ES2001774A6 - Procedimiento para la preparacion de nuevos pirrolo-bencimidazoles, pirrolo-benzoxazoles y pirrolo-benzotiazoles. - Google Patents

Procedimiento para la preparacion de nuevos pirrolo-bencimidazoles, pirrolo-benzoxazoles y pirrolo-benzotiazoles.

Info

Publication number
ES2001774A6
ES2001774A6 ES8601647A ES8601647A ES2001774A6 ES 2001774 A6 ES2001774 A6 ES 2001774A6 ES 8601647 A ES8601647 A ES 8601647A ES 8601647 A ES8601647 A ES 8601647A ES 2001774 A6 ES2001774 A6 ES 2001774A6
Authority
ES
Spain
Prior art keywords
pyrrolobenzimidazoles
products
preparation
medicaments containing
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601647A
Other languages
English (en)
Inventor
Der Saal Wolfgang Von
Alfred Mertenz
Herbert Berger
Bernd Muller-Beckmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of ES2001774A6 publication Critical patent/ES2001774A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • External Artificial Organs (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Indole Compounds (AREA)

Abstract

EL PRESENTE INVENTO CONCIERNE A UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE FORMULA GENERAL I EN QUE R1 SIGNIFICA UN ATOMO DE HIDROGENO, O UN GRUPO ALQUILO, ALQUENILO O CICLOALQUILO; R2 SIGNIFICA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO, ALQUENILO O CIANO, UN GRUPO CARBONILO SUSTITUIDO CON UN GRUPO HIDROXI, ALQUILO, ALCOXI, AMINO, ALQUILAMINO, DIALQUILAMINO O HIDRAZINO O EN COMUN CON R1 REPRESENTA UN GRUPO CICLOALQUILENO, O R1 Y R2 FORMAN EN COMUN UN GRUPO ALQUILIDENO O CICLOALQUILIDENO; T SIGNIFICA OXIGENO, AZUFRE O EL GRUPO NR4, SIGNIFICANDO R4 HIDROGENO O UN GRUPO ALQUILO, R3 SIGNIFICA UN ATOMO DE HIDROGENO, EL GRUPO HIDROXI, UN GRUPO MERCAPTO, ALQUILMERCAPTO, UN GURPO AMINO, PRIDILCARBONILAMINO, ALQUILCARBONILAMINO, O UN GRUPO ALQUILO, CICLOALQUILO, ALQUENILO, CICLOALQUENILO, ALQUINILO, HALOGENOALQUILO, ALCOXIALQUILO, CARBOXIALQUILO O ALCOXICARBONILALQUILO; X SIGNIFICA OXIGENO, AZUFRE O EL GRUPO NR5, REPRESENTANDO R5 HIDROGENO O BIEN UN GRUPO ALQUILO, SUS TAUTOMEROS Y SUS SALESFISIOLOGICAMENTE COMPATIBLES DE ACIDOS INORGANICOS Y ORGANICOS, PARA EL TRATAMIENTO DE ENFERMENDADES CARDIACAS Y CIRCULATORIAS.
ES8601647A 1985-09-05 1986-09-05 Procedimiento para la preparacion de nuevos pirrolo-bencimidazoles, pirrolo-benzoxazoles y pirrolo-benzotiazoles. Expired ES2001774A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853531678 DE3531678A1 (de) 1985-09-05 1985-09-05 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES2001774A6 true ES2001774A6 (es) 1988-06-16

Family

ID=6280182

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601647A Expired ES2001774A6 (es) 1985-09-05 1986-09-05 Procedimiento para la preparacion de nuevos pirrolo-bencimidazoles, pirrolo-benzoxazoles y pirrolo-benzotiazoles.

Country Status (17)

Country Link
US (1) US4730003A (es)
EP (1) EP0214592B1 (es)
JP (1) JPS6259279A (es)
KR (1) KR870003109A (es)
AT (1) ATE66230T1 (es)
AU (1) AU584235B2 (es)
DD (1) DD253821A5 (es)
DE (2) DE3531678A1 (es)
DK (1) DK418986A (es)
ES (1) ES2001774A6 (es)
FI (1) FI863565A (es)
GR (1) GR862247B (es)
HU (1) HU197010B (es)
IL (1) IL79910A (es)
NZ (1) NZ217418A (es)
PT (1) PT83309B (es)
ZA (1) ZA866704B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3642315A1 (de) * 1986-12-11 1988-06-23 Boehringer Mannheim Gmbh Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation
DE3855327D1 (de) * 1987-12-30 1996-07-04 Orion Yhtymae Oy Heterocyclische Verbindungen
US4963677A (en) * 1987-12-30 1990-10-16 Orion Corporation Ltd. Heterocyclic lactam compounds
DE3809868A1 (de) * 1988-03-24 1989-10-05 Boehringer Mannheim Gmbh Neue heterocyclisch substituierte 5,7-dihydro-pyrrolo(3,2-f)benzoxazol-6-one, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
BR9916324A (pt) 1998-12-17 2001-10-02 Hoffmann La Roche 4,5-pirazinoxindóis como inibidores de proteìna quinase
US6153634A (en) * 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
EP1598353A1 (en) * 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones and their use as antiproliferative agents
CN102140099A (zh) * 2010-02-02 2011-08-03 山东轩竹医药科技有限公司 新的吡啶衍生物
DK3241878T4 (da) 2014-09-25 2024-02-05 Daikin Ind Ltd Sammensætning, der omfatter hfc og hfo

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR65025B (en) * 1977-07-21 1980-06-16 Thomae Gmbh Dr K Method for the preparation of new imidazo-isokinolin-diones
DE3410168A1 (de) * 1984-03-20 1985-09-26 Boehringer Mannheim Gmbh, 6800 Mannheim Neue isochinolin-dione, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
PL147842B1 (en) * 1984-05-12 1989-08-31 Method of obtaining novel pyroisobenzimidazoles
US4695571A (en) * 1984-08-24 1987-09-22 Pfizer Inc. Tricyclic oxindole antiinflammatory agents
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3639466A1 (de) * 1986-11-18 1988-05-19 Thomae Gmbh Dr K Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI863565A0 (fi) 1986-09-04
EP0214592A2 (de) 1987-03-18
HU197010B (en) 1989-02-28
PT83309A (de) 1986-10-01
IL79910A (en) 1990-02-09
KR870003109A (ko) 1987-04-15
EP0214592B1 (de) 1991-08-14
PT83309B (de) 1988-01-11
ZA866704B (en) 1987-05-27
HUT42770A (en) 1987-08-28
DE3680845D1 (de) 1991-09-19
DD253821A5 (de) 1988-02-03
DK418986A (da) 1987-03-06
FI863565A (fi) 1987-03-06
AU6216586A (en) 1987-03-12
NZ217418A (en) 1988-11-29
EP0214592A3 (en) 1988-07-06
IL79910A0 (en) 1986-12-31
JPS6259279A (ja) 1987-03-14
GR862247B (en) 1986-12-31
AU584235B2 (en) 1989-05-18
ATE66230T1 (de) 1991-08-15
US4730003A (en) 1988-03-08
DK418986D0 (da) 1986-09-02
DE3531678A1 (de) 1987-03-12

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