DE69033223T2 - Derivate von 6-substituierten azyklischen Pyrimidin-Nukleosiden und diese als Wirkstoff enthaltende antivirale Mittel - Google Patents

Derivate von 6-substituierten azyklischen Pyrimidin-Nukleosiden und diese als Wirkstoff enthaltende antivirale Mittel

Info

Publication number
DE69033223T2
DE69033223T2 DE69033223T DE69033223T DE69033223T2 DE 69033223 T2 DE69033223 T2 DE 69033223T2 DE 69033223 T DE69033223 T DE 69033223T DE 69033223 T DE69033223 T DE 69033223T DE 69033223 T2 DE69033223 T2 DE 69033223T2
Authority
DE
Germany
Prior art keywords
alkyl
atom
group
hydrogen atom
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033223T
Other languages
English (en)
Other versions
DE69033223D1 (de
Inventor
Tadashi Miyasaka
Hiromichi Tanaka
Clercq Erik Desire Alice De
Masanori Baba
Richard Thomas Walker
Masaru Ubasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2200895A external-priority patent/JPH0751567B2/ja
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of DE69033223D1 publication Critical patent/DE69033223D1/de
Publication of DE69033223T2 publication Critical patent/DE69033223T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69033223T 1989-09-29 1990-09-28 Derivate von 6-substituierten azyklischen Pyrimidin-Nukleosiden und diese als Wirkstoff enthaltende antivirale Mittel Expired - Fee Related DE69033223T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25453189 1989-09-29
JP5970090 1990-03-09
JP2200895A JPH0751567B2 (ja) 1989-09-29 1990-07-27 ６―置換アシクロピリミジンヌクレオシド誘導体及び該誘導体を有効成分とする抗ウイルス剤

Publications (2)

Publication Number Publication Date
DE69033223D1 DE69033223D1 (de) 1999-09-02
DE69033223T2 true DE69033223T2 (de) 1999-12-23

Family

ID=27296972

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69033998T Expired - Fee Related DE69033998T2 (de) 1989-09-29 1990-09-28 6-Substituierte Acylopyrimidin-Nucleoside-Derivate und diese als wirksamen Stoff enthaltende Antivirusmittel
DE69033223T Expired - Fee Related DE69033223T2 (de) 1989-09-29 1990-09-28 Derivate von 6-substituierten azyklischen Pyrimidin-Nukleosiden und diese als Wirkstoff enthaltende antivirale Mittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69033998T Expired - Fee Related DE69033998T2 (de) 1989-09-29 1990-09-28 6-Substituierte Acylopyrimidin-Nucleoside-Derivate und diese als wirksamen Stoff enthaltende Antivirusmittel

Country Status (10)

Country Link
EP (2) EP0829476B1 (de)
AT (2) ATE222891T1 (de)
CA (1) CA2026226C (de)
DD (1) DD299297A5 (de)
DE (2) DE69033998T2 (de)
DK (2) DK0829476T3 (de)
ES (2) ES2134758T3 (de)
GR (1) GR3031231T3 (de)
HU (1) HU205917B (de)
PH (1) PH30766A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278167A (en) * 1992-05-13 1994-01-11 Brown University Research Foundation 6-pyridyl substituted pyrimidine derivatives
EP0631783A1 (de) * 1993-06-03 1995-01-04 Mitsubishi Chemical Corporation Antivirale Kombinationen von 2',3-Di-deoxyribonukleosiden mit 6-benzyl-1-ethoxy-methyl-5-substituierten Uracil-Derivaten
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
JP2683297B2 (ja) * 1994-02-28 1997-11-26 スンキョン インダストリーズ カンパニー リミテッド ピリミジンアシクロヌクレオシド誘導体
JP3049095B2 (ja) * 1996-02-22 2000-06-05 サムジン ファーマシューチカル カンパニー，リミテッド 新規抗ウイルス性置換ピリミジンジオン単素炭素環式ヌクレオシド誘導体及びその製造方法とこれを活性成分として含有する組成物
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
FR2781219B1 (fr) 1998-07-16 2000-08-25 Synthelabo Procede pour la preparation de 5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4 (1h, 3h) -dione
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
AU2946300A (en) * 1999-03-04 2000-09-21 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
US6545152B1 (en) 2000-07-18 2003-04-08 Parker Hughes Institute R-isomers of nonnucleoside inhibitors
US6689793B2 (en) 2000-12-06 2004-02-10 Parker Hughes Institute Piperidinylethyl-, phenoxyethyl-, and β-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity
FR2820135B1 (fr) * 2001-01-29 2005-01-14 Univ Geneve Derives d'acyclonucleosides pyrimidiniques, leur procede de preparation et leur utilisation
EP1355887B1 (de) 2001-01-29 2007-08-15 Universite De Geneve Pyrimidinische azyklonukleoside, verfahren zur ihrer herstellung und ihre verwendung
AU2003205536A1 (en) * 2002-01-11 2003-07-24 Statens Serum Institut Anti-retroviral 5,6-disubstituted acyclopyrimidine nucleoside derivatives
ES2283851T3 (es) * 2002-08-13 2007-11-01 Warner-Lambert Company Llc Derivados de pirimidin-2,4-diona como inhibidores de las metaloproteinasas de matriz.
HRPK20090508B3 (hr) 2009-09-25 2012-12-31 Sveučilište u Zagrebu Novi 6-supstituirani derivati pirimidina
CN115960148B (zh) * 2021-08-27 2023-12-12 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3497515A (en) * 1966-02-04 1970-02-24 Du Pont 3,5,6-substituted uracils
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2142317A1 (de) * 1971-08-24 1973-03-01 Bayer Ag Hypnotisches mittel
DE3206197A1 (de) * 1982-02-20 1983-09-01 Henkel KGaA, 4000 Düsseldorf Uracil-derivate als antiseborrhoische zusaetze fuer kosmetische mittel
JPS61205261A (ja) * 1985-03-08 1986-09-11 Sagami Chem Res Center ６―置換―５―フルオロウラシル誘導体
JPS63290867A (ja) * 1987-05-22 1988-11-28 Sds Biotech Kk ウラシル系化合物及び殺菌剤
DE68918804T2 (de) * 1988-03-31 1995-02-23 Mitsubishi Chem Ind Acyclische 6-substituierte pyrimidin nukleosid-abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten.

Also Published As

Publication number Publication date
HUT55006A (en) 1991-04-29
EP0420763A2 (de) 1991-04-03
PH30766A (en) 1997-10-17
ATE182587T1 (de) 1999-08-15
EP0420763A3 (en) 1991-09-18
DD299297A5 (de) 1992-04-09
AU642906B2 (en) 1993-11-04
DE69033998T2 (de) 2003-05-08
EP0829476A3 (de) 1999-02-24
DK0420763T3 (da) 2000-03-06
EP0829476B1 (de) 2002-08-28
CA2026226C (en) 2003-08-19
HU906019D0 (en) 1991-03-28
AU6326290A (en) 1991-04-11
GR3031231T3 (en) 1999-12-31
EP0420763B1 (de) 1999-07-28
DE69033223D1 (de) 1999-09-02
CA2026226A1 (en) 1991-03-30
EP0829476A2 (de) 1998-03-18
ES2134758T3 (es) 1999-10-16
DK0829476T3 (da) 2002-11-11
ATE222891T1 (de) 2002-09-15
HU205917B (en) 1992-07-28
ES2177861T3 (es) 2002-12-16
DE69033998D1 (de) 2002-10-02

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: MITSUBISHI CHEMICAL CORP., TOKIO/TOKYO, JP

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee