WO1989006974A3 - Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues - Google Patents

Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues Download PDF

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Publication number
WO1989006974A3
WO1989006974A3 PCT/US1989/000388 US8900388W WO8906974A3 WO 1989006974 A3 WO1989006974 A3 WO 1989006974A3 US 8900388 W US8900388 W US 8900388W WO 8906974 A3 WO8906974 A3 WO 8906974A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugate vaccines
conjugates
cell epitope
epitopes
carriers molecule
Prior art date
Application number
PCT/US1989/000388
Other languages
English (en)
Other versions
WO1989006974A2 (fr
Inventor
Garvin Bixler
Subramonia Pillai
Richard Insel
Original Assignee
Praxis Biolog Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Biolog Inc filed Critical Praxis Biolog Inc
Priority to EP89908669A priority Critical patent/EP0399001B1/fr
Priority to DE68917126T priority patent/DE68917126T2/de
Publication of WO1989006974A2 publication Critical patent/WO1989006974A2/fr
Publication of WO1989006974A3 publication Critical patent/WO1989006974A3/fr
Priority to FI903292A priority patent/FI104374B/fi
Priority to NO902909A priority patent/NO179164C/no
Priority to DK199001829A priority patent/DK174416B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La présente invention concerne de nouveaux épitopes de cellules T de produits bactériens. On peut utiliser les épitopes de l'invention dans la préparation de conjugués entre les épitopes et des antigènes, des haptènes, ou des déterminants antigéniques médicalement utiles. Ces conjugués peuvent provoquer des réactions d'anticorps similaires à des conjugués d'antigènes couplés de manière covalente à des protéines porteuses, et dans une composition de vaccins, fournir des vaccins conjugués sûrs et plus économiques.
PCT/US1989/000388 1988-02-01 1989-01-31 Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues WO1989006974A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP89908669A EP0399001B1 (fr) 1988-02-01 1989-01-31 Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues
DE68917126T DE68917126T2 (de) 1988-02-01 1989-01-31 T-zellen-epitope als träger für einen konjugierten impfstoff.
FI903292A FI104374B (fi) 1988-02-01 1990-06-29 T-solu-epitooppi-oligopeptidejä ja niitä sisältävien konjugaattien valmistus
NO902909A NO179164C (no) 1988-02-01 1990-06-29 Fremgangsmåte for fremstilling av et immunogenkonjugat
DK199001829A DK174416B1 (da) 1988-02-01 1990-07-31 Oligopeptider, immunogene konjugater heraf med et antigen samt vacciner indeholdende disse konjugater

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15068888A 1988-02-01 1988-02-01
US150,688 1988-02-01

Publications (2)

Publication Number Publication Date
WO1989006974A2 WO1989006974A2 (fr) 1989-08-10
WO1989006974A3 true WO1989006974A3 (fr) 1989-08-24

Family

ID=22535596

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/000388 WO1989006974A2 (fr) 1988-02-01 1989-01-31 Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues

Country Status (10)

Country Link
EP (1) EP0399001B1 (fr)
JP (1) JP2921574B2 (fr)
AT (1) ATE109008T1 (fr)
AU (1) AU634153B2 (fr)
CA (2) CA1340958C (fr)
DE (1) DE68917126T2 (fr)
DK (1) DK174416B1 (fr)
FI (1) FI104374B (fr)
NO (1) NO179164C (fr)
WO (1) WO1989006974A2 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69032484T4 (de) * 1989-10-27 1999-09-16 Arch Dev Corp Zusammensetzungen und deren verwendung zur förderung der immunopotentiation
GB8924438D0 (en) * 1989-10-31 1989-12-20 Hoffmann La Roche Vaccine composition
US5500366A (en) * 1990-09-18 1996-03-19 Biotech Australia Pty. Ltd. Polynucleotide encoding T-cell epitopes of the protein TraT
WO1993011157A1 (fr) * 1991-11-27 1993-06-10 The Council Of The Queensland Institute Of Medical Research VACCIN ET PEPTIDES CONTRE LA MALARIA COMPRENANT UN EPITOPE DE CELLULE T HUMAINE DE PROTEINE CIRCUMSPOROZOITE DE $i(P.VIVAX)
IL105503A (en) * 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
IL106436A0 (en) * 1992-07-22 1993-11-15 Proteus Molecular Design Synthetic polypeptides and their use
ATE174628T1 (de) * 1992-07-31 1999-01-15 Medeva Holdings Bv Expression rekombinanter fusionsproteine in attenuierten bakterien
ATE258188T1 (de) 1992-08-27 2004-02-15 Deakin Res Ltd Retro-, inverso-, und retro-inverso synthetische peptidanaloge
DK140992D0 (da) * 1992-11-24 1992-11-24 Ole Buchardt Fremgangsmaade til frembringelse af antistoffer mod haptener og andre b-celle-antigener, antistoffer opnaaet ved fremgangsmaaden og anvendelse af disse antistoffer til fremstilling af vacciner, isaer til veterinaermedicinsk brug
US5759551A (en) * 1993-04-27 1998-06-02 United Biomedical, Inc. Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
GB9401787D0 (en) 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
AU7235794A (en) * 1993-07-30 1995-02-28 Medeva Holdings B.V. Vaccine compositions
GB9401795D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccines
GB2295394B (en) * 1994-01-31 1997-09-24 Medeva Holdings Bv DNA encoding a fusion protein comprising the C fragment of tetanus toxin
WO1995024216A1 (fr) * 1994-03-07 1995-09-14 Auckland Uniservices Limited Prevention du diabete
US5840307A (en) * 1995-03-31 1998-11-24 Immulogic Pharmacuetical Corp. Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation
DE69637089T2 (de) * 1995-03-31 2008-01-17 Xenova Research Ltd., Slough Hapten-Träger-Konjugate zur Anwendung in der Drogen-Missbrauchs-Therapie
US5843462A (en) * 1995-11-30 1998-12-01 Regents Of The University Of Minnesota Diphtheria toxin epitopes
US7709002B1 (en) 1996-04-19 2010-05-04 The United States Of America As Represented By The Department Of Health And Human Services Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes
ATE220718T1 (de) 1996-04-19 2002-08-15 Us Gov Sec Health Mutierte ras peptide zur zeugung von cd8+ zytitoxischen t lymphoizyten
GB9713156D0 (en) * 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
TWI229679B (en) 1998-06-20 2005-03-21 United Biomedical Inc Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens
US6025468A (en) 1998-06-20 2000-02-15 United Biomedical, Inc. Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides
DE19856052A1 (de) * 1998-12-04 2000-06-08 Deutsches Krebsforsch Konjugat zur Anreicherung in neuronalen Zellen
US6663861B2 (en) 2000-11-09 2003-12-16 Antibodyshop A/S Method of producing antibodies by immunization with conjugates of molecules coupled to charge-modified proteins
JP5667062B2 (ja) 2008-10-10 2015-02-12 エラ、ビオテック、ソシエダッド、アノニマＥｒａ Ｂｉｏｔｅｃｈ， Ｓ．Ａ． 免疫原特異的アジュバントとしての組換えタンパク粒
CA2756170C (fr) * 2009-03-23 2019-04-02 The Brigham And Women's Hospital, Inc. Vaccins glycoconjugues
EP2418284A1 (fr) 2010-08-13 2012-02-15 ERA Biotech, S.A. Séquences de polypeptides induisant le corps protéiques
EP2870974A1 (fr) * 2013-11-08 2015-05-13 Novartis AG Vaccins conjugués de salmonelle
US9815886B2 (en) 2014-10-28 2017-11-14 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
JP7186166B2 (ja) 2016-12-30 2022-12-08 バックスサイト・インコーポレイテッド 非天然アミノ酸とのポリペプチド抗原接合体
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
AU2019299836A1 (en) 2018-07-04 2021-02-25 Vaxcyte, Inc. Improvements in immunogenic conjugates
WO2020010016A1 (fr) 2018-07-04 2020-01-09 Sutrovax, Inc. Conjugués immunogènes auto-adjuvés
WO2020010000A1 (fr) 2018-07-04 2020-01-09 Sutrovax, Inc. Procédés améliorés pour la préparation de conjugués immunogènes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172107A1 (fr) * 1984-08-10 1986-02-19 Praxis Biologics, Inc. Conjugués immunogènes d'unité secondaire d'entérotoxine LT-B d'E. coli et polymères capsulaires
EP0186576A2 (fr) * 1984-12-20 1986-07-02 Merck & Co. Inc. Polysaccharides bactériens neutres modifiés de manière covalente, conjugés stables covalents entre ces polysaccharides et des protéines immunogéniques et méthodes de préparation de ces polysaccharides et conjugués
EP0245045B1 (fr) * 1986-05-05 1993-11-03 Praxis Biologics, Inc. Conjugués immunogènes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172107A1 (fr) * 1984-08-10 1986-02-19 Praxis Biologics, Inc. Conjugués immunogènes d'unité secondaire d'entérotoxine LT-B d'E. coli et polymères capsulaires
EP0186576A2 (fr) * 1984-12-20 1986-07-02 Merck & Co. Inc. Polysaccharides bactériens neutres modifiés de manière covalente, conjugés stables covalents entre ces polysaccharides et des protéines immunogéniques et méthodes de préparation de ces polysaccharides et conjugués
EP0245045B1 (fr) * 1986-05-05 1993-11-03 Praxis Biologics, Inc. Conjugués immunogènes

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Infection and Immunity, vol. 55, no. 11, November 1987, American Society for Microbiology (US), L.D. Lise et al.: "Enhanced epitopic response to a synthetic human malarial peptide by preimmunization with tetanus toxoid carrier", pages 2658-2661 *
Infection and Immunity, vol. 55, no. 6, June 1987, American Society for Micro-biology (US), M.E. Jolivet et al.: "Induction of biologically active antibodies by a polyvalent synthetic vaccine constructed without carrier", pages 1498-1502 *
Nature, vol. 300, 12 November 1987, M.J. Francis et al.: "Non-responsiveness to a foot and mouth disease virus peptide overcome by addition of foreign helper T-cell determinants ", pages 168-170 *
Nucleic Acids Research, vol. 14, no. 19, 19 November 1986, IRL Press Ltd (Oxford, GB), N.F. Fairweather et al.: "The complete nucleotide sequence of tetanus toxin", pages 7809-7812 *
Proceedings of the National Academy of Sciences of the USA, vol. 80, no. 22, November 1983, L. Greenfield et al.: "Nucleotide sequence of the structural gene for diptheria toxin carried by coryne-bacteriophage beta", pages 6853-6857 *
Science, vol. 235, 27 February 1987, M.F. Good et al.: "Construction of synthetic immunogen: use of new T-helper epitome on malaria circum-sporoziteprotein", pages 1059-1062 *
The European Journal of Immunology, vol. 16, 1986,, VCH Verlagsgesellschaft mbh, (Weinheim, DE), F. Triebel et al.: "Immune response to diptheria toxin and to different CNBr fragments: evidence for different B and T cell reactivities", pages47-53 *
The Journal of Immunology, vol. 138, no. 12, 15 June 1987, The American Association of Immunologists (US), D.R. Milich et al.: "A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg", pages 4457 -4465 *
The Journal of Immunology, vol. 142, no. 2, 15 January 1989, The American Association of Immunologists (US), S. Demotz et al.: "Delineation of several DR-restricted tetanus toxin T cell epitopes", pages 394-402 *

Also Published As

Publication number Publication date
DK182990D0 (da) 1990-07-31
CA1340956C (fr) 2000-04-11
AU634153B2 (en) 1993-02-18
DE68917126D1 (de) 1994-09-01
AU3065489A (en) 1989-08-25
EP0399001B1 (fr) 1994-07-27
FI104374B (fi) 2000-01-14
NO902909L (no) 1990-08-27
DE68917126T2 (de) 1995-02-02
NO179164C (no) 1996-08-21
ATE109008T1 (de) 1994-08-15
JPH03502691A (ja) 1991-06-20
WO1989006974A2 (fr) 1989-08-10
DK182990A (da) 1990-07-31
DK174416B1 (da) 2003-02-17
NO179164B (no) 1996-05-13
JP2921574B2 (ja) 1999-07-19
EP0399001A1 (fr) 1990-11-28
CA1340958C (fr) 2000-04-11
NO902909D0 (no) 1990-06-29
FI903292A0 (fi) 1990-06-29

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