UY24774A1 - Procedimiento para piridinas sustituidas - Google Patents

Procedimiento para piridinas sustituidas

Info

Publication number
UY24774A1
UY24774A1 UY24774A UY24774A UY24774A1 UY 24774 A1 UY24774 A1 UY 24774A1 UY 24774 A UY24774 A UY 24774A UY 24774 A UY24774 A UY 24774A UY 24774 A1 UY24774 A1 UY 24774A1
Authority
UY
Uruguay
Prior art keywords
compound
procedure
useful
substituted pyridines
acetylaminopyridin
Prior art date
Application number
UY24774A
Other languages
English (en)
Inventor
Lee Dow Robert
Michael Devries Keith
Wayne Wright Stephen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY24774A1 publication Critical patent/UY24774A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un compuesto de fórmula (VIII) (figura 1) en la que Y5 es como se representa en la figura 2 y en la figura 3, donde Q3 es, entre otras posibilidades, un heterociclo seleccionado entre el grupo compuesto por -(CH2)n-piridilo, -(CHe)n-pirimidilo, entre otros. Como ejemplo no limitante: N-metil4-(2-(2-(2-acetilaminopiridin-5-il)-2-(R)-hidroxietil-N-terc-butiloxicarbonilamino)-etoxi)-fenilacetamida. Se describe además un procedimiento para preparar el compuesto. Los productos según la invención son útiles como agonistas de receptores beta-andrenérgicos, y en particular son útiles como agentes hipoglucemicos y contra la obesidad.
UY24774A 1996-11-14 1997-11-12 Procedimiento para piridinas sustituidas UY24774A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3088096P 1996-11-14 1996-11-14

Publications (1)

Publication Number Publication Date
UY24774A1 true UY24774A1 (es) 1998-05-05

Family

ID=21856496

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24774A UY24774A1 (es) 1996-11-14 1997-11-12 Procedimiento para piridinas sustituidas

Country Status (32)

Country Link
US (1) US6291489B1 (es)
EP (1) EP0938476B1 (es)
JP (1) JP3510635B2 (es)
KR (1) KR20000053314A (es)
CN (1) CN1237160A (es)
AP (1) AP805A (es)
AR (1) AR010584A1 (es)
AT (1) ATE319687T1 (es)
AU (1) AU4634697A (es)
BG (1) BG103393A (es)
BR (1) BR9712951A (es)
CA (1) CA2270386C (es)
CO (1) CO4930261A1 (es)
DE (1) DE69735433D1 (es)
EA (1) EA199900375A1 (es)
GT (1) GT199700118A (es)
HR (1) HRP970612A2 (es)
ID (1) ID18898A (es)
IL (1) IL129688A0 (es)
IS (1) IS5029A (es)
MA (1) MA24401A1 (es)
MY (1) MY132507A (es)
NO (1) NO992296L (es)
OA (1) OA11044A (es)
PA (1) PA8441401A1 (es)
PE (1) PE10299A1 (es)
TN (1) TNSN97172A1 (es)
TR (1) TR199901063T2 (es)
UY (1) UY24774A1 (es)
WO (1) WO1998021184A1 (es)
YU (1) YU22099A (es)
ZA (1) ZA9710186B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052892A2 (en) * 1998-04-08 1999-10-21 Novartis Ag Novel herbicides
US6090942A (en) * 1998-10-15 2000-07-18 Pfizer Inc. Process and intermediates for a β3 -adrenergic receptor agonist
US6515134B1 (en) * 1999-02-16 2003-02-04 Kaneka Corporation Substituted acetylpridine derivatives and process for the preparation of intermediates for optically active beta-3 agonist by the use of the same
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
DE60015036T2 (de) * 1999-07-23 2006-03-02 Pfizer Products Inc., Groton Zwischenprodukte und ein Verfahren zur Herstellung von beta3-Adrenergischer Rezeptor-Agoniste
JPWO2003033468A1 (ja) * 2001-10-17 2005-02-03 株式会社カネカ （Ｓ）−α−ハロメチルピリジンメタノール誘導体の製造方法
WO2003072573A1 (en) * 2002-02-27 2003-09-04 Pfizer Products Inc. Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol
US6864268B2 (en) 2002-02-27 2005-03-08 Pfizer Inc. β3 adrenergic receptor agonists
CA2471646A1 (en) 2002-02-27 2003-09-04 Yong Tao Processes and intermediates useful in preparing .beta.3-adrenergic receptor agonists
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
KR100751163B1 (ko) 2003-05-09 2007-08-22 에프. 호프만-라 로슈 아게 알파-1 아드레날린 작용물질로서의 메틸 인돌 및 메틸피롤로피리딘
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
MX2010012814A (es) 2008-05-23 2010-12-20 Amira Pharmaceuticals Inc Inhibidor de proteina activadora de 5-lipoxigenasa.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4358455A (en) 1980-12-23 1982-11-09 Merck & Co., Inc. Aralkylamindethanol heterocyclic compounds
US5019578A (en) 1987-11-27 1991-05-28 Merck & Co., Inc. β-adrenergic agonists
DE69404039T2 (de) * 1993-06-14 1997-10-16 Pfizer Zweite amine als antidiabetische mittel und für die behandlung von fettleibigkeit
IL113410A (en) * 1994-04-26 1999-11-30 Merck & Co Inc Substituted sulfonamides having an asymmetric center and pharmaceutical compositions containing them
EP0828712A1 (en) * 1995-05-10 1998-03-18 Pfizer Inc. Beta-adrenergic agonists
WO1996035671A1 (en) * 1995-05-10 1996-11-14 Pfizer Inc. β-ADRENERGIC AGONISTS

Also Published As

Publication number Publication date
NO992296D0 (no) 1999-05-12
BR9712951A (pt) 1999-12-07
CA2270386A1 (en) 1998-05-22
TR199901063T2 (xx) 1999-08-23
BG103393A (en) 2000-07-31
EA199900375A1 (ru) 1999-12-29
IS5029A (is) 1999-04-16
MY132507A (en) 2007-10-31
PE10299A1 (es) 1999-02-10
CN1237160A (zh) 1999-12-01
WO1998021184A1 (en) 1998-05-22
JP2000504347A (ja) 2000-04-11
EP0938476B1 (en) 2006-03-08
DE69735433D1 (de) 2006-05-04
YU22099A (sh) 2001-09-28
NO992296L (no) 1999-05-12
HRP970612A2 (en) 1998-08-31
KR20000053314A (ko) 2000-08-25
AP805A (en) 2000-01-28
EP0938476A1 (en) 1999-09-01
IL129688A0 (en) 2000-02-29
ATE319687T1 (de) 2006-03-15
AR010584A1 (es) 2000-06-28
OA11044A (en) 2002-02-20
CO4930261A1 (es) 2000-06-27
GT199700118A (es) 1999-05-05
ID18898A (id) 1998-05-20
ZA9710186B (en) 1999-05-12
AP9701147A0 (en) 1998-01-31
MA24401A1 (fr) 1998-07-01
CA2270386C (en) 2004-08-03
US6291489B1 (en) 2001-09-18
JP3510635B2 (ja) 2004-03-29
AU4634697A (en) 1998-06-03
PA8441401A1 (es) 2000-05-24
TNSN97172A1 (fr) 2005-03-15

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Legal Events

Date Code Title Description
ABAN Application deemed to be withdrawn (no publication fee paid)

Effective date: 20001222