WO1998002240A1 - Preservation by foam formation - Google Patents

Preservation by foam formation Download PDF

Info

Publication number
WO1998002240A1
WO1998002240A1 PCT/US1997/012156 US9712156W WO9802240A1 WO 1998002240 A1 WO1998002240 A1 WO 1998002240A1 US 9712156 W US9712156 W US 9712156W WO 9802240 A1 WO9802240 A1 WO 9802240A1
Authority
WO
WIPO (PCT)
Prior art keywords
foam
drying
biologically active
vacuum
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/012156
Other languages
English (en)
French (fr)
Other versions
WO1998002240B1 (en
Inventor
Victor Bronshtein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universal Preservation Technologies Inc
Original Assignee
Universal Preservation Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26695104&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998002240(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to HU9903917A priority Critical patent/HUP9903917A3/hu
Application filed by Universal Preservation Technologies Inc filed Critical Universal Preservation Technologies Inc
Priority to JP10506201A priority patent/JP2000515856A/ja
Priority to AU36606/97A priority patent/AU714328B2/en
Priority to IL12797197A priority patent/IL127971A/en
Priority to NZ333738A priority patent/NZ333738A/xx
Priority to EA199900268A priority patent/EA001138B1/ru
Priority to DE0914202T priority patent/DE914202T1/de
Priority to BR9711808-7A priority patent/BR9711808A/pt
Priority to EP97933415A priority patent/EP0914202A4/en
Publication of WO1998002240A1 publication Critical patent/WO1998002240A1/en
Publication of WO1998002240B1 publication Critical patent/WO1998002240B1/en
Priority to NO990158A priority patent/NO990158D0/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Definitions

  • the invention relates to methods for preserving sensitive biologically active solutes and suspensions, emulsions and dispersions of, for example, enzymes, proteins, viruses, serums, vaccines, liposomes and cell suspensions .
  • the present invention is a method of preserving sensitive biological suspensions and solutions by forming stable foams from fluid materials to be dried, as an aid both to the drying of one or more biologically active substrates in the fluid and as an aid in preparing an easily soluble dried product suitable for further commercial use.
  • the stable foams are formed by partially removing water in the biologically active sample to form a viscous liquid and by further subjecting the reduced liquid to vacuum to cause it to "boil" during further drying at temperatures substantially lower than 100 degrees C.
  • the present invention is a method of preserving sensitive biological dispersions, suspensions, emulsions and solutions by forming stable foams from fluid materials to be dried, as an aid both to the drying of one or more biologically active substrates in the fluid and as an aid in preparing an easily divisible dried product suitable for further commercial use.
  • the stable foams are formed by partially removing the water to form a viscous liquid and by further subjecting the reduced liquid to vacuum, to cause it to "boil" during further drying at temperatures substantially lower than 100 degrees C.
  • reduced pressure is applied to viscous solutions or suspensions of biologically active materials to cause the solutions or suspensions to foam during boiling, and during the foaming process further solvent removal causes the ultimate production of a stable open-cell or closed-cell foam.
  • foams are easily divisible by cutting, milling or other dividing techniques, and the foaming action itself enhances water removal by maximizing liquid surface area available for evaporation.
  • the solvent fraction of the materials to be dried will be aqueous, however, it should be understood that the present method may be applied to solutions and suspensions of various types including those containing nonaqueous solvents or mixture of such solvents .
  • the inventive apparatus is a novel combination of a vacuum pump with a temperature controlled desiccator device.
  • Optional features of such a combination include sensors for temperature measurement and heat flow control, microprocessors for calculating other process parameters based on data collected from these and other sensors and etc.
  • Such a device allows implementation of a novel two- dimensional vacuum and temperature protocol for drying.
  • the foam forming process includes two steps: (a) an intensive dehydration of the solution or dispersion containing the biologically active agent by boiling under vacuum, to form a stable, non-collapsing foam and (b) subsequent secondary drying of the foams, to the extent that the foams are stable and do not collapse during storage.
  • the invention provides a scalable method for preserving sensitive biologically active materials (proteins, enzymes, serums, vaccines, viruses, liposomes and cell suspensions) with a uniquely engineered drying method. Using this method, it is possible to rehydrate the samples with water or aqueous solutions to reverse the process to the initial biological activity. The method may be applied for the preservation of pharmaceutical, fluid or virtually any other biologically active products or solutes.
  • foams are a kinetic process and depends on the rate of temperature and vacuum changes during formation of the foam as well as the initial concentration and composition of the solution or dispersion containing the biologically active substance. Stability of the foams may be further enhanced by the addition of surfactants or other synthetic or biological polymers as long as those additives do not interfere with the biological activity of the solute intended for conversion to dry form. Secondary drying and optional cooling of the formed and initially dry foams may be conducted to assure stability of the foam during storage. Cooling may be used to convert the foamed material to the glass state. Foams prepared according to the present invention may be stored whole or subdivided or milled, and when they are to be used need only be rehydrated in order to restore their original biologic activity.
  • Aqueous 50% glycerol isocitrate dehydrogenase solution from Sigma Chemical Co. containing 59.4 units of activity per ml. was dialyzed for 5 hours in 0.1 M TRIS HC1 buffer (pH 7.4).
  • the activity decrease was associated with decrease in the enzyme concentration because of dilution during the dialysis.
  • the samples were rehydrated with 500 microliters water. Rehydration of the samples containing dry foams was an easy process that was completed within several seconds. Reconstituted sample was assayed for activity by assaying ability to reduce NADP, measured spectrophotometrically at 340 nm.
  • the activity was 2.6 +/- 0.2 units/ml. which means there was no loss of activity during drying and subsequent storage at room temperature .

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Drying Of Solid Materials (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Colloid Chemistry (AREA)
PCT/US1997/012156 1996-07-15 1997-07-14 Preservation by foam formation Ceased WO1998002240A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DE0914202T DE914202T1 (de) 1996-07-15 1997-07-14 Konservierung durch schaumformung
EA199900268A EA001138B1 (ru) 1996-07-15 1997-07-14 Защита пенообразованием
JP10506201A JP2000515856A (ja) 1996-07-15 1997-07-14 泡沫形成による保存
AU36606/97A AU714328B2 (en) 1996-07-15 1997-07-14 Preservation by foam formation
IL12797197A IL127971A (en) 1996-07-15 1997-07-14 Preservation by creating foam
NZ333738A NZ333738A (en) 1996-07-15 1997-07-14 Shelf preservation of biological active material by forming a mechanically stable foam thereof
BR9711808-7A BR9711808A (pt) 1996-07-15 1997-07-14 Preservação através de formação de espuma.
HU9903917A HUP9903917A3 (en) 1996-07-15 1997-07-14 Preservation by foam formation
EP97933415A EP0914202A4 (en) 1996-07-15 1997-07-14 CONSERVATION THROUGH FOAM FORMING
NO990158A NO990158D0 (no) 1996-07-15 1999-01-14 Konservering ved skumdannelse

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2179696P 1996-07-15 1996-07-15
US60/021,796 1996-07-15
US08/785,473 US5766520A (en) 1996-07-15 1997-01-17 Preservation by foam formation
US08/785,473 1997-01-17

Publications (2)

Publication Number Publication Date
WO1998002240A1 true WO1998002240A1 (en) 1998-01-22
WO1998002240B1 WO1998002240B1 (en) 1998-03-05

Family

ID=26695104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012156 Ceased WO1998002240A1 (en) 1996-07-15 1997-07-14 Preservation by foam formation

Country Status (18)

Country Link
US (1) US5766520A (enExample)
EP (1) EP0914202A4 (enExample)
JP (1) JP2000515856A (enExample)
KR (1) KR100457748B1 (enExample)
CN (1) CN1116104C (enExample)
AU (1) AU714328B2 (enExample)
BR (1) BR9711808A (enExample)
CA (1) CA2260233A1 (enExample)
CZ (1) CZ7999A3 (enExample)
DE (1) DE914202T1 (enExample)
EA (1) EA001138B1 (enExample)
HU (1) HUP9903917A3 (enExample)
IL (1) IL127971A (enExample)
NO (1) NO990158D0 (enExample)
NZ (1) NZ333738A (enExample)
PL (1) PL331174A1 (enExample)
TR (1) TR199900127T2 (enExample)
WO (1) WO1998002240A1 (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027071A1 (en) * 1997-11-26 1999-06-03 Universal Preservation Technologies, Inc. Preservation of sensitive biological samples by vitrification
WO2000040696A1 (en) * 1999-01-05 2000-07-13 Universal Preservation Technologies, Inc. Preservation of sensitive biological materials at ambient temperatures by vitrification
WO2000066710A3 (en) * 1999-05-04 2001-02-08 Eric Edward Worrall Method for the preservation of viruses and mycoplasma
WO2001037804A3 (en) * 1999-11-22 2001-11-22 Universal Preservation Technologies Inc Preservation and formulation of bioactive materials
WO2002000201A3 (en) * 2000-06-27 2002-04-18 Hoffmann La Roche Method for preparing a composition
US6537666B1 (en) 2000-10-23 2003-03-25 Universal Preservation Technologies, Inc. Methods of forming a humidity barrier for the ambient temperature preservation of sensitive biologicals
US6692695B1 (en) 1999-05-06 2004-02-17 Quadrant Drug Delivery Limited Industrial scale barrier technology for preservation of sensitive biological materials
US7153472B1 (en) 2000-11-22 2006-12-26 Quadrant Drug Delivery Limited Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers
EP1494651A4 (en) * 2002-04-11 2010-10-13 Medimmune Vaccines Inc PRESERVATION OF BIOACTIVE MATERIALS WITH FREEZZED FOAM
US20230357807A1 (en) * 2020-07-27 2023-11-09 Karlsruher Institut Fuer Technologie Catalytically active protein foams, and method for producing same

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0679088T3 (da) * 1992-09-29 2002-10-28 Inhale Therapeutic Syst Pulmonal levering af aktive fragmenter af parathyreoideaea hormon
DE69535897D1 (de) 1994-03-07 2009-01-22 Nektar Therapeutics Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
CZ88697A3 (en) 1994-09-22 1997-09-17 Quadrant Holdings Cambridge Composition used for re-hydration and nourishment in the course of athletic outputs and processes for preparing thereof
US6964771B1 (en) * 1995-06-07 2005-11-15 Elan Drug Delivery Limited Method for stably incorporating substances within dry, foamed glass matrices
US6509146B1 (en) 1996-05-29 2003-01-21 Universal Preservation Technologies, Inc. Scalable long-term shelf preservation of sensitive biological solutions and suspensions
US6468782B1 (en) * 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
GB9705588D0 (en) 1997-03-18 1997-05-07 Anglia Research Foundation Stable particle in liquid formulations
US20020035071A1 (en) * 1997-07-08 2002-03-21 Josef Pitha Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites
US20060116330A1 (en) * 1997-07-08 2006-06-01 The Iams Company Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose
US8563522B2 (en) * 1997-07-08 2013-10-22 The Iams Company Method of maintaining and/or attenuating a decline in quality of life
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6214054B1 (en) 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
CA2360112A1 (en) 1999-01-05 2000-07-13 Victor Bronshtein Vacuum control system for foam drying apparatus
EP1402003A4 (en) * 1999-08-19 2004-07-14 Universal Preservation Technologies Inc Preservation of bacterial cells below room temperature
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
EP1290390A1 (en) 2000-06-07 2003-03-12 Universal Preservation Technologies, Inc. Industrial scale barrier technology for preservation of sensitive biological materials
US6872357B1 (en) * 2000-11-22 2005-03-29 Quadrant Drug Delivery Limited Formulation of preservation mixtures containing sensitive biologicals to be stabilized for ambient temperature storage by drying
US20050074867A1 (en) * 2001-05-07 2005-04-07 Victor Bronshtein Preservation of competent cells at ambient temperatures
US6884866B2 (en) * 2001-10-19 2005-04-26 Avant Immunotherapeutics, Inc. Bulk drying and the effects of inducing bubble nucleation
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
CA2503871C (en) * 2002-11-01 2012-12-11 Glaxosmithkline Biologicals S.A. An immunogenic composition for generating an immune response against polio virus
US20050100559A1 (en) * 2003-11-07 2005-05-12 The Procter & Gamble Company Stabilized compositions comprising a probiotic
US20050100636A1 (en) * 2003-11-10 2005-05-12 Megan Botteri [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity]
US7785635B1 (en) 2003-12-19 2010-08-31 The Procter & Gamble Company Methods of use of probiotic lactobacilli for companion animals
US8877178B2 (en) * 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
US20050152884A1 (en) * 2003-12-19 2005-07-14 The Procter & Gamble Company Canine probiotic Bifidobacteria globosum
US8894991B2 (en) * 2003-12-19 2014-11-25 The Iams Company Canine probiotic Lactobacilli
US20050158294A1 (en) * 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
AU2005249530B2 (en) 2004-06-02 2012-04-12 Victor Bronshtein Preservation by vaporization
US9744227B2 (en) 2004-06-02 2017-08-29 Universal Stabilization Technologies, Inc. Compositions containing ambient-temperature stable, inactivated but therapeutically active biopharmaceuticals and methods for formulation thereof
JP2007277094A (ja) * 2004-06-29 2007-10-25 Chemo Sero Therapeut Res Inst 改変ダニ主要アレルゲン含有医薬組成物
AU2005266812B2 (en) * 2004-07-30 2010-07-29 Enwave Corporation Method for producing hydrocolloid foams
EP2261323A1 (en) * 2005-05-31 2010-12-15 The Iams Company Feline probiotic lactobacilli
JP4938006B2 (ja) * 2005-05-31 2012-05-23 ザ・アイムス・カンパニー ネコ科動物プロバイオティク・ビフィドバクテリア
WO2007079147A2 (en) 2005-12-28 2007-07-12 Advanced Bionutrition Corporation A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US9453675B2 (en) * 2006-02-10 2016-09-27 Sp Industries, Inc. Method of inducing nucleation of a material
US8007992B2 (en) * 2006-10-27 2011-08-30 Edwards Lifesciences Corporation Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C1-C3 alcohol
JP5285617B2 (ja) 2006-12-18 2013-09-11 アドバンスド バイオニュートリション コーポレーション 生きたプロバイオティクスを含む乾燥食物製品
WO2008093303A2 (en) 2007-02-01 2008-08-07 The Iams Company Method for decreasing inflammation and stress in a mammal using glucose antimetaboltes, avocado or avocado extracts
DK2148923T3 (da) * 2007-05-18 2012-12-03 Medimmune Llc Konservering af biologisk aktive materialer med frysetørret skum
US9101691B2 (en) * 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
JP2010534622A (ja) 2007-07-26 2010-11-11 サノフィ パストゥール リミテッド 抗原−アジュバント組成物および方法
CA2699120C (en) * 2007-09-13 2014-07-08 Enwave Corporation Apparatus and method for dehydrating biological materials
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US9771199B2 (en) 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
WO2010028488A1 (en) 2008-09-12 2010-03-18 Enwave Corporation Apparatus and method for dehydrating biological materials with freezing and microwaving
EP3266448B1 (en) 2009-03-27 2022-02-16 Intervet International B.V. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
SG176253A1 (en) 2009-05-26 2011-12-29 Advanced Bionutrition Corp Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
EP2475393A4 (en) * 2009-09-14 2013-08-21 Vu Truong-Le FORMULATION FOR THE ROOM TEMPERATURE STABILIZATION OF A WEAKED LIVING BACTERIAL VACCINE
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
NZ601017A (en) 2010-01-28 2014-07-25 Advanced Bionutrition Corp Dry glassy composition comprising a bioactive material
BR122014006876B1 (pt) 2010-03-23 2020-09-29 Edwards Lifesciences Corporation Método para preparar material de membrana de tecido bioprotético
CN102946916B (zh) 2010-06-17 2015-03-18 爱德华兹生命科学公司 通过化学修饰抗原性碳水化合物稳定生物假体组织的方法
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
CL2011001984A1 (es) 2010-08-13 2012-06-29 Advanced Bionutrition Corp Composicion seca estabilizadora para material biologico que comprende carbohidrato, proteinas hidrolizadas de animal o de planta y un componente de acido carboxilico; metodo de preparacion; y formulacion de entrega oral que comprende la composicion seca estabilizadora.
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
ES2856187T3 (es) 2013-05-31 2021-09-27 Victor Bronshtein Composiciones poliméricas que contienen productos biofarmacéuticos estables a temperatura ambiente y métodos para la formulación de las mismas
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
ES2978111T3 (es) 2015-06-25 2024-09-05 Native Microbials Inc Métodos, aparatos y sistemas para analizar cepas de microorganismos de comunidades heterogéneas complejas, predecir e identificar relaciones funcionales e interacciones de las mismas, y seleccionar y sintetizar conjuntos microbianos basados en las mismas
US9938558B2 (en) 2015-06-25 2018-04-10 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
US10851399B2 (en) 2015-06-25 2020-12-01 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
WO2018126026A1 (en) 2016-12-28 2018-07-05 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and identifying and synthesizing bioreactive modificators based thereon
US12558395B2 (en) 2015-07-29 2026-02-24 Advanced Bionutrition Corp. Stable dry probiotic compositions for special dietary uses
EP3328215B1 (en) 2015-07-29 2021-07-07 Advanced BioNutrition Corp. Stable dry probiotic compositions for special dietary uses
BR112018071198A2 (pt) 2016-04-15 2019-04-24 Ascus Biosciences, Inc. métodos para melhorar a produção agrícola de aves pela administração de consórcios microbianos ou de cepas purificadas dos mesmos
CN106434840B (zh) * 2016-12-02 2019-08-09 北京中检葆泰生物技术有限公司 一种用于微生物法定量检测维生素b12的微孔板、其试剂盒及其制备方法
MX2019007760A (es) 2016-12-28 2020-02-10 Ascus Biosciences Inc Metodos, aparatos y sistemas para analisis de cepa de microorganismo de comunidades heterogeneas complejas con analisis rastreador, determinacion de relaciones funcionales e interacciones de estas, y sintesis de agrupaciones microbianas que incluyen agrupaciones microbianas dosificadas y agrupaciones microbianas inoculativas.
CN106591415B (zh) * 2017-01-03 2019-12-10 北京中检葆泰生物技术有限公司 一种用于微生物法定量检测生物素的微孔板、其试剂盒及其制备方法
CN106676160B (zh) * 2017-01-03 2020-02-21 北京中检葆泰生物技术有限公司 一种用于微生物法定量检测泛酸的微孔板、其试剂盒及其制备方法
CN106676161B (zh) * 2017-01-03 2020-01-21 北京中检葆泰生物技术有限公司 一种用于微生物法定量检测烟酸的微孔板、其试剂盒及其制备方法
CN106701887B (zh) * 2017-01-03 2020-01-17 北京中检葆泰生物技术有限公司 一种用于微生物法定量检测叶酸的微孔板、其试剂盒及其制备方法
US10617756B2 (en) 2017-01-05 2020-04-14 Shimojani, LLC Drug regimen for treatment of cerebral ischemia
WO2018201154A1 (en) * 2017-04-28 2018-11-01 Universal Stabilization Technologies, Inc. Antigenic thermostable polio vaccines & related methods
CN110678590B (zh) 2017-05-31 2022-07-19 爱德华兹生命科学公司 胶原纤维和由其形成的制品
WO2019079629A1 (en) 2017-10-18 2019-04-25 Ascus Biosciences, Inc. IMPROVING POULTRY PRODUCTION BY ADMINISTERING A SYNTHETIC BIO-ASSEMBLY OF MICROBES OR PURIFIED STEM THEREFOR
AU2019212059A1 (en) 2018-01-23 2020-05-21 Edwards Lifesciences Corporation Method for pre-stretching implantable biocompatible materials, and materials and devices produced thereby
JP7138336B2 (ja) * 2018-06-29 2022-09-16 国立大学法人九州工業大学 生体由来の水溶性高分子乾燥品の製造方法及びその製造装置
CN113164258B (zh) 2018-11-01 2024-08-27 爱德华兹生命科学公司 经导管再生肺动脉瓣
CA3143206A1 (en) 2019-12-09 2021-06-17 Edwards Lifesciences Corporation Bioprosthetic tissue preparation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271881A (en) * 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
US5409703A (en) * 1993-06-24 1995-04-25 Carrington Laboratories, Inc. Dried hydrogel from hydrophilic-hygroscopic polymer
US5565318A (en) * 1994-09-02 1996-10-15 Pharmacia Biotech, Inc. Room temperature stable reagent semi-spheres

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
JPH0779694B2 (ja) * 1985-07-09 1995-08-30 カドラント バイオリソ−シズ リミテツド 蛋白質および同類品の保護
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
US5200399A (en) * 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
AU659645B2 (en) * 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
CN1245957C (zh) * 1995-06-07 2006-03-22 廓德伦特控股剑桥有限公司 将物质稳定掺入干燥泡沫玻璃基质中的方法以及由此制得的组合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5271881A (en) * 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
US5409703A (en) * 1993-06-24 1995-04-25 Carrington Laboratories, Inc. Dried hydrogel from hydrophilic-hygroscopic polymer
US5565318A (en) * 1994-09-02 1996-10-15 Pharmacia Biotech, Inc. Room temperature stable reagent semi-spheres

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027071A1 (en) * 1997-11-26 1999-06-03 Universal Preservation Technologies, Inc. Preservation of sensitive biological samples by vitrification
US6306345B1 (en) 1998-05-06 2001-10-23 Universal Preservation Technologies, Inc. Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures
WO2000040696A1 (en) * 1999-01-05 2000-07-13 Universal Preservation Technologies, Inc. Preservation of sensitive biological materials at ambient temperatures by vitrification
WO2000066710A3 (en) * 1999-05-04 2001-02-08 Eric Edward Worrall Method for the preservation of viruses and mycoplasma
US6692695B1 (en) 1999-05-06 2004-02-17 Quadrant Drug Delivery Limited Industrial scale barrier technology for preservation of sensitive biological materials
WO2001037804A3 (en) * 1999-11-22 2001-11-22 Universal Preservation Technologies Inc Preservation and formulation of bioactive materials
US6534087B2 (en) 2000-06-27 2003-03-18 Hoffmann-La Roche Inc. Process for preparing a pharmaceutical composition
WO2002000201A3 (en) * 2000-06-27 2002-04-18 Hoffmann La Roche Method for preparing a composition
US7074431B2 (en) * 2000-06-27 2006-07-11 Hoffmann-La Roche Inc. Process for preparing a pharmaceutical composition
HRP20021009B1 (hr) * 2000-06-27 2011-07-31 F. Hoffmann - La Roche Ag Postupak za pripremu pripravka
US6537666B1 (en) 2000-10-23 2003-03-25 Universal Preservation Technologies, Inc. Methods of forming a humidity barrier for the ambient temperature preservation of sensitive biologicals
US7153472B1 (en) 2000-11-22 2006-12-26 Quadrant Drug Delivery Limited Preservation and formulation of bioactive materials for storage and delivery in hydrophobic carriers
EP1494651A4 (en) * 2002-04-11 2010-10-13 Medimmune Vaccines Inc PRESERVATION OF BIOACTIVE MATERIALS WITH FREEZZED FOAM
US8067017B2 (en) 2002-04-11 2011-11-29 Medimmune, Llc Preservation of bioactive materials by freeze dried foam
US8343518B2 (en) 2002-04-11 2013-01-01 Medimmune, Llc Preservation of bioactive materials by freeze dried foam
EP2591771A1 (en) * 2002-04-11 2013-05-15 MedImmune, LLC Preservation of bioactive materials by freeze dried foam
US20230357807A1 (en) * 2020-07-27 2023-11-09 Karlsruher Institut Fuer Technologie Catalytically active protein foams, and method for producing same

Also Published As

Publication number Publication date
NZ333738A (en) 2000-09-29
US5766520A (en) 1998-06-16
HUP9903917A2 (hu) 2000-03-28
KR20000023779A (ko) 2000-04-25
AU3660697A (en) 1998-02-09
CN1226842A (zh) 1999-08-25
EP0914202A4 (en) 2004-09-01
BR9711808A (pt) 2000-01-18
NO990158L (no) 1999-01-14
JP2000515856A (ja) 2000-11-28
CZ7999A3 (cs) 1999-11-17
IL127971A (en) 2001-09-13
EA199900268A1 (ru) 1999-10-28
IL127971A0 (en) 1999-11-30
PL331174A1 (en) 1999-06-21
TR199900127T2 (xx) 1999-04-21
AU714328B2 (en) 1999-12-23
EA001138B1 (ru) 2000-10-30
EP0914202A1 (en) 1999-05-12
NO990158D0 (no) 1999-01-14
CN1116104C (zh) 2003-07-30
HUP9903917A3 (en) 2000-06-28
KR100457748B1 (ko) 2004-11-17
CA2260233A1 (en) 1998-01-22
DE914202T1 (de) 2000-02-17

Similar Documents

Publication Publication Date Title
US5766520A (en) Preservation by foam formation
US6509146B1 (en) Scalable long-term shelf preservation of sensitive biological solutions and suspensions
EP1032647B1 (en) Preservation of sensitive biological samples by vitrification
WO1998002240B1 (en) Preservation by foam formation
EP1750760B1 (en) Preservation by vaporization
Hahn-Hägerdal Water activity: a possible external regulator in biotechnical processes
US5240843A (en) Enzyme stabilisation
EP1231837B1 (en) Preservation of sensitive biological material
US20030022333A1 (en) Long-term shelf preservation by vitrification
CA2040815C (en) Enzyme stabilisation
AU2001268057A1 (en) Preservation and storage medium for biological materials
WO2002009515A1 (en) Preservation and storage medium for biological materials
Ekdawi‐Sever et al. Effects of annealing on freeze‐dried Lactobacillus acidophilus
CN1286725A (zh) 敏感性生物样品的玻化保质法
Roos et al. Freezing and freeze-drying
MXPA00005123A (en) Preservation of sensitive biological samples by vitrification
Salemink Cell and cell constituent freeze-drying: fundamentals and principles
Rapoporta et al. Anhydrobiosis in Yeast: Stabilization by Exogenous Lactose1

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 97196422.X

Country of ref document: CN

AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2260233

Country of ref document: CA

Ref document number: 2260233

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PV1999-79

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 333738

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: PA/A/1999/000592

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 1019997000253

Country of ref document: KR

Ref document number: 1999/00127

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 1997933415

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 199900268

Country of ref document: EA

WWP Wipo information: published in national office

Ref document number: 1997933415

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV1999-79

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1019997000253

Country of ref document: KR

WWR Wipo information: refused in national office

Ref document number: PV1999-79

Country of ref document: CZ

WWG Wipo information: grant in national office

Ref document number: 1019997000253

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1997933415

Country of ref document: EP