Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
  • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23K—FODDER
  • A23K20/00—Accessory food factors for animal feeding-stuffs
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23K—FODDER
  • A23K20/00—Accessory food factors for animal feeding-stuffs
  • A23K20/10—Organic substances
  • A23K20/174—Vitamins
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23K—FODDER
  • A23K50/00—Feeding-stuffs specially adapted for particular animals
  • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

• the invention relates to anti-stress agents for improving the resistance of aquatic animals, in particular fish, shrimp and invertebrates in fresh and sea water, under loads of all kinds, also usable as anti-stress agents for warm and cold water ornamental fish containing a vitamin or a combination of vitamins in Mega doses and one or more immune stimulators.
• immunostimulators e.g. glucan
• the application is carried out via the feed in a dosage of
• EP-A-0 466 037 describes the increase in the resistance of fish and shrimp to pathogens.
• the dry feed contains 5 - 100 mg glucan per kg feed.
• EP-A-0 384 323 describes the synergistic effect of vaccination against Aeromonas in fish by simultaneous administration of 15-20 mg of glucan via the feed per kg of body weight. It is also known from EP-A-0 559 450 to use glucan as a binder in fish feed.
• the vitamin contents in the natural raw materials commonly used, which are processed into compound feed for aguatic animals, are usually not sufficient to prevent symptoms of deficiency. Because the most common nutritional diseases include vitamin deficiency symptoms.
• anti-stress agents in particular feed or aqueous suspensions for incorporation into the housing water, Holding an overdose of one or more vitamins in combination with one or more immune stimulators are outstandingly suitable for increasing the resistance of aquatic animals to loads of all kinds, but especially due to stress.
• Stress situations occur almost permanently in aquatic animals and lead to a heavy burden on the animals. Examples of stressful situations are hunger, high stocking density, water changes, changes in water parameters, territorial battles, aggression behavior, handling, medicinal therapy, transport, diseases.
• the invention therefore relates to anti-stress agents for aquatic animals, in particular fish, shrimp and invertebrates in fresh and sea water, containing at least one vitamin or a vitamin combination in an overdose (megadose) and at least one immune stimulator.
• Preferred immune stimulators are polysaccharides such as e.g. Glucan, Zymosan, Mannan, Lichenan, Pustulan, Lentinan, Schizophyllan, Scleroglucan, M-Glucan, Yeast Glucan, Muramyl Dipeptide, Chitin.
• immunostimulators which can be used according to the invention are lactoferrin, lactoperoxidases, glycyrrhizines, diaminopimelic acid peptide derivatives, e.g. N - [(R) -6-carboxy-N2- [N- (1-oxohepty1) -D-.gamma.-glutamy1] -L-lysy1] - D-alanine, levamisole, inosiplex, 4-methyluracil, tiloron,
• the immunostimulator is in the anti-stress agent in an amount of 0.0001-10% by weight, preferably 0.1% by weight, and the preferred immunostimulator is a ⁇ -glucan.
• the vitamins are used in an overdose of 2.5 times to 5000 times the recommended values.
• the water- and / or fat-soluble vitamins are preferably dosed in the following ranges (per kg of feed):
• An agent containing per kg of feed is particularly preferred:
• Vitamin A 2.8 x 10 3 IU
• Vitamin E 1.9 g
• Vitamin B- 330 mg Vitamin B. 950 mg
• Vitamin B 190 mg
• Vitamin C 6.35 g Vitamin K 96 mg
• Nicotinic acid 4.7 g
• chitin is to be used as an immune stimulator, this is expediently prepared in accordance with JP 6271470.
• 10 g of chitin PSH are mixed with 150 ml of 36% HCl and stirred at room temperature for 2 hours.
• the reaction is terminated by adding 1 l of distilled water and the filtered product is washed with distilled water.
• the novel anti-stress agent for aquatic animals was tested on the feed on territorial, ornamental fish (Cichlasoma nicaraguense) with regard to stress behavior compared to the control (without megadoses of vitamins and without immunostimulators) with three parallels each.
• daily stress was induced in every aquarium by stirring several times with a fishing net in the tank.
• the anti-stress agent according to the invention can be applied to the water as flakes, extrudates, pellets and tablets in the dry, moist or semi-moist state or in liquid form.
• the application can be prophylactic or also for acute loads on the aquatic animals.
• the anti-stress agent is applied in a combination of megadoses of one or more vitamins and one or more immune stimulators.

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• Life Sciences & Earth Sciences (AREA)
• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Polymers & Plastics (AREA)
• Engineering & Computer Science (AREA)
• Zoology (AREA)
• Animal Husbandry (AREA)
• Food Science & Technology (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Organic Chemistry (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• General Chemical & Material Sciences (AREA)
• Neurology (AREA)
• Neurosurgery (AREA)
• Biomedical Technology (AREA)
• Insects & Arthropods (AREA)
• Marine Sciences & Fisheries (AREA)
• Birds (AREA)
• Molecular Biology (AREA)
• Epidemiology (AREA)
• Psychiatry (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Feed For Specific Animals (AREA)
• Fodder In General (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Priority Applications (10)

Applications Claiming Priority (2)

Publications (1)

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Cited By (14)

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Citations (11)

• 1996
  • 1996-08-22 CA CA002231244A patent/CA2231244C/en not_active Expired - Fee Related
  • 1996-08-22 US US09/029,388 patent/US6306453B1/en not_active Expired - Lifetime
  • 1996-08-22 DE DE59606099T patent/DE59606099D1/de not_active Expired - Lifetime
  • 1996-08-22 AT AT96930072T patent/ATE197225T1/de active
  • 1996-08-22 EP EP96930072A patent/EP0848592B2/de not_active Expired - Lifetime
  • 1996-08-22 AU AU69269/96A patent/AU718898B2/en not_active Ceased
  • 1996-08-22 JP JP51081197A patent/JP4838919B2/ja not_active Expired - Lifetime
  • 1996-08-22 PT PT96930072T patent/PT848592E/pt unknown
  • 1996-08-22 DK DK96930072T patent/DK0848592T4/da active
  • 1996-08-22 SI SI9630242T patent/SI0848592T1/xx unknown
  • 1996-08-22 WO PCT/EP1996/003689 patent/WO1997008960A1/de not_active Ceased
  • 1996-08-22 ES ES96930072T patent/ES2152039T5/es not_active Expired - Lifetime
• 2001
  • 2001-01-11 GR GR20010400044T patent/GR3035228T3/el not_active IP Right Cessation

Patent Citations (11)

Non-Patent Citations (7)

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