013128A (ko) 2018-05-18 2021-02-03 트위스트 바이오사이언스 코포레이션 핵산 하이브리드화를 위한 폴리뉴클레오타이드, 시약 및 방법
US11131615B2 (en) 2018-06-07 2021-09-28 Nanohmics, Inc. Sensor and methods for detecting and quantifying ions and molecules
JP7430701B2 (ja) 2018-07-23 2024-02-13 ディーエヌエー スクリプト 核酸鎖の大規模並列酵素合成
SG11202109283UA (en) 2019-02-26 2021-09-29 Twist Bioscience Corp Variant nucleic acid libraries for antibody optimization
AU2020229349A1 (en) 2019-02-26 2021-10-14 Twist Bioscience Corporation Variant nucleic acid libraries for GLP1 receptor
EP3987019A4 (en) 2019-06-21 2023-04-19 Twist Bioscience Corporation BARCODE-BASED NUCLEIC ACID SEQUENCE ARRANGEMENT
CN114729389B (zh) 2019-09-23 2024-03-08 Dna斯克瑞普特公司 增加多核苷酸的无模板酶促合成中的长序列产率

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
WO1993002992A1 (en) * 1991-08-07 1993-02-18 H & N Instruments, Inc. Synthesis of chain chemical compounds
WO1996011878A1 (en) * 1994-10-18 1996-04-25 The Regents Of The University Of California The combinatorial synthesis of novel materials
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
WO1997039151A1 (en) * 1996-04-17 1997-10-23 Affymetrix, Inc. Photolabile polymer array synthesis methods

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2644341C2 (de) * 1976-10-01 1984-08-02 Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar Verfahren und Anordnungen zur automatischen Verwirklichung des Köhler'schen Beleuchtungsprinzipes
US4146329A (en) * 1977-09-14 1979-03-27 The United States Of America As Represented By The Secretary Of The Navy Autoalignment system for high power laser
JPS5534490A (en) * 1978-09-01 1980-03-11 Canon Inc Alignment device
US4367251A (en) * 1980-04-21 1983-01-04 General Electric Company UV Curable compositions and substrates treated therewith
US4571603A (en) * 1981-11-03 1986-02-18 Texas Instruments Incorporated Deformable mirror electrostatic printer
US4719615A (en) * 1983-08-22 1988-01-12 Optical Data, Inc. Erasable optical data storage medium
US4662746A (en) * 1985-10-30 1987-05-05 Texas Instruments Incorporated Spatial light modulator and method
US4596992A (en) * 1984-08-31 1986-06-24 Texas Instruments Incorporated Linear spatial light modulator and printer
US5096279A (en) * 1984-08-31 1992-03-17 Texas Instruments Incorporated Spatial light modulator and method
US4615595A (en) * 1984-10-10 1986-10-07 Texas Instruments Incorporated Frame addressed spatial light modulator
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5525464A (en) * 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US6031091A (en) 1987-09-21 2000-02-29 Gen-Probe Incorporated Non-nucleotide linking reagents for nucleotide probes
US5585481A (en) * 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5158855A (en) 1987-09-24 1992-10-27 Hitachi, Ltd. α-diazoacetoacetates and photosensitive resin compositions containing the same
US5028939A (en) * 1988-08-23 1991-07-02 Texas Instruments Incorporated Spatial light modulator system
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5141813A (en) * 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5083857A (en) * 1990-06-29 1992-01-28 Texas Instruments Incorporated Multi-level deformable mirror device
DE69132531T2 (de) * 1990-12-06 2001-09-13 Affymetrix Inc Verbindungen und ihre Verwendung in einer binären Synthesestrategie
US5401607A (en) * 1991-04-17 1995-03-28 Polaroid Corporation Processes and compositions for photogeneration of acid
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
EP0537524A1 (en) 1991-10-17 1993-04-21 Shipley Company Inc. Radiation sensitive compositions and methods
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5247180A (en) * 1991-12-30 1993-09-21 Texas Instruments Incorporated Stereolithographic apparatus and method of use
US5656741A (en) * 1992-03-30 1997-08-12 Barrskogen, Inc. Process and reagents for processing synthetic oligonucleotides
GB9207381D0 (en) * 1992-04-03 1992-05-13 Ici Plc Synthesis of oligonucleotides
US6219015B1 (en) 1992-04-28 2001-04-17 The Board Of Directors Of The Leland Stanford, Junior University Method and apparatus for using an array of grating light valves to produce multicolor optical images
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US5583688A (en) * 1993-12-21 1996-12-10 Texas Instruments Incorporated Multi-level digital micromirror device
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US6051374A (en) 1994-02-14 2000-04-18 Abbott Laboratories Non-A, non-B, non-C, non-D, non-E hepatitis reagents and methods for their use
US5517280A (en) * 1994-04-12 1996-05-14 The Board Of Trustees Of The Leland Stanford, Jr. University Photolithography system
US5666190A (en) * 1994-04-12 1997-09-09 The Board Of Trustees Of The Leland Stanford, Jr. University Method of performing lithography using cantilever array
US5883705A (en) * 1994-04-12 1999-03-16 The Board Of Trustees Of The Leland Stanford, Jr. University Atomic force microscope for high speed imaging including integral actuator and sensor
US5514789A (en) 1994-04-21 1996-05-07 Barrskogen, Inc. Recovery of oligonucleotides by gas phase cleavage
US5571639A (en) * 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5539567A (en) * 1994-06-16 1996-07-23 Texas Instruments Incorporated Photolithographic technique and illuminator using real-time addressable phase shift light shift
AU689924B2 (en) * 1994-06-23 1998-04-09 Affymax Technologies N.V. Photolabile compounds and methods for their use
US5552471A (en) * 1994-08-17 1996-09-03 The Perkin-Elmer Corporation Solid support reagents for the synthesis of 3'-Nitrogen containing polynucleotides
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5504614A (en) * 1995-01-31 1996-04-02 Texas Instruments Incorporated Method for fabricating a DMD spatial light modulator with a hardened hinge
US5599695A (en) * 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5535047A (en) * 1995-04-18 1996-07-09 Texas Instruments Incorporated Active yoke hidden hinge digital micromirror device
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
TW284907B (en) * 1995-06-07 1996-09-01 Cauldron Lp Removal of material by polarized irradiation and back side application for radiation
US5835256A (en) * 1995-06-19 1998-11-10 Reflectivity, Inc. Reflective spatial light modulator with encapsulated micro-mechanical elements
JP2000502341A (ja) 1995-12-22 2000-02-29 ユーニヴァスィティ テクノロヂィズ インタナショナル インク． オリゴヌクレオチド合成のための再利用可能の固体支持体、その製法、およびその使用法
US6043353A (en) 1995-12-22 2000-03-28 University Technologies International, Inc. Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof
US5567294A (en) * 1996-01-30 1996-10-22 Board Of Governors, University Of Alberta Multiple capillary biochemical analyzer with barrier member
US5869696A (en) 1996-04-22 1999-02-09 Beckman Instruments, Inc. Universal solid supports and methods for their use
US6005125A (en) 1996-05-06 1999-12-21 Rutgers The State University Of New Jersey Universal allyl linker for solid-phase nucleic acid synthesis
JP3456348B2 (ja) * 1996-09-19 2003-10-14 トヨタ自動車株式会社 ディーゼル機関の排気浄化装置
US5942608A (en) 1996-10-29 1999-08-24 Council of Sciemtific & Industrial Research and Department of Biotechnology Process for preparing a universal support for the synthesis of oligonucleotides
US5953153A (en) * 1996-10-29 1999-09-14 Texas Instruments Incorporated Spatial light modulator with improved light shield
WO1998020967A1 (en) 1996-11-14 1998-05-22 Affymetrix, Inc. Chemical amplification for the synthesis of patterned arrays
US5750672A (en) 1996-11-22 1998-05-12 Barrskogen, Inc. Anhydrous amine cleavage of oligonucleotides
DE19707432A1 (de) * 1997-02-25 1998-08-27 Bodenseewerk Geraetetech Vorrichtung zur Umschaltung von optischen Bildern zwischen verschiedenen Kanälen
US5768009A (en) * 1997-04-18 1998-06-16 E-Beam Light valve target comprising electrostatically-repelled micro-mirrors
US6210878B1 (en) * 1997-08-08 2001-04-03 The Regents Of The University Of California Array-based detection of genetic alterations associated with disease
AU9220498A (en) 1997-09-04 1999-03-22 Bayer Corporation Oligonucleotide probes bearing quenchable fluorescent labels, and methods of usethereof
US20040035690A1 (en) * 1998-02-11 2004-02-26 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
CA2319587C (en) 1998-02-11 2004-09-21 University Of Houston Method and apparatus for chemical and biochemical reactions using photo-generated reagents
EP2259046A3 (en) * 1998-02-23 2011-11-30 Wisconsin Alumni Research Foundation Method for synthesis of arrays of dna probes
US6271957B1 (en) * 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
US6295153B1 (en) * 1998-06-04 2001-09-25 Board Of Regents, The University Of Texas System Digital optical chemistry micromirror imager
US6215579B1 (en) * 1998-06-24 2001-04-10 Silicon Light Machines Method and apparatus for modulating an incident light beam for forming a two-dimensional image
WO2000012524A1 (en) 1998-08-27 2000-03-09 Bayer Corporation Purification of oligomers using dual-end selection
DE59915204D1 (de) 1998-08-28 2010-10-28 Febit Holding Gmbh Verfahren zur herstellung von biochemischen reaktionsträgern
US5991066A (en) * 1998-10-15 1999-11-23 Memsolutions, Inc. Membrane-actuated charge controlled mirror
EP1149109B1 (en) 1999-02-05 2009-09-16 Amersham Biosciences Corp. Method for deprotecting oligonucleotides
WO2000047598A1 (en) 1999-02-10 2000-08-17 Macrogen Inc. Method and apparatus for compound library preparation using optical modulator
JP2002538790A (ja) 1999-03-08 2002-11-19 プロトジーン・ラボラトリーズ・インコーポレーテッド 長いｄｎａ配列を経済的に合成し、そして組み立てるための方法および組成物
DE19914279C1 (de) * 1999-03-25 2000-09-07 Jena Optronik Gmbh Anordnung zum optischen Auslesen der Information von einem matrixförmigen Substrat mit einer Vielzahl von Einzelproben
AU2001272714A1 (en) 2000-06-13 2001-12-24 Proligo Llc Universal solid supports for solid phase oligosynthesis and methods for their preparation and use
US6869696B2 (en) * 2002-05-10 2005-03-22 Sensient Imaging Technologies Gmbh Organic red electro-luminescent device including a heterocyclic emitter
JP4505763B2 (ja) 2007-01-31 2010-07-21 ヒューレット−パッカード デベロップメント カンパニー エル．ピー． ノードクラスタの管理

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
WO1993002992A1 (en) * 1991-08-07 1993-02-18 H & N Instruments, Inc. Synthesis of chain chemical compounds
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
WO1996011878A1 (en) * 1994-10-18 1996-04-25 The Regents Of The University Of California The combinatorial synthesis of novel materials
WO1997039151A1 (en) * 1996-04-17 1997-10-23 Affymetrix, Inc. Photolabile polymer array synthesis methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1054726A2 *

Cited By (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491680B2 (en) 1998-02-11 2009-02-17 The Regents Of The University Of Michigan Device for chemical and biochemical reactions using photo-generated reagents
US7544638B2 (en) 1998-02-11 2009-06-09 The Regents Of The University Of Michigan Device for chemical and biochemical reactions using photo-generated reagents
EP1066506A4 (en) * 1998-02-23 2005-02-23 Wisconsin Alumni Res Found METHOD AND APPARATUS FOR SYNTHESIZING DNA PROBE NETWORKS
US6375903B1 (en) 1998-02-23 2002-04-23 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of DNA probes
EP1066506A1 (en) * 1998-02-23 2001-01-10 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
US8030477B2 (en) 1998-02-23 2011-10-04 Wisconsin Alumni Research Foundation Methods for the synthesis of arrays of DNA probes
WO1999060156A3 (de) * 1998-05-18 2000-02-17 Epigenomics Gmbh Verfahren und vorrichtung zur photolithographischen herstellung von dna, pna und protein chips
WO1999060156A2 (de) * 1998-05-18 1999-11-25 Epigenomics Gmbh Verfahren und vorrichtung zur photolithographischen herstellung von dna, pna und protein chips
EP0961174A3 (en) * 1998-05-29 2001-01-17 Affymetrix, Inc. (a California Corporation) Compositions and methods involving direct write optical lithography
US6271957B1 (en) 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
EP0961174A2 (en) * 1998-05-29 1999-12-01 Affymetrix, Inc. (a California Corporation) Compositions and methods involving direct write optical lithography
US6480324B2 (en) 1998-05-29 2002-11-12 Affymetrix, Inc. Methods involving direct write optical lithography
US6295153B1 (en) 1998-06-04 2001-09-25 Board Of Regents, The University Of Texas System Digital optical chemistry micromirror imager
US8415101B2 (en) 1998-06-04 2013-04-09 Roche Nimblegen, Inc. Digital optical chemistry micromirror imager
EP2273270A1 (de) * 1998-08-28 2011-01-12 febit holding GmbH Verfahren und Vorrichtung zur Herstellung und/oder Analyse von biochemischen Reaktionsträgern
WO2000013017A3 (de) * 1998-08-28 2000-07-20 Febit Ferrarius Biotech Gmbh Verfahren und vorrichtung zur herstellung und/oder analyse von biochemischen reaktionsträgern
WO2000013017A2 (de) * 1998-08-28 2000-03-09 Febit Ferrarius Biotechnology Gmbh Verfahren und vorrichtung zur herstellung und/oder analyse von biochemischen reaktionsträgern
US7097974B1 (en) 1998-08-28 2006-08-29 Febit Biotech Gmbh Support for a method for determining an analyte and a method for producing the support
EP1180111A1 (en) * 1999-02-10 2002-02-20 Macrogen Inc. Method and apparatus for compound library preparation using optical modulator
EP1180111A4 (en) * 1999-02-10 2003-03-26 Macrogen Inc METHOD AND DEVICE FOR PRODUCING CONNECTION LIBRARIES BY MEANS OF OPTICAL MODULATOR
FR2798675A1 (fr) * 1999-09-16 2001-03-23 Centre Nat Rech Scient Procede et dispositif de fabrication d'un support porteur d'une pluralite de sequences polynucleotidiques et/ou peptidiques differentes
EP2045005A2 (en) 2000-07-03 2009-04-08 Xeotron Corporation Devices and methods for carrying out chemical reactions using photogenerated reagents
EP2045005A3 (en) * 2000-07-03 2011-12-21 Xeotron Corporation Devices and methods for carrying out chemical reactions using photogenerated reagents
JP2004501665A (ja) * 2000-07-03 2004-01-22 ゼオトロン　コーポレイション 光生成試薬を用いて化学反応を行なうためのデバイスおよび方法
WO2002026373A1 (fr) * 2000-09-27 2002-04-04 Centre National De La Recherche Scientifique (C.N.R.S.) Procede et dispositif de fabrication d'un support porteur d'une pluralite de sequences polynucleotidiques et/ou peptidiques differentes
US7470540B2 (en) 2000-10-17 2008-12-30 Febit Ag Method and device for the integrated synthesis and analysis of analytes on a support
US7435575B2 (en) 2000-12-28 2008-10-14 Roche Molecular Systems, Inc. Method for processing a nucleic acid sample by oscillating a cartridge, a system and a cartridge for performing such a method
US7807807B2 (en) 2001-03-14 2010-10-05 The Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
EP2048149A2 (en) 2001-03-14 2009-04-15 The Regents of the University of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid support
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US8053187B2 (en) 2001-03-14 2011-11-08 The Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US8461317B2 (en) 2001-03-14 2013-06-11 The Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US9303055B2 (en) 2001-03-14 2016-04-05 The Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US7553958B2 (en) 2001-03-14 2009-06-30 The Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US6855501B2 (en) 2001-03-26 2005-02-15 Linden Technologies, Inc. Transfer of arrayed chemical compositions
US6838447B2 (en) 2001-03-26 2005-01-04 Linden Technologies, Inc. Particulate compositions for chemical synthesis
WO2003000644A1 (en) * 2001-06-21 2003-01-03 The Institute Of Cancer Research Photolabile esters and their uses
US7301049B2 (en) 2001-06-21 2007-11-27 The Institute Of Cancer Research Photolabile esters and their uses
WO2003008088A3 (de) * 2001-07-17 2003-05-30 Frieder Breitling Verfahren und anordnung zum anbringen von in transportmitteln immobilisierten substanzen sowie monomerpartikel
WO2003008088A2 (de) * 2001-07-17 2003-01-30 Frieder Breitling Verfahren und anordnung zum anbringen von in transportmitteln immobilisierten substanzen sowie monomerpartikel
WO2003064026A1 (en) 2002-01-31 2003-08-07 Nimblegen Systems Llc Pre-patterned substrate, device and method for optical synthesis of dna probes
WO2004004885A1 (de) * 2002-07-05 2004-01-15 Marcel Rogalla Verfahren und programmierbare beleuchtungsvorrichtung zur hochauflösenden, massiv parallelen, räumlichen synthese und analyse von microarrays
US7354777B2 (en) 2002-08-07 2008-04-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
US6962822B2 (en) 2002-08-07 2005-11-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
US10450560B2 (en) 2002-09-12 2019-10-22 Gen9, Inc. Microarray synthesis and assembly of gene-length polynucleotides
US10640764B2 (en) 2002-09-12 2020-05-05 Gen9, Inc. Microarray synthesis and assembly of gene-length polynucleotides
US10774325B2 (en) 2002-09-12 2020-09-15 Gen9, Inc. Microarray synthesis and assembly of gene-length polynucleotides
EP1547678A3 (en) * 2003-12-22 2005-09-21 Affymetrix, Inc. (a Delaware Corporation) Process for high-yield synthesis of nucleic acid arrays
WO2006117556A2 (en) * 2005-05-04 2006-11-09 The Institute Of Cancer Research: Royal Cancer Hospital Materials and methods for the photodirected synthesis of oligonucleotide arrays
WO2006117556A3 (en) * 2005-05-04 2007-03-29 Cancer Res Inst Royal Materials and methods for the photodirected synthesis of oligonucleotide arrays
US7956011B2 (en) 2005-05-04 2011-06-07 The Institute Of Cancer Research: Royal Cancer Hospital Materials and methods for the photodirected synthesis of oligonucleotide arrays
US7722824B2 (en) 2005-08-02 2010-05-25 Wisconsin Alumni Research Foundation Synthesis of arrays of oligonucleotides and other chain molecules
EP1795965A2 (en) * 2005-12-08 2007-06-13 Electronics And Telecommunications Research Institute Programmable mask for fabricating biomolecule array or polymer array
US7760274B2 (en) 2005-12-08 2010-07-20 Electronics And Telecommunications Research Institute Programmable mask for fabricating biomolecule array or polymer array, apparatus for fabricating biomolecule array or polymer array including the programmable mask, and method of fabricating biomolecule array or polymer array using the programmable mask
EP1795965A3 (en) * 2005-12-08 2008-12-17 Electronics And Telecommunications Research Institute Programmable mask for fabricating biomolecule array or polymer array
US8062844B2 (en) 2005-12-29 2011-11-22 Affymetrix, Inc. Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
US7910312B2 (en) 2005-12-29 2011-03-22 Affymetrix, Inc. Use of acid scavengers for the synthesis of standard length and long-mer polymer arrays
US7862996B2 (en) 2005-12-29 2011-01-04 Affymetrix, Inc. Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
US8318427B2 (en) 2005-12-29 2012-11-27 Affymetrix, Inc. Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
US8822158B2 (en) 2009-02-25 2014-09-02 Roche Molecular Systems, Inc. Miniaturized, high-throughput nucleic acid analysis
US9347092B2 (en) 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
EP2417147A4 (en) * 2009-04-09 2013-05-29 California Inst Of Techn MULTPLEX PLACES FOR POLYMER SYNTHESIS
WO2010118264A2 (en) 2009-04-09 2010-10-14 California Institute Of Technology Multiplexed sites for polymer synthesis
EP2417147A2 (en) * 2009-04-09 2012-02-15 California Institute of Technology Multiplexed sites for polymer synthesis
GB2511600B (en) * 2011-05-09 2019-12-04 Woodbury Neal Methods for performing patterned chemistry
US11565231B2 (en) 2012-02-07 2023-01-31 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
US10486129B2 (en) 2012-02-07 2019-11-26 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
KR20150007284A (ko) * 2012-03-14 2015-01-20 알베올르 기판 상에 단백질의 마이크로 구조의 그라프팅을 위한 디바이스
US10024866B2 (en) 2012-03-14 2018-07-17 Alveole Device for the microstructured grafting of proteins onto a substrate
FR2988093A1 (fr) * 2012-03-14 2013-09-20 Alveole Dispositif de greffage micro-structure de proteines sur un substrat
WO2013135844A1 (fr) * 2012-03-14 2013-09-19 Alveole Dispositif de greffage micro-structure de proteines sur un substrat
KR102084810B1 (ko) 2012-03-14 2020-03-04 알베올르 기판 상에 단백질의 마이크로 구조의 그라프팅을 위한 디바이스
US10746732B2 (en) 2012-09-28 2020-08-18 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10175234B2 (en) 2012-09-28 2019-01-08 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US11815512B2 (en) 2012-09-28 2023-11-14 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US11674956B2 (en) 2012-09-28 2023-06-13 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10799845B2 (en) 2012-11-14 2020-10-13 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
EP2920272B1 (en) * 2012-11-14 2019-08-21 Vibrant Holdings, LLC Methods for array synthesis
US10816553B2 (en) 2013-02-15 2020-10-27 Vibrant Holdings, Llc Methods and compositions for amplified electrochemiluminescence detection
EP3107926B1 (en) * 2014-02-21 2020-09-09 Vibrant Holdings, LLC Selective photo activation of amino acids for single step peptide coupling
US10577391B2 (en) 2014-02-21 2020-03-03 Vibrant Holdings, Llc Selective photoactivation of amino acids for single step peptide coupling
EP3805207A1 (en) * 2014-02-21 2021-04-14 Vibrant Holdings, LLC Formulation for the selective photo activation of amino acids for single step peptide coupling
RU2702559C2 (ru) * 2014-10-03 2019-10-08 Юниверсите Де Бордо Печать адгезивного шаблона на необрастающей подложке
US11168365B2 (en) 2017-05-26 2021-11-09 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing

Also Published As

Publication number Publication date
AU2671499A (en) 1999-08-30
EP1054726B1 (en) 2003-07-30
CA2319587A1 (en) 1999-08-19
US20040023368A1 (en) 2004-02-05
US20030143131A1 (en) 2003-07-31
CA2319587C (en) 2004-09-21
DE69909972T2 (de) 2004-05-13
US20080318806A1 (en) 2008-12-25
WO1999041007B1 (en) 2000-01-13
AU755239B2 (en) 2002-12-05
US20020081582A1 (en) 2002-06-27
US7491680B2 (en) 2009-02-17
US20110170075A1 (en) 2011-07-14
JP2002502698A (ja) 2002-01-29
JP4503828B2 (ja) 2010-07-14
US20030138363A1 (en) 2003-07-24
WO1999041007A3 (en) 1999-11-11
US7544638B2 (en) 2009-06-09
ATE246041T1 (de) 2003-08-15
EP1054726A2 (en) 2000-11-29
US20030186427A1 (en) 2003-10-02
US6426184B1 (en) 2002-07-30
US7838466B2 (en) 2010-11-23
DE69909972D1 (de) 2003-09-04
EP2332645A1 (en) 2011-06-15

Similar Documents

Publication Publication Date Title
US6426184B1 (en) Method and apparatus for chemical and biochemical reactions using photo-generated reagents
US6887665B2 (en) Methods of array synthesis
US5510270A (en) Synthesis and screening of immobilized oligonucleotide arrays
US8193336B2 (en) Method and apparatus for combinatorial chemistry
JP2000511560A (ja) パターン化したアレイの合成用の化学増幅
US20040035690A1 (en) Method and apparatus for chemical and biochemical reactions using photo-generated reagents
WO2008118167A1 (en) Method for forming molecular sequences on surfaces
EP1258288A2 (en) Method and apparatus for chemical and biochemical reactions using photo-generated reagents
AU772531B2 (en) Method and apparatus for chemical and biochemical reactions using photo-generated reagents
US20240091731A1 (en) Devices and methods for multiplexing chemical synthesis
US20050181421A1 (en) Methods of array synthesis

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: B1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: B1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1999906913

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2319587

Country of ref document: CA

Ref country code: CA

Ref document number: 2319587

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 26714/99

Country of ref document: AU

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 531248

Kind code of ref document: A

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: KR

WWP Wipo information: published in national office

Ref document number: 1999906913

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 26714/99

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1999906913

Country of ref document: EP