WO1996023788B1 - Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobien - Google Patents
Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobienInfo
- Publication number
- WO1996023788B1 WO1996023788B1 PCT/US1996/000718 US9600718W WO9623788B1 WO 1996023788 B1 WO1996023788 B1 WO 1996023788B1 US 9600718 W US9600718 W US 9600718W WO 9623788 B1 WO9623788 B1 WO 9623788B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- alkoxy
- alkyl
- cycloalkyl
- phenyl
- Prior art date
Links
- 125000001072 heteroaryl group Chemical group 0.000 title abstract 4
- NCTCGHLIHJJIBK-UHFFFAOYSA-N 3-phenyl-1,3-oxazolidin-2-one Chemical class O=C1OCCN1C1=CC=CC=C1 NCTCGHLIHJJIBK-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000845 anti-microbial Effects 0.000 title abstract 2
- 239000004599 antimicrobial Substances 0.000 title 1
- 239000000460 chlorine Substances 0.000 claims abstract 10
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 10
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 8
- 125000004423 acyloxy group Chemical group 0.000 claims abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 4
- 125000002252 acyl group Chemical group 0.000 claims abstract 4
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000011737 fluorine Substances 0.000 claims abstract 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 229910052794 bromium Inorganic materials 0.000 claims abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 201000002674 obstructive nephropathy Diseases 0.000 claims abstract 2
- 230000000063 preceeding Effects 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 abstract 2
- 101710019688 COR4 Proteins 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 abstract 1
- -1 or O2CCH2N(CH3)2 Chemical group 0.000 abstract 1
Abstract
L'invention concerne une phényloxazolidinone substituée par un noyau hétéroaromatique (Q) ayant des propriétés antimicrobiennes. Ce composé a la formule I. Dans cette formule, Q est un groupe hétéro-aromatique à 5 éléments ayant d'un à quatre atomes d'azote ou un groupe hétéroaromatique à 5 éléments condensé avec un noyau benzénique et ayant d'un à quatre atomes d'azote, R1 est d'une manière indépendante H, OCH¿3?, F ou Cl; R?2¿ est un hydrogène, un C¿1?-C8alkyle (éventuellement substitué avec un ou plusieurs F, Cl, hydroxy, C1-C8alcoxy, C1-C8acyloxy), C3-C6cycloalkyle, amino, C1-C8alkylamino, C1-C8dialkylamino, C1-C8alcoxy; et chaque Q est éventuellement substitué avec un ou plusieurs H, F, Cl, Br, OR?4, SR4¿, S(O)¿nR?4 (n = 1 ou 2), CN, O¿2?CR?4, NHCOR4¿, NHCO¿2R?4, NHSO¿2R?4, CO2R?4, CON(R4)¿2, COR4, C1-C8alkyle droit ou ramifié ou C3-C8cycloalkyle, éventuellement substitué par un ou plusieurs groupes (a)-(m) ou phényle, éventuellement substitué par un ou plusieurs des groupes énumérés sous (a)-(n); et R4 est H, un groupe C¿1?-C6alkyle droit ou ramifié ou un C3-C8cycloalkyle, éventuellement substitué par un ou plusieurs atomes de fluor, de chlore, hydroxy, C1-C4alcoxy, C1-C4acyle, C1-C4acyloxy ou O2CCH2N(CH3)2 ou phényle, éventuellement substitué par un ou plusieurs atomes de fluor, de chlore, C1-C4alkyle droit ou ramifié, hydroxy, C1-C4alcoxy, C1-C4acyle, C1-C4acyloxy ou O2CCH2N(CH3)2.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ302844A NZ302844A (en) | 1995-02-03 | 1996-01-29 | Antimicrobial hetero-aromatic ring substituted phenyloxazolidinones |
SI9630357T SI0807112T1 (en) | 1995-02-03 | 1996-01-29 | Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials |
EP96905168A EP0807112B1 (fr) | 1995-02-03 | 1996-01-29 | Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobien |
DK96905168T DK0807112T3 (da) | 1995-02-03 | 1996-01-29 | Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon |
US08/875,800 US5910504A (en) | 1995-02-03 | 1996-01-29 | Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials |
PL96321663A PL185872B1 (pl) | 1995-02-03 | 1996-01-29 | Nowe podstawione fenylooksazolidynonyNowe podstawione fenylooksazolidynony |
JP8523572A JPH10513446A (ja) | 1995-02-03 | 1996-01-29 | ヘテロ芳香族環置換フェニルオキサゾリジノン抗微生物剤 |
AU48998/96A AU703465C (en) | 1995-02-03 | 1996-01-29 | Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials |
DE69615002T DE69615002T2 (de) | 1995-02-03 | 1996-01-29 | Durch hetero-aromatische ring substituierte phenyloxazolidinone als antimikrobielles mittel |
BR9607017A BR9607017A (pt) | 1995-02-03 | 1996-01-29 | Composto e uso do mesmo |
AT96905168T ATE205205T1 (de) | 1995-02-03 | 1996-01-29 | Durch hetero-aromatische ring substituierte phenyloxazolidinone als antimikrobielles mittel |
NO973550A NO309526B1 (no) | 1995-02-03 | 1997-08-01 | Hetero-aromatiske ring-substituerte fenyloksazolidinon- antimikrobielle midler og anvendelse av disse for fremstilling av et medikament |
FI973217A FI973217A0 (fi) | 1995-02-03 | 1997-08-04 | Heteroaromaattisella renkaalla substituoituja antimikrobiaalisia fenyylioksatsolidinoniyhdisteitä |
HK98109662A HK1008898A1 (en) | 1995-02-03 | 1998-08-04 | Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials |
US09/223,413 US6124334A (en) | 1995-02-03 | 1998-12-30 | Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38427895A | 1995-02-03 | 1995-02-03 | |
US08/384,278 | 1995-02-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996023788A1 WO1996023788A1 (fr) | 1996-08-08 |
WO1996023788B1 true WO1996023788B1 (fr) | 1996-09-19 |
Family
ID=23516681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/000718 WO1996023788A1 (fr) | 1995-02-03 | 1996-01-29 | Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobien |
Country Status (20)
Country | Link |
---|---|
US (1) | US5910504A (fr) |
EP (1) | EP0807112B1 (fr) |
JP (1) | JPH10513446A (fr) |
KR (1) | KR100441334B1 (fr) |
CN (1) | CN1075073C (fr) |
AT (1) | ATE205205T1 (fr) |
BR (1) | BR9607017A (fr) |
CA (1) | CA2208603A1 (fr) |
CZ (1) | CZ231497A3 (fr) |
DE (1) | DE69615002T2 (fr) |
DK (1) | DK0807112T3 (fr) |
ES (1) | ES2163004T3 (fr) |
FI (1) | FI973217A0 (fr) |
HK (1) | HK1008898A1 (fr) |
NO (1) | NO309526B1 (fr) |
NZ (1) | NZ302844A (fr) |
PL (1) | PL185872B1 (fr) |
PT (1) | PT807112E (fr) |
RU (1) | RU2154645C2 (fr) |
WO (1) | WO1996023788A1 (fr) |
Families Citing this family (69)
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EP2602248A1 (fr) | 2011-12-05 | 2013-06-12 | University Of Leicester | Nouveaux composés pyrroliques |
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CN106831615B (zh) * | 2017-02-15 | 2019-02-15 | 南京农业大学 | 一类1,2,3-三唑-5-酰胺类化合物作为农用杀菌剂的应用 |
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-
1996
- 1996-01-29 DK DK96905168T patent/DK0807112T3/da active
- 1996-01-29 PT PT96905168T patent/PT807112E/pt unknown
- 1996-01-29 US US08/875,800 patent/US5910504A/en not_active Expired - Fee Related
- 1996-01-29 DE DE69615002T patent/DE69615002T2/de not_active Expired - Fee Related
- 1996-01-29 CN CN96191740A patent/CN1075073C/zh not_active Expired - Fee Related
- 1996-01-29 EP EP96905168A patent/EP0807112B1/fr not_active Expired - Lifetime
- 1996-01-29 BR BR9607017A patent/BR9607017A/pt not_active Application Discontinuation
- 1996-01-29 ES ES96905168T patent/ES2163004T3/es not_active Expired - Lifetime
- 1996-01-29 CZ CZ972314A patent/CZ231497A3/cs unknown
- 1996-01-29 KR KR1019970705305A patent/KR100441334B1/ko not_active IP Right Cessation
- 1996-01-29 NZ NZ302844A patent/NZ302844A/xx unknown
- 1996-01-29 JP JP8523572A patent/JPH10513446A/ja not_active Withdrawn
- 1996-01-29 RU RU97114833/04A patent/RU2154645C2/ru not_active IP Right Cessation
- 1996-01-29 PL PL96321663A patent/PL185872B1/pl not_active IP Right Cessation
- 1996-01-29 AT AT96905168T patent/ATE205205T1/de not_active IP Right Cessation
- 1996-01-29 WO PCT/US1996/000718 patent/WO1996023788A1/fr not_active Application Discontinuation
- 1996-01-29 CA CA002208603A patent/CA2208603A1/fr not_active Abandoned
-
1997
- 1997-08-01 NO NO973550A patent/NO309526B1/no not_active IP Right Cessation
- 1997-08-04 FI FI973217A patent/FI973217A0/fi unknown
-
1998
- 1998-08-04 HK HK98109662A patent/HK1008898A1/xx not_active IP Right Cessation
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