WO1988003923A1 - Guanines substitutees en position 9 - Google Patents

Guanines substitutees en position 9 Download PDF

Info

Publication number
WO1988003923A1
WO1988003923A1 PCT/SU1987/000135 SU8700135W WO8803923A1 WO 1988003923 A1 WO1988003923 A1 WO 1988003923A1 SU 8700135 W SU8700135 W SU 8700135W WO 8803923 A1 WO8803923 A1 WO 8803923A1
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
acetylguanine
introduction
ethoxymethyl
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SU1987/000135
Other languages
English (en)
French (fr)
Russian (ru)
Inventor
Regina Abramovna Zhuk
Marger Jurievich Lidak
Marina Anatolievna Madre
Veniamin Iosifovich Votyakov
Olga Trifonovna Andreeva
Evgeny Ivanovich Boreko
Ljudmila Viktorovna Korobchenko
Vyacheslav Anatolievich Rusyaev
Olga Ivanovna Starkova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Belorussky Nauchno-Issledovatelsky Institut Epidem
INSTITUT ORGANICHESKOGO SINTEZA AKADEMII NAUK LATV
Original Assignee
Belorussky Nauchno-Issledovatelsky Institut Epidem
INSTITUT ORGANICHESKOGO SINTEZA AKADEMII NAUK LATV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Belorussky Nauchno-Issledovatelsky Institut Epidem, INSTITUT ORGANICHESKOGO SINTEZA AKADEMII NAUK LATV filed Critical Belorussky Nauchno-Issledovatelsky Institut Epidem
Priority to JP88500627A priority Critical patent/JPH01501478A/ja
Publication of WO1988003923A1 publication Critical patent/WO1988003923A1/ru
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Definitions

  • the area of technology The current invention is missing from the domestic chemical industry, and more specifically, there are 9 new-substituting guanine compounds. Respectable connections are dominated by active English activity.
  • the product has a small water-solubility (2 mg / ml) and, as a result of this application, the phenomenon of inactivity is observed.
  • the internal circuit is used as a long (two-hour) infusion.
  • the task is to receive new connections having a more efficient activity and increased productivity in water and lime.
  • the claimed compounds are 9-substituted guanines, a general formula
  • mice with a herbal encephalitis infected by intravenous infusion of a simple virus type I, when administered 9- / 2- (2-test-load-free)
  • the wide frequency of the claimed compounds is more than 10 times higher than that of the zverex.
  • the claimed compounds are susceptible to non-tradable water products (7,4L), but are hydrated in the case of 5 and 5.
  • the bottle equipped with a stirrer, accommodates 9- (2-acetoxyethoxymethyl) - ig-acetylguine and adds water.
  • the resulting suspension is stirred and cooled to 0–5 ° C, and added is the cooled 2 ⁇ solution.
  • Consistent flasks stir at the same temperature for another I hour and do not neutralize the acetic acid to ⁇ 6-7. As a result, they receive a solution, which can withstand temperatures from 0 ⁇ -5 ° ⁇ for a day. Hopper 9- (2-hydroxyethoxymethyl) - Acetylguarate is removed, washed and dried.
  • Derivatives 9- (2-oxoethoxymethyl) - ⁇ -acetylguanine dissolves at a temperature of 50-60 ° C in dimethylphamide.
  • the refrigerant is cooled to 0–5 ° C and, at the same time, it is saturated with coolant. After this, and after the addition, add 2,3-dihydrogen or 2,3-dihydrogen.
  • the mixed mixture is stirred for 3 hours at a temperature of 0 ⁇ -5 ° C, after which it does not trap the ethylamine. After the loss of the hydrated hydrate of thiethylamine, it is found to be present.
  • the filter is evaporated in a vacuum and the residue is removed from the ethyl acetate, and then from ethanol. It produces 9- / 2- (2-tetrahydrohydroxy) ethoxymethyl / - ⁇ - acetylguine or, if 2,3-dihydrogen is used, 2,3-dihydrometer is used, but 2-case etoximethyl / - ⁇ - -acetylguanine.
  • a flask equipped with a stirrer holds 3.0 g (97 mmol) of 9- (2-acetoxymethyl) - ⁇ -acetylguanine and .. 60 g of water.
  • the flask equipped with the bag holds 1.18 g. (3.5 mmol) of 9- / 2- (2-tetrahydroxydehyde) ethoxymethyl- - ⁇ 2- acetylguanine, obtained in the case of i. 25% Methylamine amine.
  • the mixture is mixed and mixed at room temperature.

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/SU1987/000135 1986-11-25 1987-11-23 Guanines substitutees en position 9 Ceased WO1988003923A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP88500627A JPH01501478A (ja) 1986-11-25 1987-11-23 ９―置換グアニン

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SU4152348/23 1986-11-25
SU4152348 1986-11-25

Publications (1)

Publication Number Publication Date
WO1988003923A1 true WO1988003923A1 (fr) 1988-06-02

Family

ID=21269444

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SU1987/000135 Ceased WO1988003923A1 (fr) 1986-11-25 1987-11-23 Guanines substitutees en position 9

Country Status (4)

Country Link
US (1) US4916225A (https=)
EP (1) EP0290630A4 (https=)
JP (1) JPH01501478A (https=)
WO (1) WO1988003923A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0771799A1 (de) * 1995-11-06 1997-05-07 Bayer Ag Purin-6-one-Derivate

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7374494A (en) * 1993-07-23 1995-02-20 Apple Computer, Inc. Method and apparatus for fuzzy logic rule execution
US7658913B2 (en) * 2005-11-28 2010-02-09 Verrow Pharmaceuticals, Inc. Compositions useful for reducing nephrotoxicity and methods of use thereof
CN102250126A (zh) * 2010-05-18 2011-11-23 北京化工大学 一种双嘌呤类衍生物及其合成

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122197A (en) * 1982-06-21 1984-01-11 Astra Laekemedel Ab Antiviral guanine derivatives
GB2122198A (en) * 1982-06-21 1984-01-11 Astra Laekemedel Ab Antiviral guanine derivatives
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228937A (en) * 1963-07-17 1966-01-11 Shell Oil Co Adenine derivative
US3903169A (en) * 1973-08-27 1975-09-02 Polaroid Corp Process of reacting cyclopentanone with lactones
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4241063A (en) * 1979-08-06 1980-12-23 Bristol-Myers Company Purine derivatives and their use as bronchodilators
EP0052964A1 (en) * 1980-11-20 1982-06-02 Beecham Group Plc Adenine derivatives possessing pharmacological activity
US4826981A (en) * 1984-12-22 1989-05-02 Krka Process for preparing 9-(2-hydroxyethoxymethyl)-guanine
YU45690B (sh) * 1984-12-22 1992-07-20 Krka Tovarna Zdraviln.Sol.O. Postopek za pripravo 9-(2-hidroksietoksimetil)-gvanina
JPH0633263B2 (ja) * 1985-05-27 1994-05-02 鐘淵化学工業株式会社 ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
GB2122197A (en) * 1982-06-21 1984-01-11 Astra Laekemedel Ab Antiviral guanine derivatives
GB2122198A (en) * 1982-06-21 1984-01-11 Astra Laekemedel Ab Antiviral guanine derivatives
WO1984000167A1 (en) * 1982-06-21 1984-01-19 Astra Laekemedel Ab Novel derivatives of guanine i
EP0103551B1 (en) * 1982-06-21 1986-02-26 Astra Läkemedel Aktiebolag Novel derivatives of guanine
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0290630A4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0771799A1 (de) * 1995-11-06 1997-05-07 Bayer Ag Purin-6-one-Derivate
US5861396A (en) * 1995-11-06 1999-01-19 Bayer Aktiengesellschaft Purin-6-one derivatives

Also Published As

Publication number Publication date
EP0290630A4 (de) 1990-02-26
JPH0587073B2 (https=) 1993-12-15
EP0290630A1 (de) 1988-11-17
US4916225A (en) 1990-04-10
JPH01501478A (ja) 1989-05-25

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