WO1985003507A3 - Sels de metallicenium et leur utilisation en tant qu'agents cytostatiques pour la lutte contre le cancer - Google Patents

Sels de metallicenium et leur utilisation en tant qu'agents cytostatiques pour la lutte contre le cancer

Info

Publication number
WO1985003507A3
WO1985003507A3 PCT/EP1985/000047 EP8500047W WO8503507A3 WO 1985003507 A3 WO1985003507 A3 WO 1985003507A3 EP 8500047 W EP8500047 W EP 8500047W WO 8503507 A3 WO8503507 A3 WO 8503507A3
Authority
WO
WIPO (PCT)
Prior art keywords
pct
metallicenium
salts
xrx
eta
Prior art date
Application number
PCT/EP1985/000047
Other languages
German (de)
English (en)
Other versions
WO1985003507A2 (fr
Inventor
Petra Koepf-Maier
Hartmut Koepf
Eberhard Wilhelm Neuse
Original Assignee
Koepf Maier Petra
Hartmut Koepf
Eberhard Wilhelm Neuse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koepf Maier Petra, Hartmut Koepf, Eberhard Wilhelm Neuse filed Critical Koepf Maier Petra
Priority to JP60501069A priority Critical patent/JPH0714877B2/ja
Publication of WO1985003507A2 publication Critical patent/WO1985003507A2/fr
Publication of WO1985003507A3 publication Critical patent/WO1985003507A3/fr
Priority to FI853818A priority patent/FI81358C/fi
Priority to DK456585A priority patent/DK456585A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Sels de métallicénium de formule générale (I) où M représente Fe, Co, Ni, Ru ou Os; C5H5-xRx et C5H5-yR'y représentent des cycles cyclopentadiényle qui peuvent être indépendamment non-substitués (x, y = 0) ou substitués entre une et cinq fois (x, y = 1, 2, 3, 4 ou 5), R et R' représentant indépendamment l'un de l'autre des substituants semblables ou différents, des groupes alkyles, cycloalkyles, hydroxyalkyles, aminoalkyles, halogénoalkyles, alcényles, aryles, aralkyles, ferrocényles, ferrocényliums, ferrocénylalkyles, acyles, halogényles, trialkylsilyles, tricycloalkylsilyles, triarylsilyles, triaralkylsilyles ou carboxyles, esters, amides ou hydrazides, R et R' formant ensemble un pont alkylène avec de 2 à 4 atomes de pont; a, b, m et n sont des nombres entiers, m valant 1 ou 2 et n 1, 2 ou 3, alors que a.m = b.n; A représentant un anion complexant ou à densité élevée, stabilisant le cation métallicénium; ainsi que les solvates de ces sels à utiliser en tant que médicaments, en particulier en tant qu'agents cytostatiques pour lutter contre le cancer.
PCT/EP1985/000047 1984-02-08 1985-02-08 Sels de metallicenium et leur utilisation en tant qu'agents cytostatiques pour la lutte contre le cancer WO1985003507A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP60501069A JPH0714877B2 (ja) 1984-02-08 1985-02-08 メタリセニウム塩および癌の治療における細胞増殖抑制剤としてのその使用
FI853818A FI81358C (fi) 1984-02-08 1985-10-02 Foerfarande foer framstaellning av ferriceniumtrikloracetat-mono(trikloraettiksyra).
DK456585A DK456585A (da) 1984-02-08 1985-10-07 Metallicenium-salte og deres anvendelse som cytostatika ved cancerbehandling

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3404443.4 1984-02-08
DE19843404443 DE3404443A1 (de) 1984-02-08 1984-02-08 Metallicenium-salze und deren verwendung als cytostatica bei der krebsbekaempfung

Publications (2)

Publication Number Publication Date
WO1985003507A2 WO1985003507A2 (fr) 1985-08-15
WO1985003507A3 true WO1985003507A3 (fr) 1985-09-26

Family

ID=6227132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1985/000047 WO1985003507A2 (fr) 1984-02-08 1985-02-08 Sels de metallicenium et leur utilisation en tant qu'agents cytostatiques pour la lutte contre le cancer

Country Status (8)

Country Link
US (1) US4851430A (fr)
EP (1) EP0153636B1 (fr)
JP (1) JPH0714877B2 (fr)
AT (1) ATE48430T1 (fr)
DE (2) DE3404443A1 (fr)
DK (1) DK456585A (fr)
FI (1) FI81358C (fr)
WO (1) WO1985003507A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258403A (en) * 1986-05-13 1993-11-02 Chai-Tech Corporation Metallo-organic salt compounds and pharmaceutical uses thereof
US5049557A (en) * 1986-05-13 1991-09-17 Chai-Tech Corporation Metallo-organic salt compounds and pharmaceutical uses thereof
IL82376A (en) * 1986-05-13 1991-06-10 Chai Tech Corp Pharmaceutical composition for the treatment of inflammatory conditions
DE3923270A1 (de) * 1989-07-14 1991-01-17 Medac Klinische Spezialpraep Wasserloesliche pharmazeutische metallocen-komplex-zusammensetzung
DE4135291A1 (de) * 1991-10-25 1993-04-29 Koepf Maier Petra Cytostatisch wirksame ionische metallocen-komplexe und diese komplexe enthaltende arzneimittel
EP0591756B1 (fr) * 1992-09-22 1998-11-25 Idemitsu Kosan Company Limited Catalyseurs de polymérisation et procédé de production de polymères
US5863911A (en) * 1994-10-12 1999-01-26 Modelisation Et Mise Au Point De Molecules Medicinales Diarylethylene metallocene derivatives, their processes of preparation and pharmaceutical compositions containing said derivatives
FR2725720B1 (fr) * 1994-10-12 1997-01-03 Modelisation Et Mise Au Point Derives metalloceniques du diarylethylene, leurs procedes de preparation et compositions pharmaceutiques contenant lesdits derives
DE19505960A1 (de) * 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
US5595763A (en) * 1995-07-19 1997-01-21 Quimica Farmaceutica Bayer S.A. Tungsten (VI) compositions for the oral treatment of diabetes mellitus
US6255507B1 (en) 1998-09-18 2001-07-03 3M Innovative Properties Company Process for preparing cyclopentadienyliron (II) arene complex
GB9929353D0 (en) 1999-12-13 2000-02-02 Univ Leeds Metallocene synthesis
GB0215593D0 (en) * 2002-07-05 2002-08-14 Univ Leeds New anticancer drugs
DE102008004100A1 (de) 2008-01-11 2009-07-16 Westfälische Wilhelms-Universität Münster Körperschaft des öffentlichen Rechts Metallocenophane als Cytostatika
EP2368895A1 (fr) * 2010-03-03 2011-09-28 Centre National de la Recherche Scientifique (CNRS) Flavonoïdes de ferrocényl
CN106995471B (zh) * 2017-04-17 2019-06-28 陕西师范大学 含能二茂铁鎓离子盐及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL46027A (en) * 1973-11-21 1977-06-30 Fisons Ltd Organo-metallic compounds their preparation and pharmaceutical compositions containing them
DE2623487A1 (de) * 1976-05-26 1977-12-15 Hoechst Ag Ferrocenderivate und verfahren zu ihrer herstellung
DE2623486C2 (de) * 1976-05-26 1982-12-30 Hoechst Ag, 6000 Frankfurt 3.5.5-Trimethylhexanoyl-ferrocen, Verfahren zu seiner Herstellung und pharmazeutische Präparate
DE2923334C2 (de) * 1979-06-08 1985-03-07 Hartmut Prof. Dipl.-Chem. Dr. Köpf Verwendung von Cyclopentadienylmetall-Acido-Komplexen bei der Krebsbekämpfung und diese Komplexe enthaltende Arzneipräparate

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL COMMUNICATIONS, 1965, London, (GB) M. ALY et al: "Paramagnetic ferrocene acid adducts. Kinetics of electron transfer to proton acids", Seiten 404-406 *
CHEMISCHE BERICHTE, Band 93, 1960, Weinheim, (DE) A.N. NESMEJANOW et al: "Unmittelbare Cyanierung der Ferriciniumsalze", Seiten 2729-2735 *
JOURNAL OF ORGANOMETALLIC CHEMISTRY, Band 60, (1973), Seiten c17,c18. Elsevier Sequoia S.A. Lausanne (CH) M. CASTAGNOLA et al: "The electron donor properteis of ferrocene. The oxidation of ferrocene by carboxylic acids" *

Also Published As

Publication number Publication date
ATE48430T1 (de) 1989-12-15
FI853818L (fi) 1985-10-02
DK456585D0 (da) 1985-10-07
WO1985003507A2 (fr) 1985-08-15
FI81358C (fi) 1990-10-10
DE3404443A1 (de) 1985-08-08
FI81358B (fi) 1990-06-29
EP0153636A2 (fr) 1985-09-04
DK456585A (da) 1985-10-07
EP0153636B1 (fr) 1989-12-06
DE3574596D1 (de) 1990-01-11
JPH0714877B2 (ja) 1995-02-22
JPS61501092A (ja) 1986-05-29
US4851430A (en) 1989-07-25
FI853818A0 (fi) 1985-10-02
EP0153636A3 (en) 1985-11-06

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