WO1999006555A1 - Nouvelle proteine humaine mmp-20 et son utilisation - Google Patents

Nouvelle proteine humaine mmp-20 et son utilisation Download PDF

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Publication number
WO1999006555A1
WO1999006555A1 PCT/JP1998/003381 JP9803381W WO9906555A1 WO 1999006555 A1 WO1999006555 A1 WO 1999006555A1 JP 9803381 W JP9803381 W JP 9803381W WO 9906555 A1 WO9906555 A1 WO 9906555A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
human
salt
mmp
dna
Prior art date
Application number
PCT/JP1998/003381
Other languages
English (en)
Japanese (ja)
Inventor
Alberto M. PENDÁS
Elena Llano Cuadra
Carlos LÓPEZ-OTÍN
Takanori Aoki
Kazushi Iwata
Original Assignee
Fuji Yakuhin Kogyo Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Yakuhin Kogyo Kabushiki Kaisha filed Critical Fuji Yakuhin Kogyo Kabushiki Kaisha
Publication of WO1999006555A1 publication Critical patent/WO1999006555A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention porte sur de nouvelles protéines utilisées dans l'étude du développement des dents et du processus de maturation de l'émail, notamment, la formation de l'émail ou la minéralisation de la matrice dentaire, ou sont utilisées à d'autres fins médicales et physiologiques. L'invention porte notamment sur la protéine humaine énamelysine (MMP-20) qui est une des protéines humaines dont l'activité décompose la protéine de l'émail. L'invention porte également sur des gènes codant ces protéines, et sur des anticorps contre ces protéines. L'invention porte encore sur de nouvelles métalloprotéases matricielles (notamment la MMP-20 humaine) clonées par une banque d'ADNc provenant de la pulpe dentaire humaine, sur des ADN contenant une séquence de base les codant; sur des cellules hôtes transformées par ces ADN, sur un procédé de production des protéines métalloprotéases matricielles au moyen des cellules hôtes, sur des anticorps (y compris les anticorps monoclonaux) capables de se lier aux protéines métalloprotéases matricielles et sur les utilisations de ces protéines, de leurs peptides, des anticorps, des acides nucléiques ou des oligomères d'acide nucléique.
PCT/JP1998/003381 1997-07-29 1998-07-29 Nouvelle proteine humaine mmp-20 et son utilisation WO1999006555A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21703897 1997-07-29
JP9/217038 1997-07-29

Publications (1)

Publication Number Publication Date
WO1999006555A1 true WO1999006555A1 (fr) 1999-02-11

Family

ID=16697875

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/003381 WO1999006555A1 (fr) 1997-07-29 1998-07-29 Nouvelle proteine humaine mmp-20 et son utilisation

Country Status (1)

Country Link
WO (1) WO1999006555A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061655A1 (fr) * 1998-05-29 1999-12-02 Hawaii Biotechnology Group, Inc. Essai par fixation determinant un etat de transition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BARTLETT J.D. et al., "Molecular Cloning and mRNA Tissue Distribution of Novel Matrix Metalloproteinase Isolated from Porcine Enamel Organ", GENE, (1996), Vol. 183, p. 123-128. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061655A1 (fr) * 1998-05-29 1999-12-02 Hawaii Biotechnology Group, Inc. Essai par fixation determinant un etat de transition
US6569636B2 (en) 1998-05-29 2003-05-27 Hawaii Biotechnology Group, Inc. Assay for modulators of metallo-enzyme activity

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