ES8700246A1 - Procedimiento para la fabricacion de nuevos derivados de la cumarina - Google Patents
Procedimiento para la fabricacion de nuevos derivados de la cumarinaInfo
- Publication number
- ES8700246A1 ES8700246A1 ES545238A ES545238A ES8700246A1 ES 8700246 A1 ES8700246 A1 ES 8700246A1 ES 545238 A ES545238 A ES 545238A ES 545238 A ES545238 A ES 545238A ES 8700246 A1 ES8700246 A1 ES 8700246A1
- Authority
- ES
- Spain
- Prior art keywords
- same
- group
- substituted
- cancer
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA FABRICACION DE NUEVOS DERIVADOS DE LA CUMARINA. CONSISTENTE EN CONDENSAR MEDIANTE REACCION DE PECHMANN UN COMPUESTO FENOLICO DE FORMULA (VIII) CON UN COMPUESTO CARBONILO DE FORMULA (IX), UTILIZANDO AGENTES CONDENSANTES HABITUALES TALES COMO EL ACIDO SULFURICO, CLORHIDRICO Y FOSFORICO, OXICLORURO DE FOSFORO Y OTROS, A UNA TEMPERATURA ENTRE 0J Y 80JC, PARA DAR COMPUESTOS DE FORMULA (I). SIENDO: R1 F HALOGENO; R2, R5, R6 Y R7 F GRUPOS HIDROCARBILO, SUSTITUIDOS O NO, QUE PUEDEN QUEDAR INTERRUMPIDOS EN LA CADENA DEL ATOMO DE CARBONO POR HETEROATOMOS, O POR HIDROGENO; R3 Y R4 CONJUNTAMENTE GRUPOS HIDROCARBILO; R5 F HALOGENO O UN GRUPO HIDROXIDO LIBRE O PROTEGIDO; Y R F H O UN GRUPO HIDROCARBURO. SE UTILIZAN EN MEDICINA POR SUS PROPIEDADES ANTIAGREGANTES, ANTITUMORALES Y ANTIMETASTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8348791A IT1212882B (it) | 1983-07-29 | 1983-07-29 | Derivati basici della cumarina |
Publications (2)
Publication Number | Publication Date |
---|---|
ES545238A0 ES545238A0 (es) | 1986-11-16 |
ES8700246A1 true ES8700246A1 (es) | 1986-11-16 |
Family
ID=11268572
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES534581A Expired ES8602739A1 (es) | 1983-07-29 | 1984-07-24 | Procedimiento para la fabricacion de nuevos derivados de la cumarina |
ES545240A Expired ES8706139A1 (es) | 1983-07-29 | 1985-07-16 | Procedimiento para la fabricacion de nuevos derivados de la cumarina |
ES545238A Expired ES8700246A1 (es) | 1983-07-29 | 1985-07-16 | Procedimiento para la fabricacion de nuevos derivados de la cumarina |
ES545239A Expired ES8608503A1 (es) | 1983-07-29 | 1985-07-16 | Procedimiento para la fabricacion de nuevos derivados de la cumarina |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES534581A Expired ES8602739A1 (es) | 1983-07-29 | 1984-07-24 | Procedimiento para la fabricacion de nuevos derivados de la cumarina |
ES545240A Expired ES8706139A1 (es) | 1983-07-29 | 1985-07-16 | Procedimiento para la fabricacion de nuevos derivados de la cumarina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545239A Expired ES8608503A1 (es) | 1983-07-29 | 1985-07-16 | Procedimiento para la fabricacion de nuevos derivados de la cumarina |
Country Status (25)
Country | Link |
---|---|
US (1) | US4737517A (es) |
EP (1) | EP0133766B1 (es) |
JP (1) | JPS6054378A (es) |
KR (1) | KR870001483B1 (es) |
AR (2) | AR240816A1 (es) |
AT (1) | ATE60329T1 (es) |
AU (1) | AU581853B2 (es) |
BE (1) | BE900225A (es) |
CH (1) | CH662563A5 (es) |
DE (1) | DE3483989D1 (es) |
DK (1) | DK354784A (es) |
ES (4) | ES8602739A1 (es) |
FI (1) | FI85269C (es) |
FR (1) | FR2549832B1 (es) |
GR (1) | GR82014B (es) |
HU (2) | HUT36815A (es) |
IL (1) | IL72515A (es) |
IN (1) | IN161176B (es) |
IT (1) | IT1212882B (es) |
LU (1) | LU85476A1 (es) |
MX (1) | MX162759A (es) |
NO (1) | NO843042L (es) |
NZ (1) | NZ209003A (es) |
PT (1) | PT78986B (es) |
ZA (1) | ZA845670B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5356929A (en) * | 1989-01-23 | 1994-10-18 | Lehigh University | Reduced and quaternized psoralens as photo-activated therapeutics |
WO1990008529A2 (en) * | 1989-01-23 | 1990-08-09 | Lehigh University | 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor |
US6251644B1 (en) | 1990-04-16 | 2001-06-26 | Baxter International, Inc. | Method for inactivating non-enveloped viral contaminants with a photosensitizer by increasing viral permeability to the photosensitizer |
US5516629A (en) | 1990-04-16 | 1996-05-14 | Cryopharm Corporation | Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins |
US5484951A (en) * | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
US5877185A (en) * | 1991-10-22 | 1999-03-02 | Octamer, Inc. | Synergistic compositions useful as anti-tumor agents |
US5482975A (en) * | 1991-10-22 | 1996-01-09 | Octamer, Inc. | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents |
US5783599A (en) * | 1993-02-24 | 1998-07-21 | Octamer Inc | Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones |
US5574062A (en) * | 1993-04-13 | 1996-11-12 | Morinaga Milk Industry Co., Ltd. | Coumarin derivative and use thereof |
DE10352535A1 (de) * | 2003-11-07 | 2005-06-16 | Steag Microparts Gmbh | Mikrostrukturierte Trennvorrichtung und Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Partikel enthaltenden Flüssigkeit |
US20050245489A1 (en) * | 2004-05-03 | 2005-11-03 | Pinney Kevin G | Chromene-containing compounds with anti-tubulin and vascular targeting activity |
US7456214B2 (en) * | 2004-05-03 | 2008-11-25 | Baylor University | Chromene-containing compounds with anti-tubulin and vascular targeting activity |
BRPI0404130A (pt) * | 2004-09-20 | 2006-05-02 | Univ Rio De Janeiro | cumarinas substituìdas, processo de produção de tais cumarinas e composições contendo as mesmas |
CN104529972B (zh) * | 2014-10-10 | 2016-05-18 | 北京工业大学 | 蛋白激酶抑制剂香豆素及其制备方法和医药应用 |
KR102053748B1 (ko) | 2017-12-20 | 2019-12-09 | 강원대학교산학협력단 | 쿠마린 유도체를 포함하는 알레르기성 염증성 질환의 예방 또는 치료용 약학 조성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3515721A (en) * | 1967-06-26 | 1970-06-02 | Cassella Farbwerke Mainkur Ag | 3-tertiary-aminoethyl-4-methyl or phenyl-7-ethoxycarbonylmethoxy - halo or mononitro coumarins and congeners |
BE761985A (fr) * | 1970-10-19 | 1971-07-01 | Recordati Chem Pharm | Procede de preparation de n-alcoyl-dimethylamines |
US3880885A (en) * | 1971-11-23 | 1975-04-29 | Sandoz Ag | Tertiary aminoethyl isochromans and isocoumarins |
IT1088554B (it) * | 1977-11-17 | 1985-06-10 | F I D I A Spa | Procedimento sellettivo per la preparazione di derivati della 7-indrossi cumarina |
IT1160366B (it) * | 1978-12-19 | 1987-03-11 | F I D I A Spa | Applicazioni in campo farmacologico e terapeutico dell'8-cloro-3(beta-dietilamincetil)-4-metil-7-etossi-carbonilmetossi cumarina cloridrato preparato allo stato puro con procedimento selettivo con particolare riguardo alla sua attivita' anti-aggregante piastrinica |
US4321270A (en) * | 1981-01-29 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Substituted chromans |
CA1205028A (en) * | 1981-07-01 | 1986-05-27 | Jerald C. Hinshaw | Fluorescent chelates and labeled specific binding reagents prepared therefrom |
-
1983
- 1983-07-29 IT IT8348791A patent/IT1212882B/it active
-
1984
- 1984-07-19 DK DK354784A patent/DK354784A/da not_active Application Discontinuation
- 1984-07-20 EP EP84304976A patent/EP0133766B1/en not_active Expired - Lifetime
- 1984-07-20 AT AT84304976T patent/ATE60329T1/de not_active IP Right Cessation
- 1984-07-20 FR FR8411537A patent/FR2549832B1/fr not_active Expired
- 1984-07-20 DE DE8484304976T patent/DE3483989D1/de not_active Expired - Lifetime
- 1984-07-21 IN IN522/CAL/84A patent/IN161176B/en unknown
- 1984-07-23 ZA ZA845670A patent/ZA845670B/xx unknown
- 1984-07-24 ES ES534581A patent/ES8602739A1/es not_active Expired
- 1984-07-24 LU LU85476A patent/LU85476A1/fr unknown
- 1984-07-25 AR AR297339A patent/AR240816A1/es active
- 1984-07-25 MX MX202136A patent/MX162759A/es unknown
- 1984-07-25 GR GR75420A patent/GR82014B/el unknown
- 1984-07-25 NZ NZ209003A patent/NZ209003A/en unknown
- 1984-07-26 IL IL72515A patent/IL72515A/xx not_active IP Right Cessation
- 1984-07-26 CH CH3634/84A patent/CH662563A5/fr not_active IP Right Cessation
- 1984-07-26 BE BE1/011065A patent/BE900225A/nl not_active IP Right Cessation
- 1984-07-27 AU AU31274/84A patent/AU581853B2/en not_active Ceased
- 1984-07-27 JP JP59158542A patent/JPS6054378A/ja active Granted
- 1984-07-27 NO NO843042A patent/NO843042L/no unknown
- 1984-07-27 PT PT78986A patent/PT78986B/pt not_active IP Right Cessation
- 1984-07-27 FI FI842997A patent/FI85269C/fi not_active IP Right Cessation
- 1984-07-27 HU HU842898A patent/HUT36815A/hu unknown
- 1984-07-27 KR KR1019840004492A patent/KR870001483B1/ko not_active IP Right Cessation
- 1984-07-27 US US06/635,166 patent/US4737517A/en not_active Expired - Fee Related
-
1985
- 1985-07-16 ES ES545240A patent/ES8706139A1/es not_active Expired
- 1985-07-16 ES ES545238A patent/ES8700246A1/es not_active Expired
- 1985-07-16 ES ES545239A patent/ES8608503A1/es not_active Expired
-
1987
- 1987-07-27 HU HU842898A patent/HU199819B/hu not_active IP Right Cessation
- 1987-09-01 AR AR308584A patent/AR240926A1/es active
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960506 |