WO1993001774A1 - Dispositif hyperthermique - Google Patents

Dispositif hyperthermique Download PDF

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Publication number
WO1993001774A1
WO1993001774A1 PCT/DE1992/000582 DE9200582W WO9301774A1 WO 1993001774 A1 WO1993001774 A1 WO 1993001774A1 DE 9200582 W DE9200582 W DE 9200582W WO 9301774 A1 WO9301774 A1 WO 9301774A1
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WO
WIPO (PCT)
Prior art keywords
shaft
prostate
area
probe
coating
Prior art date
Application number
PCT/DE1992/000582
Other languages
German (de)
English (en)
Inventor
Alfred BÖCKMANN
Original Assignee
Boeckmann Alfred
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boeckmann Alfred filed Critical Boeckmann Alfred
Publication of WO1993001774A1 publication Critical patent/WO1993001774A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00142—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with means for preventing contamination, e.g. by using a sanitary sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00274—Prostate operation, e.g. prostatectomy, turp, bhp treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00547—Prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water

Definitions

  • the present invention relates to a hyperthermic device for the treatment of prostate ailments.
  • Such ailments occur comparatively frequently, particularly in older men. They are caused by the fact that the prostate located below the bladder begins to proliferate, these proliferations mostly being of a benign nature. They lead to problems with urination and, in the worst case, to the fact that this is impossible without external aids.
  • prostate hypertrophy in which the prostate is heated locally above the body temperature. If such treatment is used repeatedly (e.g. ten times an hour), it causes the tissue of the diseased enlarged prostate to soften and thus enables more painless urination, and in some cases a reduction in the size of the prostate has also been observed.
  • microwave transmitters may have a range that is too great, so that under certain circumstances tissue is heated which is not necessary at all. This is particularly disadvantageous since the tissue areas in question have no heat receptors, so that the correct effect of the probe cannot be felt by the patient. This applies both to the effective depth of the microwave radiation and to the direction of the radiation. Control by the attending doctor is therefore necessary.
  • a device for the treatment of the protasta which in this case has a probe that can be inserted into the urethra and in the head of which an electric heating device is provided. This emits heat in the form of intermittent heat pulses of adjustable size. The temperature increase is determined with a sensor, which is also arranged in the probe head and which switches off the heating device when a maximum temperature is reached.
  • an electrical heating device for the treatment of prostate ailments which has an insertable plastic probe with an electrically conductive coating.
  • a thermostat is provided for temperature control. Both devices cannot be used essentially without medical help; moreover, the temperature control is insufficient, so that tissue damage, in particular epidermis damage, cannot be ruled out. Long-term and therefore effective heat treatments are not possible with such devices without risk.
  • the object of the present invention is to provide a hyperthermia device which has a simple and safe structure and which can be applied by the user himself, whereby this application should of course be preceded by an examination by the doctor, likewise a first application by the doctor and a detailed instruction with information on further self-treatment.
  • the prostate is treated with directed heat radiation; it is also envisaged to cool the shaft to be inserted into the rectum in areas that are not directed against the prostate.
  • the temperature- Setting is preferably carried out with the aid of a temperature sensor which is arranged in the front region of the shaft facing the prostate and directly determines the temperature on the outer region of the shaft. In this way, overheating is excluded.
  • FIG. 2 shows a perspective view of the hyperthermia device according to the invention
  • FIG. 3 shows a side view of the device according to the invention
  • Fig. 7 shows the temperature profile in the longitudinal direction
  • 10 shows a section through a modified shaft of a hyperthermia device with an infrared radiator
  • 11 shows a section through a modified shaft of a hyperthermia device with a leaf-shaped electrical resistance heater.
  • a hyperthermia device If a hyperthermia device is to be applied and used by a user, preferably at home, the following requirements must be observed:
  • the probe must also be able to be safely inserted into the anus by inexperienced persons, in particular no injuries to the intestinal wall or intestinal mucosa may occur.
  • the probe must be easy to place and secure against slipping.
  • the positionability must be given in all three spatial dimensions, and rotation of the probe around its longitudinal axis must also be prevented.
  • FIG. 2 shows the perspective illustration of a body probe according to the invention.
  • the probe consists of a base body 1, which is divided into a shaft la, lb and a supply part lc.
  • Shaft la, lb and supply part lc lie with respect to the longitudinal axis 10 of the probe. one after the other and are coaxial to each other.
  • the supply part 1c can, however, also be fastened to the shank 1a, 1b to a greater or lesser degree.
  • a positioning device 4, 4a is attached to the junction of the two.
  • the positioning device 4, 4a can, however, also be attached at any other suitable location on the probe.
  • a cover 2 is placed over the shaft la, lb over most of its length.
  • the shaft la, lb is inserted into the anus in approximately up to a third of its length and is adjusted in its position by the positioning device 4. Almost all people have a prostate about 8 cm behind the anus. However, since especially fat people can have a comparatively wide buttocks, it is necessary to make the shaft significantly longer than this 8 cm.
  • the front end region la of the shaft can be heated in a region 11 determined by the construction of the probe. For this purpose, a heated fluid is fed to him inside the shaft, which flows in through appropriate channels and flows out through other channels.
  • a temperature sensor 3 can also be provided, by means of which the temperature control is possible.
  • the fluid used for heating is preferably water or air; depending on the selected fluid, flow velocity and channel diameter within the body probe are to be selected. Since water has a greater heat capacity than air, rather small duct diameters and flow velocities are sufficient to achieve heating when water is the warming fluid, whereas higher duct diameters and flow velocities are to be chosen when air is the warming fluid.
  • the temperature is controlled in a known manner by feeding back the signal obtained by the temperature sensor to a control circuit. If the warming fluid is water, the corresponding amounts of water are supplied and discharged via the supply part by means of connected hoses. Is there -1-
  • the leads 5, 6 are corresponding electrical lines.
  • the cover 2, 2a is made of an elastomer and preferably has a taper 2a, which projects beyond the front end of the shaft 1a, 1b. Where the coating lies against the shaft la, lb, it is designed so that it is approximately form-fitting with it. This means that it can be pulled over the shaft without too much stretching.
  • the taper 2a like the entire covering, is elastic and serves as an aid when inserting the probe. The tapered tip makes it easier for the user to find the correct position of the probe immediately before inserting the probe and also leads to a certain centering of the shaft tip while it is inserted into the anus.
  • the coating 2 should correspond approximately to those of the preservatives. However, a higher wall thickness should be selected, and the material used should have a higher notch toughness and better elongation at break. In contrast to condoms, the coating is then not produced by a dipping process, but rather according to the manufacturing process as is customary for thin-walled molded articles. The last-mentioned manufacturing process allows a free selection of material mixture variations and accordingly a free choice of material constants.
  • a heat-conducting paste can additionally be applied to the shaft. Only after this has been done is the cover 2 then pulled over the shaft.
  • the heat paste can also be applied to the inside of the coating during the manufacture of the coating.
  • the coating 2 can have a thickening 2b running around its circumference at its rear end. Its distance from the tip of the shaft is selected so that it remains just outside the anus when the probe is correctly positioned. It thus enables the user to feel the correct penetration depth of the probe.
  • the cover can be provided as a disposable article so that it is used only once. This also leads to an improvement in the hygienic conditions.
  • the internal structure of the probe is shown schematically in FIG. From it it can be seen that not only one warming circuit is provided within the probe, but that it can also have a cooling circuit.
  • the warming circuit serves the actual treatment of the user as explained above, whereas the cooling circuit serves those
  • the reference numerals 5 and 6 designate the inflow or outflow of the heating circuit 12, whereas the reference numerals 7 and 8 designate the inflow or outflow of the cooling circuit 13.
  • the cooling circuit is implemented in a similar way to the warming circuit by a circulating or continuous fluid. Here either air or water can be used.
  • Both heating and cooling devices can be designed as closed circuits. Each of the two then has its own reservoir.
  • the probe is then connected to the correct reservoirs via connections 5 to 8 and corresponding hoses.
  • the corresponding fluids are kept in circulation by pumps.
  • the temperature of the warming liquid is then regulated in its reservoir in accordance with the output signal of the temperature sensor.
  • the temperature sensor is located directly at the tip of the shaft. But be constructive Ma met ß took, so that the temperature difference of the warming fluid between the application site in the shaft tip and the reservoir does not become too large, the temperature sensor can also be provided at the probe inlet or immediately in the reservoir itself. This leads to a simplified probe design.
  • the circuits can also be open. Practical tests have shown that a total water consumption of 90 l per hour can then be expected, at hot and cold water temperatures of about 50 ° C. and 20 ° C., respectively.
  • the positioning device 4, 4a serves two purposes. On the one hand, it should fix the angular position of the longitudinal axis 10 of the probe with respect to a base 9, on the other hand, it should stabilize the angular position of the probe about its longitudinal axis 10. This last-mentioned stabilization is important since, as already mentioned, the prostate to be treated and the corresponding intestinal parts acted upon have no heat receptors, so that the probe cannot be sensed in the correct direction.
  • the probe is applied in a half-sitting, half-lying position of the user.
  • the legs are raised, the upper body more or less reclined.
  • An embodiment of the positioning device 4, 4a is described below.
  • the crossbar 4a which runs approximately at right angles to the longitudinal axis 10 of the probe.
  • the crossbar is rotatably connected to the probe body about its axis and projects from it on both sides. At the ends of the crossbar 4a, roundish discs 4 are attached, but these are eccentric to the crossbar 4a. Due to the angular position of the crossbar 4a, the distance can thus of the fastening point of the crossbar 4a can be determined by the base 9.
  • the pad 9 is the same on which the user is located.
  • the angular position of the positioning device 4, 4a can be fixed by a clamping mechanism on the connecting part towards the probe or also by a drag wedge between the base 9 and the eccentric disc 4. When positioned correctly, the crossbar 4a is approximately horizontal to the base 9. The probe is then secured against rotation about its longitudinal axis 10.
  • Figure 4 shows a cross section through the probe shaft along the plane AB in Fig. 3.
  • the cross-sectional shape has rounded edges and is preferably approximately round.
  • the cross section can have a flattened area in the manner of a "shark head". Only in the rear shaft section 1b does the cross-sectional shape approximate the circular shape.
  • the asymmetrical cross-sectional shape of the front shaft section 1 a is not only anatomically particularly favorable, but also allows the user to feel the correct positioning of the probe better.
  • the front shaft section la can be, for example, about 4 to 5 cm long, so that a certain area of the rear shaft section 1b is also inserted into the anus.
  • the corresponding cover 2 should preferably be designed such that it is approximately form-fitting with the entire shaft.
  • the positive fit then causes the cover to lie flat against the shaft and prevents the cover from tearing where the shaft thickens.
  • the warming zone 11 of the probe lies prin ⁇ zipiell in the upper, circular portion of the periphery, the cooling Zone 14 in the flattened lower part.
  • the warming or cooling zones 11, 14 extend from the shaft tip in the longitudinal direction to the rear.
  • the warming area 11 then ends after a certain length. Either a cooling area 14 adjoins it, or an area in which neither heating nor cooling takes place.
  • the warming area 11 is flushed from the inside of the probe by the warming fluid, a cooling area 14 by the cooling fluid.
  • the areas are separated from one another by corresponding walls in the cavity of the shaft and have appropriate inlets and outlets.
  • FIG. 5 shows the top view of the front end of the shaft, as shown in FIG. 3.
  • the hatched area 11 is the area that is heated by the supplied fluid. In the circumferential direction it extends approximately over half of the arch, in the longitudinal direction starting at the tip of the shaft to an end point which is 4-9 cm, preferably 7 cm from the tip of the shaft.
  • FIG. 6 shows a detailed illustration of the flow conditions prevailing within the probe.
  • the feed line 5 of the heating circuit 12 (FIG. 3) is designed as a thin tube which runs approximately in the middle of the shaft parallel to the probe axis 10 up to the foremost tip of the probe. There it opens into a chamber, the outer wall of which defines the area 11 to be heated. Right.
  • the warming fluid is returned via a tube 6a which surrounds the feeding tube 5a. As a result, heat loss during the supply of the fluid to the warming region 11 is avoided. With this construction, it is no longer necessary to arrange the temperature sensor in the tip of the shaft, it can either be attached in the supply part or immediately in the reservoir of the warming circuit.
  • the inlet 7a of the cooling circuit is designed as a thin tube which extends into the front shaft section la and has its outlet opening there.
  • the cooling fluid thus fills half or the entire shaft la and the
  • Supply part 1c and is discharged via a connection 8. Due to the slow flow rate, it is heated to a certain extent by the body heat and in the thickened supply part 1c in turn heats up the incoming cooling fluid in its feed 7a. This measure ensures that the cooling only takes place to a physiologically sensible degree.
  • the various inlets and outlets running in the rear section of the shaft can be seen from section C-D.
  • the warming fluid is directly Brauchwasser ⁇ the circuit taken at the home of • patients.
  • Such a method is advantageously used when there is a shower connection in which the temperature can be set directly by means of a scaling. If there is such a connection, it is no longer absolutely necessary to regulate the temperature of the
  • REPLACEMENT LEAF warming water In such an embodiment, however, either a regulated heater or a valve regulating the flow rate can be provided for fine adjustment of the temperature.
  • a comparatively large flow-through channel cross section leads to low flow velocities, so that comparatively more thermal energy is absorbed by the cooling fluid or released by the warming fluid.
  • only a part of the shaft cross section can be filled with fluid. Accordingly, there is a higher flow velocity, which leads to a comparatively smaller exchange of heat quantities.
  • the temperature can be controlled by several parameters. As just mentioned, different flow velocities and thus heat exchange coefficients can be selected in the factory by dimensioning the fluid channels. In the application itself, the temperatures of the fluids used can then also be set. It is also possible to influence the flow velocity by regulating the pressure difference. In this context, it has proven to be particularly advantageous to provide the warming circuit with a pressure pump on the inlet side and with a suction pump on the outlet side with at least twice the delivery capacity compared to that of the pressure pump. The flow rates can then be easily adjusted over a wide range. Is it enough for the cooling circuit? only to provide a pressure pump.
  • FIG. 7 shows an example of a temperature profile, as can occur in the warming region 11 of the probe in the longitudinal direction.
  • a temperature is set in the area to be heated, which is preferably between 42 ° C and 45 ° C. But the desired healing or soothing effect is obtained even at approximately 40 ° C.
  • the temperatures mentioned were chosen with a view to the fact that the prostate mainly consists of heat-sensitive protein.
  • a cooling area follows immediately behind the warming area, so that the sudden temperature drop shown in FIG. 7 results from about a third of the probe shaft in accordance with the area limits, in the transverse direction the same applies, so that there is a "heat window" in the first third of about 1/3 of the probe shaft width and area length.
  • the entire probe body la, lb, lc can optionally be made of glass, plastic or metal. Glass has the best values in terms of resistance to harsh cleaning agents, a plastic body is the easiest to manufacture. Metal would be the most desirable in terms of mechanical stability and in terms of thermal conductivity.
  • the bead 2b described in connection with the coating 2 can also be provided on the probe shaft 1a, 1b itself. It is then formed by a material thickening running around the circumference.
  • FIG. 8 shows the front part of a shaft 1 a in the hyper thermal device according to a further exemplary embodiment.
  • the shaft is divided by a transverse wall 31 running in the longitudinal direction, so that an upper one Area 11 and a lower area 14 is formed, in the upper area 11 a rod-shaped electrical resistance heater 32 is provided, which is shielded by a reflector 33 on the side facing the lower area 14.
  • the reflector 33 is designed in such a way that heat radiation emanating from the resistance heater 32 is at least partially reflected and directed in the direction of the prostate, that is, as seen in FIG. 9, upwards.
  • the lower region 14 of the shaft is cooled, for example with the aid of water, the reflector 33 advantageously also being thermally coupled to the partition 31 in order to be additionally cooled in this way.
  • a temperature sensor 3 is again provided, as shown in FIGS. 2, 3 or 5, the output signals of which are used for temperature control.
  • the shaft la is, as can be seen from Fig. 9, still provided with a firmly adhering coating 34 which e.g. consists of an ethylene vinyl alcohol copolymer, on the surface of which a polyurethane lacquer 35 is also applied.
  • a firmly adhering coating 34 which e.g. consists of an ethylene vinyl alcohol copolymer, on the surface of which a polyurethane lacquer 35 is also applied.
  • a firmly adhering coating 34 which e.g. consists of an ethylene vinyl alcohol copolymer, on the surface of which a polyurethane lacquer 35 is also applied.
  • FIG. 10 shows a cross section through a shaft la of a modified hyperthermia device, approximately according to the section line IX-IX in FIG. 8.
  • the shaft has an adherent coating 34 and consists of two coaxial areas, namely an inner area 11 and an outer area 14, which are separated from one another by a separating tube 41.
  • the outer region 14 is cooled with the aid of water, while an infrared radiator 42 is turned on in the inner region 11.
  • REPLACEMENT LEAF is ordered, which emits infrared radiation in the so-called A-range with wavelengths around 1100 nanometers.
  • the infrared radiator 42 is partially surrounded by a reflector 43 which bears against the inner wall of the separating tube 41.
  • directional heat radiation is also emitted onto the prostate, the IR-A radiation being known to take effect only after a certain depth of penetration into the tissue, ie in this case on the prostate.
  • the entire outer surface of the shaft can be cooled.
  • FIG. 11 shows a cross section through a modified glass shaft 1a, which is divided by a partition 51 into an upper region 11 and into a lower region 14 to be cooled.
  • a sheet-shaped resistance heater 52 is provided on the outer surface of the glass shaft, which occupies approximately the area that is designated 11 in FIG. 6, that is, the area of the shaft to be heated there.
  • the sheet-shaped resistance heater 42 and also the other parts of the shaft la are covered with an electrically insulating, adherent coating 34.
  • the entire probe is not shown in the exemplary embodiments according to FIGS. 8 to 11, it is clear that this is designed approximately according to FIG. in addition to the shaft also includes the supply part and the positioning device.
  • the positioning device in particular enables a comfortable posture of the patient during application of the probe, which can also be adjusted sensitively with the aid of the lever of the positioning device.
  • a hyperthermia probe namely the positioning device, the use of a coating, the heating with directed heat radiation, preferably with a fluid, and the cooling by means of a fluid, with the addition of direct temperature measurement and control.
  • This construction can be provided individually or in any combination with one another.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Thermal Sciences (AREA)
  • Vascular Medicine (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

Un dispositif hyperthermique, utile notamment pour traiter des affections de la prostate, comprend une tige allongée (1a) qui peut être introduite partiellement ou entièrement dans l'anus, son extrémité antérieure en avant. Un organe d'échauffement (5, 6, 32, 42, 52) situé dans la tige émet un rayonnement thermique à diriger dans la direction de la prostate. Les autres zones (14) de la tige qui ne sont pas orientées vers la prostate sont refroidies afin d'éviter des lésions de l'épiderme. En outre, la température est réglée au moyen d'un capteur (3) de la température situé à l'extrémité antérieure de la tige (1a), dans la zone de celle-ci dirigée vers la prostate.
PCT/DE1992/000582 1991-07-15 1992-07-15 Dispositif hyperthermique WO1993001774A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19914123418 DE4123418C2 (de) 1991-07-15 1991-07-15 Hyperthermie-Vorrichtung, insbesondere zur Behandlung von Prostataleiden
DEP4123418.9 1991-07-15

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WO1993001774A1 true WO1993001774A1 (fr) 1993-02-04

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WO1995030373A1 (fr) * 1994-05-06 1995-11-16 Oratec Interventions, Inc. Procede et appareil permettant la contraction controlee des tissus mous
US6176857B1 (en) * 1997-10-22 2001-01-23 Oratec Interventions, Inc. Method and apparatus for applying thermal energy to tissue asymmetrically
AU733147B2 (en) * 1997-02-03 2001-05-10 Elizabeth Marie Carlin Medical speculum and a sleeve therefor
US6757565B2 (en) 2002-02-08 2004-06-29 Oratec Interventions, Inc. Electrosurgical instrument having a predetermined heat profile

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AT513U1 (de) * 1992-11-17 1995-12-27 Mgaloblischwili Gurami Dr Operationsfeldkuehlvorrichtung
US5335669A (en) * 1993-04-21 1994-08-09 American Medical Systems, Inc. Rectal probe with temperature sensor
US5653692A (en) * 1995-09-07 1997-08-05 Innerdyne Medical, Inc. Method and system for direct heating of fluid solution in a hollow body organ
US5891094A (en) * 1995-09-07 1999-04-06 Innerdyne, Inc. System for direct heating of fluid solution in a hollow body organ and methods
SE9702983D0 (sv) * 1997-08-19 1997-08-19 Hans Ivar Wallsten Device for heat treatment
EP3328332B1 (fr) * 2015-07-31 2022-03-23 Agency for Science, Technology And Research Dispositif pour l'insertion dans une cavité corporelle, et son procédé de fabrication

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US2056678A (en) * 1933-09-14 1936-10-06 Arthur J Kolling Apparatus for applying thermopenetration
GB658662A (en) * 1949-01-25 1951-10-10 Walter J Reich Improvements in or relating to internal heat-treatment device
US4086608A (en) * 1975-11-28 1978-04-25 The United States Of America As Represented By The Secretary Of The Navy Light emitting diode
GB1529289A (en) * 1977-06-20 1978-10-18 Mckimmey A Device for the therapeutic treatment of haemorrhoids
GB2045620A (en) * 1979-03-23 1980-11-05 Rca Corp Coaxial applicator for hyperthermic treatment of the body
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WO1995030373A1 (fr) * 1994-05-06 1995-11-16 Oratec Interventions, Inc. Procede et appareil permettant la contraction controlee des tissus mous
US5569242A (en) * 1994-05-06 1996-10-29 Lax; Ronald G. Method and apparatus for controlled contraction of soft tissue
AU733147B2 (en) * 1997-02-03 2001-05-10 Elizabeth Marie Carlin Medical speculum and a sleeve therefor
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DE4123418A1 (de) 1992-04-09

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