YU22099A - Dobijanje supstituisanih piridina - Google Patents
Dobijanje supstituisanih piridinaInfo
- Publication number
- YU22099A YU22099A YU22099A YU22099A YU22099A YU 22099 A YU22099 A YU 22099A YU 22099 A YU22099 A YU 22099A YU 22099 A YU22099 A YU 22099A YU 22099 A YU22099 A YU 22099A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- formula
- amino
- nitro
- processes
- substituted pyridines
- Prior art date
Links
- 150000003222 pyridines Chemical class 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 nitro, amino Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 239000000048 adrenergic agonist Substances 0.000 abstract 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na postupke dobijanja jedinjenja formule (I) koji su Гџ-adrenergični receptor agonisti, i na postupke dobijanja izvesnih intermedijara formule (IIA) gde R1 je nitro, amino, ili zaštićena amino; R2 je H, fluoro, hloro CF3, nitro (C1-C4) alkil, (C1-C4) alkoksi, amino ili zaštićena amino; i X1 je OH ili odgovarajuća odlazeća grupa, upotrebljena u tom procesu. Ovaj pronalazak se takodje odnosi na nova jedinjenja formule (II).[This invention relates to processes for preparing compounds of formula (I) which are 'beta'-adrenergic receptor agonists, and to processes for preparing certain intermediates of formula (IIA) wherein R1 is nitro, amino or protected amino; R2 is H, fluoro, chloro CF3, nitro, (C1-C4)alkyl, (C1-C4)alkoxy, amino or protected amino; and X1 is OH or a suitable leaving group, used in that process. The invention also relates to novel compounds of the formula (II).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3088096P | 1996-11-14 | 1996-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU22099A true YU22099A (sh) | 2001-09-28 |
Family
ID=21856496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU22099A YU22099A (sh) | 1996-11-14 | 1997-11-03 | Dobijanje supstituisanih piridina |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6291489B1 (sh) |
| EP (1) | EP0938476B1 (sh) |
| JP (1) | JP3510635B2 (sh) |
| KR (1) | KR20000053314A (sh) |
| CN (1) | CN1237160A (sh) |
| AP (1) | AP805A (sh) |
| AR (1) | AR010584A1 (sh) |
| AT (1) | ATE319687T1 (sh) |
| AU (1) | AU4634697A (sh) |
| BG (1) | BG103393A (sh) |
| BR (1) | BR9712951A (sh) |
| CA (1) | CA2270386C (sh) |
| CO (1) | CO4930261A1 (sh) |
| DE (1) | DE69735433D1 (sh) |
| EA (1) | EA199900375A1 (sh) |
| GT (1) | GT199700118A (sh) |
| HR (1) | HRP970612A2 (sh) |
| ID (1) | ID18898A (sh) |
| IL (1) | IL129688A0 (sh) |
| IS (1) | IS5029A (sh) |
| MA (1) | MA24401A1 (sh) |
| MY (1) | MY132507A (sh) |
| NO (1) | NO992296D0 (sh) |
| OA (1) | OA11044A (sh) |
| PA (1) | PA8441401A1 (sh) |
| PE (1) | PE10299A1 (sh) |
| TN (1) | TNSN97172A1 (sh) |
| TR (1) | TR199901063T2 (sh) |
| UY (1) | UY24774A1 (sh) |
| WO (1) | WO1998021184A1 (sh) |
| YU (1) | YU22099A (sh) |
| ZA (1) | ZA9710186B (sh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3605299A (en) * | 1998-04-08 | 1999-11-01 | Novartis Ag | Novel herbicides |
| US6090942A (en) * | 1998-10-15 | 2000-07-18 | Pfizer Inc. | Process and intermediates for a β3 -adrenergic receptor agonist |
| EP1153919A4 (en) * | 1999-02-16 | 2002-10-02 | Kaneka Corp | SUBSTITUTED ACETYLPYRIDINE DERIVATIVES AND PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR OPTICALLY ACTIVE BETA3 ADRENERGIC RECEPTOR AGONIST USING THE SAME |
| US6455734B1 (en) * | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| EP1078924B1 (en) * | 1999-07-23 | 2004-10-20 | Pfizer Products Inc. | Intermediates and a process for producing beta-adrenergic receptor agonists |
| WO2003033468A1 (fr) * | 2001-10-17 | 2003-04-24 | Kaneka Corporation | Procede de preparation de derives de (s)-$g(a)-halomethylpyridine-methanol |
| WO2003072573A1 (en) * | 2002-02-27 | 2003-09-04 | Pfizer Products Inc. | Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol |
| US6864268B2 (en) | 2002-02-27 | 2005-03-08 | Pfizer Inc. | β3 adrenergic receptor agonists |
| MXPA04008298A (es) * | 2002-02-27 | 2004-11-26 | Pfizer Prod Inc | Procesos e intermedios utiles en la preparacion de agonistas de receptor beta-3 adrenergico. |
| EP1424079A1 (en) * | 2002-11-27 | 2004-06-02 | Boehringer Ingelheim International GmbH | Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine |
| ATE406363T1 (de) | 2003-05-09 | 2008-09-15 | Hoffmann La Roche | Methylindole und methylpyrrolopyridine als alpha- 1-adrenerge agonisten |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| CA2724726C (en) | 2008-05-23 | 2018-02-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein inhibitor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4358455A (en) | 1980-12-23 | 1982-11-09 | Merck & Co., Inc. | Aralkylamindethanol heterocyclic compounds |
| US5019578A (en) | 1987-11-27 | 1991-05-28 | Merck & Co., Inc. | β-adrenergic agonists |
| AU675536B2 (en) | 1993-06-14 | 1997-02-06 | Pfizer Inc. | Secondary amines as antidiabetic and antiobesity agents |
| IL113410A (en) * | 1994-04-26 | 1999-11-30 | Merck & Co Inc | Substituted sulfonamides having an asymmetric center and pharmaceutical compositions containing them |
| US5977124A (en) * | 1995-05-10 | 1999-11-02 | Pfizer Inc. | β-adrenergic agonists |
| CA2220538A1 (en) | 1995-05-10 | 1996-11-14 | Pfizer Inc. | .beta.-adrenergic agonists |
-
1997
- 1997-11-03 EA EA199900375A patent/EA199900375A1/ru unknown
- 1997-11-03 WO PCT/IB1997/001367 patent/WO1998021184A1/en active IP Right Grant
- 1997-11-03 US US09/297,694 patent/US6291489B1/en not_active Expired - Fee Related
- 1997-11-03 EP EP97945047A patent/EP0938476B1/en not_active Expired - Lifetime
- 1997-11-03 TR TR1999/01063T patent/TR199901063T2/xx unknown
- 1997-11-03 JP JP52233298A patent/JP3510635B2/ja not_active Expired - Fee Related
- 1997-11-03 AT AT97945047T patent/ATE319687T1/de not_active IP Right Cessation
- 1997-11-03 DE DE69735433T patent/DE69735433D1/de not_active Expired - Lifetime
- 1997-11-03 BR BR9712951-8A patent/BR9712951A/pt not_active Application Discontinuation
- 1997-11-03 CN CN97199663A patent/CN1237160A/zh active Pending
- 1997-11-03 IL IL12968897A patent/IL129688A0/xx unknown
- 1997-11-03 YU YU22099A patent/YU22099A/sh unknown
- 1997-11-03 CA CA002270386A patent/CA2270386C/en not_active Expired - Fee Related
- 1997-11-03 KR KR1019990704312A patent/KR20000053314A/ko active IP Right Grant
- 1997-11-03 AU AU46346/97A patent/AU4634697A/en not_active Abandoned
- 1997-11-11 PE PE1997001004A patent/PE10299A1/es not_active Application Discontinuation
- 1997-11-11 MA MA24864A patent/MA24401A1/fr unknown
- 1997-11-11 GT GT199700118A patent/GT199700118A/es unknown
- 1997-11-12 MY MYPI97005396A patent/MY132507A/en unknown
- 1997-11-12 ZA ZA9710186A patent/ZA9710186B/xx unknown
- 1997-11-12 UY UY24774A patent/UY24774A1/es unknown
- 1997-11-12 PA PA19978441401A patent/PA8441401A1/es unknown
- 1997-11-12 TN TNTNSN97172A patent/TNSN97172A1/fr unknown
- 1997-11-12 AR ARP970105279A patent/AR010584A1/es not_active Application Discontinuation
- 1997-11-13 AP APAP/P/1997/001147A patent/AP805A/en active
- 1997-11-13 ID IDP973662A patent/ID18898A/id unknown
- 1997-11-13 HR HR60/030,880A patent/HRP970612A2/hr not_active Application Discontinuation
- 1997-11-13 CO CO97066763A patent/CO4930261A1/es unknown
-
1999
- 1999-04-16 IS IS5029A patent/IS5029A/is unknown
- 1999-05-07 OA OA9900096A patent/OA11044A/en unknown
- 1999-05-11 BG BG103393A patent/BG103393A/xx unknown
- 1999-05-12 NO NO992296A patent/NO992296D0/no not_active Application Discontinuation
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