Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
  • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
  • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Definitions

• This invention provides an improved process for preparing intermediates useful in the preparation of bromo-substituted tricyclic compounds known as antihistamines and as inhibitors of famesyl protein transferase (FPT).
• antihistamines such as those disclosed in U.S. Patent 5,151 ,423, and of FPT inhibitors disclosed in International Application No. PCT/US96/19603, filed December 19, 1996.
• This invention provides a process for preparing a compound of the formula
• R 1 , R 2 , R 3 and R 4 are independently selected from the group consisting of hydrogen and halo, provided that at least one of R 1 , R 2 , R3 and R 4 is hydrogen and at least one of R 1 , R 2 , R 3 and R 4 is halo; and the dotted line represents an optional double bond; comprising:
• R 1 , R 2 , R 3 and R 4 are as defined above and R 7 is Cl or Br, in the presence of a strong base to obtain a compound of formula 4
• L is a leaving group selected from the group consisting of Cl and Br, to obtain a ketone of formula 7a or an alcohol of formula 7b, respectively:
• Preferred compounds of formula I are those wherein R 2 is halo. Also preferred are compounds wherein R 1 and R 3 are each hydrogen. Another group of preferred compounds is that wherein R 1 , R 3 and R 4 are hydrogen and R 2 is halo. Still another group of preferred compounds is that wherein R 1 and R 3 are each hydrogen and R 2 is halo. Yet another group of preferred compounds is that wherein R 1 and R 3 are each hydrogen and R 2 and R 4 are independently selected from the group consisting of halo. Halo is preferably Cl or Br.
• lower alkyl means straight or branched alkyl chains of 1 to 6 carbon atoms.
• Halo refers to fluorine, chlorine, bromine or iodine radicals.
• Aryl means phenyl, substituted phenyl wherein the substituents are 1 to 3 substituents independently selected from the group consisting of Ci to C ⁇ alkyl and Ci to CQ alkoxy, benzyloxy or naphthyl.
• Heteroaryl means a 5- or 6-membered aromatic ring comprising one or two nitrogen atoms, e.g., pyridyl, pyrimidyl, imidazolyl or pyrrolyl.
• the compounds prepared by the process disclosed above are useful as intermediates in the procedures described in PCT/US96/19603 and U.S. 5,151 ,423 to obtain the desired compounds wherein the piperidinyl ring is N-substituted.
• the desired tricyclic antihistamines and FPT inhibitors described above can be made by an eleven-step process rather than the fifteen-step process disclosed in the art.
• step (a) the di-bromo-substituted pyridine of formula 1 is reacted with the amine NHR 5 R 6 in the presence of a palladium catalyst, carbon monoxide (CO) and a base.
• the amines of formula NHR 5 R 6 are exemplified by t-butylamine, aniline, N-methyl- aniline, pyrrolidine, piperidine, perhydroazepine, piperazine, N-methyl- piperazine, N-phenyl-piperazine and morpholine.
• Preferred amines are pyrrolidine and t-butylamine, with t-butylamine being most preferred.
• Palladium catalysts are exemplified by Pd(OAc)2/P(R 11 ) 3 at ratios of 1 :1 or 1 :2; (PPh 3 )2PdCl2 at a range of 0.5 to 40 mol%, preferably 1 to 10 mol%, and most prefereably 1 to 5 mol%; Pd(PPh3) 4 ; (R 11 ) 3 P/Pd (dba) 3 ; Pd(OAc) 2 /2,2'-bipyridine at ratios of 1 :1 to 1 :2, preferably 1 to 10 mol%; and Pd/C, wherein Ac is acetyi, R 11 is Ci to CQ alkyl or aryl, Ph is phenyl, and dba is dibenzylidene acetone.
• Preferred catalysts are Pd(OAc) 2 /P(R 11 )3 and (PPh 3 ) 2 PdCI 2 .
• Suitable bases include, but are not limited to, Ci to CQ alkyl amines such as triethylamine (Et3N), t-butylamine and 1 ,8-diazobicyclo[5.4.0]undec-7- ene (DBU), and inorganic bases such as K 2 C0 3 , Na C ⁇ 3, Na 2 HP04 and NaOH.
• Preferred bases are K2CO3 and Et3N, with Et3N being most preferred.
• Suitable solvents are tetrahydrofuran (THF), dimethylformamide (DMF), acetonitrile (CH3CN) and toluene or a combination thereof.
• CH3CN is preferred for reaction with an amine and a combination of CH3CN and toluene is preferred for reaction with an alcohol.
• the temperature range for the reaction is 35°C to 100°C, preferably about 55°C for reaction with the amine and preferably about 80°C for reaction with an alcohol.
• the reaction is carried out at a pressure of 5 psi to 500 psi, preferably 40 to 200 psi, and most preferably at 50 to 150 psi.
• the time for reaction ranges from 2 hours to 4 days, preferably 4 hours to 2 days, and most preferably 16 to 48 hours.
• Conversion of the ester of formula 2A to the amide of formula 2 is accomplished by methods well known in the art, for example by reacting the ester directly with the amine or by using the conditions described by Basha et al in Tetrahedron Letters. (1977), p. 4171.
• step (b) the amide formed in step (a) is reacted with the halomethyl-substituted compound of formula 3 in a solvent such as THF, t-butyl methyl ether (t-BuOMe), diethyl ether (Et 2 0), diglyme or a mixture thereof, preferably a mixture of THF and t-buty! methyl ether, in the presence of a strong base such as lithium diisopropylamide (LDA), lithium hexamethyldisilylamide or sodium amide, preferably LDA.
• LDA lithium diisopropylamide
• the concentration of the base ranges from 2.0 to 4.0 equivalents, preferably 2.0 to 2.2 equivalents.
• the compound of formula 3 is reacted in a concentration range of 1.0 to 1.5 equivalents, preferably 1.1 equivalents.
• the reaction is carried out in a temperature range of -78°C to -20°C, preferably -50°C to -30°C.
• step (c)(i) the product of step (b) is converted to the corresponding cyano compound of formula 5a by reacting with POCI3 or SOCI 2 in a solvent such as CH 2 CI 2 or without a solvent, preferably without a solvent.
• the reaction is carried out in a temperature range of 50°C to reflux, preferably at reflux.
• step (c)(ii) the product of step (b) or step (c)(i) is converted to the corresponding aldehyde of formula 5b by reacting with DIBALH or UAIH4 and its derivatives, preferably DIBALH, in a solvent such as toluene, THF or t-BuOMe, preferably toluene.
• a solvent such as toluene, THF or t-BuOMe, preferably toluene.
• the reaction is carried out in a temperature range of -78°C to -30°C, preferably -78°C to -50°C.
• step (d) the product of step 5a or 5b is reacted with a piperidine derivative of formula 6 as defined above to obtain a ketone or alcohol, respectively.
• the reaction is carried out in a solvent such as THF, toluene or t-BuOMe, preferably THF.
• the concentration of the piperidine derivative ranges from 1.0 to 2.0 equivalents, preferably 1.1 to 1.2 equivalents.
• the reaction is carried out in a temperature range from -20°C to 50°C, preferably 35°C to 45°C, for the product of step 5a, and in a range from -78°C to 0°C, preferably -78°C to -60°C, for the product of step 5b.
• step (e)(i) the ketone of formula 7a is cyclized to a compound of formula I wherein the dotted line represents a double bond by treatment with a strong acid such as CF3SO3H, CH3SO3H or BF3-HF, preferably CF3SO3H, in a temperature range of 50°C to 120°C, preferably 90°C to 95°C.
• a strong acid such as CF3SO3H, CH3SO3H or BF3-HF, preferably CF3SO3H
• step (e)(ii) the alcohol of formula 7b is cyclized to a compound of formula I wherein the dotted line represents a single bond by treatment with an acid such as H2SO4, polyphosphoric acid or CH3SO3H, preferably polyphosphoric acid, in a temperature range of 100°C to 200°C, preferably 160°C to 180°C.
• an acid such as H2SO4, polyphosphoric acid or CH3SO3H, preferably polyphosphoric acid
• Step (b) The amide (16 g ) of Step (b) was dissolved in POCI3 (100ml) and the solution was refluxed for 2.5 hr and then concentrated to a third of its volume under vaccum, poured into 200 g ice and adjusted to pH 8 with 50% NaOH at 25°C. The resultant mixture was stirred for 2 hr at 25°C and the pH maintained at 8 with NaOH. Extraction with EtOAc (100ml x 2) and evaporation gave a solid residue which was washed with hexane. After drying, 10 g of product was obtained; the yield was 88% in two steps.

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• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Nitrogen Condensed Heterocyclic Rings (AREA)
• Hydrogenated Pyridines (AREA)
• Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
• Plural Heterocyclic Compounds (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
• Pyridine Compounds (AREA)

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Citations (4)

• 1997
  • 1997-06-16 US US08/882,753 patent/US5760232A/en not_active Expired - Lifetime
• 1998
  • 1998-06-12 AR ARP980102809A patent/AR015886A1/es unknown
  • 1998-06-12 MY MYPI98002633A patent/MY133531A/en unknown
  • 1998-06-15 AT AT98928873T patent/ATE214062T1/de not_active IP Right Cessation
  • 1998-06-15 ZA ZA985207A patent/ZA985207B/xx unknown
  • 1998-06-15 WO PCT/US1998/011403 patent/WO1998057958A1/en active IP Right Grant
  • 1998-06-15 DE DE69804100T patent/DE69804100T2/de not_active Expired - Lifetime
  • 1998-06-15 JP JP50447999A patent/JP3210023B2/ja not_active Expired - Fee Related
  • 1998-06-15 EP EP98928873A patent/EP0991640B1/en not_active Expired - Lifetime
  • 1998-06-15 ES ES98928873T patent/ES2169917T3/es not_active Expired - Lifetime
  • 1998-06-15 DK DK98928873T patent/DK0991640T3/da active
  • 1998-06-15 CA CA002293709A patent/CA2293709C/en not_active Expired - Fee Related
  • 1998-06-15 IN IN1294MA1998 patent/IN187755B/en unknown
  • 1998-06-15 PT PT98928873T patent/PT991640E/pt unknown
  • 1998-06-15 AU AU80568/98A patent/AU8056898A/en not_active Abandoned

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