WO1998046588A2 - Compounds and therapies for the prevention of vascular and non-vascular pathologies - Google Patents
Compounds and therapies for the prevention of vascular and non-vascular pathologies Download PDFInfo
- Publication number
- WO1998046588A2 WO1998046588A2 PCT/US1998/007063 US9807063W WO9846588A2 WO 1998046588 A2 WO1998046588 A2 WO 1998046588A2 US 9807063 W US9807063 W US 9807063W WO 9846588 A2 WO9846588 A2 WO 9846588A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- tgf
- beta
- phenyl
- halo
- Prior art date
Links
- 0 C*CC[N+](C1=CNC(C)(*C)C=C1C*[N+](*(C)=I)[O-])[O-] Chemical compound C*CC[N+](C1=CNC(C)(*C)C=C1C*[N+](*(C)=I)[O-])[O-] 0.000 description 6
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/495—Transforming growth factor [TGF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/108—Osteoporosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/323—Arteriosclerosis, Stenosis
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU69598/98A AU6959898A (en) | 1997-04-11 | 1998-04-09 | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4385297P | 1997-04-11 | 1997-04-11 | |
US60/043,852 | 1997-04-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998046588A2 true WO1998046588A2 (en) | 1998-10-22 |
WO1998046588A3 WO1998046588A3 (en) | 1999-01-07 |
Family
ID=21929208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/007063 WO1998046588A2 (en) | 1997-04-11 | 1998-04-09 | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
Country Status (3)
Country | Link |
---|---|
US (5) | US6117911A (US07511070-20090331-C00018.png) |
AU (1) | AU6959898A (US07511070-20090331-C00018.png) |
WO (1) | WO1998046588A2 (US07511070-20090331-C00018.png) |
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EP0702557A1 (en) * | 1993-05-13 | 1996-03-27 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
EP0710116A1 (en) * | 1993-05-13 | 1996-05-08 | Neorx Corporation | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
WO2001060778A3 (en) * | 2000-02-16 | 2003-01-16 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
US7030159B2 (en) | 2001-12-18 | 2006-04-18 | The Brigham And Women's Hospital, Inc. | Approach to anti-microbial host defense with molecular shields with EPA and DHA analogs |
US7341840B2 (en) | 2003-03-05 | 2008-03-11 | The Brigham And Women's Hospital, Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
US7582785B2 (en) | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
US7585856B2 (en) | 2002-08-12 | 2009-09-08 | The Brigham And Women's Hospital, Inc. | Resolvins: Biotemplates for novel therapeutic interventions |
US7629375B2 (en) | 2001-07-23 | 2009-12-08 | Johnson & Johnson Consumer Companies, Inc. | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
US9364454B2 (en) | 2005-10-03 | 2016-06-14 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers |
US20190216844A1 (en) * | 2017-12-14 | 2019-07-18 | Morningbell Wellness Llc | Methods to stabilize and reverse atherosclerotic lesions by sulfated polysaccharides |
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US9364454B2 (en) | 2005-10-03 | 2016-06-14 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers |
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Also Published As
Publication number | Publication date |
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US20060084696A1 (en) | 2006-04-20 |
US7511070B2 (en) | 2009-03-31 |
WO1998046588A3 (en) | 1999-01-07 |
US6734208B2 (en) | 2004-05-11 |
US6117911A (en) | 2000-09-12 |
US6410587B1 (en) | 2002-06-25 |
US20050020667A1 (en) | 2005-01-27 |
US20030064970A1 (en) | 2003-04-03 |
AU6959898A (en) | 1998-11-11 |
US7084171B2 (en) | 2006-08-01 |
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