WO1994009801A1 - Piegeur de radicaux libres d'oxygene actif - Google Patents

Piegeur de radicaux libres d'oxygene actif Download PDF

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Publication number
WO1994009801A1
WO1994009801A1 PCT/JP1993/001525 JP9301525W WO9409801A1 WO 1994009801 A1 WO1994009801 A1 WO 1994009801A1 JP 9301525 W JP9301525 W JP 9301525W WO 9409801 A1 WO9409801 A1 WO 9409801A1
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WO
WIPO (PCT)
Prior art keywords
active oxygen
oxygen free
group
green tea
free active
Prior art date
Application number
PCT/JP1993/001525
Other languages
English (en)
Japanese (ja)
Inventor
Keiichi Togasaki
Original Assignee
Sky. Food Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Sky. Food Co., Ltd. filed Critical Sky. Food Co., Ltd.
Priority to AU52861/93A priority Critical patent/AU5286193A/en
Publication of WO1994009801A1 publication Critical patent/WO1994009801A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to an active oxygen free radical scavenger that eliminates active oxygen free radicals generated in metabolic systems in living organisms. You.
  • the active oxygen free radicals generated in the metabolic system in living organisms include nucleic acid, tannic acid, nucleotides, amino acids, sugars, It is known that it attacks organic acids, etc., and has a profound effect on arterial sclerosis, stroke, carcinogenesis, radiation damage, cataracts, aging, etc. It has been done.
  • the present invention provides an active oxygen free radical capable of effectively eliminating active oxygen free radicals generated in the body. It was intended to provide an eradicating agent.
  • the present invention provides a green tea leaf extract containing epigallocate kingallate,
  • the inventor of the present application has measured the elimination effect of active oxygen radicals on various chemical substances, and as a result, When green tea leaf extract containing gallettes and chinoku chinoid pigments were administered at the same time, they were It was found that the elimination action of active oxygen free radicals was dramatically improved as compared to the case of administering alone.
  • the carotenoid pigment is derived from animal tissue and plant tissue, for example, 5) force Taxanchin, cantaxanthin, etc., and their various isomers (eg, S—force rotin) Includes all types such as transformer, 9-cis, 13-cis, and 15-cis.
  • the present invention contains a green tea leaf extract containing epigallocate kingaret and a carotenoid chromophore, it has an active acid. It has good erasing action for elementary free radicals.
  • the amount of green tea leaf extract and carotenoid pigments to be mixed is, for example, when these are dispersed in water, the extract of green tea leaves and It is preferable to use 0 to 10.00.0% by weight for both rotinoid pigments, and more preferred are ascorbic acid, vitamin E, and Himawari. It may be supplemented with antioxidant fragrances such as seed extract.
  • Examples of the method of dispersing are, for example, xanthan gam, guar gam, carboxymethylcellulose, saponin, and fatty acid
  • the method of adding ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ , ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ .
  • the amount of each compound can be freely selected, and is the same as that when dispersed in water.
  • lactose may be supplemented with antioxidant compounds such as ascorbic acid, vitamin E, and sunflower seed extract.
  • antioxidant compounds such as ascorbic acid, vitamin E, and sunflower seed extract.
  • FIG. 1 is a graph showing the action of the active oxygen free radical scavenger of the embodiment.
  • Experimental animal Male Wistar rat, 6 weeks old.
  • Experimental method The test samples shown in the following experimental sections were distributed in 25 rats per each experimental section (the eight-week oral route was provided by two cate- ters).
  • the active oxygen free radical alpha diet was a solid feed MF as a basic feed. (Trade name: Oriental Yeast Co., Ltd.) with 5% by weight of linoleic acid as an additive Q.
  • Green tea leaves The extract is obtained by extracting Japanese green tea leaves with ethyl acetate and then filtering and powdering the green tea leaves. It is 98%, and contains epigallocate kin gallate as the main component, but the minute component is unknown. Eleven
  • TBA reaction amount The amount of active oxygen free radicals in the blood every two weeks while administering the above-mentioned sample. Observation of the changes in the TBA reaction amount) ⁇ Fig. 1 shows the observation results.
  • the method for measuring the above-mentioned active oxygen free radical amount (TBA reaction amount) is as shown below. --Rats were subjected to ether anesthesia, and blood was recollected from the inferior major artery in the presence of EDTA (ethylendiamine tetraacetic acid); to its blood The plasma collected by centrifugation is reacted with TBA (thionolbituric acid), and activated oxygen is determined by colorimetric determination. The free radical (TBA reaction) was measured.
  • the method for measuring the TBA reaction (the amount of active oxygen free radicals (TBA reaction)) is the method of Yagi et al. ⁇ hkawa,
  • active oxygen free radical boosting and erosion were administered, and despite this, about 2.
  • the green tea leaf extract and the active oxygen free radical scavenger of the example containing S-potassin were administered. By doing so, it is possible to effectively prevent linoleic acid from becoming an oxide and causing radical oxidation of active oxygen.
  • the amount of active oxygen free radicals (TBA reaction) in the second group, to which only the basic feed was administered was greater than that in the fifth group in this example. The increase was mainly due to the fact that mainly the fats contained in the basic feed became peroxidized in the body, and the active oxygen was radicalized. It is considered that.
  • the active oxygen free radical scavenger of the example was obtained by the administration of the active oxygen free radical in the organism.
  • the active oxygen free radical scavenger of the present embodiment is suitable for the active oxygen free radical scavenger. It can prevent illness, stroke, carcinogenesis of arterial arteries, radiation disorder, cataract, aging, etc.
  • the active oxygen free radical scavenger of the present embodiment can be used as a natural food additive as described below. As a result, its use in industry is remarkably wide.
  • the active oxygen free radical scavenger of this example is Himawari seed extract, ascorbic acid, and alpha. It can be mixed easily with tocopherols, etc. --It is possible to produce beverages, foods, etc. as shown in the above application examples without reducing the operation of the lever. Also, since tea and) 3-carotene have been eaten and consumed as food since ancient times, the active oxygen free radicals used in this example were used. It is said that the exfoliant is extremely safe.
  • jS—carotene is used as a carotenoid pigment, and other carotenoid pigments are used.
  • the same effect can be obtained by using, for example, a taxan shuntin or a tantaxanthin.
  • the same active oxygen free-radical elimination beverage and active oxygen free radical elimination food are manufactured. be able to.
  • the active oxygen free radical scavenger of the present invention is a green tea leaf extract containing epigallocate kingaret. And the Carotenoid pigment. These have active oxygen free radical razor elimination action alone, but their action is scarce and they must be mixed. This operation is dramatically higher. -1-In addition, the therapeutic and preventive effects become practical. That is, the active oxygen free radical scavenger of the present invention is used for arterial scleritis, stroke, carcinogenesis, radiation damage, cataract, and senility. Active oxygen free radicals that cause daggers can be satisfactorily erased. In addition, tea and carotenoid pigments have been eaten and consumed as foods since ancient times. It is said that the exfoliant is extremely safe.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Est décrit un piégeur de radicaux libres d'oxygène actif, s'utilisant pour éliminer efficacement des radicaux libres d'oxygène actif produits in vivo. Bien que le groupe 3 de rats nourris avec un régime enrichi avec des espèces de radicaux libres d'oxygène actif et de la β-carotène, et que le groupe 4 de rats nourris avec le régime enrichi et un extrait de feuilles de thé vert aient présentés une réduction de la teneur en radicaux libres d'oxygène actif (valeur de réaction ATB), dans une certaine mesure, par rapport au groupe 1 de rats nourris avec uniquement le régime enrichi, une augmentation importante de la teneur en radicaux (valeur de réaction ATB) a été observée après 8 semaines. Le groupe 2 de rats nourris avec un régime de base n'a pas subi de changement notable à cet égard. En revanche, le groupe 5 de rats nourris avec le régime enrichi, la β-carotène, et l'extrait de feuilles de thé vert a présenté une réduction de la teneur en radicaux (valeur de réaction ATB). Ainsi, l'administration simultanée de β-carotène et d'extrait de feuilles de thé vert permet de piéger efficacement les radicaux libres d'oxygène actif.
PCT/JP1993/001525 1992-11-04 1993-10-21 Piegeur de radicaux libres d'oxygene actif WO1994009801A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52861/93A AU5286193A (en) 1992-11-04 1993-10-21 Free active oxygen radical scavenger

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4/295336 1992-11-04
JP4295336A JPH07112980B2 (ja) 1992-11-04 1992-11-04 活性酸素フリーラジカル消去剤

Publications (1)

Publication Number Publication Date
WO1994009801A1 true WO1994009801A1 (fr) 1994-05-11

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ID=17819300

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1993/001525 WO1994009801A1 (fr) 1992-11-04 1993-10-21 Piegeur de radicaux libres d'oxygene actif

Country Status (3)

Country Link
JP (1) JPH07112980B2 (fr)
AU (1) AU5286193A (fr)
WO (1) WO1994009801A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659402A2 (fr) * 1993-12-21 1995-06-28 INDENA S.p.A. Compositions contenant de caroténoides et de procaroténoides en association avec des polyphénoles pour la prévention de dommages provoqués par la production anormale des radicaux libres
DE19733892C2 (de) * 1996-09-09 2002-06-20 Hadasit Med Res Service Bestrahlungsschutz-Verfahren
WO2002081027A1 (fr) * 2001-04-10 2002-10-17 Natura Cosméticos S.A. Composition antioxydante et composition cosmetique ou pharmaceutique
US6576660B1 (en) 1997-10-31 2003-06-10 Arch Development Corporation Methods and compositions for regulation of 5-α-reductase activity
WO2004012522A1 (fr) * 2002-07-26 2004-02-12 Dsm Ip Assets B.V. Compositions comprenant une lactoferrine
US6696484B2 (en) 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
EP1072254A4 (fr) * 1998-04-24 2005-01-05 Sunstar Inc Compositions alimentaires, compositions orales et compositions medicinales servant a prevenir ou traiter la parodontose et procede de prevention ou de traitement de la parodontose
US20140363529A1 (en) * 2013-06-07 2014-12-11 The Hershey Company Compounds influencing fatty acid uptake and metabolism and methods of isolating from cocoa products

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2718653B2 (ja) * 1995-01-31 1998-02-25 日本配合飼料株式会社 新規卵および卵質改良方法
KR20000061483A (ko) * 1999-03-26 2000-10-25 유상옥 해바라기 씨 추출물을 함유한 자유라디칼 소거용 화장료 조성물
GB0026018D0 (en) 2000-10-24 2000-12-13 Novartis Nutrition Ag New composition
KR101398747B1 (ko) 2004-08-19 2014-05-26 디에스엠 아이피 어셋츠 비.브이. 지용성 물질의 신규한 조성물
BRPI0404331A (pt) * 2004-09-24 2006-05-16 Natura Cosmeticos Sa complexo antioxidante e composição cosmética e farmacêutica compreendendo o referido complexo
JP4564471B2 (ja) * 2006-07-06 2010-10-20 株式会社コーセー 外用に適する組成物
EP1958611A1 (fr) * 2006-12-20 2008-08-20 DSMIP Assets B.V. Composition orale contenant du EGCG et du lycopène

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5945385A (ja) * 1982-09-09 1984-03-14 Kiyouiku Bunka Kenkyusho 抗酸化剤
JPS6425726A (en) * 1987-04-24 1989-01-27 Yuutoku Yakuhin Kogyo Kk Agent for eliminating active oxygen free radical
JPH02264720A (ja) * 1989-04-04 1990-10-29 Nikken Food Kk 抗酸化的ストレス物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5945385A (ja) * 1982-09-09 1984-03-14 Kiyouiku Bunka Kenkyusho 抗酸化剤
JPS6425726A (en) * 1987-04-24 1989-01-27 Yuutoku Yakuhin Kogyo Kk Agent for eliminating active oxygen free radical
JPH02264720A (ja) * 1989-04-04 1990-10-29 Nikken Food Kk 抗酸化的ストレス物

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659402A2 (fr) * 1993-12-21 1995-06-28 INDENA S.p.A. Compositions contenant de caroténoides et de procaroténoides en association avec des polyphénoles pour la prévention de dommages provoqués par la production anormale des radicaux libres
EP0659402A3 (fr) * 1993-12-21 1996-12-18 Indena Spa Compositions contenant de caroténoides et de procaroténoides en association avec des polyphénoles pour la prévention de dommages provoqués par la production anormale des radicaux libres.
DE19733892C2 (de) * 1996-09-09 2002-06-20 Hadasit Med Res Service Bestrahlungsschutz-Verfahren
US6576660B1 (en) 1997-10-31 2003-06-10 Arch Development Corporation Methods and compositions for regulation of 5-α-reductase activity
US6696484B2 (en) 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
EP1072254A4 (fr) * 1998-04-24 2005-01-05 Sunstar Inc Compositions alimentaires, compositions orales et compositions medicinales servant a prevenir ou traiter la parodontose et procede de prevention ou de traitement de la parodontose
WO2002081027A1 (fr) * 2001-04-10 2002-10-17 Natura Cosméticos S.A. Composition antioxydante et composition cosmetique ou pharmaceutique
WO2004012522A1 (fr) * 2002-07-26 2004-02-12 Dsm Ip Assets B.V. Compositions comprenant une lactoferrine
US20140363529A1 (en) * 2013-06-07 2014-12-11 The Hershey Company Compounds influencing fatty acid uptake and metabolism and methods of isolating from cocoa products

Also Published As

Publication number Publication date
AU5286193A (en) 1994-05-24
JPH07112980B2 (ja) 1995-12-06
JPH06145062A (ja) 1994-05-24

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