WO1987000521A3 - Nouveaux derives d'acide carboxylique, leur procede de fabrication, leur utilisation, et medicaments contenant ces composes - Google Patents

Nouveaux derives d'acide carboxylique, leur procede de fabrication, leur utilisation, et medicaments contenant ces composes

Info

Publication number
WO1987000521A3
WO1987000521A3 PCT/EP1986/000406 EP8600406W WO8700521A3 WO 1987000521 A3 WO1987000521 A3 WO 1987000521A3 EP 8600406 W EP8600406 W EP 8600406W WO 8700521 A3 WO8700521 A3 WO 8700521A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
carboxylic acid
acid derivatives
pct
manufacturing process
Prior art date
Application number
PCT/EP1986/000406
Other languages
German (de)
English (en)
Other versions
WO1987000521A2 (fr
Inventor
Hans Peter Wolff
Ernst-Christian Witte
Hans-Frieder Kuehnle
Original Assignee
Boehringer Mannheim Gmbh
Hans Peter Wolff
Witte Ernst Christian
Kuehnle Hans Frieder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh, Hans Peter Wolff, Witte Ernst Christian, Kuehnle Hans Frieder filed Critical Boehringer Mannheim Gmbh
Priority to HU863741A priority Critical patent/HUT43037A/hu
Priority to AT86904797T priority patent/ATE40681T1/de
Priority to DE8686904797T priority patent/DE3662041D1/de
Publication of WO1987000521A2 publication Critical patent/WO1987000521A2/fr
Priority to DK100487A priority patent/DK100487D0/da
Publication of WO1987000521A3 publication Critical patent/WO1987000521A3/fr
Priority to NO871059A priority patent/NO166939C/no
Priority to FI871143A priority patent/FI871143A0/fi
Priority to KR870700223A priority patent/KR870700599A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)

Abstract

Nouveaux dérivés d'acide carboxylique de formule générale (I) dans laquelle R1 est un résidu aryle ou aryloxy éventuellement substitué, R2 est hydrogène, un résidu alkyle inférieur ou le groupe R1-A-, ainsi que pour le cas où X représente le groupe cyano, un groupe acylamino ou amino, A est un groupe d'alkyles à chaîne droite ou ramifiée, saturé ou non avec de 3 à 8 atomes de carbone, qui possède une longueur de chaîne d'au moins 3 atomes de carbone; X représente le groupe cyano ou un groupe de formule -B-R3 ou -D- NR4R5, où B est O, S, So, SO2, O(O), OSO2, NHCO, NHSO2 ou CO, D représente un tiret de valence, SO2 ou bien CO, R3 est un groupe alkyle, trifluorométhyle, cycloalkyle, aralkyle, aralkényle ou aryle, le résidu aryle respectif pouvant être éventuellement substitué, R4 est hydrogène, un résidu alkyle inférieur, un résidu aryle ou aralkyle éventuellement substitué, R5 est hydrogène, un résidu alkyle inférieur, ou bien R4 et R5 ensemble sont une chaîne d'alkyles avec de 4 à 6 atomes de carbone, qui peut être interrompue par O, S ou NR6, et R6 est hydrogène, un résidu alkyle inférieur ou un résidu phényle ou benzyle éventuellement substitué. Sont également décrits leurs sels, esters, amides et nitriles physiologiquement neutres, à condition que, dans le cas a) où A est un groupe d'alkyles avec 3 atomes de carbone, a1) dans tous les cas le résidu aryle du R1 ne puisse représenter le résidu phényle non substitué et que a2) X ne puisse représenter les groupes -CN, -NHCOR3 et NR4R5, b) où X est un résidu de formule -SCH3, R2 ne puisse représenter du méthyle, c) où X est le groupe -NH2 ou -NHCOCH3, R1A- ne puisse représenter du 4-phénylbutyle ou 4-(4-méthoxyphényl)butyle, d) où X est le groupe 2,4-dinitrophényle, R1A- ne puisse représenter 4-phénylbutyle ou 5-phénylpentyle, e) où X est le groupe -COCH3, R1A- ne puisse représenter 3-(2-chlorphényl)propyle ou 5-(4-méthoxyphényl)-pentyle. Ces composés sont utilisés comme médicaments pour abaisser le taux de sucre dans le sang.
PCT/EP1986/000406 1985-07-16 1986-07-10 Nouveaux derives d'acide carboxylique, leur procede de fabrication, leur utilisation, et medicaments contenant ces composes WO1987000521A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
HU863741A HUT43037A (en) 1986-07-10 1986-07-10 Process for preparing novel carboxylic acid derivatives and pharmaceutical compositions comprising the same as active substance
AT86904797T ATE40681T1 (de) 1985-07-16 1986-07-10 Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten.
DE8686904797T DE3662041D1 (en) 1985-07-16 1986-07-10 New carboxylic acid derivatives, their manufacturing process, use and medicines containing these compounds
DK100487A DK100487D0 (da) 1985-07-16 1987-02-26 Hidtil ukendte carbonsyrederivater, fremgangsmaade til deres fremstilling, deres anvendelse samt laegemidler indeholdende disse forbindelser
NO871059A NO166939C (no) 1985-07-16 1987-03-13 Analogifremgangsmaate for fremstilling av terapeutisk aktive carboxylsyrederivater.
FI871143A FI871143A0 (fi) 1985-07-16 1987-03-16 Nya derivater av karboxylsyra, foerfarande foer framstaellning av dessa, deras anvaendning samt laekemedel som innehaoller dessa foereningar.
KR870700223A KR870700599A (ko) 1985-07-16 1987-03-16 카르복실산유도체, 그의 제조방법, 이화합물을 함유한 약제조성물 및 그의 용도

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853525284 DE3525284A1 (de) 1985-07-16 1985-07-16 Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten
DEP3525284.7 1985-07-16

Publications (2)

Publication Number Publication Date
WO1987000521A2 WO1987000521A2 (fr) 1987-01-29
WO1987000521A3 true WO1987000521A3 (fr) 1987-03-12

Family

ID=6275845

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000406 WO1987000521A2 (fr) 1985-07-16 1986-07-10 Nouveaux derives d'acide carboxylique, leur procede de fabrication, leur utilisation, et medicaments contenant ces composes

Country Status (21)

Country Link
US (1) US4933367A (fr)
EP (1) EP0226636B1 (fr)
JP (1) JPS63500310A (fr)
KR (1) KR870700599A (fr)
AT (1) ATE40681T1 (fr)
AU (2) AU595814B2 (fr)
CA (1) CA1316922C (fr)
DD (1) DD254193A5 (fr)
DE (2) DE3525284A1 (fr)
DK (1) DK100487D0 (fr)
ES (1) ES2001163A6 (fr)
FI (1) FI871143A0 (fr)
GR (1) GR861803B (fr)
IL (1) IL79379A0 (fr)
NO (1) NO166939C (fr)
NZ (1) NZ216830A (fr)
PH (1) PH25313A (fr)
PT (1) PT82987B (fr)
SU (1) SU1708156A3 (fr)
WO (1) WO1987000521A2 (fr)
ZA (1) ZA865192B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987007265A1 (fr) * 1986-05-29 1987-12-03 E.I. Du Pont De Nemours And Company Acylation et sulfonation d'acetales de silylcetene
DE3700729A1 (de) * 1987-01-13 1988-07-21 Boehringer Mannheim Gmbh Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3935512A1 (de) * 1989-10-25 1991-05-02 Boehringer Mannheim Gmbh Neues herstellungsverfahren fuer verbindungen mit wertvollen pharmakologischen eigenschaften sowie neue zwischenprodukte zur herstellung dieser verbindungen
DE4112103C2 (de) * 1991-02-18 1994-07-14 Matthias Mueller Verwendung von Essigsäure zur Regulierung der Blutzuckerwerte
JP2785162B2 (ja) * 1991-04-05 1998-08-13 富士写真フイルム株式会社 写真用ポリエステル支持体およびハロゲン化銀写真感光材料
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
IL115995A0 (en) * 1994-11-15 1996-01-31 Bayer Ag Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6197791B1 (en) 1997-02-27 2001-03-06 American Cyanamid Company N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6720450B2 (en) * 2001-12-13 2004-04-13 North Carolina State University Pesticidal activity of functionalized cyclopropanes
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
EP1749000A4 (fr) * 2004-05-25 2009-12-30 Metabolex Inc Triazoles substitués bicyliques comme modulateurs de ppar et méthodes de préparation
RU2006145872A (ru) * 2004-05-25 2008-06-27 Метаболекс, Инк. (Us) Замещенные триазолы в качестве модуляторов ppar и способы их получения
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
EP2708262A3 (fr) * 2007-10-12 2014-04-23 The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services Applications thérapeutiques d'inhibiteurs d'hydrolase d'amide d'acide gras
CN114075106B (zh) * 2020-08-12 2023-09-12 广东省稀有金属研究所 一种脂肪醇醚羧酸的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1382267A (en) * 1970-05-05 1975-01-29 Rorer Inc William H Phenylalkanoic acid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562330A (en) 1968-07-18 1971-02-09 Parke Davis & Co 2-phenoxy-4- and 5-phenyl-butyl and -pentyl-amines and salts
BE760034A (fr) * 1969-12-08 1971-06-08 Ici Ltd Production d'esters
EP0025192B1 (fr) * 1979-09-07 1983-05-11 Byk Gulden Lomberg Chemische Fabrik GmbH Acides oxiranne-carboxyliques substitués, procédé pour leur préparation, leur utilisation et médicaments les contenant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1382267A (en) * 1970-05-05 1975-01-29 Rorer Inc William H Phenylalkanoic acid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Organic Chemistry, Volume 43, 1978, Easton, Pa. (US) B.M. TROST et al.: "Synthesis of Thermodynamically Less Stable Enol Thioethers: An alternative Oxidative Decarboxylation of alpha-Thioacids", pages 4549-4551, see page 4549 (cited in the application) *
Journal of the American Chemical Society, Volume 105, 1983, Easton, Pa. (US) B.M. TROST et al.: "Tungsten-Catalyzed Allylic Alkylations. New Avenues for Selectivity", pages 7757-7759, see page 7759, left hand column (cited in the application) *

Also Published As

Publication number Publication date
DD254193A5 (de) 1988-02-17
GR861803B (en) 1986-11-10
SU1708156A3 (ru) 1992-01-23
ATE40681T1 (de) 1989-02-15
KR870700599A (ko) 1987-12-30
CA1316922C (fr) 1993-04-27
JPS63500310A (ja) 1988-02-04
AU595814B2 (en) 1990-04-12
NO871059L (no) 1987-03-13
AU6194286A (en) 1987-02-10
ES2001163A6 (es) 1988-05-01
NO166939C (no) 1991-09-18
PT82987B (pt) 1988-07-01
PT82987A (de) 1986-08-01
FI871143A (fi) 1987-03-16
DK100487A (da) 1987-02-26
DE3662041D1 (en) 1989-03-16
US4933367A (en) 1990-06-12
EP0226636B1 (fr) 1989-02-08
EP0226636A1 (fr) 1987-07-01
DE3525284A1 (de) 1987-01-29
WO1987000521A2 (fr) 1987-01-29
PH25313A (en) 1991-04-30
DK100487D0 (da) 1987-02-26
AU5988086A (en) 1987-01-22
IL79379A0 (en) 1986-10-31
NO166939B (no) 1991-06-10
FI871143A0 (fi) 1987-03-16
NZ216830A (en) 1990-11-27
ZA865192B (en) 1987-03-25
NO871059D0 (no) 1987-03-13

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