WO1993024142A1 - New pharmaceutical uses of krill enzymes - Google Patents

New pharmaceutical uses of krill enzymes Download PDF

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Publication number
WO1993024142A1
WO1993024142A1 PCT/SE1993/000455 SE9300455W WO9324142A1 WO 1993024142 A1 WO1993024142 A1 WO 1993024142A1 SE 9300455 W SE9300455 W SE 9300455W WO 9324142 A1 WO9324142 A1 WO 9324142A1
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WO
WIPO (PCT)
Prior art keywords
treatment
phim
days
infections
protein
Prior art date
Application number
PCT/SE1993/000455
Other languages
English (en)
French (fr)
Inventor
Ragnvald Lindblom
Johan De Faire
Original Assignee
Phairson Medical Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1019940704201A priority Critical patent/KR100290266B1/ko
Priority to DK93910549T priority patent/DK0642351T3/da
Priority to EP93910549A priority patent/EP0642351B1/en
Priority to SK1405-94A priority patent/SK140594A3/sk
Priority to JP6500454A priority patent/JPH08501068A/ja
Priority to DE69331739T priority patent/DE69331739T2/de
Application filed by Phairson Medical Ab filed Critical Phairson Medical Ab
Priority to AU41000/93A priority patent/AU675942B2/en
Priority to CA002136331A priority patent/CA2136331C/en
Priority to AT93910549T priority patent/ATE214610T1/de
Publication of WO1993024142A1 publication Critical patent/WO1993024142A1/en
Priority to NO944448A priority patent/NO944448L/no
Priority to US10/750,184 priority patent/US7947270B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P27/02—Ophthalmic agents
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    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Birds (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
PCT/SE1993/000455 1992-05-22 1993-05-21 New pharmaceutical uses of krill enzymes WO1993024142A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DK93910549T DK0642351T3 (da) 1992-05-22 1993-05-21 Nye farmaceutiske anvendelser af krillenzymer
EP93910549A EP0642351B1 (en) 1992-05-22 1993-05-21 New pharmaceutical uses of krill enzymes
SK1405-94A SK140594A3 (en) 1992-05-22 1993-05-21 Manufacture and application of non-immunogenic enzymatic pharmaceutical agents isolated from antarctic krill
JP6500454A JPH08501068A (ja) 1992-05-22 1993-05-21 クリル酵素の新規な薬学的用法
DE69331739T DE69331739T2 (de) 1992-05-22 1993-05-21 Neuartige pharmazeutische verwendungen von krill-enzymen
KR1019940704201A KR100290266B1 (ko) 1992-05-22 1993-05-21 크릴 효소의 신규 제약상 용도
AU41000/93A AU675942B2 (en) 1992-05-22 1993-05-21 New pharmaceutical uses of krill enzymes
CA002136331A CA2136331C (en) 1992-05-22 1993-05-21 New pharmaceutical uses of krill enzymes
AT93910549T ATE214610T1 (de) 1992-05-22 1993-05-21 Neuartige pharmazeutische verwendungen von krill- enzymen
NO944448A NO944448L (no) 1992-05-22 1994-11-21 Nye farmasöytiske anvendelser av krill-enzymer
US10/750,184 US7947270B2 (en) 1992-05-22 2003-12-31 Removing dental plaque with krill enzymes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9201628-6 1992-05-22
SE9201628A SE9201628D0 (sv) 1992-05-22 1992-05-22 Pharmaceutical composition

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US08338501 A-371-Of-International 1993-05-21
US08/385,540 Continuation-In-Part US5945102A (en) 1992-05-22 1995-02-08 Crustacean and fish derived multifunctional enzyme

Publications (1)

Publication Number Publication Date
WO1993024142A1 true WO1993024142A1 (en) 1993-12-09

Family

ID=20386327

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1993/000455 WO1993024142A1 (en) 1992-05-22 1993-05-21 New pharmaceutical uses of krill enzymes

Country Status (18)

Country Link
EP (3) EP0838213B1 (es)
JP (2) JPH08501068A (es)
KR (1) KR100290266B1 (es)
CN (1) CN1090507C (es)
AT (2) ATE214610T1 (es)
AU (1) AU675942B2 (es)
CA (2) CA2136331C (es)
CZ (1) CZ286794A3 (es)
DE (2) DE69333931T2 (es)
DK (1) DK0642351T3 (es)
ES (2) ES2255097T3 (es)
HU (1) HUT69989A (es)
NO (1) NO944448L (es)
RU (1) RU94046254A (es)
SE (1) SE9201628D0 (es)
SK (1) SK140594A3 (es)
WO (1) WO1993024142A1 (es)
ZA (1) ZA933598B (es)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014489A1 (en) * 1993-11-22 1995-06-01 Phairson Medical Inc. Composition comprising compounds for use as therapeutical agent
WO1995033471A1 (en) * 1994-06-07 1995-12-14 Hellgren, Lars Intravasal thrombolysis
WO1995033470A1 (en) * 1994-06-07 1995-12-14 Kristian Hellgren Composition for dental use comprising krill enzyme
WO1996024371A1 (en) * 1995-02-08 1996-08-15 Phairson Medical, Inc. Multifunctional enzyme
US5945102A (en) * 1994-11-22 1999-08-31 Phairson Medical Inc. Crustacean and fish derived multifunctional enzyme
US5958406A (en) * 1994-11-22 1999-09-28 Phairson Medical Inc. Acne treatment with multifunctional enzyme
US6040155A (en) * 1996-08-28 2000-03-21 Kay; John Multifunctional protein and DNA sequence encoding same
US6232088B1 (en) 1995-02-08 2001-05-15 Phairson Medical, Inc. Treatment and prevention of immune rejection reactions
EP1553913A1 (en) * 2002-06-14 2005-07-20 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
WO2006065521A3 (en) * 2004-12-16 2006-07-27 Colgate Palmolive Co Oral compositions for prevention and reduction of bacterial adhesion to oral surfaces
US7947270B2 (en) 1992-05-22 2011-05-24 Arcimboldo Ab Removing dental plaque with krill enzymes
US8372812B2 (en) 2009-02-26 2013-02-12 Aker Biomarine Asa Phospholipid and protein tablets
US8697138B2 (en) 2007-03-28 2014-04-15 Aker Biomarine As Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders
US8894977B2 (en) 2004-12-16 2014-11-25 Colgate-Palmolive Company Oral treatment compositions containing an anti-adhesion agent, antibacterial agent and incompatible compound
US9028877B2 (en) 2007-03-28 2015-05-12 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9867856B2 (en) 2014-01-10 2018-01-16 Aker Biomarine Antarctic As Phospholipid compositions and their preparation
US10456412B2 (en) 2015-02-11 2019-10-29 Aker Biomarine Antarctic As Lipid extraction processes
US10704011B2 (en) 2013-06-14 2020-07-07 Aker Biomarine Antarctic As Lipid extraction processes
US10864223B2 (en) 2015-02-11 2020-12-15 Aker Biomarine Antarctic As Lipid compositions

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10237317B4 (de) 2002-08-15 2010-04-08 3M Espe Ag Enzymhaltige Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung
US7332179B2 (en) 2003-12-12 2008-02-19 Kimberly-Clark Worldwide, Inc. Tissue products comprising a cleansing composition
EP1600141B1 (en) 2004-05-24 2013-04-17 3M Deutschland GmbH Collagenolytic active enzyme containing compositions for the treatment of dental caries
US7642395B2 (en) 2004-12-28 2010-01-05 Kimberly-Clark Worldwide, Inc. Composition and wipe for reducing viscosity of viscoelastic bodily fluids
CN113429458B (zh) * 2021-08-03 2022-07-01 浙江海洋大学 一种抑制二肽基肽酶iv功能的南极磷虾降血糖寡肽及用途

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0170115A1 (en) * 1984-07-20 1986-02-05 Kao Corporation Thrombus dissolvent

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EP0107634B1 (en) * 1982-10-25 1989-04-12 Lars Gustav Inge Hellgren Enzyme composition for cleaning, the use thereof and preparation of the composition
JP2568833B2 (ja) * 1987-02-27 1997-01-08 大洋香料株式会社 う蝕予防剤
JPS63218610A (ja) * 1987-03-09 1988-09-12 Hayashikane Sangyo Kk プロテア−ゼ配合化粧品
JPH06168418A (ja) * 1992-11-26 1994-06-14 Matsushita Electric Ind Co Ltd 薄膜磁気ヘッド

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0170115A1 (en) * 1984-07-20 1986-02-05 Kao Corporation Thrombus dissolvent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Dialog Information Services, file 347, Japio, Dialog Accession No. 01854319, HARA KENJI et al.: "Anti-inflammatory Agent", Section: C, Section No. 366, Vol. 10, No. 235, pg. 85, August 14, 1986 (19860814). *

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947270B2 (en) 1992-05-22 2011-05-24 Arcimboldo Ab Removing dental plaque with krill enzymes
WO1995014489A1 (en) * 1993-11-22 1995-06-01 Phairson Medical Inc. Composition comprising compounds for use as therapeutical agent
AU700252B2 (en) * 1994-06-07 1998-12-24 Antarctic Pharma Ab Composition for dental use comprising krill enzyme
WO1995033471A1 (en) * 1994-06-07 1995-12-14 Hellgren, Lars Intravasal thrombolysis
WO1995033470A1 (en) * 1994-06-07 1995-12-14 Kristian Hellgren Composition for dental use comprising krill enzyme
US6030612A (en) * 1994-11-22 2000-02-29 Phairson Medical Inc. Antimicrobial uses of multifunctional enzyme
US5945102A (en) * 1994-11-22 1999-08-31 Phairson Medical Inc. Crustacean and fish derived multifunctional enzyme
US5958406A (en) * 1994-11-22 1999-09-28 Phairson Medical Inc. Acne treatment with multifunctional enzyme
EP0810875A4 (en) * 1995-02-08 1999-09-01 Phairson Medical Inc MULTIFUNCTIONAL ENZYME
EP0810875A1 (en) * 1995-02-08 1997-12-10 Phairson Medical Inc. Multifunctional enzyme
WO1996024371A1 (en) * 1995-02-08 1996-08-15 Phairson Medical, Inc. Multifunctional enzyme
US6232088B1 (en) 1995-02-08 2001-05-15 Phairson Medical, Inc. Treatment and prevention of immune rejection reactions
CN1090505C (zh) * 1995-02-08 2002-09-11 费尔森医疗有限公司 多功能酶
US6040155A (en) * 1996-08-28 2000-03-21 Kay; John Multifunctional protein and DNA sequence encoding same
EP1553913A4 (en) * 2002-06-14 2007-01-10 Carol J Buck COMPOSITIONS AND METHODS FOR ACQUIRING, THINNING AND REMOVING HYPERKERATOTIC TISSUE
EP1553913A1 (en) * 2002-06-14 2005-07-20 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
WO2006065521A3 (en) * 2004-12-16 2006-07-27 Colgate Palmolive Co Oral compositions for prevention and reduction of bacterial adhesion to oral surfaces
AU2005316918B2 (en) * 2004-12-16 2011-12-08 Colgate-Palmolive Company Oral compositions for prevention and reduction of bacterial adhesion to oral surfaces
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DE69333931D1 (de) 2006-01-12
DE69331739T2 (de) 2002-11-14
NO944448L (no) 1995-01-23
HU9403343D0 (en) 1995-02-28
NO944448D0 (no) 1994-11-21
KR100290266B1 (ko) 2001-05-15
JP2000351734A (ja) 2000-12-19
AU675942B2 (en) 1997-02-27
ES2173887T3 (es) 2002-11-01
DK0642351T3 (da) 2002-07-15
EP0838213B1 (en) 2005-12-07
JPH08501068A (ja) 1996-02-06
DE69333931T2 (de) 2006-09-07
EP0824910A2 (en) 1998-02-25
CA2306952A1 (en) 1993-12-09
CA2136331C (en) 2005-08-30
ZA933598B (en) 1993-12-13
CZ286794A3 (en) 1995-08-16
JP4012665B2 (ja) 2007-11-21
HUT69989A (en) 1995-09-28
SK140594A3 (en) 1996-10-02
EP0838213A1 (en) 1998-04-29
DE69331739D1 (de) 2002-04-25
SE9201628D0 (sv) 1992-05-22
ATE311853T1 (de) 2005-12-15
CA2136331A1 (en) 1993-12-09
ATE214610T1 (de) 2002-04-15
EP0642351A1 (en) 1995-03-15
EP0824910A3 (en) 1998-03-04
CN1090507C (zh) 2002-09-11
AU4100093A (en) 1993-12-30
RU94046254A (ru) 1996-11-20
ES2255097T3 (es) 2006-06-16
CN1089505A (zh) 1994-07-20
EP0642351B1 (en) 2002-03-20

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