UY29172A1 - Composición de trombina estable - Google Patents

Composición de trombina estable

Info

Publication number
UY29172A1
UY29172A1 UY29172A UY29172A UY29172A1 UY 29172 A1 UY29172 A1 UY 29172A1 UY 29172 A UY29172 A UY 29172A UY 29172 A UY29172 A UY 29172A UY 29172 A1 UY29172 A1 UY 29172A1
Authority
UY
Uruguay
Prior art keywords
stable
thrombin
thrombin composition
stable thrombin
human albumin
Prior art date
Application number
UY29172A
Other languages
English (en)
Spanish (es)
Inventor
Juan Ignacio Jorquera Nieto
Pere Ristol Debart
Jesus Fernandez Rodriguez
Isabel Bravo Camison
Rafael Lopez Gomez
Original Assignee
Grifols Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34384852&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY29172(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grifols Sa filed Critical Grifols Sa
Publication of UY29172A1 publication Critical patent/UY29172A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
UY29172A 2004-10-22 2005-10-18 Composición de trombina estable UY29172A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200402523A ES2226587B1 (es) 2004-10-22 2004-10-22 Composicion de trombina estable.

Publications (1)

Publication Number Publication Date
UY29172A1 true UY29172A1 (es) 2006-04-28

Family

ID=34384852

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29172A UY29172A1 (es) 2004-10-22 2005-10-18 Composición de trombina estable

Country Status (14)

Country Link
US (2) US20060088518A1 (pt)
EP (1) EP1649867B8 (pt)
JP (1) JP5105734B2 (pt)
AR (1) AR051396A1 (pt)
AU (1) AU2005225085B2 (pt)
BR (1) BRPI0504445A (pt)
CA (1) CA2523844C (pt)
ES (2) ES2226587B1 (pt)
HU (1) HUE052760T2 (pt)
MX (1) MXPA05011283A (pt)
NZ (1) NZ543084A (pt)
PL (1) PL1649867T3 (pt)
PT (1) PT1649867T (pt)
UY (1) UY29172A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008001353A1 (en) * 2006-06-26 2008-01-03 Omrix Biopharmaceuticals Inc. Virus removal by nanofiltration
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
JP5437236B2 (ja) 2008-04-16 2014-03-12 一般財団法人化学及血清療法研究所 トロンビン固定化生体吸収性シート製剤の製造方法
AU2011260258B2 (en) 2010-06-01 2015-07-09 Baxter Healthcare S.A. Process for making dry and stable hemostatic compositions
AU2011260274B2 (en) 2010-06-01 2015-07-02 Baxter Healthcare S.A. Process for making dry and stable hemostatic compositions
MX345479B (es) 2010-06-01 2017-02-01 Baxter Int Inc * Proceso para elaborar composiciones hemostaticas secas y estables.
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
EP2825216B1 (en) 2012-06-12 2015-08-19 Ferrosan Medical Devices A/S Dry haemostatic composition
US9149529B2 (en) * 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
US9212357B2 (en) 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
KR102223275B1 (ko) * 2012-12-03 2021-03-09 옴릭스 바이오파머슈티컬스 리미티드 트롬빈 용액 및 이의 사용 방법
CN105358071B (zh) 2013-06-21 2018-07-31 弗罗桑医疗设备公司 真空膨胀的干组合物和用于保留该干组合物的注射器
CN105828844B (zh) 2013-12-11 2019-09-27 弗罗桑医疗设备公司 包含挤出增强剂的干组合物
CN106999621B (zh) 2014-10-13 2020-07-03 弗罗桑医疗设备公司 用于止血和伤口愈合的干组合物
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
EP3268030A4 (en) * 2015-03-13 2018-08-01 Vitrum Biologies Inc. Method of stabilizing thrombin and composition thereof
BR112017027695A2 (pt) 2015-07-03 2018-09-04 Ferrosan Medical Devices As seringa para retenção e mistura de primeira e segunda substâncias
ES2968412T3 (es) 2018-05-09 2024-05-09 Ferrosan Medical Devices As Método para preparar una composición hemostática
WO2023115427A1 (en) 2021-12-23 2023-06-29 Guangzhou Bioseal Biotech Co., Ltd. Spray dried thrombin
AU2022426762A1 (en) 2021-12-30 2024-07-04 Baxter Healthcare Sa Fibrinogen and thrombin solutions for a fibrin sealant and fibrin sealant kit

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5639782A (en) * 1979-09-04 1981-04-15 Dai Ichi Pure Chem Co Ltd Stabilization of thrombin
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
JPS63243032A (ja) * 1987-03-27 1988-10-07 Green Cross Corp:The トロンビンの加熱処理方法
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AU683834B2 (en) * 1991-12-31 1997-11-27 Zymogenetics Inc. Methods for producing thrombin
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
GB9503750D0 (en) * 1995-02-24 1995-04-12 Common Services Agency Thrombin preparation
JPH10215875A (ja) * 1997-02-06 1998-08-18 Mitsubishi Chem Corp 蛋白質の精製方法
US5981254A (en) * 1997-10-30 1999-11-09 Haemacure Corporation Process for producing thrombin from plasma
DE60032001T2 (de) * 1999-09-27 2007-05-31 Sysmex Corp. Verfahren zur stabilisierung von thrombin
DE10022092A1 (de) * 2000-05-08 2001-11-15 Aventis Behring Gmbh Stabilisiertes Protein-Präparat und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
AU2005225085A1 (en) 2006-05-11
ES2226587A1 (es) 2005-03-16
EP1649867A1 (en) 2006-04-26
JP2006117678A (ja) 2006-05-11
NZ543084A (en) 2007-03-30
ES2845143T8 (es) 2021-11-17
MXPA05011283A (es) 2006-05-25
ES2845143T3 (es) 2021-07-26
EP1649867B8 (en) 2021-09-08
HUE052760T2 (hu) 2021-05-28
AR051396A1 (es) 2007-01-10
ES2226587B1 (es) 2005-12-16
CA2523844C (en) 2012-06-19
JP5105734B2 (ja) 2012-12-26
BRPI0504445A (pt) 2006-06-27
US9376674B2 (en) 2016-06-28
AU2005225085B2 (en) 2007-05-31
CA2523844A1 (en) 2006-04-22
US20140322791A1 (en) 2014-10-30
PT1649867T (pt) 2021-02-03
US20060088518A1 (en) 2006-04-27
EP1649867B1 (en) 2020-11-25
PL1649867T3 (pl) 2021-06-14

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Effective date: 20180108