WO1996019253A1 - An inhalation device, a method of dispersing a pharmaceutically acitve substance and a method of administering a dose of a pharmaceutically active substance - Google Patents

An inhalation device, a method of dispersing a pharmaceutically acitve substance and a method of administering a dose of a pharmaceutically active substance Download PDF

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Publication number
WO1996019253A1
WO1996019253A1 PCT/SE1995/001539 SE9501539W WO9619253A1 WO 1996019253 A1 WO1996019253 A1 WO 1996019253A1 SE 9501539 W SE9501539 W SE 9501539W WO 9619253 A1 WO9619253 A1 WO 9619253A1
Authority
WO
WIPO (PCT)
Prior art keywords
inhaler
inhalation
inhalation device
air outlet
piston
Prior art date
Application number
PCT/SE1995/001539
Other languages
English (en)
French (fr)
Inventor
Kjell Wetterlin
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE69522119T priority Critical patent/DE69522119T2/de
Priority to EP95942340A priority patent/EP0799067B1/en
Priority to AU43590/96A priority patent/AU698815B2/en
Priority to PL95320860A priority patent/PL179323B1/pl
Priority to NZ298166A priority patent/NZ298166A/xx
Priority to BR9510210A priority patent/BR9510210A/pt
Priority to CZ971913A priority patent/CZ191397A3/cs
Priority to US08/663,266 priority patent/US5983893A/en
Priority to SK782-97A priority patent/SK78297A3/sk
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Priority to EE9700132A priority patent/EE9700132A/xx
Priority to AT95942340T priority patent/ATE203919T1/de
Priority to JP51972996A priority patent/JP3712415B2/ja
Publication of WO1996019253A1 publication Critical patent/WO1996019253A1/en
Priority to NO972780A priority patent/NO972780L/no
Priority to MXPA/A/1997/004489A priority patent/MXPA97004489A/xx
Priority to IS4509A priority patent/IS4509A/is
Priority to FI972697A priority patent/FI972697A0/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A61M15/0088—Inhalation chambers with variable volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
PCT/SE1995/001539 1994-12-21 1995-12-19 An inhalation device, a method of dispersing a pharmaceutically acitve substance and a method of administering a dose of a pharmaceutically active substance WO1996019253A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
SK782-97A SK78297A3 (en) 1994-12-21 1995-12-19 An inhalation device, a method of dispersing a pharmaceutically active substance and a method of administering a dose of a pharmaceutically active substance
AU43590/96A AU698815B2 (en) 1994-12-21 1995-12-19 An inhalation device, a method of dispersing a pharmaceutically active substance and a method of administering a dose of pharmaceutically active substance
PL95320860A PL179323B1 (pl) 1994-12-21 1995-12-19 Urzadzenie inhalacyjne do podawania dawki substancji aktywnej farmaceutycznie i sposób podawania dawki substancji aktywnej farmaceutycznie PL PL PL PL
NZ298166A NZ298166A (en) 1994-12-21 1995-12-19 An inhalation device designed for patients who are unable to actively inhale
BR9510210A BR9510210A (pt) 1994-12-21 1995-12-19 Dispositivo de inalação e processo para dispersão de uma substância farmaceuticamente ativa em uma câmara de dispersão e para administração de uma dose de uma substância farmaceuticamente ativa em pó
CZ971913A CZ191397A3 (en) 1994-12-21 1995-12-19 Inhalation apparatus, dispersion process of a pharmaceutically active compound method of applying a dosage of the pharmaceutically active compound
US08/663,266 US5983893A (en) 1994-12-21 1995-12-19 Inhalation device
DE69522119T DE69522119T2 (de) 1994-12-21 1995-12-19 Inhaliervorrichtung, verfahren zum verteilen von pharmazeutisch aktiven substanzen und ein verfahren zum verabreichen von dosen von pharmazeutisch aktiven substanzen
EE9700132A EE9700132A (et) 1994-12-21 1995-12-19 Inhalatsiooniseade, meetod farmatseutilise toimeaine pihustamiseks ning meetod farmatseutilise toimeaine doosi manustamiseks
EP95942340A EP0799067B1 (en) 1994-12-21 1995-12-19 An inhalation device, a method of dispersing a pharmaceutically active substance and a method of administering a dose of a pharmaceutically active substance
AT95942340T ATE203919T1 (de) 1994-12-21 1995-12-19 Inhaliervorrichtung, verfahren zum verteilen von pharmazeutisch aktiven substanzen und ein verfahren zum verabreichen von dosen von pharmazeutisch aktiven substanzen
JP51972996A JP3712415B2 (ja) 1994-12-21 1995-12-19 吸入装置
NO972780A NO972780L (no) 1994-12-21 1997-06-16 Inhalasjonsanordning, fremgangsmåte for fordeling av et farmasöytisk aktivt stoff og fremgangsmåte for administrering av en dose med et farmasöytisk aktivt stoff
MXPA/A/1997/004489A MXPA97004489A (en) 1994-12-21 1997-06-17 Inhalation device, method for dispersing a pharmaceutically active substance and method for administering a dose of a pharmaceutically acting substance
IS4509A IS4509A (is) 1994-12-21 1997-06-18 Innúðatæki, aðferð við að dreifa lyfjafræðilega virku efni og aðferð við inngjöf á skammti af lyfjafræðilega virku efni
FI972697A FI972697A0 (fi) 1994-12-21 1997-06-23 Inhalaatiolaite, menetelmä farmaseuttisesti vaikuttavan aineen dispergoimiseksi ja menetelmä farmaseuttisesti vaikuttavan aineen annoksen jakamiseksi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9404439A SE9404439D0 (sv) 1994-12-21 1994-12-21 Inhalation device
SE9404439-3 1994-12-21

Publications (1)

Publication Number Publication Date
WO1996019253A1 true WO1996019253A1 (en) 1996-06-27

Family

ID=20396408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1995/001539 WO1996019253A1 (en) 1994-12-21 1995-12-19 An inhalation device, a method of dispersing a pharmaceutically acitve substance and a method of administering a dose of a pharmaceutically active substance

Country Status (25)

Country Link
US (1) US5983893A (forum.php)
EP (1) EP0799067B1 (forum.php)
JP (1) JP3712415B2 (forum.php)
CN (1) CN1171056A (forum.php)
AR (1) AR000522A1 (forum.php)
AT (1) ATE203919T1 (forum.php)
AU (1) AU698815B2 (forum.php)
BR (1) BR9510210A (forum.php)
CA (1) CA2207436A1 (forum.php)
CZ (1) CZ191397A3 (forum.php)
DE (1) DE69522119T2 (forum.php)
EE (1) EE9700132A (forum.php)
FI (1) FI972697A0 (forum.php)
HU (1) HUT77661A (forum.php)
IL (1) IL116457A0 (forum.php)
IS (2) IS4508A (forum.php)
NO (1) NO972780L (forum.php)
NZ (1) NZ298166A (forum.php)
PL (1) PL179323B1 (forum.php)
SE (1) SE9404439D0 (forum.php)
SK (1) SK78297A3 (forum.php)
TR (1) TR199501636A1 (forum.php)
TW (1) TW286285B (forum.php)
WO (1) WO1996019253A1 (forum.php)
ZA (1) ZA9510747B (forum.php)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001365A1 (en) * 1995-06-29 1997-01-16 Fisons Plc Inhalation device and method
WO1998041255A3 (en) * 1997-03-14 1999-02-18 Astra Ab Inhalation device
US6286506B1 (en) 1995-09-27 2001-09-11 Astra Aktiebolag Inhalation device
US6550493B2 (en) 2001-06-13 2003-04-22 Baxter International Inc. Vacuum demand valve
US6554023B2 (en) 2001-06-13 2003-04-29 Baxter International Inc. Vacuum demand flow valve
US6752145B1 (en) 1999-05-18 2004-06-22 Smithkline Beecham Corporation Medication dispenser
USD499793S1 (en) 2003-03-17 2004-12-14 Baxter International Inc. Valve
US6863261B2 (en) 2002-03-12 2005-03-08 Baxter International Inc. Valve stop
US6901929B2 (en) 1998-06-04 2005-06-07 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
USD507631S1 (en) 2003-03-17 2005-07-19 Baxter International Inc. Valve
US8082918B2 (en) 2000-03-18 2011-12-27 Astrazeneca Ab Inhaler
EP2653182A4 (en) * 2010-12-17 2015-11-25 Qingtang Chen MOUTHPIECES AND CONTAINERS FOR POWDER MEDICINES AND APPLICATIONS

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US6237591B1 (en) * 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
RO121834B1 (ro) 1998-03-16 2008-06-30 Inhale Therapeutic Systems, Inc. Dispozitiv pentru administrarea unui agent activ
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UA73924C2 (en) 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
ES2258458T3 (es) 1999-05-20 2006-09-01 Kos Life Sciences, Inc. Sistema de atomizacion de baja fuerza de pulverizacion y baja retencion.
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
US6644305B2 (en) * 2000-04-14 2003-11-11 Trudell Medical International Nasal inhaler
US6443152B1 (en) * 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
ATE385193T1 (de) 2002-03-20 2008-02-15 Mannkind Corp Inhalationsgerät
US7185651B2 (en) 2002-06-18 2007-03-06 Nektar Therapeutics Flow regulator for aerosol drug delivery and methods
US7107987B2 (en) * 2004-02-10 2006-09-19 Cfd Research Corporation Spacer for delivery of medications from an inhaler to children and breathing impaired patients
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
PT1804871E (pt) * 2004-10-15 2012-09-25 Cipla Ltd Espaçador melhorado
US7493898B2 (en) * 2005-04-13 2009-02-24 Healthline Medical, Inc. Inhalation apparatus
JP5167133B2 (ja) 2005-09-14 2013-03-21 マンカインド コーポレイション 結晶性微粒子表面に対する活性薬剤の親和性の増大に基づく薬物処方の方法
US20070101991A1 (en) * 2005-11-08 2007-05-10 Mederio Ag Optimizing release of dry medicament powder
US20070114480A1 (en) * 2005-11-23 2007-05-24 Burke Joseph M Vorticity generators for use with fluid control systems
US7987845B2 (en) * 2006-01-31 2011-08-02 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
DE102006007495A1 (de) * 2006-02-17 2007-08-23 Siegfried Generics International Ag Dispergiereinheit
JP5599975B2 (ja) 2006-02-22 2014-10-01 マンカインド コーポレイション ジケトピペラジン及び活性薬剤を含有する微粒子の製剤特性の改善方法
WO2008144106A1 (en) * 2007-05-16 2008-11-27 Aradigm Corporation Burst valve for aerosol device
EP2534957B1 (en) 2007-12-14 2015-05-27 AeroDesigns, Inc Delivering aerosolizable products
PL2254629T3 (pl) * 2008-03-27 2016-06-30 Mannkind Corp Układ inhalatora suchego proszku
CA3153292A1 (en) 2008-06-13 2009-12-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN103751892B (zh) 2008-06-20 2017-03-01 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
JP5667095B2 (ja) 2009-03-11 2015-02-12 マンカインド コーポレイション 吸入器の抵抗を測定するための装置、システムおよび方法
MY186975A (en) 2009-06-12 2021-08-26 Mannkind Corp Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
CN102985125A (zh) 2010-06-21 2013-03-20 曼金德公司 干粉药物输送系统和方法
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
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US9603906B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Inhalable liquid formulations of DNase I
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
JP6523247B2 (ja) 2013-03-15 2019-05-29 マンカインド コーポレイション 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法
KR102465025B1 (ko) 2013-07-18 2022-11-09 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016057693A1 (en) 2014-10-10 2016-04-14 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
TWI595902B (zh) 2016-05-10 2017-08-21 明基材料股份有限公司 攜帶型負壓裝置
EP3962472A4 (en) 2019-04-29 2023-01-25 Insmed Incorporated DRY POWDER COMPOSITIONS OF TREPROSTINIL PRODRUGS AND METHODS OF USE THEREOF
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US5341801A (en) * 1991-12-03 1994-08-30 Sandoz Ltd. Inhaler

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Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001365A1 (en) * 1995-06-29 1997-01-16 Fisons Plc Inhalation device and method
US6138673A (en) * 1995-06-29 2000-10-31 Fisons Limited Inhalation device and method
US6286506B1 (en) 1995-09-27 2001-09-11 Astra Aktiebolag Inhalation device
WO1998041255A3 (en) * 1997-03-14 1999-02-18 Astra Ab Inhalation device
US7422013B2 (en) 1998-06-04 2008-09-09 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
US6901929B2 (en) 1998-06-04 2005-06-07 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
US6752145B1 (en) 1999-05-18 2004-06-22 Smithkline Beecham Corporation Medication dispenser
US8082918B2 (en) 2000-03-18 2011-12-27 Astrazeneca Ab Inhaler
US6684903B2 (en) 2001-06-13 2004-02-03 Baxter International Inc. Vacuum demand valve
US6679288B2 (en) 2001-06-13 2004-01-20 Baker International Inc. Vacuum demand valve
US6672333B2 (en) 2001-06-13 2004-01-06 Baxter International Inc. Vacuum demand valve
US6712095B2 (en) 2001-06-13 2004-03-30 Baxter International Inc. Vacuum demand valve
US6648011B2 (en) 2001-06-13 2003-11-18 Baxter International Inc. Vacuum demand valve
US6863083B2 (en) 2001-06-13 2005-03-08 Baxter International Inc. Vacuum demand flow valve
US6604545B2 (en) 2001-06-13 2003-08-12 Baxter International Inc. Vacuum demand valve
US6554023B2 (en) 2001-06-13 2003-04-29 Baxter International Inc. Vacuum demand flow valve
US6550493B2 (en) 2001-06-13 2003-04-22 Baxter International Inc. Vacuum demand valve
US6863261B2 (en) 2002-03-12 2005-03-08 Baxter International Inc. Valve stop
USD499793S1 (en) 2003-03-17 2004-12-14 Baxter International Inc. Valve
USD507631S1 (en) 2003-03-17 2005-07-19 Baxter International Inc. Valve
EP2653182A4 (en) * 2010-12-17 2015-11-25 Qingtang Chen MOUTHPIECES AND CONTAINERS FOR POWDER MEDICINES AND APPLICATIONS

Also Published As

Publication number Publication date
NZ298166A (en) 1999-01-28
AR000522A1 (es) 1997-07-10
MX9704489A (es) 1997-10-31
US5983893A (en) 1999-11-16
IL116457A0 (en) 1996-03-31
TW286285B (forum.php) 1996-09-21
ATE203919T1 (de) 2001-08-15
FI972697A7 (fi) 1997-06-23
IS4508A (is) 1997-06-16
CZ191397A3 (en) 1997-10-15
CA2207436A1 (en) 1996-06-27
PL320860A1 (en) 1997-11-10
EE9700132A (et) 1997-12-15
JPH10510742A (ja) 1998-10-20
DE69522119D1 (de) 2001-09-13
JP3712415B2 (ja) 2005-11-02
IS4509A (is) 1997-06-18
NO972780D0 (no) 1997-06-16
EP0799067A1 (en) 1997-10-08
AU4359096A (en) 1996-07-10
ZA9510747B (en) 1996-06-28
DE69522119T2 (de) 2002-06-06
CN1171056A (zh) 1998-01-21
TR199501636A1 (tr) 1997-03-21
SE9404439D0 (sv) 1994-12-21
HUT77661A (hu) 1998-07-28
FI972697A0 (fi) 1997-06-23
EP0799067B1 (en) 2001-08-08
NO972780L (no) 1997-06-16
AU698815B2 (en) 1998-11-05
PL179323B1 (pl) 2000-08-31
SK78297A3 (en) 1998-02-04
BR9510210A (pt) 1997-11-04

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