FI104374B - T-solu-epitooppi-oligopeptidejä ja niitä sisältävien konjugaattien valmistus - Google Patents
T-solu-epitooppi-oligopeptidejä ja niitä sisältävien konjugaattien valmistus Download PDFInfo
- Publication number
- FI104374B FI104374B FI903292A FI903292A FI104374B FI 104374 B FI104374 B FI 104374B FI 903292 A FI903292 A FI 903292A FI 903292 A FI903292 A FI 903292A FI 104374 B FI104374 B FI 104374B
- Authority
- FI
- Finland
- Prior art keywords
- crm
- peptide
- cell
- prp
- antigen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Optical Couplings Of Light Guides (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15068888A | 1988-02-01 | 1988-02-01 | |
US15068888 | 1988-02-01 | ||
PCT/US1989/000388 WO1989006974A2 (fr) | 1988-02-01 | 1989-01-31 | Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues |
US8900388 | 1989-01-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI903292A0 FI903292A0 (fi) | 1990-06-29 |
FI104374B true FI104374B (fi) | 2000-01-14 |
Family
ID=22535596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI903292A FI104374B (fi) | 1988-02-01 | 1990-06-29 | T-solu-epitooppi-oligopeptidejä ja niitä sisältävien konjugaattien valmistus |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0399001B1 (fr) |
JP (1) | JP2921574B2 (fr) |
AT (1) | ATE109008T1 (fr) |
AU (1) | AU634153B2 (fr) |
CA (2) | CA1340958C (fr) |
DE (1) | DE68917126T2 (fr) |
DK (1) | DK174416B1 (fr) |
FI (1) | FI104374B (fr) |
NO (1) | NO179164C (fr) |
WO (1) | WO1989006974A2 (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0497883B1 (fr) * | 1989-10-27 | 1998-07-15 | Arch Development Corporation | Compositions et leur utilisation pour le promotion de l'immunopotentialisation |
GB8924438D0 (en) * | 1989-10-31 | 1989-12-20 | Hoffmann La Roche | Vaccine composition |
DE4192335T1 (de) * | 1990-09-18 | 1993-10-07 | Biotech Australia Pty Ltd | T-Zell-Epitope |
WO1993011157A1 (fr) * | 1991-11-27 | 1993-06-10 | The Council Of The Queensland Institute Of Medical Research | VACCIN ET PEPTIDES CONTRE LA MALARIA COMPRENANT UN EPITOPE DE CELLULE T HUMAINE DE PROTEINE CIRCUMSPOROZOITE DE $i(P.VIVAX) |
IL105503A (en) * | 1992-04-28 | 1999-05-09 | Astra Ab | Carbon peptide couplets capable of eliciting an immune response of T cells |
AU4580093A (en) * | 1992-07-22 | 1994-02-14 | Proteus Molecular Design Limited | Polypeptide antigens of mycobacterium bovis |
DK0652962T3 (da) * | 1992-07-31 | 1999-08-23 | Medeva Holdings Bv | Ekspression af rekombinante fusionsproteiner i attenuerede bakterier |
KR950702839A (ko) | 1992-08-27 | 1995-08-23 | 스티븐 딕 | 레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(retro-, inverso-, and retro-inverso synthetic peptide analogues) |
DK140992D0 (da) * | 1992-11-24 | 1992-11-24 | Ole Buchardt | Fremgangsmaade til frembringelse af antistoffer mod haptener og andre b-celle-antigener, antistoffer opnaaet ved fremgangsmaaden og anvendelse af disse antistoffer til fremstilling af vacciner, isaer til veterinaermedicinsk brug |
US5759551A (en) * | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
GB9401787D0 (en) | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccine compositions |
JPH09500540A (ja) * | 1993-07-30 | 1997-01-21 | メデヴァ ホールディングス ビー.ヴイ. | ワクチン組成物 |
GB2295394B (en) * | 1994-01-31 | 1997-09-24 | Medeva Holdings Bv | DNA encoding a fusion protein comprising the C fragment of tetanus toxin |
GB9401795D0 (en) * | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccines |
AU1864195A (en) * | 1994-03-07 | 1995-09-25 | Auckland Uniservices Limited | Prevention of diabetes |
US5773003A (en) * | 1995-03-31 | 1998-06-30 | Immulogic, Inc. | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
AU5374996A (en) * | 1995-03-31 | 1996-10-16 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy |
US5843462A (en) * | 1995-11-30 | 1998-12-01 | Regents Of The University Of Minnesota | Diphtheria toxin epitopes |
EP0895538B1 (fr) | 1996-04-19 | 2002-07-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Peptides ras ayant subi une mutation et servant a generer des lymphocytes t cytotoxiques cd8+ |
US7709002B1 (en) | 1996-04-19 | 2010-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes |
GB9713156D0 (en) * | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
US6025468A (en) | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
TWI229679B (en) | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
DE19856052A1 (de) * | 1998-12-04 | 2000-06-08 | Deutsches Krebsforsch | Konjugat zur Anreicherung in neuronalen Zellen |
US6663861B2 (en) | 2000-11-09 | 2003-12-16 | Antibodyshop A/S | Method of producing antibodies by immunization with conjugates of molecules coupled to charge-modified proteins |
KR20110084906A (ko) | 2008-10-10 | 2011-07-26 | 에라 바이오테크, 에스.에이. | 면역원-특이적 면역보강제로서의 재조합 단백질체들 |
EP2411039A4 (fr) * | 2009-03-23 | 2015-05-06 | Brigham & Womens Hospital | Vaccins glycoconjugués |
EP2418284A1 (fr) | 2010-08-13 | 2012-02-15 | ERA Biotech, S.A. | Séquences de polypeptides induisant le corps protéiques |
EP2870974A1 (fr) * | 2013-11-08 | 2015-05-13 | Novartis AG | Vaccins conjugués de salmonelle |
US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
EP3562503A2 (fr) | 2016-12-30 | 2019-11-06 | Sutrovax, Inc. | Conjugués polypeptide-antigène avec des acides aminés non naturels |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
CN112543649A (zh) | 2018-07-04 | 2021-03-23 | Vaxcyte公司 | 免疫原性缀合物的改进 |
WO2020010000A1 (fr) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Procédés améliorés pour la préparation de conjugués immunogènes |
WO2020010016A1 (fr) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Conjugués immunogènes auto-adjuvés |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
-
1989
- 1989-01-31 AT AT89908669T patent/ATE109008T1/de not_active IP Right Cessation
- 1989-01-31 JP JP1502396A patent/JP2921574B2/ja not_active Expired - Fee Related
- 1989-01-31 WO PCT/US1989/000388 patent/WO1989006974A2/fr active IP Right Grant
- 1989-01-31 AU AU30654/89A patent/AU634153B2/en not_active Ceased
- 1989-01-31 EP EP89908669A patent/EP0399001B1/fr not_active Expired - Lifetime
- 1989-01-31 DE DE68917126T patent/DE68917126T2/de not_active Expired - Fee Related
- 1989-02-01 CA CA000616882A patent/CA1340958C/fr not_active Expired - Fee Related
- 1989-02-01 CA CA000589806A patent/CA1340956C/fr not_active Expired - Fee Related
-
1990
- 1990-06-29 NO NO902909A patent/NO179164C/no not_active IP Right Cessation
- 1990-06-29 FI FI903292A patent/FI104374B/fi not_active IP Right Cessation
- 1990-07-31 DK DK199001829A patent/DK174416B1/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK174416B1 (da) | 2003-02-17 |
WO1989006974A2 (fr) | 1989-08-10 |
CA1340958C (fr) | 2000-04-11 |
DK182990D0 (da) | 1990-07-31 |
FI903292A0 (fi) | 1990-06-29 |
DE68917126T2 (de) | 1995-02-02 |
WO1989006974A3 (fr) | 1989-08-24 |
CA1340956C (fr) | 2000-04-11 |
EP0399001A1 (fr) | 1990-11-28 |
AU3065489A (en) | 1989-08-25 |
EP0399001B1 (fr) | 1994-07-27 |
NO179164B (no) | 1996-05-13 |
JP2921574B2 (ja) | 1999-07-19 |
ATE109008T1 (de) | 1994-08-15 |
AU634153B2 (en) | 1993-02-18 |
JPH03502691A (ja) | 1991-06-20 |
DK182990A (da) | 1990-07-31 |
NO902909D0 (no) | 1990-06-29 |
DE68917126D1 (de) | 1994-09-01 |
NO179164C (no) | 1996-08-21 |
NO902909L (no) | 1990-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI104374B (fi) | T-solu-epitooppi-oligopeptidejä ja niitä sisältävien konjugaattien valmistus | |
US5785973A (en) | Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines | |
AU634154B2 (en) | Decoupled fiber optic feedthrough assembly | |
Paoletti et al. | Effects of chain length on the immunogenicity in rabbits of group B Streptococcus type III oligosaccharide-tetanus toxoid conjugates. | |
US5425946A (en) | Vaccines against group C Neisseria meningitidis | |
CA2142981C (fr) | Vaccins contre neisseria meningitidis du groupe c | |
AU572821B2 (en) | Synthetic heat-stable enterotoxin polypeptide of escherichia coli and multimers thereof | |
US5773007A (en) | Vaccine compositions | |
EP0427347B1 (fr) | Peptides synthétiques utiles comme porteurs universels pour la préparation des conjugués immunogéniques el leur emploi dans le développment des vaccins synthétiques | |
AU754890B2 (en) | Enterococcus antigens and vaccines | |
KR101446238B1 (ko) | 단백질 매트릭스 백신 및 그의 제조방법 및 백신 투여방법 | |
Paoletti et al. | An oligosaccharide-tetanus toxoid conjugate vaccine against type III group B Streptococcus. | |
PL174082B1 (pl) | Koniugat kapsularnego polisacharydu (Vi) i związanego z nim nośnika oraz sposób wytwarzania koniugatu | |
JPH11507964A (ja) | 2,5−アンヒドロ−d−マンノース末端構造を持つ、抗原性グループb連鎖球菌▲ii▼型および▲iii▼型多糖断片とその複合ワクチン | |
US5043158A (en) | Immunogenic compositions containing ordered carriers | |
BR112012009014B1 (pt) | Processo para preparar conjugado de polissacarídeo capsular de s. aureus tipo 5 ou tipo 8 e molécula de transporte crm197, conjugado e composição imunogênica | |
Elsayed et al. | Synthetic allergenic epitopes from the amino-terminal regions of the major allergens of hazel and birch pollen | |
EP0302887A1 (fr) | Antigenes, anticorps, vaccins bacteriens et leur procede de production. | |
Richter et al. | Preparation of dextran-protein conjugates and studies of their immunogenicity | |
Jennings | Further approaches for optimizing polysaccharide-protein conjugate vaccines for prevention of invasive bacterial disease | |
Lett et al. | Immunogenicity of polysaccharides conjugated to peptides containing T-and B-cell epitopes | |
Lugowski et al. | Enterobacterial common antigen-tetanus toxoid conjugate as immunogen | |
WO1991012819A1 (fr) | Compositions immunogeniques ameliorees | |
Michaelides | Chemical and enzymatic fragmentation of tetanus toxin and immunological studies on anti-tetanus toxin and toxoid sera. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Owner name: WYETH HOLDINGS CORPORATION |
|
MA | Patent expired |