DK0420763T3 - 6-substituerede acyclopyrimiddinnukleosidderivater og antiviralt middel indeholdende disse som aktiv bestanddel - Google Patents

6-substituerede acyclopyrimiddinnukleosidderivater og antiviralt middel indeholdende disse som aktiv bestanddel

Info

Publication number
DK0420763T3
DK0420763T3 DK90402693T DK90402693T DK0420763T3 DK 0420763 T3 DK0420763 T3 DK 0420763T3 DK 90402693 T DK90402693 T DK 90402693T DK 90402693 T DK90402693 T DK 90402693T DK 0420763 T3 DK0420763 T3 DK 0420763T3
Authority
DK
Denmark
Prior art keywords
alkyl
atom
group
hydrogen atom
oxygen
Prior art date
Application number
DK90402693T
Other languages
English (en)
Inventor
Richard Thomas Walker
Tadashi Miyasaka
Hiromichi Tanaka
Clercq Erik Desire Alice De
Masanori Baba
Masaru Ubasawa
Original Assignee
Mitsubishi Chem Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2200895A external-priority patent/JPH0751567B2/ja
Application filed by Mitsubishi Chem Corp filed Critical Mitsubishi Chem Corp
Application granted granted Critical
Publication of DK0420763T3 publication Critical patent/DK0420763T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK90402693T 1989-09-29 1990-09-28 6-substituerede acyclopyrimiddinnukleosidderivater og antiviralt middel indeholdende disse som aktiv bestanddel DK0420763T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25453189 1989-09-29
JP5970090 1990-03-09
JP2200895A JPH0751567B2 (ja) 1989-09-29 1990-07-27 ６―置換アシクロピリミジンヌクレオシド誘導体及び該誘導体を有効成分とする抗ウイルス剤

Publications (1)

Publication Number Publication Date
DK0420763T3 true DK0420763T3 (da) 2000-03-06

Family

ID=27296972

Family Applications (2)

Application Number Title Priority Date Filing Date
DK97110658T DK0829476T3 (da) 1989-09-29 1990-09-28 6-substituerede acyclopyrimidin-nucleosid-derivater og antivirale midler, der indeholder disse derivater som aktive ingredienser
DK90402693T DK0420763T3 (da) 1989-09-29 1990-09-28 6-substituerede acyclopyrimiddinnukleosidderivater og antiviralt middel indeholdende disse som aktiv bestanddel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK97110658T DK0829476T3 (da) 1989-09-29 1990-09-28 6-substituerede acyclopyrimidin-nucleosid-derivater og antivirale midler, der indeholder disse derivater som aktive ingredienser

Country Status (10)

Country Link
EP (2) EP0829476B1 (da)
AT (2) ATE182587T1 (da)
CA (1) CA2026226C (da)
DD (1) DD299297A5 (da)
DE (2) DE69033223T2 (da)
DK (2) DK0829476T3 (da)
ES (2) ES2177861T3 (da)
GR (1) GR3031231T3 (da)
HU (1) HU205917B (da)
PH (1) PH30766A (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278167A (en) * 1992-05-13 1994-01-11 Brown University Research Foundation 6-pyridyl substituted pyrimidine derivatives
EP0631783A1 (en) * 1993-06-03 1995-01-04 Mitsubishi Chemical Corporation Antiviral combinations of 2',3'-di-deoxyribonucleosides with 6-benzyl-1-ethoxymethyl-5-substituted uracil derivatives
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
WO1995023138A1 (en) * 1994-02-28 1995-08-31 Sunkyong Industries Co., Ltd. Pyrimidine acyclonucleoside derivatives
EP0827498B1 (en) * 1996-02-22 2003-06-18 Samjin Pharmaceutical Co., Ltd. New antiviral substituted pyrimidinedione homocarbocyclic nucleoside derivatives and methods for the preparation thereof and compositions containing the same as active ingredients
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
FR2781219B1 (fr) 1998-07-16 2000-08-25 Synthelabo Procede pour la preparation de 5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4 (1h, 3h) -dione
US6136335A (en) * 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
DE60013260T2 (de) * 1999-03-04 2005-08-11 Korea Research Institute Of Chemical Technology Antivirale 2,4-Pyrimidinedion-Derivate und ein Verfahren zu ihrer Herstellung
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
US6545152B1 (en) 2000-07-18 2003-04-08 Parker Hughes Institute R-isomers of nonnucleoside inhibitors
US6689793B2 (en) 2000-12-06 2004-02-10 Parker Hughes Institute Piperidinylethyl-, phenoxyethyl-, and β-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity
FR2820135B1 (fr) * 2001-01-29 2005-01-14 Univ Geneve Derives d'acyclonucleosides pyrimidiniques, leur procede de preparation et leur utilisation
WO2002060880A1 (fr) * 2001-01-29 2002-08-08 Universite De Geneve Derives d'acyclonucleosides pyrimidiniques, leur procede de preparation et leur utilisation
AU2003205536A1 (en) * 2002-01-11 2003-07-24 Statens Serum Institut Anti-retroviral 5,6-disubstituted acyclopyrimidine nucleoside derivatives
JP2006500351A (ja) * 2002-08-13 2006-01-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー マトリックスメタロプロテアーゼ−１３阻害剤としてのピリミジン−２，４−ジオン誘導体
HRPK20090508B3 (hr) 2009-09-25 2012-12-31 Sveučilište u Zagrebu Novi 6-supstituirani derivati pirimidina
CN115960148B (zh) * 2021-08-27 2023-12-12 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3497515A (en) * 1966-02-04 1970-02-24 Du Pont 3,5,6-substituted uracils
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2142317A1 (de) * 1971-08-24 1973-03-01 Bayer Ag Hypnotisches mittel
DE3206197A1 (de) * 1982-02-20 1983-09-01 Henkel KGaA, 4000 Düsseldorf Uracil-derivate als antiseborrhoische zusaetze fuer kosmetische mittel
JPS61205261A (ja) * 1985-03-08 1986-09-11 Sagami Chem Res Center ６―置換―５―フルオロウラシル誘導体
JPS63290867A (ja) * 1987-05-22 1988-11-28 Sds Biotech Kk ウラシル系化合物及び殺菌剤
WO1989009213A1 (en) * 1988-03-31 1989-10-05 Mitsubishi Kasei Corporation 6-substituted acyclicpyrimidine nucleoside derivatives and antiviral agents containing same as active ingredients

Also Published As

Publication number Publication date
PH30766A (en) 1997-10-17
EP0829476B1 (en) 2002-08-28
ES2177861T3 (es) 2002-12-16
EP0829476A3 (en) 1999-02-24
DE69033223D1 (de) 1999-09-02
DE69033998T2 (de) 2003-05-08
ATE182587T1 (de) 1999-08-15
AU642906B2 (en) 1993-11-04
DK0829476T3 (da) 2002-11-11
DE69033998D1 (de) 2002-10-02
CA2026226A1 (en) 1991-03-30
CA2026226C (en) 2003-08-19
HU205917B (en) 1992-07-28
HU906019D0 (en) 1991-03-28
AU6326290A (en) 1991-04-11
ATE222891T1 (de) 2002-09-15
EP0829476A2 (en) 1998-03-18
ES2134758T3 (es) 1999-10-16
HUT55006A (en) 1991-04-29
EP0420763A3 (en) 1991-09-18
DD299297A5 (de) 1992-04-09
EP0420763B1 (en) 1999-07-28
DE69033223T2 (de) 1999-12-23
GR3031231T3 (en) 1999-12-31
EP0420763A2 (en) 1991-04-03

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