WO1995034210A1 - Composition contenant du hinokitiol, placee dans un recipient de polyester - Google Patents

Composition contenant du hinokitiol, placee dans un recipient de polyester Download PDF

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Publication number
WO1995034210A1
WO1995034210A1 PCT/JP1995/001175 JP9501175W WO9534210A1 WO 1995034210 A1 WO1995034210 A1 WO 1995034210A1 JP 9501175 W JP9501175 W JP 9501175W WO 9534210 A1 WO9534210 A1 WO 9534210A1
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WO
WIPO (PCT)
Prior art keywords
hinokitiol
composition
salt
polyester container
filled
Prior art date
Application number
PCT/JP1995/001175
Other languages
English (en)
Japanese (ja)
Inventor
Yasuo Furuta
Yaeno Arima
Kozo Ishida
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Priority to KR1019960700746A priority Critical patent/KR960703517A/ko
Priority to AU26311/95A priority patent/AU2631195A/en
Publication of WO1995034210A1 publication Critical patent/WO1995034210A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone

Definitions

  • the present invention relates to a light-shielding polyester container composition containing hinokitiol or a salt thereof.
  • preservatives are generally incorporated into pharmaceuticals, cosmetics, agricultural chemicals, foods, etc., and hinokitiol and its salts are known as one of them, but they are more preservative and safer.
  • hinokitiol and its salts are known as one of them, but they are more preservative and safer.
  • the development of preservatives with high properties and stability is required in these fields.
  • a polyethylene container contains a composition containing hinokitiol or a salt thereof as a preservative component
  • the preservative component penetrates the polyethylene container wall. Recognized
  • the preservative component is usually unstable to light. If a polyethylene container to which an additive (light-shielding agent) is added is used, the above preservative component may be decomposed by the additive, or the component may be adsorbed or adhered to the polyethylene container. Also, a disadvantage of coloring was recognized.
  • the present inventors have used hinokitiol and its salts as preservatives, and when storing a composition containing the preservative component in a polyester container having light-shielding properties, The preservative component does not penetrate through the container wall, and in the case of a polyester to which a light-shielding agent has been added. Therefore, the desired preservative component, which is fully exhibited without preserving the original preservative effect at all, is not impaired at all, and is stable for a long time and excellent in safety. This led to the completion of the present invention.
  • the present invention relates to a hinokitiol-containing polyester container composition, characterized in that a composition containing hinokitiol or a salt thereof is filled in a polyester container having a light-shielding property;
  • compositions containing hinokitiol or its salts Liquid, gel, ointment, cream and oily compositions containing hinokitiol or its salts
  • hinokitiol-containing polyester container composition wherein the composition is filled in a polyester container.
  • the above-mentioned hinokitiol-containing polyester container composition characterized in that a cosmetic containing hinokitiol or a salt thereof is filled in a polyester container having a light-shielding property; an external preparation containing hinokitiol or a salt thereof has a light-shielding property.
  • Container composition; the above-mentioned hinokitiol-containing polyester container composition containing 0 to 10 wZw% of lower alcohol together with hinokitiol or a salt thereof;
  • a hinokitiol-containing polyester container composition characterized in that an ointment, gel, cream, or oil-like composition containing hinokitiol or a salt thereof is filled in a light-shielding polyester container;
  • a hinokitiol-containing polyester container composition wherein a detergent composition containing hinokitiol or a salt thereof is filled in a polyester container having a light-shielding property;
  • a hinokitiol-containing polyester container characterized in that a liquid, gel, ointment, cream and oil-like composition containing steal is filled in a light-shielding polyester container.
  • a composition comprising, in combination with hinokitiol or a salt thereof, one or more selected from polyhydric alcohols, sugars, sugar alcohols and polyhydric alcohol alkyl ethers, and ethanol and pantothenyl alcohol;
  • a hinokitiol-containing polyester container composition characterized in that a gel-, ointment-, cream-, and oil-like composition is filled in a light-shielding polyester container; and hinokitiol or a mixture thereof.
  • an oily composition containing a hydrocarbon and a fatty acid ester together with hinokitiol or a salt thereof;
  • the following hinokitiol-containing polyester container composition is provided.
  • R 1 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms, represents a lower alkyl group, and A represents a lower alkylene group.
  • Anionic surfactant represented by or a salt thereof and a general formula
  • R 3 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms
  • R 4 and R 5 each represent a lower alkyl group
  • B represents a lower alkylene group.
  • a hinokitiol-containing polyester container characterized in that a detergent composition containing an amphoteric surfactant represented by the following formula is filled in a polyester container having a light-shielding property.
  • Composition ;
  • R 1 -CN—A—C0H wherein R 1 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms, R 2 represents a lower alkyl group, and A represents a lower alkylene group.
  • Anionic surfactant represented by or a salt thereof and a general formula
  • R 3 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms
  • R 4 and R 5 each represent a lower alkyl group
  • B represents a lower alkylene group.
  • R 6 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms
  • R 8 represents a hydrogen atom
  • R 7 and R 9 represent an alkali metal, an alkaline earth metal copper or zinc
  • m represents 1 or 2
  • Z represents OH
  • a hinokitiol-containing polyester container composition characterized in that a detergent composition containing an amphoteric surfactant represented by the formula:
  • R 1 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms
  • R 2 represents a lower alkyl group
  • A represents a lower alkylene group.
  • Anionic surfactant represented by or a salt thereof and a general formula
  • R 3 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms
  • R 4 and R 5 each represent a lower alkyl group
  • B represents a lower alkylene group.
  • R 1Q represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms, and n is an integer satisfying 1 ⁇ n ⁇ 10) or an anionic surfactant represented by the formula:
  • a hinokitiol-containing polyester container composition wherein a detergent composition containing a salt is filled in a polyester container having a light-shielding property;
  • a liquid, gel, ointment, cream and oil composition containing at least one selected from zinc compounds together with hinokitiol or a salt thereof is filled in a light-shielding polyester container.
  • Hinokitiol-containing polyester container composition
  • Examples of the hinokitiol salt used in the composition of the present invention include alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as magnesium salts, copper salts, and zinc salts.
  • Inorganic salts such as metal salts such as lead salts, diethanolamine salts, 2 —amino 2 —ethyl 1, 3 —Propandiol salts, triethanolamine salts and other alkanolamine salts, morpholin salts, piperazine salts, piperidine salts, etc.
  • Organic salts such as basic amino salts such as telocyclic amine salts, ammonium salts, arginine salts, lysine salts and histidine salts can be mentioned.
  • As the basic amino acid any of D-form, L-form and mixtures thereof can be used.
  • One of the above salts may be used alone, or two or more of them, or a mixture of such and hinokitiol may be used
  • the above-mentioned hinokitiol and salts thereof used in the composition of the present invention are all characterized by having a strong antibacterial activity, a wide antibacterial range, and a low selectivity for their antibacterial activity. It also shows excellent safety in the treatment of conjunctivitis, blepharitis, etc., with very little irritation to the skin and little irritation to the eyes, for example in skin irritation tests.
  • the material of the light-shielding polyester container used in the composition of the present invention is not particularly limited as long as it is composed of a light-shielding polyester.
  • the polyester used herein is not particularly limited, but is preferably a polyethylene terephthalate resin, and is usually dimethyl terephthalate resin. Or a product obtained by condensing terephthalic acid and ethylene daryl. In addition, some of the glycol components
  • a polyester having a desired light-blocking property By adding and mixing various light-blocking agents conventionally used for the purpose of light-blocking properties to the above-mentioned polyester, a polyester having a desired light-blocking property can be obtained.
  • the light-blocking agent include dyes such as titanium dioxide, iron dioxide, and carbon black; dyes such as anthraquinone yellow and phthalocyanine blue; and 2- (2'-hydroxy-5 '). UV absorbers such as (methinolephenyl) benzotriazole and the like.
  • the amount of the polyester compounded in the polyester is an amount usually used as a light-shielding agent, and is not particularly limited.
  • the polyester container having a light-shielding property used in the present invention includes, for example, a metal foil of aluminum or the like or a light of sheet or the like on one surface (the surface not in contact with the composition) of one of the above-mentioned various polyester films or sheets. It may be composed of a laminate in which sheets of a material capable of blocking the air are laminated.
  • the shape of the polyester container having light-shielding properties is, for example, a bottle-like shape such as a bottle, a pot-like shape such as a jar, a bag-like shape such as a bouch, etc. It may be in any form such as a rum packaging form.
  • the tube or the like can be formed into a tube-like shape using an adhesive layer.
  • Polyethylene film may be laminated as an adhesive layer on one side (the surface in contact with the composition, on the inner side) of the polyester film or sheet having light-shielding properties.
  • the preservative component in the composition contained in the container is transmitted through the polyethylene film, but the container outside the container is formed by the polyester. Dissipation to the outside is prevented, and the intended effect of the present invention can be achieved.
  • the above-mentioned polyethylene film which does not contain a light-shielding agent component which may react with the preservative component.
  • the size of the light-shielding polyester container and the thickness of the polyester container wall used in the present invention are arbitrary and have no limitation.
  • the composition containing hinokitiol or a salt thereof to be contained in the container is not particularly limited in its composition, use, etc., and has been conventionally used in pharmaceuticals, quasi-drugs, cosmetics, daily necessities, foods, Any of various compositions used in various fields such as pesticides may be used.
  • compositions are prepared using commonly used diluents or excipients such as fillers, extenders, binders, humectants, disintegrants, surfactants and lubricants.
  • This composition can be selected from various forms depending on the purpose of use. Representative examples are tablets, pills, powders, solutions, oils, suspensions, emulsions, granules, capsules, suppositories, injections. (Solutions, suspensions, etc.), and sprays such as inhalants and external aerosols, as well as liquid coatings, lotions, gels, oily ointments, OZW hydrophilic ointments, W / Emulsion ointment bases such as Type 0 water-absorbing ointments, water-soluble ointment bases, external preparations such as creams, liniments, cataplasms, sheet-like preparations, etc., but containing the hinokitiol of the present invention
  • the polyester container composition is particularly effective in the above-mentioned forms, particularly in the case of a liquid, gel, ointment, cream, oil, etc. composition having high fluidity and frequent contact with the container.
  • carriers conventionally known in this field can be widely used as carriers, for example, lactose, sucrose, sodium chloride, glucose, urea, starch, calcium carbonate, kaolin. , Crystalline cellulose, excipients such as gay acid, water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cell Binders such as loin, ceramics, methylcellulose, calcium phosphate, polyvinylpyrrolidone, dried starch, sodium alginate, powdered agar, powdered lamina, carbonated water Disintegrators such as sodium sodium, calcium carbonate, polyoxyethylene sorbitan fatty acid esters, sodium lauryl sulfate, monoglyceride stearate, starch, lactose, sucrose, stearate , Cocoa butter, disintegration inhibitors such as hydrogenated oils, quaternary ammonium salts, absorption promoters such as sodium lauryl sulf
  • the tablet may be a tablet coated with a usual coating as required, for example, a sugar-coated tablet, a gelatin-encapsulated tablet, an enteric-coated tablet, a film coating tablet or a double tablet, a multilayer tablet, or the like. .
  • a wide variety of carriers conventionally known in this field can be used as a carrier, for example, pudose-lactose, starch, cocoa butter, hydrogenated vegetable oil, kaolin, evening silk, etc.
  • Excipients arabic gum powder, tragacanth powder, binders such as gelatin, ethanol, and the like, and disintegrants such as laminaran, carten, and the like.
  • conventionally known carriers can be widely used, for example, polyethylene glycol-cocoa butter, higher alcohols, higher alcohol esters, gelatin, semi-synthetic glyceride, etc. You can list them.
  • a wide variety of dispersants and propellants known in the art can be used.
  • the dispersant include lecithins such as soybean lecithin and egg yolk lecithin, and oleys Fatty acids such as carboxylic acid, linoleic acid, and linolenic acid-sorbitan triolate; and sorbitan fatty acid esters such as sorbitan monooleate.
  • the propellant include, for example, liquefied petroleum gas, dimethyl ether, freon 22, freon 123, freon 11, freon 12, freon 114, etc. Liquefied gas and compressed gas such as nitrogen gas and carbon dioxide gas.
  • solutions and suspensions are preferably sterile and isotonic with blood, and are formulated into solutions, emulsions and suspensions.
  • all diluents commonly used in this field can be used, for example, water, ethyl alcohol, propylene glycol, ethoxylated isostearyl alcohol, polyoxylated isostearino alcohol, and polyisocyanate.
  • oxyethylene sorbitan fatty acid esters a sufficient amount of salt, glucose or glycerin to adjust the isotonic solution may be included in the above preparation, and the usual solubilizing agents, buffers, and soothing agents may be used. An agent may be added.
  • Emulsifiable ointment bases such as lotions, liniments, oleaginous ointments, OZW-type hydrophilic ointments, and W / 0-type water-absorbing ointments. You can use what you know widely.
  • an oily base can be used alone or as a mixture of two or more, or a water-soluble base can be used alone or as a mixture of two or more.
  • Mineral oils Isopropyl myristate, n-butyl myristate, isopropyl linoleate, propyl ricinoleate, isopropyl ricinoleate, isopropyl butyrate, heptyl lysinolate, heptyl lysinolate, getylse
  • Higher fatty acid esters such as baguette, diisopropylpropyladipate, cetyl alcohol, stearyl alcohol, salami beeswax, gay wax, wood wax, lanolin, carnauba wax, ceramic wax, higher fatty alcohols and waxes Classes
  • higher fatty acids such as stearic acid, oleic acid, and palmitic acid
  • ethylene glycol Polyhydric alcohols such as sorbitol, mannitol
  • Additives such as gelling agents, preservatives, solubilizers, antioxidants, buffers, PH regulators, wetting agents, preservatives, coloring agents, fragrances, pigments, fragrances, thickeners, sequestering Agents, ultraviolet absorbers, various surfactants, and the like can be appropriately added.
  • medicinal ingredients such as vitamins or vitamin-like active substances, hormonal agents, anti-inflammatory agents, antibacterial agents and the like can be appropriately added.
  • cosmetics include liquids, solids, foams, pastes, jewels, creams, lotions, oils, emulsions, packs, and preparations before use. These forms can be prepared according to a conventional method.
  • a detergent composition such as a shampoo, a body shampoo, a cream-like face wash, and a gel-like face wash, those conventionally known in this field can be widely used.
  • anionic surfactants include alkyl sulfates, polyoxyethylene alkyl ether acetates, N-acylamino salts, N-acylmethyltaurine salts, polyoxyethylene alkyl ether acetates, Alkyl sulfosuccinates, alkyl sulfonates, alkyl phosphates, polyoxyethylene alkyl ether phosphates, monoglyceride sulfates, minerals, ether carboxylates, ⁇ -olefin sulfonates And alkanesulfonates, dialkylsulfosuccinates, alkylarylsulfonates, and the like. One or more of these can be used.
  • Nonionic surfactants include sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, and polio.
  • Examples of the cationic surfactant include an amine salt, an alkylamine salt, a polyamine and an alkanolamine fatty acid derivative, an alkyl quaternary ammonium salt, an alkyltrimethylammonium salt, and a dialkyldimension.
  • Chillammonium salts examples thereof include alkyldimethylbenzylammonium salts and quaternary ammonium salts, and one or more of these salts can be used.
  • amphoteric surfactant examples include a betaine type, an imidazoline type, a sulfate ester type and the like, and one or more of these can be used.
  • the amount of the surfactant is not particularly limited as long as the cleaning effect is sufficiently exhibited, but the total amount of the surfactant is in the range of about 0.5 to 90% by weight of the total composition. And more preferably in the range of 1 to 50% by weight.
  • Other components include phosphoric acid, citric acid, hydrochloric acid, etc. pH regulators; humectants such as propylene glycol, glycerin, sorbitol, and maltitol; disinfection of parabens; antiseptics; oils such as higher alcohols; hair such as cationized cell mouth Softeners; viscosity modifiers such as methylcellulose, hydroxymethylcellulose, carboxyvinyl polymer and polyvinyl alcohol; film-forming agents such as hydrolyzed collagen; solubilizers such as ethanol and ultraviolet absorbers; Antioxidants such as coferol, sezamol, sezamolin, gossypol, phospholipids, nordihydroguaiaretinic acid, butylhydroxyanisole, butylhydroxytoluene, and propyl gallate; sequestering agents; inorganic salts; antidandruff agents; Pharmaceutical agents such as antifungals, antiperspirants, anti-inflammatory agents, and plant and animal
  • a zinc compound such as zinc oxide or zinc chloride or a copper compound such as copper oxide or copper chloride increases the antibacterial activity and is effective in preventing itching.
  • the cleaning composition of the present invention also includes daily necessities such as a bottle shampoo, a kitchen detergent, and a laundry detergent.
  • Cream, lotion, oil, latex, pack, makeup In producing cosmetics such as water, those which are conventionally known in this field can be widely used.
  • an oily base can be used alone or as a mixture of two or more, or a water-soluble base can be used alone or as a mixture of two or more.
  • Higher fatty acid esters such as norin, carnapa wax and silk wax, higher fatty alcohols and waxes; higher fatty acids such as stearinic acid, oleic acid, palmitic acid; saturated with 12 to 18 carbon atoms Or a mixture of mono-, di-, and triglycerides of unsaturated fatty acids; ethylene glycol Alcohol, poly (ethylene glycol), propylene glycol, glycerin, butyl alcohol, pentaerythritol, etc. Polyhydric alcohols such as sorbitol, mannitol; arabia gum, benzoin gum, guaiac oil, tragacanth gum, etc.
  • Gum substance gelatin, starch, casein, dextrin, pectin, pectin sodium, sodium alginate, methylsenorelose, ethylcellulose, potato boxime chinoresenorelose, hydroxyxetinore
  • Natural water-soluble polymers such as senorellose hydroxypropynoresenorelose, nitrosenorelose and crystalline cellulose; polyvinyl alcohol, polyvinyl methyl ether, polyvinyl alcohol, and sodium polyacrylate Lithium, carboxybi Synthetic water-soluble polymers such as polymer and polyethyleneimine; nonionic, anionic, amphoteric and cationic surfactants such as ethanol, isopropanol, water, etc.
  • Additives such as aluminum stearate, magnesium stearate, calcium stearate, zinc stearate, zinc palmitate, zinc myristate, magnesium myristate, laurine Metallic stones such as zinc acid and zinc perdecylate; animal and plant extracts, vitamins A1, A2, B1, B2, B6, B12, C.D, E, K, F , Folic acid, nicotinic acid, nose, Acid, biotin, Bismin or vitamin-like substances such as inositol, carnitine, furulic acid, ⁇ -orizonol, ⁇ -lipoic acid, orotic acid, vitamin P and U; hormones; Amino acid Antiperspirant; Anti-inflammatory agent; Dye; UV absorber; UV inhibitor; NMF (Natural moi sturizing factor) such as pyrrolidone carboxylic acid, pyrrolidone carboxylate, lactate; , Glycerin, sorbitol, maltitol, hyalur
  • a composition in which a lotion containing hinokitiol or a salt thereof and a lower alcohol in an amount of 0 to 10 w / w% is contained in a polyester container is preferable.
  • the cosmetic composition of the present invention uses cosmetics, It can be used in a normal pH range, preferably in the range of about 3.0 to 11.0, and most preferably in the range of about 5.0 to 8.0.
  • Examples of the food include beverages and the like.
  • pesticides examples include insecticides; acaricides; fungicides.
  • animal supplies include pet goods such as shampoos and rinses.
  • the content of hinokitiol or a salt thereof is not particularly limited as long as it has the effect, but when used as a preservative, it is usually preferably 0.0001% by weight or more. More preferably, it is about 0.001 to 10.0% by weight.
  • an antibacterial agent When used as an antibacterial agent, it is usually contained in an amount of 0.0001% by weight or more, preferably about 0.001 to 90% by weight.
  • the administration method is not particularly limited, and is administered by a method according to various formulation forms, patient age, gender and other conditions, degree of disease, and the like. Is done.
  • a solution, suspension, or emulsion it is orally administered.
  • intravenous administration alone or in combination with normal replacement fluid such as glucose and amino acid
  • normal replacement fluid such as glucose and amino acid
  • it is also administered alone, if necessary, intramuscularly, intradermally, subcutaneously or intraperitoneally.
  • it is applied or sprayed on the affected area.
  • the composition of the present invention is not used even if diluted.
  • the composition of the present invention may be applied to a place requiring external bactericidal according to a conventional means.
  • conventional means include, for example, spray coating, brush coating, cloth wipes, paper towels, towels, wiping with a tissue, etc., and aerosols.
  • composition of the present invention is added to detergents, finishing pastes, softeners, bleaching agents, etc. of general or medical supplies (clothing, food, tableware, furniture, gauze, sheets, curtains, etc.) which require external sterilization. Can be used. Further, the composition of the present invention can be applied to animals or animal products requiring external sterilization.
  • composition A a container containing the following mild detergent composition in a polyester container (hereinafter referred to as “composition A”) is used. Can be illustrated.
  • the detergent compositions eg, shampoos
  • the detergent compositions are highly irritating, and thus promote the occurrence of itching or cause allergy, and are atopic.
  • hinokitiol or its salt is used as a preservative component, and the following general formula ( At least one selected from the group consisting of an anionic surfactant represented by 1) or a salt thereof (hereinafter simply referred to as a surfactant including this salt) and an amphoteric surfactant represented by the following general formula (2)
  • a general formula (1) that can provide a hypoallergenic detergent composition that can be used:
  • R 1 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms, represents a lower alkyl group, and A represents a lower alkylene group] or an anionic surfactant represented by the formula: Its salt.
  • R 3 is a saturated or unsaturated hydrocarbon having 1 to 40 carbon atoms.
  • R 4 and R 5 each represent a lower alkyl group; and B represents a lower alkylene group.
  • amphoteric surfactant represented by the formula:
  • the lower alkyl group may be a straight or branched chain having 1 to 6 carbon atoms such as methyl, ethyl, propyl, isopropyl, butyl, isoptyl, tert-butyl, pentyl, and hexyl.
  • a chain alkyl group is particularly preferably a methyl group.
  • saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms examples include methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, pentyl, hexyl, heptyl-octyl, and nonyl.
  • Decyl pendecyl, dodecyl, 11-methyldodecyl, 10-methyldidecyl, tridecyl, tetradecyl, pentadecyl, hepdecyldecyl, heptadecyl, nonadecyl, icosyl, henikosyl , Docosyl, tetracosyl, triacontyl, pentatriacontyl, tetracontyl, vinyl, aryl, isopropenyl, ethynyl, 2-pentynyl, 3-pentenyl, 9-decenyl, cis-one 8 —Heptadecenyl, trans- 8 —Heptadecenyl, 2-decinyl, 2 —Cutinyl, alkyl alkyl ether, etc.
  • a saturated or unsaturated hydrocarbon group having 5 to 19 carbon atoms is preferable, and Saturated or unsaturated hydrocarbon groups of numbers 7 to 13 are more preferred.
  • a saturated hydrocarbon group having 9 to 13 carbon atoms such as pendecyl and tridecyl is preferable, and the group represented by the above formula (2)
  • R 3 a saturated hydrocarbon group having 9 to 13 carbon atoms, such as coconut oil alkyl group undecyl and tridecyl, is preferable.
  • Examples of the lower alkylene group include methylene, ethylene, trimethylene, 2-methylinoletrimethylene, 2,2-dimethyldimethylene, 1-methyltrimethylene, and methylene.
  • a straight-chain or branched alkylene group having 1 to 6 carbon atoms such as tylmethylene, ethylmethylene, tetramethylene, pentamethylene, and hexmethylene may be mentioned. it can.
  • examples of the group defined by A in the above formula (1) are preferably an ethylene group and an ethylene group, more preferably an ethylene group.
  • examples of the group defined by B in the above include, preferably, an ethylene and a trimethylene group, and more preferably, a trimethylene group.
  • Alkali metal salts such as lithium and calcium salts, alkaline earth metal salts such as magnesium salts, inorganic salts such as metal salts such as Cu salts and Zn salts, diethanolamine salts, 2-amido No. 2 —ethyl 1,3 — alkanolamine salts such as prono, 0- diol salts, triethanolamine and reaamine salts, morpholin salts, piperazine salts, piperidine salts, etc., ammonium salts, arginine Organic salts such as basic amino acid salts such as salts, lysine salts and histidine salts can be mentioned.
  • the basic amino acid any of a D-form, an L-form and a mixture thereof can be used.
  • the hinokitiol or a salt thereof is as described above, and among them, in the present composition A, hinokitiol, hinokitiol Na, K, L-arginine, L-histidine, 1,3-propanediol, triethanolamine, Salts such as Zn and Cu are preferred.
  • the anionic surfactant of the general formula (1) and the amphoteric surfactant of the general formula (2) may be used as the surfactant.
  • These surfactants have excellent detergency and very low irritation to the skin.
  • this combination results in extremely good detergency and low irritation.
  • the total amount of the anionic surfactant of the general formula (1) and the amphoteric surfactant of the general formula (2) is 3 to 40% by weight, preferably 5 to 30% by weight in the detergent composition. It is good to make it by weight%.
  • the amount of hinokitiol or a salt thereof is not particularly limited as long as the antiseptic effect is exhibited, but is preferably 0.01% by weight or more in the detergent composition.
  • L is more preferably 0.01% by weight, and the decomposition of hinokitiol or a salt thereof is suppressed by filling hinokitiol or a salt thereof in a polyester container as a preservative. Since it can maintain a low concentration, it can be combined with the above-mentioned surfactants to significantly reduce skin irritation and further improve cleaning performance. A cleaning composition that exhibits antiseptic performance, etc. Is obtained.
  • composition A (hypoallergenic detergent composition) further comprises: The compound represented by the general formula (3) may be added.
  • R 6 represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms
  • R 8 represents a hydrogen atom
  • CH 2 C 00 R 9 and R 7 and R 9 are sodium.
  • Al metal such as chromium and calcium
  • Al metal such as magnesium
  • alkaline earth metal metal ions such as copper and zinc
  • m represents 1 or 2
  • Z represents OH; C 12 H 25 OS 0 3 ,
  • Specific examples of the compound represented by the above general formula (3) include: alkyl-alkyl-N-carboxymethoxethyl-N-potassium-l-oxymethylimidazolyzindium sodium hydroxide, coconut oil fatty acid N-carboxymethoxethyl-N-carboxy Methylimidazolinium dinadium sulfuric acid, lauryl N-carboxymethoxethyl I-N-carboxymethyl imidazolium dinadium dodecanoyl sarcosine and the like, and among them, coconut oil alkyl-N-carboxymethoxethyl, N-carboxymethyl imidazolium dinatrium hydroxide is preferred.
  • New The addition amount is preferably about 10 to 200% by weight of the anionic surfactant of the general formula (1).
  • composition A may further contain a compound represented by the following general formula (4).
  • R 1Q represents a saturated or unsaturated hydrocarbon group having 1 to 40 carbon atoms, and n is an integer satisfying 1 ⁇ n ⁇ 10) or an anionic surfactant represented by the formula: salt.
  • the composition By adding the compound represented by the general formula (4) to the hypoallergenic composition A, the composition has the characteristic of having a low degreasing power in addition to the hypoallergenicity.
  • Examples of the salt of the surfactant represented by the general formula (4) include alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as magnesium salts, copper salts, and the like.
  • Inorganic salts such as metal salts such as zinc salts, diethanolamine salts, alkanolamine salts such as 2-amino-2-ethyl-1,3-propanediol salt and triethanolamine salts, and morpholine
  • organic salts such as basic amic acid salts such as heterocyclic amide salts, ammonium salts, arginine salts, lysine salts, histidine salts, etc. be able to.
  • the basic amino acid any of a D-form, an L-form and a mixture thereof can be used.
  • the surfactant represented by the general formula (4) is used in combination with the present composition A, the degreasing power is weakened, and the dryness and crispness of the skin can be reduced.
  • the proportion of the surfactant used is determined by the total amount of the anionic surfactant of the general formula (1) and the zwitterionic surfactant of the general formula (2) and the amount of the surfactant of the general formula (4).
  • other components described above can be appropriately compounded.
  • the skin irritation index should be about 30 or less when used as a detergent composition for healthy persons. It is desirable to mix them so that
  • the present composition A can be used in the pH range in which the above-mentioned cosmetics can be used, but is more preferably in the range of about pH 6.0 to 7.5.
  • It can be used by diluting with water as needed when using it.
  • composition A is not only extremely irritating to the skin, but also fully satisfies essential performances as a detergent such as foaming properties and detergency, and has atopic properties. It can be used for patients with dermatitis or other skin diseases, and is also useful for healthy people.
  • composition B in another embodiment of the hinokitiol-containing polyester container composition of the present invention in the form of a detergent, the composition of the formula A preservative comprising at least one selected from the group consisting of an anionic surfactant or a salt thereof represented by (1) and an amphoteric surfactant represented by the same general formula (2), and hinokitiol or a salt thereof; 0.001% by weight or more, 0.3 to 5% by weight of maltitol, and 0.5 to 5% by weight of polyethylene glycol having an average molecular weight of 400 to 1500.
  • composition B a composition in which a detergent composition having a pH of 6.0 to 8.0 is filled in a polyester container having a light-shielding property
  • This composition B can provide an excellent cleaning effect, foaming, foam quality (for example, good fineness and a blushy feeling), good foam removal, and feeling of use (for example, non-stickiness, It has a moist feeling and a refreshing feeling, and does not get stuck after use), is excellent in qualitative properties, and is suitable not only for healthy people but also for skin disease patients such as atopic dermatitis patients, acne vulgaris (two-pimple) patients, etc. It is a mild detergent composition that can be used with confidence.
  • the anionic surfactant of the general formula (1) and the zwitterionic surfactant of the general formula (2) are used.
  • Are used in an amount sufficient to exert a cleaning effect-the total amount of the anionic surfactant of the general formula (1) and the zwitterionic surfactant of the general formula (2) Is about 1% to 80% by weight, preferably about 5% to 30% by weight, in the detergent composition.
  • the amount of hinokitiol or a salt thereof is not particularly limited as long as the antiseptic effect is exhibited, but is preferably 0.001% by weight or more in the detergent composition.
  • the mulberry is usually 0.3 to 5% by weight, preferably 0.5 to 5% in the detergent composition as a humectant. 3% by weight is blended.
  • Polyethylene glycol having an average molecular weight of 4,000 to 15,000, preferably 4,000 to 100,000 is used, and usually 0.5 to 5% by weight, preferably, in the detergent composition. 1-3% by weight is blended.
  • the composition B may contain a humectant other than maltitol.
  • a humectant other than maltitol.
  • the total humectant component together with maltitol be 10% by weight or less in the total composition.
  • humectants include the above-mentioned polyhydric alcohols and sugars, and among them, glycerin is preferred.
  • the amount of the humectant used is multi-tol. Is preferably in the range of 5 to 100% of the total humectant component.
  • the present composition B can also be used in the pH range where cosmetics can be used, but more preferably 6.0 to 6.0.
  • composition B there is no particular limitation on the dosage form of the composition B, and it can be used as various dosage forms conventionally known including the liquid shampoo described above. Of course, the present composition B Can also be used, if necessary, diluted with water as needed.
  • an antibacterial / antifungal agent containing a zinc compound and at least one selected from hinokitiol or a salt thereof is filled in a polyester container having a light-shielding property.
  • Hinokitiol-containing polyester container composition hereinafter referred to as “composition C”.
  • a liquid, gel, ointment, cream, and oily composition containing an effective amount of a zinc compound and an effective amount of hinokitiol or a salt thereof is a polyester having a light-shielding property.
  • an antibacterial and antifungal agent contained in a container more preferably an antibacterial and antifungal agent contained in a tube whose inner surface is made of polyethylene and whose outer surface is made of a polyester having light-shielding properties, and cosmetics.
  • the zinc compound there is no particular limitation, and conventionally known compounds can be widely used.
  • zinc stearate Preferably zinc stearate, zinc pyrithione, zinc myristate, zinc palmitate, zinc laurate, zinc chloride, sulfite Lead and zinc oxide, most preferably zinc oxide.
  • these zinc compounds may be used alone or in a combination of two or more.
  • hinokitiol or a salt thereof any of the above-mentioned ones can be used, and particularly, hinokitiol, a sodium salt of hinokitiol, an L-arginine salt, a copper salt and the like are preferable.
  • the ratio between the zinc compound and hinokitiol or a salt thereof to be incorporated into the composition of the present invention in the form of an external preparation or a cosmetic is not particularly limited as long as the desired effect of the present invention can be exhibited.
  • the zinc compound is used in an amount of about 0.05 to 99.5% by weight, preferably 10 to 99.95% by weight based on the total amount of the zinc compound and hinokitiol or a salt thereof.
  • About 95% by weight, most preferably about 50 to 99.9% by weight, and hinokitiol or a salt thereof is used for about 99.9 to 0.05% by weight, preferably about 90 to 0. It is preferable to use about 0.5% by weight, most preferably about 50 to 0.1% by weight.
  • composition C of the present invention may be used by preparing a zinc compound and hinokitiol or a salt thereof so as to be contained in a single pharmaceutical preparation, respectively. Can also be used. Before the composition C Any of the aforementioned forms of medicine, quasi-drugs, and cosmetics can be selected.
  • an external preparation is most preferable because the antibacterial and antifungal effects of the composition C are effectively used.
  • the amount thereof is not particularly limited as long as it has the efficacy, and the total amount of the zinc compound and hinokitiol or a salt thereof is usually about 0.01 to 20% by weight.
  • the content is about 0.01 to 15% by weight-more preferably, about 0.01 to 10% by weight.
  • the zinc compound and hinokitiol or a salt thereof are usually added in a total amount of about 0.001 to: about L0.0% by weight, preferably about 0.00% by weight.
  • the content is preferably from 0.1 to 50% by weight.
  • composition C of the present invention when used as a cosmetic, it differs depending on the form and the like and cannot be stated unconditionally, and is not particularly limited.
  • a zinc compound and hinokitiol or a salt thereof are used.
  • the total content is usually about 0.001 to 99.9% by weight, preferably about 0.001 to 30% by weight.
  • the composition C can be used after further diluting it with water, olive oil or an appropriate solvent.
  • the method of administering the composition C is not particularly limited as described above.
  • the amount of the formulation C used is usually the total amount of the zinc compound and hinokitiol or its salt of the active ingredient per adult per day, about 1 to 20 mg each. It may be administered.
  • the ratio of the zinc compound and hinokitiol or a salt thereof to be blended in the composition C is not limited as long as the intended effect of the present invention can be exerted.
  • a zinc compound is usually added to the composition C in an amount of about 0.0005 to 99% by weight. Preferably, about 0.001 to 30% by weight is added.
  • composition C in addition to the above-mentioned active ingredient, various previously known additives described above can be blended.
  • composition C When the composition C is used as an external bactericide, it may be applied according to the conventional means described above.
  • the composition C of the present invention has excellent antibacterial activity and antifungal activity, and various kinds of infectious diseases caused by various bacteria and Z or mold, for example, atopic dermatitis, seborrheic Dermatitis Monetary dermatitis, self-sensitizing dermatitis, diaper dermatitis, depression Dermatitis such as persistent dermatitis, housewife (hand) eczema, eczema such as dry eczema, pustular psoriasis, flushing due to burns, burns, rash, rash, heat rash, soreness, abrasion, secondary infection due to rupture It is particularly useful for treating various skin disorders.
  • infectious diseases caused by various bacteria and Z or mold for example, atopic dermatitis, seborrheic Dermatitis Monetary dermatitis, self-sensitizing dermatitis, diaper dermatitis, depression Dermatitis such as persistent dermatitis, housewife (hand) eczema,
  • composition C of the present invention has extremely low skin irritation and allergenicity and can be applied to infants, infants, children and other skin disease patients, for example, patients susceptible to skin irritation. It can also be used to treat skin diseases in animals (dogs, cats, etc., cattle, livestock, horses, etc.).
  • composition C of the present invention has excellent antibacterial and antifungal properties, and is safe and extremely low in irritation, and is suitable for infants and toddlers. It can be suitably used. Further, the composition C of the present invention can be suitably used for atopic dermatitis patients and contact dermatitis patients.
  • the composition C of the present invention is a composition which exhibits excellent antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, has low toxicity, and has very weak side effects.
  • the above-mentioned composition includes, for example, Gram-positive bacteria such as Staphylococcus, Streptococcus, Diphtheria, Mycobacterium tuberculosis Clostridium, Neisseria, Escherichia, Citropactor, Salmonella, Gram-negative bacteria such as Gera, Klebsiella and Pseudomonas, Clostridium, Peptococcus, Peptostreptococcus, Propionibacterium, Anaerobic bacteria such as Bacteroides, conjugating fungi including Mucor, Ascomycetes including Aspergillus, Penicillium, etc., Cryptococcus, Candida, Dermatophytes, It exhibits extremely strong antibacterial activity against fungi such as incomplete fungi including Pichirosporum. '
  • composition C of the present invention contains various antibiotic-resistant bacteria such as penicillin, septum, quinolone, aminoglycoside, macrolide, and tetracycline. Demonstrates excellent antibacterial activity against clinically isolated bacteria. In particular, MRSA and MRSE exhibit a remarkable bactericidal effect.
  • the method of the present invention is also effective for multidrug-resistant MRSA and MRSE with quinolone resistance, aminoglycoside resistance, macrolide resistance, tetracycline resistance and the like.
  • the bactericidal action of hinokitiol or a salt thereof is further increased in order to suppress the reversal phenomenon of hinokitiol or a salt thereof observed in Staphylococcus sp. Can be.
  • composition C of the present invention has high safety, It is also an excellent antibacterial and antifungal agent.
  • composition D a hinokitiol-containing polyester container composition filled in a polyester container having the following formula:
  • a hinokitiol-containing polyester container composition in which an antimicrobial agent containing an effective amount of a copper compound and an effective amount of hinokitiol or a salt thereof is filled in a light-shielding polyester container, is preferred.
  • an antimicrobial agent and a cosmetic are provided in a tube whose inner surface is made of polyethylene with an adhesive layer and whose outer surface is made of polyester having light-shielding properties.
  • composition D as the copper compound, there is no particular limitation, and conventionally known compounds can be widely used.
  • any of the aforementioned hinokitiol salts can be used as the hinokitiol salt.
  • the proportion of the copper compound and hinokitiol or a salt thereof to be blended in the composition D is not particularly limited as long as the desired effect of the present invention can be exhibited.
  • the copper compound is used in an amount of about 0.05 to 99.95% by weight, preferably about 10 to 99.95% by weight, most preferably about 50% by weight based on the total amount of hinokitiol or a salt thereof.
  • About 99.9% by weight, and hinokitiol or a salt thereof is used in an amount of about 99.9 to 0.05% by weight, preferably about 90 to 0.05% by weight, and most preferably about 50% by weight. It is preferable to use about 0.1% by weight.
  • the above composition D may be used by preparing a copper compound and hinokitiol or a salt thereof so as to be contained in a single preparation, respectively. You can also.
  • composition D can also be in any of the above-mentioned forms of pharmaceuticals, quasi-drugs, and cosmetics.
  • external preparations are most preferred because they make effective use of the antimicrobial effect of Composition D.
  • the amount thereof is not limited as long as it has the efficacy, but the total amount of the copper compound and hinokitiol or a salt thereof is usually about 0.01 to 20% by weight.
  • the content is about 0.01 to 15% by weight, more preferably about 0.01 to 10% by weight.
  • preparations to be used after dilution such as preparations for use include a copper compound and hinokitiol or a salt thereof in a total amount of usually about 0.001 to 100% by weight, preferably 0.00% by weight.
  • the content is preferably about 1 to 50% by weight.
  • composition D when used as a cosmetic, it differs depending on the form and the like and cannot be stated unconditionally, and is not particularly limited.
  • a copper compound and hinokitiol or a salt thereof are used.
  • 0.0000 to 19.9% by weight in total And preferably about 0.001 to 30% by weight.
  • composition D can be further diluted with water, ethanol, olive oil, liquid gas or a suitable solvent before use.
  • the administration method of the composition D is not particularly limited as described above.
  • the amount of the composition D formulation used is usually the total amount of the active compound copper compound and hinokitiol or its salt per adult per day, about 1 to 20 m, each about 1 to 3 times at about 1 kg body weight. It may be administered.
  • the ratio between the copper compound and hinokitiol or a salt thereof to be blended in the composition D is an amount capable of exerting the intended effect of the present invention.
  • a copper compound is usually added to the composition D in an amount of about 0.0005 to 9.9% by weight, preferably about 0.001 to 30% by weight.
  • Hinokitiol or a salt thereof is usually used
  • composition D in addition to the above-mentioned active ingredients, the above-mentioned various conventionally known additives can be blended.
  • Composition D As an external fungicide, What is necessary is just to apply according to the conventional means mentioned.
  • Composition D has excellent antimicrobial activity and can be used for various infectious diseases caused by various microorganisms, for example, atopic dermatitis, seborrheic dermatitis, monetary dermatitis, self-sensitization Dermatitis such as atopic dermatitis, diaper dermatitis and stasis dermatitis, housewife (hand) eczema, eczema such as dry eczema, pustular psoriasis, boiling water, flushing due to burns, rash, rash, rash, rubbing It is especially useful for the treatment of various skin diseases, such as hypersensitivity and secondary infection due to rupture.
  • various skin diseases such as hypersensitivity and secondary infection due to rupture.
  • composition D of the present invention has extremely low skin irritation and allergic properties, and can be applied to infants, infants, children and other skin disease patients, for example, patients susceptible to skin irritation. It can also be used for the treatment of skin diseases in animals (dogs, cats, etc., cattle, livestock, horses, etc.).
  • the composition D of the present invention has excellent antimicrobial activity, is stable to light such as ultraviolet rays, and has low irritation, and is suitable for infants, toddlers, children and other patients with skin diseases and irritation. It can be suitably used for weak patients and the like.
  • the composition D of the present invention can be suitably used for atopic dermatitis patients and contact dermatitis patients.
  • the composition D of the present invention is widely used for Gram-positive bacteria and Gram- It is a composition that exhibits excellent antimicrobial activity against bacterium and has low toxicity and extremely weak side effects.
  • the composition comprises-Gram-positive bacteria such as, for example, Staphylococci, Streptococci, Diphtheria, Mycobacterium tuberculosis, Clostridium, Neisseria, Escherichia, Citrobacter, Salmonella, Gram-negative bacteria such as Shigella, Klebsiella and Pseudomonas, Clostridium, Peptococcus. Anaerobic bacteria such as Peptostreptococcus, Propionibacterium, Pacteroides, etc.
  • composition of the present invention exhibits excellent antimicrobial activity not only for standard strains but also for clinical strains.
  • composition D of the present invention is resistant to bacteria resistant to various antibiotics such as bencilin, septum quinolone, aminoglycoside, macrolide, and tetracycline, and to clinically isolated bacteria. Also exhibit excellent antimicrobial activity. Particularly, MRSA and MRSE exhibit a remarkable bactericidal effect.
  • the composition of the present invention provides a multi-drug resistance with quino-mouth resistance, aminoglycoside resistance, macrolide resistance, tetracycline resistance, etc. It is also effective for sex MRSA and MRSE.
  • the bactericidal action of hinokitiol or a salt thereof is further enhanced in order to suppress the reversal phenomenon of hinokitiol or a salt thereof, which is recognized in Staphylococcus sp. Can be increased.
  • the hinokitiol-containing polyester container composition of the present invention for pharmaceuticals and cosmetics, there is further provided a liquid, a gel, an ointment, a cream, and a liquid containing a hydrocarbon and a fatty acid ester together with hinokitiol and a salt thereof.
  • a hinokitiol-containing polyester container composition characterized by filling an oily composition (hereinafter referred to as “composition E”) into a polyester container having a light-shielding property can be exemplified.
  • This composition E is non-greasy, has excellent usability, has good transdermal absorption, has excellent moisturizing properties, has low skin irritation, prevents skin dryness and is not hermetically sealed, thus helping to protect the skin.
  • skin diseases such as dry eczema in children, diaper rash, and seborrheic eczema in infants. It is especially useful for atopic dermatitis. In addition, it prevents secondary infection of skin diseases, and the composition itself has little microbial infection.
  • the hydrocarbon has 16 carbon atoms.
  • These may be solid, semi-solid or liquid at room temperature, but are preferably liquid and can be used alone or in combination of two or more.
  • Preferred examples thereof include liquid paraffin, light liquid paraffin, light liquid isoparaffin, heavy liquid isoparaffin, squalane (hexamethilte tracosan), squalene ( Hexametilte tracosa hexen), pristane, petrolatum, yellow petrolatum, white petrolatum, synthetic hydrocarbon wax, ⁇ -olefin oligomer, ceresin, paraffin, partially hydrogenated Examples include screens, microcrystalline wax, polyethylene powder, and the like, with squalane (hexamethilte tracosan) being particularly preferred.
  • the compounding amount of the above hydrocarbon is preferably 1 to 90% by weight, and more preferably 20 to 90% by weight, based on the total amount of the composition.
  • the fatty acid constituting the fatty acid ester is usually a fatty acid used in the fields of medicine and cosmetics.
  • saturated or unsaturated fatty acids having a straight-chain or side chain having 3 to 40 carbon atoms are usually preferable, and saturated or unsaturated fatty acids having a straight-chain or side chain having 8 to 20 carbon atoms are particularly preferable.
  • Unsaturated fatty acids are good.
  • the alcohol constituting the fatty acid ester is not particularly limited as long as it is a commonly used alcohol such as a monohydric alcohol or a polyhydric alcohol, and may be cholesterol, but usually has 1 to 40 carbon atoms.
  • a saturated or unsaturated monohydric alcohol having a linear or side chain or a polyhydric alcohol having 2 to 40 carbon atoms is preferable, and particularly a saturated or unsaturated monohydric alcohol having a linear or side chain having 2 to 20 carbon atoms is preferable.
  • Alcohols and polyhydric alcohols having 3 to 6 carbon atoms are preferred.
  • fatty acid esters include, for example, apo oil oil fatty acid ethyl ester, isostearic acid ethyl ester, oleic acid ethyl ester, mink oil fatty acid ethyl ester, linoleic acid ethyl ester and isopropyl oleate. , No ,.
  • Octyl dodecyl oleate Octyl dodecyl oleate, oleyl oleate, cetyl oleate, dimethyl octylol Octyl dodecyl acid.
  • esters may be solid, semi-solid or liquid at room temperature, but are preferably liquid and can be used alone or in combination of two or more.
  • a fatty acid ester composed of a linear or side chain saturated or unsaturated fatty acid having 8 to 20 carbon atoms and a linear or side chain saturated or unsaturated monohydric alcohol having 8 to 20 carbon atoms.
  • Fatty acid esters composed of cetyl isooctanoate and straight-chain or side-chain saturated or unsaturated fatty acids having 8 to 20 carbon atoms and glycerin, preferably triglyceride glycerin, particularly preferred.
  • the compounding amount of these esters is 1 to 90% by weight, preferably 20 to 90% by weight, based on the total amount of the composition E.
  • composition E any of the above-mentioned various hinokitiol salts can be used.
  • the content of hinokitiol or a salt thereof is 0.0001 to 20% by weight, preferably,
  • composition E 0.001 to; L is preferably 0% by weight.
  • various components can be added and blended as needed, as long as the performance is not impaired.
  • addition and mixing of zinc and copper compounds, especially zinc oxide further enhances the usefulness of composition E against skin diseases, especially atopic dermatitis.
  • composition E As described above, by placing composition E in a polyester container, as described above, hinokitiol or a salt thereof does not pass through the container wall, and in the case of a polyester to which a light-shielding agent is added, decomposition or the like by the light-shielding agent may occur.
  • the component is not adsorbed or adhered to the polyester container, and the excellent preservative effect inherent to hinokitiol is fully exhibited without any impairment. It also enhances sex. It is stable for a long period of time and has excellent safety.
  • the hinokitiol-containing polyester container composition of the present invention for pharmaceuticals and cosmetics, there is further provided one or more selected from polyhydric alcohol, sugar, sugar alcohol and polyhydric alcohol alkyl ether together with hinokitiol and a salt thereof.
  • Fill a liquid-, gel-, ointment-, cream- and oil-like composition (hereinafter referred to as "Composition F") containing at least two types of ethanol and pantothenyl alcohol in a light-shielding polyester container.
  • Composition F a liquid-, gel-, ointment-, cream- and oil-like composition
  • Hino An example is a polyester container composition containing a chithiol.
  • This composition F is non-greasy and has excellent usability, good transdermal absorption, excellent moisture retention, weak skin irritation, prevents skin dryness and is not hermetically sealed, thus helping to protect the skin
  • skin diseases such as dry eczema in children, diaper rash, and seborrheic eczema in infants.
  • skin diseases such as dry eczema in children, diaper rash, and seborrheic eczema in infants. It is especially useful for atopic dermatitis. In addition, it prevents secondary infection of skin diseases, and the composition itself has little microbial contamination. It also has an excellent antidandruff effect.
  • the polyhydric alcohol in this composition is not particularly limited as long as it is commonly used in this field, but is not limited to a straight-chain or 2-1000 carbon atom.
  • a saturated or unsaturated one having a side chain is preferred, and a saturated or unsaturated one having a straight or side chain having 3 to 6 carbon atoms is particularly preferred.
  • the sugar in the composition F is not particularly limited as long as it is commonly used, and any of monosaccharides, polysaccharides, amino sugars and the like can be used.
  • Typical examples are D-erythrose, D-threose, L-albinose, D-ribose, D-mannose, D-galactose, fructose, and L-sorbose.
  • L—Rhamnose, L—Rodeose, D—Ribodeose, D—Xylose, Darcosamine, Fructosamine, Trehalose, Sucrose, Cellopose, Gentiobiose, Melibiose, Lafinoose, Gentianose, melethose, stachyose, brown sugar, mixed isomerized sugar [diluted processed product of glucose: dilute processed product of lactose 19: 1], sucrose, simple syrup Pulp [sucrose 85%], lactose, glucose, maltose and the like, but are not limited thereto. Particularly preferred are sucrose, maltose and the like. As a rule, It is not particularly limited as long as it is commonly used in the field.
  • erythritol D-tolyl, L-arabinitol, adornitol, xylitol, L-sozolevitol, D-sorbitol, D-mannitol, dulcitol And L-ramitol, maltitol, triglucopolysaccharide and the like, but are not limited thereto, and D-sonorebitol is particularly preferable.
  • the polyhydric alcohol alkyl ether is not particularly limited as long as it is one commonly used in this field.
  • the dihydric alcohol is a saturated or unsaturated alcohol having a linear or side chain having 2 to 40 carbon atoms
  • the alkyl group of the alkyl ether has a linear or side chain having 2 to 40 carbon atoms.
  • the polyhydric alcohol is a saturated or unsaturated alcohol having a straight chain or a side chain having 2 to 6 carbon atoms and the alkyl group is a straight or side chain having 2 to 20 carbon atoms. It has.
  • ethylene glycol ether diethylene glycol ether, Ethylene glycol methyl ether, ethylene glycol monobutyl ether, glyceryl monocetyl ether, glyceryl monosteayl ether, glyceryl monooleyl ether, diglyceryl oleyl ether, patchyl monostearate, and butyl monoisostearate may be mentioned.
  • glyceryl monostearate ether, bacyl monostearate and the like are particularly preferable.
  • polyhydric alcohols, sugars, sugar alcohols and polyhydric alcohol alkyl ethers contain one or more selected from these, and it is particularly preferable to select one or more from polyhydric alcohols, especially concentrated glycerin. Is preferred.
  • the amount of these components is preferably 0.1 to 50% by weight, and preferably 0.5 to 10% by weight, based on the total amount of the composition F. o
  • the amount of ethanol used in combination with the above-mentioned polyhydric alcohols in the composition F is based on the total amount of the composition F.
  • the blending amount of pantothenyl alcohol used together is 0.01 to 10% by weight based on the total amount of the composition F, preferably Is preferably selected from the range of 0.1 to 5% by weight.
  • composition F any of the various hinokitiol salts described above can be used.
  • the content of hinokitiol or a salt thereof is 0.0001 to 20% by weight based on the total amount of composition F, preferably
  • composition F the above-mentioned various components can be added and blended as needed, as long as the performance is not impaired.
  • the addition and combination of zinc and copper compounds, especially zinc oxide further enhances the usefulness of composition F against skin diseases, especially atopic dermatitis.
  • composition F when the composition F is placed in a polyester container, hinokitiol or a salt thereof does not pass through the container wall, and even in the case of a polyester to which a light-shielding agent is added, decomposition is caused by the light-shielding agent.
  • the component is not adsorbed or adhered to the polyester container, and the excellent preservative effect inherent to hinokitiol is not exerted at all without being impaired at all. It also enhances sex. It is stable for a long period of time and has excellent safety.
  • a bottle composition was prepared by filling a bottle A with a shampoo composition having the following composition.
  • a body shampoo having the following composition was filled into bottle A and prepared.
  • Aranon ACE Surfactant manufactured by Kawaken Fine Chemicals Co., Ltd. and containing N-cocoil-1N-methyl-1-alanin sodium as a main component.
  • the face wash having the following composition was filled in a bottle A to prepare.
  • Aranon A LE Surfactant mainly composed of N-lauroyl-N-methyl-y5-alaninnadium, manufactured by Kawaken Fine Chemicals Co., Ltd.
  • EMANON 329 manufactured by Kao Corporation was used as the nonionic surfactant.
  • Example A-4 A wiping agent having the following composition was filled in bottle A and prepared.
  • Aranon AME manufactured by Kawaken Fine Chemical Co., Ltd., N-Myristyl-1 N-methyl-1; Surfactant containing S-alanin sodium as a main component
  • Hinokitiol Triol Ethanol amine salt 0.01
  • Hinokitiol * L-arginine salt 0.01 1 pH adjuster qs Dye, flavor, glycerin qs
  • Example A-6 Prepared by filling bottle A with a shampoo of the following formulation
  • the face wash composition having the above composition was filled in a bottle A and prepared.
  • Example A—11 prepared by filling a bottle A with a shampoo having the above composition.
  • the body shampoo having the above composition was filled into bottle A and prepared.
  • Tube B Polyethylene (thickness: 150 m) as the outermost layer, to which ethylene methacrylic acid copolymer
  • EMA A thickness 30 / zm
  • A1 thickness 20 ⁇ m
  • polyester thickness 15 5m
  • polyethylene thickness
  • Bottle A was prepared by filling the face wash composition having the above composition into the bottle A.
  • Example C-1 2 (Zinc flower ointment)
  • Hinokitiol sodium salt 0.05 g Glycerin 30.0 g Purified water 50.0 g Total 100 0 0.Og
  • (1) Hinokitiol sodium salt 0.05 g Glycerin 30.0 g Purified water 50.0 g Total 100 0 0.Og
  • (2) Hinokitiol sodium salt were heated to about 60 ° C and uniformly stirred and dissolved.
  • (2) The lipophilic glyceryl monostearate and white glycerin were dissolved on a water bath and stirred to form a mixture at 60 ° C.
  • the mixture prepared in the above (1) was added to the mixture prepared in the above (2) little by little, and the mixture was stirred uniformly, and cooled with stirring to about 40 ° C.
  • Zinc oxide was weighed into a mortar, and the mixture prepared in the above (3) was added little by little. Then, the mixture was stirred well until it was hardened to obtain the desired zinc white ointment.
  • 1,3-butylene glycol 3.0% Hinokitiol zinc 0.05% Hinokitiol 0.05% Dye appropriate amount Purified water residue Total 10.00.0% According to the above composition, (1) polyoxyethylene lauryl ether (9E0) Photosensitizer No. 201 and fragrance were added and dissolved uniformly. (2) Concentrated glycerin, 1,3-butylene glycol and zinc hinokitiol were added to purified water and uniformly dissolved. (3) At 80 ° C, add the mixture prepared in (2) to the mixture prepared in (1) above, uniformly mix and solubilize, add hinokitiol, color with a dye, I got a lotion. This was filled into bottle A.
  • Example C-1 8 (Zinc flower ointment)
  • the above components were mixed in purified water in a total amount of 10.0 g, and the mixture was filled in bottle A.
  • Methyl 1,3-propanediol salt 0 5 g Zinc chloride 04 g Total amount in purified water 0.00.0 g 8
  • Each of the above components was filled into bottle A.
  • Example C-1 5 Wipe, undiluted solution for aerosol
  • hinokitiol and copper oxide (1 is weighed, a part of lard is added, heated to about 40 ° C, and uniformly stirred and melted.
  • (2) Dissolve the remaining lard, beeswax and white petrolatum in a water bath and stir. This formed a mixture at 80 ° C.
  • (3) The zinc oxide was weighed into a mortar, and the mixture prepared in (2) was added little by little, stirred uniformly, and cooled under stirring until the temperature reached about 40 ° C.
  • the mixture prepared in the above (1) was added at about 40 ° C., and the mixture was stirred well until it was hardened to obtain a desired ointment.
  • the total amount was 100.0.0.
  • the mouth composition having the above composition was filled into a bottle A and prepared.
  • Each of the hinokitiol-containing polyester container compositions of the present invention obtained in each of the above examples was stored at 40 ° C for 2 months, and the residual ratio of hinokitiol in each composition was determined by the following formula. The storage stability of the product was examined.
  • the storage stability was evaluated according to the following criteria.
  • Example B 2 Alaninate LN—3 0 50.0 Snoll AM—3 1 3 0 N 45.0 Maltitol 0.3 Polyethylene glycol 6 0 0 0 0.5 Ph pH adjuster 0 .3 Ethanol 1.96 Hinokitiol 0.04 mouth n 1 1 0 0
  • Example c-1-1 Example c-1-2 Hinokitiol 0.050.0 1 Lardum 20.0 0.00 Sarah beetroot 6.00 0 Zinc oxide 10.0.100.0 Leap oil 0 10.0 White white cellulose Total 1 0 0 1 0 0
  • Each comparative example in Tables 2 and 3 shows a composition prepared by filling a comparative bottle (bottle B or C described above) with a composition having the same composition as the corresponding example.
  • a detergent composition having the composition shown in Table 5 below was prepared by adding and blending hinokitiol as a preservative component, and each of these was filled into bottles A to C, and heated at 40 ° C. After storing for a month, the residual ratio of hinokitiol in each composition was determined in the same manner as in Test Example 1, and the storage stability of each composition was evaluated in the same manner.
  • composition thus obtained had a high residual ratio of the water-insoluble components after long-term storage.
  • composition thus obtained had a high residual ratio of the water-insoluble components after long-term storage.
  • composition of the present invention sufficiently exerts the excellent preservative effect inherent in the preservative component contained therein in the fields of pharmaceuticals, quasi-drugs, cosmetics, agrochemicals, foods, and the like, and is stable for a long time. It is also excellent in safety.

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  • Health & Medical Sciences (AREA)
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  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
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Abstract

Composition contenant du hinokitiol ou un sel de ladite substance, placée dans un récipient de polyester interceptant la lumière. Ladite composition présente les excellentes caractéristiques antiseptiques inhérentes à l'antiseptique qu'elle contient, elle est stable pendant une longue durée et présente une excellente sécurité.
PCT/JP1995/001175 1994-06-15 1995-06-12 Composition contenant du hinokitiol, placee dans un recipient de polyester WO1995034210A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019960700746A KR960703517A (ko) 1994-06-15 1995-06-12 폴리에스테르 용기에 충진된 히노키티올-함유 조성물(hinokitiol-containing composition filled in polyester vessel)
AU26311/95A AU2631195A (en) 1994-06-15 1995-06-12 Hinokitiol-containing composition filled in polyester vessel

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP6/132905 1994-06-15
JP13290594 1994-06-15
JP6/291360 1994-11-25
JP29136094 1994-11-25

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WO1995034210A1 true WO1995034210A1 (fr) 1995-12-21

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CN (1) CN1131900A (fr)
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WO (1) WO1995034210A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000510168A (ja) * 1996-04-17 2000-08-08 ユニリーバー・ナームローゼ・ベンノートシヤープ 洗浄剤組成物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01305021A (ja) * 1988-06-02 1989-12-08 Lion Corp 口腔用組成物
JPH0269411A (ja) * 1988-09-05 1990-03-08 Lion Corp 歯磨組成物
JPH0363216A (ja) * 1989-08-02 1991-03-19 Kansai Paint Co Ltd 皮膚洗浄料
WO1992005240A1 (fr) * 1990-09-14 1992-04-02 Otsuka Pharmaceutical Co., Ltd. Composition detergente
JPH05178753A (ja) * 1991-11-12 1993-07-20 Hinoki Shinyaku Kk 皮膚▲そう▼痒症用の外用剤
JPH05214364A (ja) * 1992-02-05 1993-08-24 Otsuka Pharmaceut Co Ltd 洗浄剤組成物
WO1993017559A1 (fr) * 1992-03-13 1993-09-16 Otsuka Pharmaceutical Co., Ltd. Procede de traitement de maladies infectieuses, procede permettant d'empecher la putrefaction des produits cosmetiques, et produit cosmetique et agent antibacteriens/antifongiques

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01305021A (ja) * 1988-06-02 1989-12-08 Lion Corp 口腔用組成物
JPH0269411A (ja) * 1988-09-05 1990-03-08 Lion Corp 歯磨組成物
JPH0363216A (ja) * 1989-08-02 1991-03-19 Kansai Paint Co Ltd 皮膚洗浄料
WO1992005240A1 (fr) * 1990-09-14 1992-04-02 Otsuka Pharmaceutical Co., Ltd. Composition detergente
JPH05178753A (ja) * 1991-11-12 1993-07-20 Hinoki Shinyaku Kk 皮膚▲そう▼痒症用の外用剤
JPH05214364A (ja) * 1992-02-05 1993-08-24 Otsuka Pharmaceut Co Ltd 洗浄剤組成物
WO1993017559A1 (fr) * 1992-03-13 1993-09-16 Otsuka Pharmaceutical Co., Ltd. Procede de traitement de maladies infectieuses, procede permettant d'empecher la putrefaction des produits cosmetiques, et produit cosmetique et agent antibacteriens/antifongiques

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000510168A (ja) * 1996-04-17 2000-08-08 ユニリーバー・ナームローゼ・ベンノートシヤープ 洗浄剤組成物

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CN1131900A (zh) 1996-09-25
AU2631195A (en) 1996-01-05

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