WO1999008675A1 - Agents therapeutiques pour traiter le colon irritable - Google Patents
Agents therapeutiques pour traiter le colon irritable Download PDFInfo
- Publication number
- WO1999008675A1 WO1999008675A1 PCT/JP1998/003665 JP9803665W WO9908675A1 WO 1999008675 A1 WO1999008675 A1 WO 1999008675A1 JP 9803665 W JP9803665 W JP 9803665W WO 9908675 A1 WO9908675 A1 WO 9908675A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- irritable bowel
- bowel syndrome
- present
- group
- therapeutic agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
Definitions
- the present invention relates to a medicament comprising a specific alkylenedioxybenzene derivative as an active ingredient, which is useful for treating and / or preventing irritable bowel syndrome.
- Irritable bowel syndrome is a disease caused by factors such as stress and mainly manifested by physical symptoms of the digestive system such as abdominal pain and diarrhea.
- the disease has been associated with spastic colon, nervous colitis, mucous colitis, functional colitis, or colitis.
- colonic neurosis it is considered not only a disease that occurs only in the large intestine, but also a functional disorder of the digestive tract, including the small intestine, so the word “intestine” is used instead of “large intestine”. It has become.
- Physiological factors such as hormones, extraneous stimuli such as food and stress, emotional factors, and genetic constitution have been suggested as factors of this disease.
- Treatment It is generally difficult to completely eliminate symptoms in the treatment of irritable bowel syndrome, and usually aimed at relieving various complaints and improving the condition without any trouble in ordinary daily life. Treatment is given. Treatment methods include psychotherapy, lifestyle guidance, diet therapy, and pharmacotherapy for patients' complaints (see above). Medications for irritable bowel syndrome include obioid agonists such as oral peramid or anticholinergic agents such as mepenzolato bromide and timevidim bromide for increased gastrointestinal motility such as diarrhea. Benzodiazepines such as diazebam are prescribed for symptoms such as anxiety and insomnia. However, pharmacotherapy that allows for causal therapy has not yet been established. On the other hand, the following equation:
- the publication also states that the above compounds No. 1, No. 2, and No. 3 have anti-conflict effects and are useful for treating anxiety disorders, schizophrenia, manic depression, etc. Is disclosed.
- Serotonin has been shown to be involved in intestinal motility, suggesting that serotonin 3 receptor subtype antagonists are effective in suppressing intestinal motility (Miyata et al., J. Pharmacol. Exp. Ther., 261, pp.297-303, 1992). It is also known that agonists of the serotonin 1A receptor subtype have an inhibitory effect on defecation due to forced swimming stress in rats (Foreman et al., Drug Dev. Res., 34, pp.66-85, 1995). However, although forced swimming has been established as a screening system for antidepressants, its validity as an animal model for irritable bowel syndrome was not disclosed.
- Tandospirone one of the serotonin 1A receptor agonists, shows a tendency to improve in double-blind studies in patients with irritable bowel syndrome, but there is no significant difference in the therapeutic effect compared to placebo. Not recognized (Kimura et al., Clinical Evaluation, 20, pp. 225-257, 1992). Japanese Unexamined Patent Publications Nos. 3-26459-28 and 4-288072 do not suggest or teach that the above compounds have a therapeutic effect on irritable bowel syndrome. Absent. Disclosure of the invention
- An object of the present invention is to provide a medicament useful for preventing and / or treating irritable bowel syndrome.
- the present inventors have made intensive efforts to solve the above-mentioned problems, and as a result, a specific alkylenedioxybenzene derivative has been shown to be effective for a pathological model of irritable bowel syndrome, preventing irritable bowel syndrome and preventing Z or It was found to be useful for treatment.
- the present invention has been completed based on the above findings.
- alkylenedioxybenzene derivative and a pharmaceutically acceptable salt thereof It is intended to provide a preventive and / or therapeutic agent for irritable bowel syndrome using a substance selected from the group consisting of those solvates as an active ingredient.
- a compound in which n is 1 in the above formula (I) [particularly preferably 5- [3-[(2S)-(1,4-benzodioxane-12-inolemethyl) amino] propoxy] ] 1,3 -benzodioxole] and its physiologically acceptable salts, and the irritable bowel syndrome described above, which contains as an active ingredient a substance selected from the group consisting of hydrates and solvates thereof.
- Prophylactic and Z or therapeutic agents are provided.
- the above-mentioned prophylactic and / or Z- or therapeutic agent is provided in the form of a pharmaceutical composition comprising a substance which is an active ingredient selected from the above-mentioned group and a pharmaceutical additive.
- the present invention provides an alkylenedioxybenzene derivative represented by the above formula (I) for the prevention of irritable bowel syndrome and the production of a therapeutic agent or a Z or a therapeutic agent thereof, and a physiologically acceptable derivative thereof.
- a method for preventing and treating irritable bowel syndrome comprising administering to a mammal, including a human, an effective amount of a substance selected from the group consisting of hydrates and solvates thereof.
- FIG. 1 is a view showing the action of a drug that suppresses the action of the medicament of the present invention.
- A shows that the action of the medicament of the present invention is similar to that of N-tert-butyl-3- (4- (2-methoxyphenyl) piperazin-l-yl) -2-phenyl-propanamide (WAY100135), which is a serotonin 1A receptor antagonist.
- B shows that 1- (2-pyrimidinyl) piperazine (1-PP), a common metabolite of the control drugs buspirone and tandospirone, inhibits the action of the drug of the present invention. It is shown that. In the figure, * indicates that a significant difference was found at a risk rate of 5% when multiple comparison was performed by the Tukey's method after one-way analysis of variance.
- the prophylactic and / or therapeutic agent of the present invention is effective for the substance comprising an alkylenedioxybenzene derivative represented by the above formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof. It is characterized by containing as a component.
- Alkylenedioxybenzene derivatives represented by the general formula (I) are known, and include, for example, JP-A-57-108880, JP-A-58-219914, and Since the production method is disclosed in Japanese Patent Application Laid-Open No. 3-264645, those skilled in the art can easily obtain these substances.
- the alkylenedioxy group included in the above formula (I) Among the benzene derivatives, those in which n is 1 are preferred.
- the bonding position of the aminoaminoalkyloxy group to be substituted on the phenyl group may be at the ortho or meta position with respect to one oxygen atom of the alkylenedioxy group, or may be at the meta position. It is preferable,
- physiologically acceptable salts thereof include mineral salts such as hydrochloride, phosphate or sulfate; and organic acid salts such as acetate, formate, citrate or paratoluenesulfonate. it can.
- a free form compound or any hydrate or solvate of the above salt may be used as an active ingredient of the medicament of the present invention.
- the solvent that can form the solvate is not particularly limited as long as it is a physiologically acceptable solvent, and examples thereof include methanol, ethanol, isopropanol, acetone, and ethyl acetate. Among them, an ethanolic solvate and the like can be preferably used.
- the alkylenedioxybenzene derivative represented by the general formula (I) has one asymmetric carbon and has two kinds of optical isomers.
- the method for producing such an optical isomer and its pharmaceutical use are described in Japanese Patent Application Laid-Open No. 288,072, and both optical isomers can be used by those skilled in the art.
- As the active ingredient of the medicament of the present invention any of the optically pure optical isomers of the above-mentioned alkylenedioxybenzene derivatives or any mixture of the optical isomers may be used.
- an optical isomer it is preferable to use an S-isomer.
- a racemic form which is an equal mixture of optical isomers, may be used.
- alkylene dioxybenzene derivatives suitable as the active ingredient of the medicament of the present invention are exemplified below, but the active ingredient of the medicament of the present invention is not limited to the following derivatives. 0 (CH 2 ) m NHCH 2 ,
- particularly preferred compounds include the compounds of No. 1, which are disclosed in JP-A-3-2464528 and JP-A-Hei. This is specifically shown in Japanese Patent Application Laid-Open No. 4_288072.
- Japanese Patent Application Laid-Open Nos. 3-26452 / 28 and JP-A-4-288072 disclose that an alkylenedioxybenzene derivative of the formula (I), which is an active ingredient of the present invention, is a serotonin 1A receptor It has high affinity for subtypes and has been shown to have anti-conflict effects.
- these publications disclose that the alkylenedioxybenzene derivatives are useful for treating anxiety disorders, schizophrenia, manic depression, and the like. There is no suggestion that it would be useful in treating the syndrome, but it is not taught.
- the medicament of the present invention is useful for prevention and Z or treatment of irritable bowel syndrome.
- Irritable bowel syndrome generally persists with constipation, diarrhea, and alternating bowel movements, and complains of various unidentified complaints of the abdomen.Sufficient organic lesions in the intestinal tract to explain these symptoms are common. Although it is defined as a functional disease of the intestinal tract that is not proven in the internal and external organs and related organs (Matsunaga et al., Irritable bowel syndrome, Masanori Takada; Ed. The disease may be called spastic colon, nervous colitis, mucous colitis, functional colitis, or colonic neurosis is there.
- the disease types generally include spastic colorectal, neurogenic diarrhea, and mucous colic, but have spastic constipation, chronic diarrhea, flaccid constipation, intestinal gas syndrome, and It may be classified as chronic abdomen.
- irritable bowel syndrome may include biliary dyskinesia, reduced gastric emptying, hysteria, nonspecific esophageal dysfunction, neurogenic vomiting, recurrent abdominal pain, and simple constipation. Therefore, the term "irritable bowel syndrome" as used herein should be interpreted in the broadest sense, including these diseases.
- NIH criteria, Manning criteria, and Cook's criteria have been proposed as diagnostic criteria for irritable bowel syndrome, but skilled physicians can easily diagnose this disease according to any of these criteria. It goes without saying that the application of the medicament of the present invention can be appropriately determined (for a review on irritable bowel syndrome, see Hitoshi Asakura, “Stress and hypersensitivity”). Gastrointestinal Syndrome ”, Clinical Gastroenterology, Vol. 8, No. 8, pp. 1373-1381, 1993).
- a substance itself selected from the group consisting of the above-mentioned alkylenedioxybenzene derivatives and pharmaceutically acceptable salts thereof, and hydrates and solvates thereof is administered to mammals including humans.
- a pharmaceutical composition containing one or more of the above-mentioned substances as active ingredients and a pharmaceutical additive is prepared and administered to a patient.
- Such pharmaceutical compositions include, for example, preparations for oral administration such as tablets, capsules, fine granules, powders, pills, troches, sublinguals, or liquids, or injections, infusions, Preparations for parenteral administration, such as drugs, transdermal absorbents, transmucosal absorbents, inhalants, and transdermal patches.
- Tablets or capsules for oral administration are usually presented as unit dosages, such as binders, fillers, diluents, tablets, lubricants, disintegrants, coloring agents, flavoring agents, or wetting agents. It can be produced using ordinary pharmaceutical additives.
- Tablets may be coated according to methods well known in the art, for example, with an enteric coating, for example, fillers such as cellulose, mannitol, or lactose; starch, polybutylpolypyrrolidone, starch derivatives. Or a disintegrating agent such as sodium starch dalycolate; a lubricant such as magnesium stearate; a wetting agent such as sodium lauryl sulfate.
- enteric coating for example, fillers such as cellulose, mannitol, or lactose; starch, polybutylpolypyrrolidone, starch derivatives.
- a disintegrating agent such as sodium starch dalycolate
- a lubricant such as magnesium stearate
- a wetting agent such as sodium lauryl sulfate.
- Liquid preparations for oral administration can be dissolved in, for example, aqueous or oily suspensions, solutions, emulsions, syrups, or elixirs, or by adding water or a suitable aqueous medium before use. It can be provided as a dry preparation such as a lyophilized product. Such liquid preparations may contain the usual pharmaceutical additives such as sorbitol, syrup, methinoresenorelose, gelatin, hydroxyxetinoresenorelose, phenolic methyloxycellulose, aluminum stearate gel or hydrogenated edible fat.
- sorbitol syrup, methinoresenorelose, gelatin, hydroxyxetinoresenorelose, phenolic methyloxycellulose, aluminum stearate gel or hydrogenated edible fat.
- Emulsifiers such as lecithin, sorbitan monoolate, gum arabic; almond oil, rectified coconut oil, oily esters (eg, esthenole of glycerin), propylene glycol, ethyl alcohol (also edible oils) Non-water) And a preservative such as a methyl ester, ethyl ester, or propyl ester of P-hydroxybenzoic acid, or sorbic acid; and, if necessary, a usual flavoring agent or coloring agent.
- a preservative such as a methyl ester, ethyl ester, or propyl ester of P-hydroxybenzoic acid, or sorbic acid.
- Preparations for oral administration can be manufactured by methods known in the art, such as mixing, filling, or tableting. Further, the active ingredient may be distributed in a preparation using a large amount of a filler or the like by using a repetitive compounding operation.
- Formulations for parenteral administration such as injections and infusions are generally provided as unit dosage formulations containing the above-mentioned active ingredients and a sterile vehicle. And then sterile-filtered, and then filled in an appropriate vial or sample and sealed to produce a product. To enhance stability, the composition may be filled into vials after freezing and the water removed under vacuum.
- Suspensions for parenteral administration are prepared substantially in the same manner as for parenteral solutions, but can be suitably prepared by suspending the active ingredient in a vehicle and sterilizing with gas such as ethylene oxide. . Further, a surfactant, a wetting agent, and the like may be added as necessary so that the active ingredient has a uniform distribution.
- the dose of the medicament of the present invention may be appropriately determined in consideration of the purpose of treatment or prevention, the type of disease to be treated or prevented, the patient's symptoms, body weight, age, sex, etc.
- a daily dose of about 0.1 mg to 100 mg, preferably about 1 to 100 mg, of the active ingredient can be administered by oral administration. Such a dose may be administered once or several times a day.
- the number of defecations was counted and compared with the control group.
- the medicament of the present invention was administered 30 minutes before restraint, and the concomitant drug was administered 1 hour before restraint.
- the load of restraint stress significantly increased the number of rat defecations from an average of 0.2 to 11.5.
- the present invention dose-dependently suppressed the increase in the number of defecations induced by restraint stress (Table 3).
- the drug of the present invention has been shown to have an anxiolytic effect in an animal model (Abe et al., J. Pharmacol. Exp. Ther., 278, pp. 898-905, 1996), the drug of the present invention is It is thought that in the treatment of the syndrome, the intestinal motor function is directly regulated, and the anxiety is removed to synergistically enhance the therapeutic effect.
- the medicament of the present invention is useful for preventing and / or treating irritable bowel syndrome.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69822846T DE69822846T2 (de) | 1997-08-19 | 1998-08-19 | Medikament zur Behandlung des Reizkolons |
JP2000509415A JP4316793B2 (ja) | 1997-08-19 | 1998-08-19 | 過敏性腸症候群の治療剤 |
EP98938887A EP1010425B1 (en) | 1997-08-19 | 1998-08-19 | Remedies for irritable bowel syndrome |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22242497 | 1997-08-19 | ||
JP9/222424 | 1997-08-19 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09485999 A-371-Of-International | 2000-06-19 | ||
US10/022,274 Continuation US6596759B2 (en) | 1997-08-19 | 2001-12-20 | Medicament for treatment of irritable bowel syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999008675A1 true WO1999008675A1 (fr) | 1999-02-25 |
Family
ID=16782186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1998/003665 WO1999008675A1 (fr) | 1997-08-19 | 1998-08-19 | Agents therapeutiques pour traiter le colon irritable |
Country Status (6)
Country | Link |
---|---|
US (1) | US6596759B2 (ja) |
EP (1) | EP1010425B1 (ja) |
JP (1) | JP4316793B2 (ja) |
DE (1) | DE69822846T2 (ja) |
ES (1) | ES2218845T3 (ja) |
WO (1) | WO1999008675A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004096208A1 (en) * | 2003-04-25 | 2004-11-11 | Mitsubishi Pharma Corporation | Composition for oral administration containing alkylene dioxybenzene derivative |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002338333A1 (en) * | 2001-04-04 | 2002-10-21 | Wyeth | Methods for treating hyperactive gastric motility |
WO2006080385A1 (ja) * | 2005-01-28 | 2006-08-03 | Astellas Pharma Inc. | 過敏性腸症候群治療薬のスクリーニング方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03264528A (ja) * | 1990-03-14 | 1991-11-25 | Mitsubishi Kasei Corp | 抗不安薬 |
JPH04288072A (ja) * | 1991-03-14 | 1992-10-13 | Mitsubishi Kasei Corp | アルキレンジオキシベンゼン誘導体およびそれを有効成分とする抗不安薬 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57108088A (en) | 1980-12-25 | 1982-07-05 | Mitsubishi Chem Ind Ltd | (omega-aminoalkoxy)alkylenedioxybenzene derivative and its acid addition salt |
US4684739A (en) | 1980-12-15 | 1987-08-04 | Mitsubishi Chemical Industries Limited | Alkylenedioxybenzene derivatives and acid addition salts thereof |
JPS58219114A (ja) | 1982-06-15 | 1983-12-20 | Mitsubishi Chem Ind Ltd | 血圧降下剤 |
CA2025398A1 (en) | 1989-09-20 | 1992-03-15 | Timothy Gerard Dinan | Diagnosis and treatment of a disorder of the gastrointestinal tract |
US5234948A (en) | 1990-03-14 | 1993-08-10 | Mitsubishi Kasei Corporation | Optically active alkylenedioxybenzene derivatives and their use in therapy |
ZA935078B (en) | 1992-07-15 | 1994-02-07 | Nicolaas Johannes Jaco Loetter | Pharmaceutical composition |
GB9417135D0 (en) * | 1994-08-23 | 1994-10-12 | Medinnova S F | Method |
EP0884049B1 (en) | 1997-05-20 | 2002-09-04 | Mitsubishi Chemical Corporation | Use of an alkylenedioxybenzene derivative for the treatment of circadian rythm sleep disorder |
-
1998
- 1998-08-19 JP JP2000509415A patent/JP4316793B2/ja not_active Expired - Fee Related
- 1998-08-19 EP EP98938887A patent/EP1010425B1/en not_active Expired - Lifetime
- 1998-08-19 ES ES98938887T patent/ES2218845T3/es not_active Expired - Lifetime
- 1998-08-19 WO PCT/JP1998/003665 patent/WO1999008675A1/ja active IP Right Grant
- 1998-08-19 DE DE69822846T patent/DE69822846T2/de not_active Expired - Lifetime
-
2001
- 2001-12-20 US US10/022,274 patent/US6596759B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03264528A (ja) * | 1990-03-14 | 1991-11-25 | Mitsubishi Kasei Corp | 抗不安薬 |
JPH04288072A (ja) * | 1991-03-14 | 1992-10-13 | Mitsubishi Kasei Corp | アルキレンジオキシベンゼン誘導体およびそれを有効成分とする抗不安薬 |
Non-Patent Citations (2)
Title |
---|
ABE M, SAITO K-I: "REDUCTION OF WRAP RESTRAINT STRESS-INDUCED DEFECATION BY MKC-242, ANOVEL BENZODIOXAN DERIVATIVE, VIA 5-HT1A-RECEPTOR AGONIST ACTION INRATS", JAPANESE JOURNAL OF PHARMACOLOGY., THE JAPANESE PHARMACOLOGICAL SOCIETY, KYOTO, JP, vol. 77, no. 03, 1 January 1998 (1998-01-01), KYOTO, JP, pages 211 - 217, XP002917808, ISSN: 0021-5198, DOI: 10.1254/jjp.77.211 * |
See also references of EP1010425A4 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004096208A1 (en) * | 2003-04-25 | 2004-11-11 | Mitsubishi Pharma Corporation | Composition for oral administration containing alkylene dioxybenzene derivative |
JP2006524684A (ja) * | 2003-04-25 | 2006-11-02 | 三菱ウェルファーマ株式会社 | アルキレンジオキシベンゼン誘導体を含む経口投与用組成物 |
JP4808612B2 (ja) * | 2003-04-25 | 2011-11-02 | 田辺三菱製薬株式会社 | アルキレンジオキシベンゼン誘導体を含む経口投与用組成物 |
Also Published As
Publication number | Publication date |
---|---|
US6596759B2 (en) | 2003-07-22 |
DE69822846T2 (de) | 2005-02-03 |
ES2218845T3 (es) | 2004-11-16 |
DE69822846D1 (de) | 2004-05-06 |
EP1010425B1 (en) | 2004-03-31 |
US20020091152A1 (en) | 2002-07-11 |
JP4316793B2 (ja) | 2009-08-19 |
EP1010425A4 (en) | 2002-12-04 |
EP1010425A9 (en) | 2000-06-21 |
EP1010425A1 (en) | 2000-06-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TWI302100B (en) | Composition for treating drug-induced constipation | |
TWI387452B (zh) | 用於治療性功能障礙之方法 | |
JP2009538893A (ja) | カンナビノイドの新規な使用 | |
JPH09505809A (ja) | ヒドロキシカルバゾール化合物類による平滑筋移動および増殖の阻害 | |
WO2007093624A2 (en) | Pharmaceutical compositions for the treatment of attention deficit hyperactivity disorder comprising flibanserin | |
JP2009536176A (ja) | 閉経後の性的欲求障害の治療のためのフリバンセリンの使用 | |
JP6408426B2 (ja) | 胃腸障害処置用プロスタグランジン誘導体 | |
KR101516677B1 (ko) | 지방성 간 질환의 치료용 의약 조성물 | |
MXPA04012659A (es) | Uso de antagonistas de mglur5 para el tratamiento de gerd. | |
JP2008156297A (ja) | セロトニン2bおよび/または2c受容体拮抗剤 | |
EP1872795A1 (en) | Therapeutic agent for irritable bowel syndrome | |
JP5259181B2 (ja) | うつ病または不安神経症の予防または治療剤 | |
WO2006000222A2 (en) | The combination of an antipsychotic and a glycine transporter type i inhibitor for the treatment of schizophrenia | |
US6849654B2 (en) | 5-methoxy-carbonylamino-N-acetyltryptamine compounds and derivates thereof | |
KR20190061027A (ko) | 비-알코올성 지방간 질환의 치료를 위한 약학 조성물 및 방법 | |
JP4316793B2 (ja) | 過敏性腸症候群の治療剤 | |
WO2017041112A1 (en) | Ketamine and cytochrome p 450 inhibitor combinations | |
JP2010536827A (ja) | ある種の炎症性障害の治療に有用なカルボニルアミノ誘導体 | |
JP2015134732A (ja) | 血管透過性亢進抑制剤 | |
KR20190013847A (ko) | 불안 장애를 치료하기 위한 (2S)-1-[4-(3,4-디클로로페닐)피페리딘-1-일]-3-[2-(5-메틸-1,3,4-옥사디아졸-2-일)벤조[b]푸란-4-일옥시]프로판-2-올 또는 그의 대사산물 | |
JP2003327529A (ja) | 鎮咳薬および該鎮咳薬を含有する医薬組成物 | |
JP2008156241A (ja) | 体重減少薬 | |
JP2008208122A (ja) | 肥満の予防及び/又は治療薬 | |
US7842702B2 (en) | Treatment for irritable bowel syndrome | |
CN108685929A (zh) | 用于治疗具有腹泻的肠易激综合征的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1998938887 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09485999 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1998938887 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1998938887 Country of ref document: EP |