WO1997025065A1 - Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent - Google Patents

Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent Download PDF

Info

Publication number
WO1997025065A1
WO1997025065A1 PCT/SE1996/001736 SE9601736W WO9725065A1 WO 1997025065 A1 WO1997025065 A1 WO 1997025065A1 SE 9601736 W SE9601736 W SE 9601736W WO 9725065 A1 WO9725065 A1 WO 9725065A1
Authority
WO
WIPO (PCT)
Prior art keywords
dosage form
enteric coating
proton pump
pump inhibitor
tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE1996/001736
Other languages
English (en)
French (fr)
Inventor
Helene Depui
Agneta Hallgren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002214033A priority Critical patent/CA2214033C/en
Priority to SK1170-97A priority patent/SK117097A3/sk
Priority to IL12165296A priority patent/IL121652A/en
Priority to US08/750,936 priority patent/US6132771A/en
Priority to PL96322176A priority patent/PL322176A1/xx
Priority to AT96944725T priority patent/ATE228010T1/de
Priority to NZ325976A priority patent/NZ325976A/xx
Priority to AU13240/97A priority patent/AU712572B2/en
Priority to JP9525130A priority patent/JPH11501949A/ja
Priority to EE9700195A priority patent/EE9700195A/xx
Priority to MX9706769A priority patent/MX9706769A/es
Application filed by Astra AB filed Critical Astra AB
Priority to DK96944725T priority patent/DK0814840T3/da
Priority to HU9904094A priority patent/HUP9904094A3/hu
Priority to BR9607344A priority patent/BR9607344A/pt
Priority to DE69624910T priority patent/DE69624910T2/de
Priority to EP96944725A priority patent/EP0814840B1/en
Publication of WO1997025065A1 publication Critical patent/WO1997025065A1/en
Priority to IS4550A priority patent/IS4550A/is
Priority to NO19974070A priority patent/NO316425B1/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Definitions

  • the present invention is related to new oral pharmaceutical preparations especially for use in the prevention and treatment of disorders associated with gastro oesophageal reflux.
  • the present preparations comprise a gastric acid suppressing agent, such as a proton pump inhibitor, in combination with one or more prokinetic agents in a new fixed unit dosage form, especially a tablet
  • the present invention refers to a method for the manufacture of such preparations and the use of such preparations in medicine, especially in the treatment of gastro oesophageal reflux diseases and other gastrointestinal disorders.
  • Antacids and alginates are still widely used. They have a short duration of action but are seen as inexpensive and safe. They do not provide a layterm symptom resolution of GORD.
  • the gastric acid suppressing agent is preferably an acid susceptible proton pump inhibitor but other gastric acid suppressing agents such as the H 2 receptor antagonists: ranitidine, cimetidine or famotidine, may be used together with a prokinetic agent in the pharmaceutical compositions according to the present invention.
  • gastric acid suppressing agents such as the H 2 receptor antagonists: ranitidine, cimetidine or famotidine, may be used together with a prokinetic agent in the pharmaceutical compositions according to the present invention.
  • the seeds which are to be layered with the proton pump inhibitor can be water insoluble seeds comprising different oxides, celluloses, organic polymers and other materials, alone or in mixtures or water-soluble seeds comprising different inorganic salts, sugars, non-pareils and other materials, alone or in mixtures. Further, the seeds may comprise the proton pump inhibitor in the form of crystals, agglomerates, compacts etc. The size of the seeds is not essential for the present invention but may vary between approximately 0.1 and 2 mm.
  • the seeds layered with the proton pump inhibitor are produced either by powder or solution/suspension layering using for instance granulation or spray coating layering equipment
  • Pellets covered with enteric coating layer(s) may further be covered with one or more over ⁇ coating layer(s).
  • the over-coating layer(s) should be water soluble or rapidly disintegrating in water.
  • the over-coating layer(s) can be applied to the enteric coating layered pellets by coating or layering procedures in suitable equipments such as coating pan, coating granulator or in a fluidized bed apparatus using water and/or organic solvents for the coating or layering process.
  • the active substance(s) in form of one or more prokinetic compound(s) is dry mixed with inactive excipients and the mixture is wet massed with a granulation liquid.
  • the wet mass is dried preferably to a loss on drying of less than 3% by weight. Thereafter the dry mass is milled to a suitable size for the granules, such as smaller than 4 mm, and preferably smaller than 1 mm.
  • suitable inactive excipients for the prokinetic mixture are for instance lactose, corn starch low substituted hydroxypropyl cellulose, microcrystalline cellulose, sodium starch glycolate and crosslinked polyvinyl pyrrolidone.
  • Suitable lubricants for the tableting process are for instance sodium stearyl fumarate, magnesium stearate and talc.
  • Multiple unit dosage form comprising magnesium omeprazole and mosapride (batch size 500 tablets).
  • Suspension layering was performed in a fluid bed apparatus. Lansoprazole was sprayed onto the sugar sphere seeds from a suspension containing the dissolved binder in a water solution. Pellets covered with separating layer and enteric coating layer were produced as in example 1.
  • a capsule formulation comprising magnesium omeprazole and mosapride (batch size 100 capsules).
  • Multiple unit dosage form comprising magnesium omeprazole with a tablet coating layer comprising mosapride (batch size 1 000 tablets).
  • Polyethylene glycol 6000 75 g Mono- and diglycerides (NF) 12.5 g

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/SE1996/001736 1996-01-08 1996-12-20 Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent Ceased WO1997025065A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
MX9706769A MX9706769A (es) 1996-01-08 1996-12-20 Formas de dosificacion farmaceutica que comprenden un inhibidor de la bomba de protones y un agente procinetico.
IL12165296A IL121652A (en) 1996-01-08 1996-12-20 Pharmaceutical dosage forms for oral administration that include a proton pump inhibitor and a prokinetic substance
US08/750,936 US6132771A (en) 1996-01-08 1996-12-20 Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
PL96322176A PL322176A1 (en) 1996-01-08 1996-12-20 Oral pharmaceutic administration forms containing the protonic pump inhibitor and a prokinetic agent
AT96944725T ATE228010T1 (de) 1996-01-08 1996-12-20 Orale pharmazeutische dosierungsformen die einen protonenpumpeninhibitor und ein prokinetisches mittel enthalten
NZ325976A NZ325976A (en) 1996-01-08 1996-12-20 Compositions comprising an enteric coated acid susceptible proton pump inhibitor and a prokinetic agent
AU13240/97A AU712572B2 (en) 1996-01-08 1996-12-20 Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
JP9525130A JPH11501949A (ja) 1996-01-08 1996-12-20 プロトンポンプ抑制剤およびプロキネティック剤を含有する経口用医薬剤形
DK96944725T DK0814840T3 (da) 1996-01-08 1996-12-20 Orale farmaceutiske doseringsformer, der omfatter en protonpumpeinhibitor og et prokinetisk middel
CA002214033A CA2214033C (en) 1996-01-08 1996-12-20 Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
SK1170-97A SK117097A3 (en) 1996-01-08 1996-12-20 Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
EE9700195A EE9700195A (et) 1996-01-08 1996-12-20 Peroraalne farmatseutiline annusvorm, mis sisaldab prootonpumba inhibiitorit ja prokineetilist ainet
HU9904094A HUP9904094A3 (en) 1996-01-08 1996-12-20 Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
BR9607344A BR9607344A (pt) 1996-01-08 1996-12-20 Formas de dosagem farmacéutica oral e de tablete processos para preparar a forma de dosagem fixada e para tratar distúrbios associados ás doenças de refluxo gastro-esofrágico e uso da forma de dosagem
DE69624910T DE69624910T2 (de) 1996-01-08 1996-12-20 Orale pharmazeutische dosierungsformen die einen protonenpumpeninhibitor und ein prokinetisches mittel enthalten
EP96944725A EP0814840B1 (en) 1996-01-08 1996-12-20 Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
IS4550A IS4550A (is) 1996-01-08 1997-08-21 Lyf í formi skammta til inntöku um munn sem inniheldur prótónupumpublokkara og prókínetískt efni
NO19974070A NO316425B1 (no) 1996-01-08 1997-09-04 Orale, farmasöytiske doseringsformer innbefattende en protonpumpeinhibitorog et prokinetisk middel, fremgangsmåte for fremstilling av slikedoseringsformer og anvendelse derav

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9600072A SE9600072D0 (sv) 1996-01-08 1996-01-08 New oral formulation of two active ingredients II
SE9600072-4 1996-01-08

Publications (1)

Publication Number Publication Date
WO1997025065A1 true WO1997025065A1 (en) 1997-07-17

Family

ID=20400970

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1996/001736 Ceased WO1997025065A1 (en) 1996-01-08 1996-12-20 Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent

Country Status (29)

Country Link
US (1) US6132771A (https=)
EP (1) EP0814840B1 (https=)
JP (1) JPH11501949A (https=)
KR (1) KR100486057B1 (https=)
CN (1) CN1142792C (https=)
AR (1) AR008750A1 (https=)
AT (1) ATE228010T1 (https=)
AU (1) AU712572B2 (https=)
BR (1) BR9607344A (https=)
CA (1) CA2214033C (https=)
CZ (1) CZ280897A3 (https=)
DE (1) DE69624910T2 (https=)
DK (1) DK0814840T3 (https=)
EE (1) EE9700195A (https=)
ES (1) ES2185816T3 (https=)
HU (1) HUP9904094A3 (https=)
ID (1) ID18383A (https=)
IL (1) IL121652A (https=)
IS (1) IS4550A (https=)
MX (1) MX9706769A (https=)
NO (1) NO316425B1 (https=)
NZ (1) NZ325976A (https=)
PL (1) PL322176A1 (https=)
PT (1) PT814840E (https=)
SE (1) SE9600072D0 (https=)
SK (1) SK117097A3 (https=)
TR (1) TR199700917T1 (https=)
WO (1) WO1997025065A1 (https=)
ZA (1) ZA9610938B (https=)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048498A1 (en) * 1998-03-20 1999-09-30 A/S Gea Farmaceutisk Fabrik Pharmaceutical formulation comprising a 2- [[(2- pyridinyl) methyl] sulfinyl] benzimidazole having anti-ulcer activity and a process for the preparation of such formulation
US6132771A (en) * 1996-01-08 2000-10-17 Astrazeneca Ab Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
JP2001525366A (ja) * 1997-12-08 2001-12-11 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 酸不安定な活性化合物を含有する新規の投与形
WO2004035090A1 (en) * 2002-10-16 2004-04-29 Orexo Ab Gastric acid secretion inhibiting composition
US6780882B2 (en) 1996-01-04 2004-08-24 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6780435B2 (en) 1997-11-14 2004-08-24 Andrx Pharmaceuticals, Inc. Omeprazole formulation
WO2004071374A3 (en) * 2003-02-11 2004-12-16 Torrent Pharmaceuticals Ltd Once a day orally administered pharmaceutical compositions
EP1173067A4 (en) * 1999-04-01 2005-11-09 Wrigley W M Jun Co STRUCTURES WITH LONG-LASTING FLAVOR FOR CHEESE
US7070805B2 (en) 1998-07-28 2006-07-04 Takeda Pharmaceutical Company Limited Rapidly disintegrable solid preparation
US7404968B2 (en) * 1999-08-18 2008-07-29 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US7431942B2 (en) 1998-05-18 2008-10-07 Takeda Pharmaceutical Company Limited Orally disintegrable tablets
US7790755B2 (en) 2002-10-16 2010-09-07 Takeda Pharmaceutical Company Limited Controlled release preparation
US7815940B2 (en) 2001-04-18 2010-10-19 Orexo Ab Gastric acid secretion inhibiting composition
WO2011136750A1 (en) * 2010-04-26 2011-11-03 Mahmut Bilgic Pharmaceutical compositions inducing synergistic effect
US8105626B2 (en) 2001-10-17 2012-01-31 Takeda Pharmaceutical Company Limited Granules containing acid-unstable chemical in large amount
JP2012031189A (ja) * 1998-11-05 2012-02-16 Astrazeneca Ab オメプラゾール含有医薬製剤
WO2011108826A3 (en) * 2010-03-04 2012-03-01 Hanmi Holdings Co., Ltd. Complex formulation for oral administration comprising probiotic formulation and 5-ht4 receptor agonist and method for the preparation thereof
WO2012162777A1 (pt) * 2011-06-03 2012-12-06 Eurofarma Laboratórios S.A Composição farmacêutica oral compreendendo um inibidor de bomba de prótons e um agente procinético para uso em transtornos de excesso de ácido gástrico
USRE45198E1 (en) 1996-01-04 2014-10-14 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US9132246B2 (en) 2007-10-09 2015-09-15 Microdose Therapeutx, Inc. Inhalation device
CN105142618A (zh) * 2013-03-15 2015-12-09 韩国联合制药株式会社 提供药理及临床效应的莫沙必利每日单次施用缓释制剂
WO2024224407A1 (en) * 2023-04-28 2024-10-31 Akums Drugs & Pharmaceuticals Limited Multi-layer pellet formulation and process of preparation thereof

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
ES2137862B1 (es) * 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
US6521255B2 (en) * 2000-01-13 2003-02-18 Osmotica Corp. Osmotic device containing ranitidine and a prokinetic agent
US6623757B2 (en) 2000-02-24 2003-09-23 Advancis Pharmaceutical Corp. Antibiotic composition
US6663891B2 (en) 2000-02-24 2003-12-16 Advancis Pharmaceutical Corp. Erythromyacin antibiotic product, use and formulation thereof
US6632453B2 (en) 2000-02-24 2003-10-14 Advancis Pharmaceutical Corp. Ciprofoxacin-metronidazole antibiotic composition
US6638532B2 (en) 2000-02-24 2003-10-28 Advancis Pharmaceutical Corp. Tetracycline—doxycycline antibiotic composition
US6610328B2 (en) 2000-02-24 2003-08-26 Advancis Pharmaceutical Corp. Amoxicillin-clarithromycin antibiotic composition
US6623758B2 (en) 2000-02-24 2003-09-23 Advancis Pharmaceutical Corp. Cephalosporin-metronidazole antibiotic composition
US7025989B2 (en) * 2000-02-24 2006-04-11 Advancis Pharmaceutical Corp. Multiple-delayed released antibiotic product, use and formulation thereof
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6627222B2 (en) 2000-02-24 2003-09-30 Advancis Pharmaceutical Corp. Amoxicillin-dicloxacillin antibiotic composition
US6991807B2 (en) * 2000-02-24 2006-01-31 Advancis Pharmaceutical, Corp. Antibiotic composition
US6669948B2 (en) 2000-02-24 2003-12-30 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6730320B2 (en) 2000-02-24 2004-05-04 Advancis Pharmaceutical Corp. Tetracycline antibiotic product, use and formulation thereof
US6667057B2 (en) 2000-02-24 2003-12-23 Advancis Pharmaceutical Corp. Levofloxacin antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6667042B2 (en) 2000-02-24 2003-12-23 Advancis Pharmaceutical Corp. Fluroquinilone antibiotic product, use and formulation thereof
US6663890B2 (en) 2000-02-24 2003-12-16 Advancis Pharmaceutical Corp. Metronidazole antibiotic product, use and formulation thereof
CN1187052C (zh) 2000-03-30 2005-02-02 布里斯托尔-迈尔斯斯奎布公司 含有司他夫定(stavudine)的持续释放微球
US20040146554A1 (en) * 2000-07-15 2004-07-29 Sharma Virender K. Method for the administration of acid-labile drugs
WO2002026210A2 (en) * 2000-09-29 2002-04-04 Geneva Pharmaceuticals Inc. Proton pump inhibitor formulation
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US7105174B2 (en) * 2000-10-13 2006-09-12 Advancis Pharmaceutical Corporation Multiple-delayed release anti-neoplastic product, use and formulation thereof
US7157095B2 (en) * 2000-10-13 2007-01-02 Advancis Pharmaceutical Corporation Multiple-delayed release antifungal product, use and formulation thereof
US7074417B2 (en) * 2000-10-13 2006-07-11 Advancis Pharmaceutical Corporation Multiple-delayed release anti-viral product, use and formulation thereof
US20020197314A1 (en) 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
JP2006282677A (ja) * 2001-10-17 2006-10-19 Takeda Chem Ind Ltd 酸に不安定な薬物の高含量顆粒
JP4331930B2 (ja) * 2001-10-17 2009-09-16 武田薬品工業株式会社 酸に不安定な薬物の高含量顆粒
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
US7125563B2 (en) * 2002-04-12 2006-10-24 Dava Pharmaceuticals, Inc. Sustained release pharmaceutical preparations and methods for producing the same
US20030228363A1 (en) * 2002-06-07 2003-12-11 Patel Mahendra R. Stabilized pharmaceutical compositons containing benzimidazole compounds
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
US20040114368A1 (en) * 2002-12-13 2004-06-17 Shyu Shing Jy Light device having rotatable or movable view
US20040185119A1 (en) * 2003-02-26 2004-09-23 Theuer Richard C. Method and compositions for treating gastric hyperacidity while diminishing the likelihood of producing vitamin deficiency
BR8300543U (pt) * 2003-04-09 2004-11-23 Medley S A Ind Farmaceutica Embalagem, ou kit de medicamentos, ou apresentação facilitadora da administração de medicamentos por parte dos pacientes
CA2533358C (en) 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004258953B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
WO2005009365A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
JPWO2005011637A1 (ja) * 2003-08-04 2006-09-14 エーザイ株式会社 用時分散型製剤
US8758820B2 (en) 2003-08-11 2014-06-24 Shionogi Inc. Robust pellet
JP2007502294A (ja) 2003-08-12 2007-02-08 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
BRPI0414046A (pt) * 2003-08-29 2006-10-24 Dynogen Pharmaceuticals Inc método de tratamento de um distúrbio de motilidade gastrintestinal, de tratamento de "gerd", de "gerd" noturno, composição farmacêutica, kit que compreende um composto e método para aumentar a motilidade esofágica em um paciente
US8246996B2 (en) * 2003-08-29 2012-08-21 Shionogi Inc. Antibiotic product, use and formulation thereof
JP2007513869A (ja) 2003-09-15 2007-05-31 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
TWI372066B (en) * 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US8153161B2 (en) * 2003-12-09 2012-04-10 Dainippon Sumitomo Pharma Co., Ltd. Medicament-containing particle and a solid preparation containing the particle
RS20050796A (sr) * 2004-01-06 2007-08-03 Panacea Biotec Ltd., Farmaceutske smeše koje sadrže inhibitor protonske pumpe i prokinetičko sredstvo
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20070224269A1 (en) * 2004-06-10 2007-09-27 Rubino Orapin P Controlled Release Pharmaceutical Formulation
US8715727B2 (en) 2004-07-02 2014-05-06 Shionogi Inc. Tablet for pulsed delivery
WO2006011638A1 (ja) * 2004-07-28 2006-02-02 Dainippon Sumitomo Pharma Co., Ltd. 複数の被覆層を有するフィルムコーティング錠
AR051654A1 (es) * 2004-11-04 2007-01-31 Astrazeneca Ab Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones
AR052225A1 (es) * 2004-11-04 2007-03-07 Astrazeneca Ab Formulaciones de tabletas de liberacion modificada par inhibidores de la bomba de protones
EP1830822A1 (en) * 2004-12-24 2007-09-12 LEK Pharmaceuticals D.D. Stable pharmaceutical composition comprising an active substance in the form of solid solution
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
KR20080096779A (ko) * 2006-01-20 2008-11-03 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규 필름 코팅정
WO2007122478A2 (en) * 2006-04-20 2007-11-01 Themis Laboratories Private Limited Multiple unit compositions
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
AU2007266574A1 (en) * 2006-06-01 2007-12-06 Dexcel Pharma Technologies Ltd. Multiple unit pharmaceutical formulation
BRPI0918492A2 (pt) 2008-09-09 2015-12-01 Astrazeneca Ab uso de naproxen, ou sal farmaceuticamente aceitável do mesmo, e esomeprazol, ou sal farmaceuticamente aceitável do mesmo
EP2398470A4 (en) * 2009-02-23 2013-03-06 Aptalis Pharmatech Inc CONTROLLED RELEASE COMPOSITIONS COMPRISING A PROTON PUMP INHIBITOR
WO2010150219A1 (en) * 2009-06-25 2010-12-29 Wockhardt Research Centre Pharmaceutical composition of duloxetine or pharmaceutically acceptable salts thereof
EP2445499A4 (en) 2009-06-25 2013-02-27 Astrazeneca Ab METHOD FOR TREATING A PATIENT WITH RISK OF DEVELOPING A NSAID-ASSOCIATED SPURGE
AU2010321874A1 (en) * 2009-11-20 2012-06-21 Handa Pharmaceuticals, Llc Oral formulation for dexlansoprazole
WO2011126327A2 (en) * 2010-04-09 2011-10-13 Hyundai Pharm Co., Ltd. Pharmaceutical composition with controlled-release properties comprising mosapride or levodropropizine, and preparing method thereof
UA115139C2 (uk) 2011-12-28 2017-09-25 Поузен Інк. Спосіб доставки фармацевтичної композиції, яка містить омепразол й ацетилсаліцилову кислоту, пацієнту
WO2016174664A1 (en) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
CN108289849A (zh) * 2015-06-26 2018-07-17 韩国联合制药株式会社 莫沙必利与雷贝拉唑的复合制剂
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
KR102034694B1 (ko) * 2017-12-14 2019-10-22 한국유나이티드제약 주식회사 모사프리드와 라베프라졸을 함유하는 유핵정 복합제제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247983A2 (en) * 1986-04-30 1987-12-02 Aktiebolaget Hässle New pharmaceutical preparation for oral use
EP0365947A1 (en) * 1988-10-26 1990-05-02 Dib Limited Novel dosage form
WO1995001803A1 (en) * 1993-07-06 1995-01-19 Merck & Co., Inc. H2 antagonist-gastrointestinal motility agent combinations

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5535031A (en) * 1978-09-04 1980-03-11 Shin Etsu Chem Co Ltd Enteric coating composition
JPS5598120A (en) * 1979-01-16 1980-07-25 Shin Etsu Chem Co Ltd Preparation of drug having enteric coating
FR2471186A1 (fr) * 1979-12-10 1981-06-19 Roussel Uclaf Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation
US4340582A (en) * 1981-01-15 1982-07-20 Abbott Laboratories Erythromycin base tablets
US4377568A (en) * 1981-08-12 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. Preparation of aqueous alcoholic dispersions of pH sensitive polymers and plasticizing agents and a method of enteric coating dosage forms using same
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
JPS5973529A (ja) * 1982-10-12 1984-04-25 Sankyo Co Ltd 被覆固形製剤の製造法
US4525339A (en) * 1982-10-15 1985-06-25 Hoffmann-La Roche Inc. Enteric coated oral dosage form
US4518433A (en) * 1982-11-08 1985-05-21 Fmc Corporation Enteric coating for pharmaceutical dosage forms
GB2132887A (en) * 1982-11-15 1984-07-18 Procter & Gamble Enteric-coated anti-inflammatory compositions
US4556552A (en) * 1983-09-19 1985-12-03 Colorcon, Inc. Enteric film-coating compositions
DE3586600T2 (de) * 1984-02-10 1993-02-18 Benzon Pharma As Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend.
US4568560A (en) * 1984-03-16 1986-02-04 Warner-Lambert Company Encapsulated fragrances and flavors and process therefor
SE450087B (sv) * 1985-10-11 1987-06-09 Haessle Ab Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial
US5330982A (en) * 1986-12-17 1994-07-19 Glaxo Group Limited Pharmaceutical composition containing a 5-HT receptor antagonist and an H+ K+ Atpase inhibitor and a method of treating gastrointestingal disorders therewith
US5026559A (en) * 1989-04-03 1991-06-25 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
NZ235877A (en) * 1989-11-02 1992-09-25 Mcneil Ppc Inc Composition comprising acetaminophen or nsaid and an h 1 or h 2 receptor blocker and/or proton pump inhibitor for treating overindulgence
JP3142919B2 (ja) * 1991-11-06 2001-03-07 旭化成株式会社 セルロース誘導体ラテックス及びその製法
US5160742A (en) * 1991-12-31 1992-11-03 Abbott Laboratories System for delivering an active substance for sustained release
EP0653935B1 (en) * 1992-08-05 2002-05-08 F.H. FAULDING & CO. LIMITED Pelletised pharmaceutical composition
US5330759A (en) * 1992-08-26 1994-07-19 Sterling Winthrop Inc. Enteric coated soft capsules and method of preparation thereof
JP3017906B2 (ja) * 1993-10-08 2000-03-13 信越化学工業株式会社 腸溶性コーティング剤分散液
WO1995010264A1 (en) * 1993-10-12 1995-04-20 Tokyo Tanabe Company Limited Tablet containing enteric granules
GB2285989A (en) * 1994-01-28 1995-08-02 Merck Frosst Canada Inc Aqueous formulations for enteric coatings
EE03305B1 (et) * 1994-07-08 2000-12-15 Astra Aktiebolag Paljuosaline tableteeritud annusvorm I
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9600072D0 (sv) * 1996-01-08 1996-01-08 Astra Ab New oral formulation of two active ingredients II

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247983A2 (en) * 1986-04-30 1987-12-02 Aktiebolaget Hässle New pharmaceutical preparation for oral use
EP0365947A1 (en) * 1988-10-26 1990-05-02 Dib Limited Novel dosage form
WO1995001803A1 (en) * 1993-07-06 1995-01-19 Merck & Co., Inc. H2 antagonist-gastrointestinal motility agent combinations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE NEW ENGLAND JOURNAL OF MEDICINE, October 1995, ALBERTO PILOTTO M.D. et al., "A Comparison of Five Maintenance Therapies for Reflux Esophagitis", pages 1106, 1109. *

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780882B2 (en) 1996-01-04 2004-08-24 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
USRE45198E1 (en) 1996-01-04 2014-10-14 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6132771A (en) * 1996-01-08 2000-10-17 Astrazeneca Ab Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
US6780435B2 (en) 1997-11-14 2004-08-24 Andrx Pharmaceuticals, Inc. Omeprazole formulation
JP2001525366A (ja) * 1997-12-08 2001-12-11 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 酸不安定な活性化合物を含有する新規の投与形
DK173431B1 (da) * 1998-03-20 2000-10-23 Gea Farmaceutisk Fabrik As Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs
US6391342B1 (en) 1998-03-20 2002-05-21 A/S Gea Farmaceutisk Fabrik Pharmaceutical formulation comprising a 2- [(2-pyridinyl) methyl] sulfinyl benzimidazole having anti-ulcer activity and a process for the preparation of such formulation
WO1999048498A1 (en) * 1998-03-20 1999-09-30 A/S Gea Farmaceutisk Fabrik Pharmaceutical formulation comprising a 2- [[(2- pyridinyl) methyl] sulfinyl] benzimidazole having anti-ulcer activity and a process for the preparation of such formulation
US7431942B2 (en) 1998-05-18 2008-10-07 Takeda Pharmaceutical Company Limited Orally disintegrable tablets
US9901546B2 (en) 1998-05-18 2018-02-27 Takeda Pharmaceutical Company Limited Orally disintegrable tablets
US7875292B2 (en) 1998-05-18 2011-01-25 Takeda Pharmaceutical Company Limited Orally disintegrable tablets
US7070805B2 (en) 1998-07-28 2006-07-04 Takeda Pharmaceutical Company Limited Rapidly disintegrable solid preparation
US7399485B1 (en) 1998-07-28 2008-07-15 Takeda Pharmaceutical Company Limited Rapidly Disintegrable solid preparation
JP2012031189A (ja) * 1998-11-05 2012-02-16 Astrazeneca Ab オメプラゾール含有医薬製剤
EP1173067A4 (en) * 1999-04-01 2005-11-09 Wrigley W M Jun Co STRUCTURES WITH LONG-LASTING FLAVOR FOR CHEESE
US7404968B2 (en) * 1999-08-18 2008-07-29 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US7815940B2 (en) 2001-04-18 2010-10-19 Orexo Ab Gastric acid secretion inhibiting composition
US8105626B2 (en) 2001-10-17 2012-01-31 Takeda Pharmaceutical Company Limited Granules containing acid-unstable chemical in large amount
WO2004035090A1 (en) * 2002-10-16 2004-04-29 Orexo Ab Gastric acid secretion inhibiting composition
US7790755B2 (en) 2002-10-16 2010-09-07 Takeda Pharmaceutical Company Limited Controlled release preparation
US7785626B2 (en) 2002-10-16 2010-08-31 Orexo Ab Gastric acid secretion inhibiting composition
US7771747B2 (en) 2002-10-16 2010-08-10 Orexo Ab Gastric acid secretion inhibiting composition
EP2258341A3 (en) * 2002-10-16 2012-08-29 Orexo AB Gastric acid secretion inhibiting composition
RU2340358C2 (ru) * 2002-10-16 2008-12-10 Орексо Аб Композиция, ингибирующая секрецию кислоты в желудке
US8722084B2 (en) 2002-10-16 2014-05-13 Takeda Pharmaceutical Company Limited Controlled release preparation
US8784885B2 (en) 2002-10-16 2014-07-22 Takeda Pharmaceutical Company Limited Controlled release preparation
WO2004071374A3 (en) * 2003-02-11 2004-12-16 Torrent Pharmaceuticals Ltd Once a day orally administered pharmaceutical compositions
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US9539400B2 (en) 2007-10-09 2017-01-10 Microdose Therapeutx, Inc. Inhalation device
US9132246B2 (en) 2007-10-09 2015-09-15 Microdose Therapeutx, Inc. Inhalation device
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US9974909B2 (en) 2010-01-05 2018-05-22 Microdose Therapeutx, Inc. Inhalation device and method
US10434267B2 (en) 2010-01-05 2019-10-08 Microdose Therapeutx, Inc. Inhalation device and method
CN102753156B (zh) * 2010-03-04 2014-10-08 韩美科学株式会社 包含益生菌组分和5-ht4受体激动剂的口服复合制剂及其制备方法
CN102753156A (zh) * 2010-03-04 2012-10-24 韩美科学株式会社 包含益生菌组分和5-ht4受体激动剂的口服复合制剂及其制备方法
WO2011108826A3 (en) * 2010-03-04 2012-03-01 Hanmi Holdings Co., Ltd. Complex formulation for oral administration comprising probiotic formulation and 5-ht4 receptor agonist and method for the preparation thereof
WO2011136750A1 (en) * 2010-04-26 2011-11-03 Mahmut Bilgic Pharmaceutical compositions inducing synergistic effect
WO2012162777A1 (pt) * 2011-06-03 2012-12-06 Eurofarma Laboratórios S.A Composição farmacêutica oral compreendendo um inibidor de bomba de prótons e um agente procinético para uso em transtornos de excesso de ácido gástrico
CN105142618A (zh) * 2013-03-15 2015-12-09 韩国联合制药株式会社 提供药理及临床效应的莫沙必利每日单次施用缓释制剂
EP2974720A4 (en) * 2013-03-15 2016-08-31 Korea United Pharm Inc PREPARATION WITH DELAYED MOSAPRIDE RELEASE TO ACHIEVE PHARMACOLOGICAL CLINICAL EFFECTS FOR DAILY ADMINISTRATION
US9962390B2 (en) 2013-03-15 2018-05-08 Korea United Pharm, Inc. Mosapride sustained-release formulation providing pharmacological and clinical effects with once-daily administration
WO2024224407A1 (en) * 2023-04-28 2024-10-31 Akums Drugs & Pharmaceuticals Limited Multi-layer pellet formulation and process of preparation thereof

Also Published As

Publication number Publication date
NO974070L (no) 1997-10-06
IL121652A0 (en) 1998-02-08
HUP9904094A3 (en) 2002-03-28
DE69624910D1 (de) 2003-01-02
EP0814840B1 (en) 2002-11-20
ATE228010T1 (de) 2002-12-15
DK0814840T3 (da) 2003-02-24
US6132771A (en) 2000-10-17
NO316425B1 (no) 2004-01-26
KR100486057B1 (ko) 2005-09-08
EP0814840A1 (en) 1998-01-07
KR19980702828A (ko) 1998-08-05
AU1324097A (en) 1997-08-01
NZ325976A (en) 1999-02-25
AR008750A1 (es) 2000-02-23
SE9600072D0 (sv) 1996-01-08
HUP9904094A2 (hu) 2000-06-28
JPH11501949A (ja) 1999-02-16
PT814840E (pt) 2003-04-30
CA2214033C (en) 2006-01-10
ZA9610938B (en) 1997-07-08
IL121652A (en) 2002-03-10
EE9700195A (et) 1998-02-16
MX9706769A (es) 1997-11-29
SK117097A3 (en) 1998-06-03
BR9607344A (pt) 1997-12-30
ES2185816T3 (es) 2003-05-01
CN1183049A (zh) 1998-05-27
CA2214033A1 (en) 1997-07-17
CZ280897A3 (cs) 1998-04-15
AU712572B2 (en) 1999-11-11
ID18383A (id) 1998-04-02
TR199700917T1 (xx) 1997-11-21
PL322176A1 (en) 1998-01-19
DE69624910T2 (de) 2003-09-04
CN1142792C (zh) 2004-03-24
IS4550A (is) 1997-08-21
NO974070D0 (no) 1997-09-04

Similar Documents

Publication Publication Date Title
EP0814840B1 (en) Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a prokinetic agent
EP0813424B2 (en) Oral pharmaceutical dosage forms comprising a proton pump inhibitor and an antacid agent or alginate
EP0814783B1 (en) Multiple unit effervescent dosage forms comprising protonpump inhibitor
EP1043976B1 (en) Oral pharmaceutical extended release dosage form
KR100384961B1 (ko) 프로톤펌프억제제를함유하는다단위제약제제
AU759311B2 (en) Oral pharmaceutical pulsed release dosage form
US20020155153A1 (en) Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a NSAID
JPH09502739A (ja) 複数単位の錠剤化された剤形▲ｉ▼
HK1001763B (en) Oral pharmaceutical dosage forms comprising a proton pump inhibitor and an antacid agent or alginate
HK1152887A (en) Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a nsaid

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 96193607.X

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 08750936

Country of ref document: US

AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG

WWE Wipo information: entry into national phase

Ref document number: 325976

Country of ref document: NZ

ENP Entry into the national phase

Ref document number: 2214033

Country of ref document: CA

Ref document number: 2214033

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 117097

Country of ref document: SK

WWE Wipo information: entry into national phase

Ref document number: 1996944725

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 1997 525130

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PV1997-2808

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 1019970706235

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 97/00917

Country of ref document: TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 1996944725

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: PV1997-2808

Country of ref document: CZ

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1019970706235

Country of ref document: KR

WWR Wipo information: refused in national office

Ref document number: PV1997-2808

Country of ref document: CZ

WWG Wipo information: grant in national office

Ref document number: 1996944725

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1019970706235

Country of ref document: KR