WO1992014438A2 - Derives de prostacycline et de carbacycline utiles comme agents therapeutiques de maladies febriles - Google Patents

Derives de prostacycline et de carbacycline utiles comme agents therapeutiques de maladies febriles Download PDF

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Publication number
WO1992014438A2
WO1992014438A2 PCT/DE1992/000100 DE9200100W WO9214438A2 WO 1992014438 A2 WO1992014438 A2 WO 1992014438A2 DE 9200100 W DE9200100 W DE 9200100W WO 9214438 A2 WO9214438 A2 WO 9214438A2
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
treatment
agent
prostacyclin
carbacyclin derivatives
Prior art date
Application number
PCT/DE1992/000100
Other languages
German (de)
English (en)
Other versions
WO1992014438A3 (fr
Inventor
Eveline Blitstein-Willinger
Karl-Heinz Thierauch
Original Assignee
Schering Aktiengesellschaft Berlin Und Bergkamen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft Berlin Und Bergkamen filed Critical Schering Aktiengesellschaft Berlin Und Bergkamen
Priority to AU12433/92A priority Critical patent/AU660449B2/en
Priority to JP4504121A priority patent/JPH06507381A/ja
Publication of WO1992014438A2 publication Critical patent/WO1992014438A2/fr
Publication of WO1992014438A3 publication Critical patent/WO1992014438A3/fr
Priority to KR1019930702386A priority patent/KR930702990A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

On utilise des dérivés de prostacycline et de carbacycline pour produire un agent thérapeutique de maladies qui s'accompagnent de fièvre ou d'une coagulopathie intravasculaire disséminée et qui peuvent être suivies de complications cérébrales.
PCT/DE1992/000100 1991-02-12 1992-02-11 Derives de prostacycline et de carbacycline utiles comme agents therapeutiques de maladies febriles WO1992014438A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU12433/92A AU660449B2 (en) 1991-02-12 1992-02-11 Prostacycline and carbacycline derivatives as agents for treating feverish complaints
JP4504121A JPH06507381A (ja) 1991-02-12 1992-02-11 熱性疾患の処置のための医薬品としてのプロスタサイクリン−およびカルバサイクリン誘導体
KR1019930702386A KR930702990A (ko) 1991-02-12 1993-08-11 섬유성 질병 치료제로서의 프로스타사이클린- 및 카르바사이클린 유도체

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4104607A DE4104607A1 (de) 1991-02-12 1991-02-12 Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
DEP4104607.2 1991-02-12

Publications (2)

Publication Number Publication Date
WO1992014438A2 true WO1992014438A2 (fr) 1992-09-03
WO1992014438A3 WO1992014438A3 (fr) 1993-01-07

Family

ID=6425075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1992/000100 WO1992014438A2 (fr) 1991-02-12 1992-02-11 Derives de prostacycline et de carbacycline utiles comme agents therapeutiques de maladies febriles

Country Status (7)

Country Link
EP (1) EP0571462A1 (fr)
JP (1) JPH06507381A (fr)
KR (1) KR930702990A (fr)
AU (1) AU660449B2 (fr)
CA (1) CA2104024A1 (fr)
DE (1) DE4104607A1 (fr)
WO (1) WO1992014438A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0623346A4 (fr) * 1991-04-11 1994-08-29 Toray Industries Inhibiteur de la metastase d'une tumeur maligne.
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
EP0925787A1 (fr) * 1997-02-27 1999-06-30 Toray Industries, Inc. Medicaments permettant d'ameliorer la circulation pulmonaire
EP0947195A1 (fr) * 1997-03-14 1999-10-06 Toray Industries, Inc. Agents protecteurs de la cellule nerveuse

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4124693A1 (de) * 1991-07-22 1993-01-28 Schering Ag Carbacyclinderivate als mittel zur behandlung von vitiligo
DE4124695C2 (de) * 1991-07-22 1994-12-22 Blitstein Willinger Eveline Dr Verwendung von Carbacyclinderivaten zur Behandlung von Psoriasis vulgaris
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
JPH11228417A (ja) * 1998-02-06 1999-08-24 Teijin Ltd 神経障害治療剤

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0011591A1 (fr) * 1978-10-19 1980-05-28 Schering Aktiengesellschaft Dérivés de prostane, leur préparation et compositions pharmaceutiques les contenant
EP0084856A1 (fr) * 1982-01-20 1983-08-03 Toray Industries, Inc. Dérivés de la 5,6,7-trinor-4,8-inter-m-phenylène-prostaglandine I2
EP0099538A1 (fr) * 1982-07-13 1984-02-01 Schering Aktiengesellschaft Carbacyclines, procédé pour leur préparation et leur utilisation comme médicaments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256883A (en) * 1979-03-14 1981-03-17 Research Corporation Pyridoza prostacyclin analogues and N-oxides thereof
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
ATE112682T1 (de) * 1988-02-23 1994-10-15 Teijin Ltd Isocarbacyclinderivate enthaltende antidiabetika.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0011591A1 (fr) * 1978-10-19 1980-05-28 Schering Aktiengesellschaft Dérivés de prostane, leur préparation et compositions pharmaceutiques les contenant
EP0084856A1 (fr) * 1982-01-20 1983-08-03 Toray Industries, Inc. Dérivés de la 5,6,7-trinor-4,8-inter-m-phenylène-prostaglandine I2
EP0099538A1 (fr) * 1982-07-13 1984-02-01 Schering Aktiengesellschaft Carbacyclines, procédé pour leur préparation et leur utilisation comme médicaments

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Biochemical Pharmacology, Band 41, Nr. 8, 1991, Pergamon Press plc, (GB), M. KAINOH et al.: "Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level", Seiten 1135-1140, siehe Zusammenfassung; Seite 1137, Zeile 39 - Seite 1140, Zeile 4 *
Blood, Band 76, Nr. 10, Suppl. 1, 15. November 1990, D.J. CRUTCHLEY et al.: "The stable prostacyclin analog, iloprost, is a potent inhibitor of human monocyte procoagulant activity", Seite 503a, siehe das ganze Dokument *
Blood, Band 78, Nr. 2, 15. Juli 1991, D.J. CRUTCHLEY et al.: "The stable prostacyclin analog, iloprost, and prostaglandin E, inhibit monocyte procoagulant activity in vitro", Seiten 382-386, siehe das ganze Dokument *
Chimical Intensive Care, Band 3, Nr. 2 (Suppl.), 1992, A. J\RRES et al.: "Specific downregulation of TNFalpha in endotoxin-stimulated mononuclear leukocytes by the prostacyclin analogue iloprost", Seite 21, siehe das ganze Dokument *
Chimical Intensive Care, Band 3, Nr. 2 (Suppl.), 1992, U. H[HNLE et al.: "Protective effect of iloprost, a prostacyclin analogue, in experimental endotoxic shock", Seite 8, siehe das ganze Dokument *
Infection and Immunity, Band 59, Nr. 10, Oktober 1991, American Society for Microbiology, K. SLIWA et al.: "Prevention of murine cerebral malaria by a stable prostacyclin analog", Seiten 3846-3848, siehe das ganze Dokument *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0623346A4 (fr) * 1991-04-11 1994-08-29 Toray Industries Inhibiteur de la metastase d'une tumeur maligne.
EP0623346A1 (fr) * 1991-04-11 1994-11-09 Toray Industries, Inc. Inhibiteur de la metastase d'une tumeur maligne
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
EP0925787A1 (fr) * 1997-02-27 1999-06-30 Toray Industries, Inc. Medicaments permettant d'ameliorer la circulation pulmonaire
EP0947195A1 (fr) * 1997-03-14 1999-10-06 Toray Industries, Inc. Agents protecteurs de la cellule nerveuse
EP0947195A4 (fr) * 1997-03-14 1999-12-01 Toray Industries Agents protecteurs de la cellule nerveuse

Also Published As

Publication number Publication date
DE4104607A1 (de) 1992-08-13
JPH06507381A (ja) 1994-08-25
WO1992014438A3 (fr) 1993-01-07
AU1243392A (en) 1992-09-15
CA2104024A1 (fr) 1992-08-13
KR930702990A (ko) 1993-11-29
EP0571462A1 (fr) 1993-12-01
AU660449B2 (en) 1995-06-29

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