USRE43793E1 - Endosseous implant - Google Patents
Endosseous implant Download PDFInfo
- Publication number
- USRE43793E1 USRE43793E1 US13/213,472 US200113213472A USRE43793E US RE43793 E1 USRE43793 E1 US RE43793E1 US 200113213472 A US200113213472 A US 200113213472A US RE43793 E USRE43793 E US RE43793E
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- United States
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- implant according
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Definitions
- the present invention relates to a metallic endosseous implant made from titanium or a titanium alloy to be applied to a human or animal bone, said implant having a smooth or rough surface texture, and wherein said surface has been treated with at least one selected organic compound carrying one or more phosphonic acid group [—P(O)(OH) 2 ] or a derivative thereof, preferably as a pharmaceutically acceptable salt or ester or amide thereof. It has been shown that such chemically modified surface surprisingly enhances the bone bonding strength. Implants according to the present invention may be used as prostheses in medicine, more specifically in orthopaedics, for replacing or strengthening broken or diseased bones, and in dentistry, for anchoring artificial teeth and for anchoring of bone anchored hearing prosthesis.
- Implants which are used as prostheses in medicine for replacing or strengthening broken or diseased bones or as artificial teeth are known. These implants must be made of a non-corrosive material and must be compatible with the surrounding tissue without producing immunologic reactions effecting rejection by the body.
- surface or “contact surface” refer to the titanium or a titanium alloy implant surface not yet treated according to the present invention and the term “modified surface” to the surface treated according to the present invention.
- titanium metal or titanium alloys for such implants.
- the titanium implant with its surface oxide exhibits biocompatibility in the sense that it remains passive for bone regeneration and does not per se induce adverse reactions such as inflammation or soft tissue generation or encapsulation.
- the interface obtained between the implant and the bone tissue normally consists of a protein layer of about 100 nm to 1 ⁇ m thickness preventing the bone tissue from being in direct molecular contact with the implant.
- the actual state of the art for endosseous implants is based on different approaches, for example (i) the creation of a suitable roughness of the implant surface giving a mechanical interlocking between bone and implant and/or (ii) coating the titanium or titanium alloy surface of the implant, e.g. with an artificial hydroxyapatite for improving the healing process and the bone-implant intimate contact.
- Coating the surface of the implant with an artificial hydroxyapatite decreases the osseointegration time.
- U.S. Pat. No. 5,733,564 suggests to use selected bisphosphonates which are known drug substances for the promotion of bone tissue formation by coating titanium metal surfaces of prostheses or implants with these compounds.
- a titanium or a titanium alloy endosseous implant has been treated with at least one selected organic compound as defined herein below carrying one or more phosphonic acid groups or a derivative thereof, preferably an ester, an amide or a salt thereof, as defined herein below, said surface shows a surprisingly improved bone bonding strength and a surprisingly shortened osseointegration time compared to the non treated surface and does not have the disadvantages as known for surfaces having a hydroxyapatite coating.
- the present invention specifically refers to an endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one organic compound corresponding to the general formula (I): A-[P(O)(OH) 2 ] p (I),
- the present invention further refers to a process for producing the implant according to the present invention which is characterized in that said surface is treated with at least one organic compound of formula (I) or a derivative thereof, which is preferably an ester, an amide or a salt thereof.
- a 1 preferably is a saturated hydrocarbon residue of the formula —(C n H 2n+2 ⁇ p )—, wherein n means 1 to 70, preferably 1 to 40, preferably 1-22.
- Preferred is the free acid or the salt form of the compound of formula (I), preferably where the pharmaceutically acceptable salt is an alkali salt, preferably of sodium or potassium salt.
- the isopropyl phosphonate or ethyl phosphonate esters are preferred, examples of such esters are: tetra isopropyl methylenediphosphonate, hexaethyl ethane-1,1,2-triphosphonate, hexaisopropyl butane-1,1,4-triphosphonate, hexaisopropyl pentane-1,1,5-triphosphonate, hexaisopropyl pentane-2,2,5-triphosphonate, hexaisopropyl hexane-2,2,6-triphosphonate, octaisopropyl propane-1,1,3,3-tetraphosphonate, octaisopropyl heptane-1,4,4,7-tetraphosphonate, octaisopropyl nonane-1,5,5,9-tetraphosphonate.
- the metallic surface of the endosseous implant to be treated according to the present invention may be made from titanium or a titanium alloy as known to be used for the production of endosseous implants.
- Titanium alloys may be made from titanium and any other metal known to form an alloy with titanium, such as chromium, niobium, tantalum, vanadium, zirconium, aluminium, cobalt, nickel and/or stainless steels.
- Such titanium metal alloys for making implants are known per se and are described for example in Breme et al., Metals as Biomaterials, pp. 1-71 (1998) the contents of which are incorporated herein by reference.
- Implants according to the present invention may be in the form of screws, plates, nails, pins, and specially formed parts and may be used as prostheses in medicine, more specifically in orthopaedics, for replacing or strengthening broken or diseased bones, and in dentistry, for anchoring artificial teeth and for anchoring of bone anchored hearing prosthesis into the skeletal structure of humans and animals.
- the surface area of the implant which is to be bound to the body tissue resp. bones may have a smooth or rough surface texture.
- Such surface textures are known and can be obtained for example by treating the surface mechanically and/or with acids and/or electrolytically and/or with a glow-discharge plasma and/or plasma spraying and/or or by electro machining.
- Such materials and processes have been described in different publications, for example in B. -O. Aronsson et al., J. Biomed. Mater. Res. 35 (1997), pp. 49f., the contents of which are incorporated herein by reference.
- Examples of compounds of formula (I) wherein A is a residue of a saturated hydrocarbon are polyphosphonic acids such as methylenediphosphonic acid, ethane-1,2-diphosphonic acid, propane-1,3-diphosphonic acid, propane-1,3-diphosphonic acid, ethane-1,1,2-triphosphonic acid, butane-1,1,4-triphosphonic acid, pentane-1,1,5-triphosphonic acid, pentane-2,2,5-triphosphonic acid, hexane-2,2,6-triphosphonic acid, pentane-1,1,5,5-tetraphosphonic acid, heptane-1,4,4,7-tetraphosphonic acid, propane-1,1,3,3-tetraphosphonic acid, or nonane-1,5,5,9-tetraphosphonic acid.
- polyphosphonic acids such as methylenediphosphonic acid, ethane-1,2-diphosphonic acid, propane-1,3-diphosphonic acid, propane-1,3-diphospho
- TGF- ⁇ Transforming Growth Factor beta
- the compound of formula (I) represents a Transforming Growth Factor beta (TGF- ⁇ ) as defined by the members of the superfamily of growth factors, preferably the TGF- ⁇ 1, TGF- ⁇ 2, TGF- ⁇ 3, TGF- ⁇ 4, and TGF- ⁇ 5, wherein each time the peptide chain has been modified to contain at least one alkylphosphonic acid group or a derivative thereof, which is preferably an ester, an amide or a salt thereof.
- TGF- ⁇ Transforming Growth Factor beta
- BMP Bone Morphogenic Protein
- BMP-2a BMP-3, BMP-4 (BMP-2b), BMP-5, BMP-6, BMP-7 (OP-1), BMP-8 (OP-2), BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, as found for example in J. M. Wozney et. al., Science 242 (1988) 1528-1534; A. J. Celeste et al., Proc. Natl. Acad. Sci. USA 87 (1990) 9843-9847; E.
- BMP Bone Morphogenic Protein
- the compound of formula (I) represents a Bone Morphogenic Protein (BMP), preferably the BMP-2 (BMP-2a), BMP-3, BMP-4 (BMP-2b), BMP-5, BMP-6, BMP-7 (OP-1), BMP-8 (OP-2), BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, wherein the peptide chain has been modified to contain at least one alkylphosphonic acid group or a derivative thereof, which is preferably an ester, an amide or a salt thereof.
- BMP Bone Morphogenic Protein
- Examples of compounds of formula (I) wherein A is a residue of an amino acid are 2-amino-4,4-bis-(diethoxyphosphoryl)-butyric acid as described for example in O. Fabulet et al., Phosphorus, Sulphur Silicon and Related Elements, 101, 225-234 (1995); 2-amino-5-(diethoxyphosphoryl)-pentanoic acid as described for example in I. G. Andronova et al., Russ. J. Gen. Chem. 66, 1068-1071 (1996); 2-amino-4-phosphonobutyric acid as described for example in X. Y. Jiao et al., Synth. Commun. 22, 1179-1186 (1992) and references therein.
- Examples of compounds of formula (I) wherein A is a residue of a peptide comprise but are not limited to RGD-containing peptides, RGDS-peptides, GRGDS-peptides, RGDV-peptides, RGDE-peptides, and/or RGDT-peptides.
- RGD-containing peptides RGDS-peptides
- GRGDS-peptides GRGDS-peptides
- RGDV-peptides RGDE-peptides
- RGDT-peptides RGDT-peptides.
- Such peptides are described for example in Y. Hirano, J. Biomed. Materials Res., 25 (1991), pp. 1523-1534 or in WO 98/52619 and references therein. Included within the scope of the present invention are also similar peptides known to have specific biological activities such as cell attachment or cell attachment prevention, and which are prepared in analogy with the peptides as mentioned above.
- the compound of formula (I) is a RGD-containing peptide, preferably a RGDS-peptide, a GRGDS-peptide, a RGDV-peptide, a RGDE-peptide, and/or a RGDT-peptide, which has been modified to contain at least one alkylphosphonic acid group or a derivative thereof, which is preferably an ester, an amide or a salt thereof.
- Preferred compounds of formula (I) are those containing a residue A 2 as defined above, preferably a residue of an amino acid or of a sequence of amino acids resp. of a protein or of a polypeptide, preferably a residue of the superfamily of Transforming Growth Factor beta (TGF- ⁇ ), preferably a Bone Morphogenic Protein (BMP).
- TGF- ⁇ Transforming Growth Factor beta
- BMP Bone Morphogenic Protein
- the implant is first cleaned in a cleaning bath for removing unwanted molecules resp. impurities from the surface.
- a degreasing agent for example an organic solvent such as alcohol, chloroform, and another organic solvent and/or an inorganic detergent such as an aqueous alkaline solution based on sodium hydroxide or potassium hydroxide.
- the implant is carefully rinsed in pure water, preferably in distilled ultra-pure water, having preferably a conductivity resistance of at least 15 Mohm*cm.
- the implant After cleaning and rinsing, the implant is dried with flowing nitrogen gas or flowing dry or hot air and stored under controlled conditions. Alternatively after degreasing the implant can be further treated in a glow-discharge plasma for cleaning the surface.
- the clean surface of the implant is then treated with at least one compound of formula (I) or an ester or a salt thereof, i.e. with at least one such compound or a mixture thereof.
- the compound or the mixture of said compounds is brought onto the surface of the implant by any suitable means, like brushing, spraying, dipping or evaporation, including glow-discharge plasma assisted vapour deposition.
- the phosphonic acid compound or the ester or the salt thereof is preferably dissolved in a polar solvent, so that a solution with a concentration of from about 1.0 ⁇ 10 ⁇ 5 mol/10 ml to 5 ⁇ 10 ⁇ 2 mol/10 ml, preferably from about 5 ⁇ 10 ⁇ 4 mol/10 ml to 2.0 ⁇ 10 ⁇ 2 mol/10 ml with reference to the weight of the solvent is obtained.
- concentration is such that a partial or full (1% to 100%, preferably 50% to 100% of a) monomolecular layer is formed on the implant surface.
- the preferred solvent is pure distilled water.
- the implant is left in contact with the solution for a sufficiently long time, preferably for a few minutes up to a few hours.
- Said pure water may contain inorganic salts, preferably alkali salts, such as alkali chlorides, sulfates, phosphates, phosphonates, preferably the sodium and/or potassium salts, and/or compounds of the formula (I) or an ester or a salt thereof, preferably in a concentration of from about 1.0 ⁇ 10 ⁇ 5 mol/10 ml to 5 ⁇ 10 ⁇ 2 mol/10 ml, preferably from about 5 ⁇ 10 ⁇ 4 mol/10 ml to 2.0 ⁇ 10 ⁇ 2 mol/10 ml of solvent, which preferably is distilled water.
- alkali salts such as alkali chlorides, sulfates, phosphates, phosphonates, preferably the sodium and/or potassium salts, and/or compounds of the formula (I) or an ester or a salt thereof, preferably in a concentration of from about 1.0 ⁇ 10 ⁇ 5 mol/10 ml to 5 ⁇ 10 ⁇ 2 mol/10 ml, preferably from about 5
- the compounds according to the general formula (I), wherein p is 3 to 6, preferably 3 or 4, and n is 4 to 70, preferably 4 to 40, preferably 4 to 22, the salts or esters or amides thereof are new.
- Examples of such compounds are butane-1,1,4-triphosphonic acid, pentane-1,1,5-triphosphonic acid, pentane-2,2,5-triphosphonic acid, hexane-2,2,6-triphosphonic acid, pentane-1,1,5,5-tetraphosphonic acid, heptane-1,4,4,7-tetraphosphonic acid, or nonane-1,5,5,9-tetraphosphonic acid.
- the compounds hexaisopropyl butane-1,1,4-triphosphonate and octaisopropyl heptane-1,4,4,7-tetraphosphonate, resp. a mixture of these compounds, are obtained in that an alkalimetal, preferably sodium, tetra lower alkyl methylenediphosphonate, preferably tetraisopropyl methylenediphosphonate, is reacting with at least a stoichiometric amount of a dihalomethane, preferably dibromomethane, in the presence of an organic solvent having no active hydrogen atoms, preferably dry hexane or benzene or toluene.
- an alkalimetal preferably sodium, tetra lower alkyl methylenediphosphonate, preferably tetraisopropyl methylenediphosphonate
- the reaction is preferably carried out at a temperature within the range of 30° C. to 125° C., preferably 40° C. to 110° C., until the reaction is completed, which generally is within a time period of 10 to 48 hours, preferably 18 to 36 hours.
- hexaisopropyl pentane-2,2,5-triphosphonate and hexaisopropyl hexane-2,2,6-triphosphonate were obtained by reacting equal parts of tetraisopropylethane-1,1-diphosphonate with diisopropyl-3-bromopropylphosphonate.
- the process is further characterised by that these products are hydrolysed to produce the analogous acids by refluxing them in molar excess of HCl for a time comprised within 1 to 12 hours, preferably 1 to 6 hours.
- the compounds are then preferably dried under vacuum over P 2 O 5 .
- Methylenediphosphonic acid was synthesized according to U.S. Pat. No. 3,400,176 and B. A. Arbusov, Pure Appl. Chem. 9 (1967), pp. 307-353 and references therein.
- the compound was characterized by NMR ( 1 H, 31 P, 13 C) mass spectroscopic elemental analysis and by its melting point. All these data are in accordance with the literature O. T. Quimby et al., J. of Organomet. Chem. 13, 199-207 (1968).
- Propane-1,1,3,3-tetraphosphonic acid was synthesized from tetraisopropyl methylenediphosphonate.
- the tetraphosphonic acidic solution was concentrated under vacuum, dried over P 2 O 5 under vacuum.
- the 1 H, 31 P and 13 C NMR results (D 2 O) are in accordance with the given literature data.
- the sample surface is provided with a smooth surface roughness by mechanical polishing with diamond paste according to standard procedures.
- Atomic force microscopy the surface roughness was measured to a S rms value of ca 6 nm over a surface area of 400 square microns.
- the implant prepared according to the preparations B(i), B(ii), and B(iii) are plated with rat bone building cells, osteoblasts.
- the osteogenesis is measured as (I) the cell proliferation and (II) the bone protein synthesis.
- Comparative test results are given for the untreated implant. The results are given in Table 1. Analogous results are obtained for all the phosphonic acids given herein above both on a smooth and on a rough surface. Analysis with XPS and ToF-SIMS indicated that a molecular (mono) layer was formed on a titanium surface as well as on a TiO 2 -surface.
- results illustrate the improved osteogenesis of the implants according to the present invention compared to the non treated implants.
- Example 2 is repeated with the difference that the implant is treated with ethane-1,1,3-triphosphonic acid which has been modified by linking the amine terminus of a Glycine molecule to one of the phosphonate groups.
- Examples 2 is repeated with the difference that the implant is treat with ethane-1,1,3-triphosphonic acid which is modified by linking the amine terminus of a GRGDS cell binding polypeptide to one of the phosphonate groups.
- Examples 2 is repeated with the difference that the compound according to formula (I) is ethane-1,1,3-triphosphonic acid which is modified by linking the amine terminus (Methionine) of a human Bone Morphogenic Protein type 2 (BMP-2) to one of the phosphonate groups, which gives analogous test results as given in Table 1.
- BMP-2 Bone Morphogenic Protein type 2
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US13/213,472 USRE43793E1 (en) | 2000-11-20 | 2001-11-19 | Endosseous implant |
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PCT/EP2000/011510 WO2002040073A1 (en) | 2000-11-20 | 2000-11-20 | Endosseous implant |
WOPCT/EP00/11510 | 2000-11-20 | ||
US13/213,472 USRE43793E1 (en) | 2000-11-20 | 2001-11-19 | Endosseous implant |
PCT/EP2001/013364 WO2002040074A1 (en) | 2000-11-20 | 2001-11-19 | Endosseous implant |
US10/432,026 US7727540B2 (en) | 2000-11-20 | 2001-11-19 | Endosseous implant |
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US10/432,026 Ceased US7727540B2 (en) | 2000-11-20 | 2001-11-19 | Endosseous implant |
US13/213,472 Active 2025-05-30 USRE43793E1 (en) | 2000-11-20 | 2001-11-19 | Endosseous implant |
US12/788,815 Expired - Lifetime US8216601B2 (en) | 2000-11-20 | 2010-05-27 | Endosseous implant |
US13/491,939 Expired - Fee Related US8802123B2 (en) | 2000-11-20 | 2012-06-08 | Endosseous implant |
US14/319,223 Expired - Lifetime US9730795B2 (en) | 2000-11-20 | 2014-06-30 | Endosseous implant |
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US13/491,939 Expired - Fee Related US8802123B2 (en) | 2000-11-20 | 2012-06-08 | Endosseous implant |
US14/319,223 Expired - Lifetime US9730795B2 (en) | 2000-11-20 | 2014-06-30 | Endosseous implant |
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EP (3) | EP1351722B2 (ja) |
JP (8) | JP5349727B2 (ja) |
AT (2) | ATE332153T1 (ja) |
AU (5) | AU2001221607A1 (ja) |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10342642B2 (en) | 2012-09-26 | 2019-07-09 | Straumann Holding Ag | Dental implant or abutment comprising a ceramic body covered with a monomolecular phosphate layer |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004224982B2 (en) * | 1996-08-30 | 2007-09-13 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflavones |
US7396594B2 (en) * | 2002-06-24 | 2008-07-08 | The Trustees Of Princeton University | Carrier applied coating layers |
US7507483B2 (en) * | 1997-02-04 | 2009-03-24 | Jeffrey Schwartz | Enhanced bonding layers on native oxide surfaces |
US7569285B2 (en) * | 1996-10-17 | 2009-08-04 | The Trustees Of Princeton University | Enhanced bonding layers on titanium materials |
US7815963B2 (en) | 1996-10-17 | 2010-10-19 | The Trustees Of Princeton University | Enhanced bonding layers on titanium materials |
US20060194008A1 (en) * | 1999-09-22 | 2006-08-31 | Princeton University | Devices with multiple surface functionality |
AU2001221607A1 (en) * | 2000-11-20 | 2002-05-27 | Ecole Polytechnique Federale De Lausanne (Epfl) | Endosseous implant |
US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
US7166133B2 (en) | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
SE523236C2 (sv) * | 2002-07-19 | 2004-04-06 | Astra Tech Ab | Ett implantat och ett förfarande för behandling av en implantatyta |
SE523288C2 (sv) * | 2002-07-19 | 2004-04-06 | Astra Tech Ab | Ett implantat och ett förfarande för behandling av en implantatyta |
PL207552B1 (pl) | 2002-09-10 | 2010-12-31 | Scil Technology Gmbh | Sposób wytwarzania urządzenia, urządzenie, kompozycja farmaceutyczna, zastosowanie urządzenia i zestaw |
EP1508343B1 (en) * | 2003-08-21 | 2015-11-04 | AddBIO AB | Bisphosponate coated implant device and method therefor |
DE102004043908A1 (de) * | 2004-09-10 | 2006-03-30 | GRÄTER, Stefan | Oberflächenstrukturierte polymere Substrate und ihre Herstellung |
US8071574B2 (en) | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
US9452001B2 (en) * | 2005-02-22 | 2016-09-27 | Tecres S.P.A. | Disposable device for treatment of infections of human limbs |
JP2007195571A (ja) * | 2006-01-23 | 2007-08-09 | Shimane Univ | 骨接合用骨製ネジ |
EP1825828B1 (en) | 2006-02-28 | 2011-08-10 | Straumann Holding AG | One-part implant with hydroxylated soft tissue contact surface |
EP1825830B1 (en) | 2006-02-28 | 2011-07-20 | Straumann Holding AG | Two-stage implant with a hydroxylated soft tissue contact surface |
EP1839617A1 (de) * | 2006-03-28 | 2007-10-03 | Biomed Est. | Schraubimplantat |
EP1887011A1 (en) * | 2006-08-09 | 2008-02-13 | Thermphos Trading GmbH | Alpha amino acid phosphonic acid compounds, method of preparation and use thereof |
DE102007003708A1 (de) * | 2007-01-25 | 2008-07-31 | Biotronik Vi Patent Ag | Mit Biomolekülen beschichtete Stents sowie Verfahren zu deren Herstellung |
DE102007007865A1 (de) * | 2007-02-14 | 2008-08-21 | Jennissen, Herbert, Prof. Dr. | Verfahren zur Herstellung von lagerfähigen Implantaten mit einer ultrahydrophilen Oberfläche |
JP2009045142A (ja) * | 2007-08-16 | 2009-03-05 | Okayama Univ | 生体内にて基材周囲に骨形成を誘導するための基材処理方法 |
US20090164012A1 (en) * | 2007-12-21 | 2009-06-25 | Howmedica Osteonics Corp. | Medical implant component and method for fabricating same |
US20090164011A1 (en) * | 2007-12-21 | 2009-06-25 | Howmedica Osteonics Corp. | Surface treatment of implants |
DE102008011963A1 (de) * | 2008-02-29 | 2009-09-10 | Axel Cyron | Zahnimplantat und Verfahren zu seiner Herstellung |
DE102008040573A1 (de) * | 2008-07-21 | 2010-01-28 | Biotronik Vi Patent Ag | Aptamer beschichtetes Implantat, Herstellverfahren und Verwendungen |
GB0902705D0 (en) | 2009-02-19 | 2009-04-01 | Neoss Ltd | Surface treatment process for implant |
EP2230702A1 (en) | 2009-03-19 | 2010-09-22 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Modified surface |
DE102009036589A1 (de) * | 2009-08-07 | 2011-02-10 | Lindauer Dornier Gmbh | Vorrichtung zum Übergeben eines bandförmigen Schussmaterials |
GB2475468A (en) * | 2009-08-14 | 2011-05-25 | Univ Manchester | Biocompatible materials |
US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
EP2744529B1 (en) * | 2011-10-21 | 2020-07-15 | Straumann Holding AG | Process for providing structures for improved protein adherence on the surface of a body |
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KR101213355B1 (ko) * | 2011-12-27 | 2012-12-18 | 오스템임플란트 주식회사 | 초기 안정성이 증진된 치과용 임플란트 및 그 제조 방법 |
CN102716513B (zh) * | 2012-05-02 | 2014-12-24 | 清华大学 | 一种在钙磷陶瓷材料表面修饰rgd的方法 |
EP3003203B1 (en) * | 2013-06-07 | 2021-07-28 | Straumann Holding AG | Process for providing sites of improved protein adherence on an abutment basic body |
US10188770B2 (en) | 2014-06-26 | 2019-01-29 | Osstemimplant Co., Ltd. | Dental implant having enhanced early stability and method for manufacturing same |
BR112018016328B1 (pt) * | 2016-02-12 | 2021-12-21 | Nano Bridging Molecules Sa | Processo de tratamento melhorado de implantes com compostos de ácido fosfônico |
EP3685865B1 (en) * | 2016-10-13 | 2023-07-05 | Straumann Holding AG | Process for preparing a body having an osseointegrative topography formed on its surface |
CA3050118A1 (en) * | 2017-01-13 | 2018-07-19 | Pharmocon Llc | Materials amd methods for buffering active chlorine solutions |
CN107630218A (zh) * | 2017-09-17 | 2018-01-26 | 贵州大学 | 一种SiO2/La2O3混合掺杂的梯度生物陶瓷复合涂层及其制备方法 |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4330537A (en) | 1977-12-07 | 1982-05-18 | The Procter & Gamble Company | Compositions for inhibiting mobilization of calcium phosphate in animal tissue |
US4712681A (en) | 1984-12-27 | 1987-12-15 | Branemark Per Ingvar | Method of packaging artificial implants in sterile and contamination-free manner and a package therefor |
WO1992009697A1 (en) | 1990-11-30 | 1992-06-11 | Celtrix Laboratories, Inc. | USE OF A BONE MORPHOGENETIC PROTEIN IN SYNERGISTIC COMBINATION WITH TGF-β FOR BONE REPAIR |
US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
WO1997014716A1 (de) | 1995-10-18 | 1997-04-24 | MERCK Patent Gesellschaft mit beschränkter Haftung | Cyclopeptidderivate |
US5646134A (en) | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
US5733564A (en) | 1993-04-14 | 1998-03-31 | Leiras Oy | Method of treating endo-osteal materials with a bisphosphonate solution |
EP0860213A2 (de) | 1997-01-03 | 1998-08-26 | Hüls Aktiengesellschaft | Bioaktive Beschichtung von Oberflächen |
US5824651A (en) | 1993-05-10 | 1998-10-20 | Universite De Montreal | Process for modification of implant surface with bioactive conjugates for improved integration |
WO1998052619A2 (de) | 1997-05-22 | 1998-11-26 | Merck Patent Gmbh | Peptid-beschichtete implantate und verfahren zu ihrer herstellung |
WO1999011202A1 (en) | 1997-09-05 | 1999-03-11 | Icet, Inc. | Biomimetic calcium phosphate implant coatings and methods for making the same |
WO1999031126A1 (de) | 1997-12-16 | 1999-06-24 | Merck Patent Gmbh | Cyclopeptidderivate mit integrin-inhibitor-eigenschaften |
WO2002013872A1 (de) | 2000-08-17 | 2002-02-21 | Merck Patent Gmbh | Peptid- und peptidmimetikakonjugate mit integrin-inhibitor-eigenschaften |
WO2002014350A2 (de) | 2000-08-17 | 2002-02-21 | Merck Patent Gmbh | Peptid- und peptidmimetika-derivate mit integrin-inhibitor-eigenschaften ii |
US7090496B2 (en) | 2000-11-20 | 2006-08-15 | Universite De Geneve | Endosseous implant |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3400176A (en) | 1965-11-15 | 1968-09-03 | Procter & Gamble | Propanepolyphosphonate compounds |
USRE29182E (en) * | 1965-12-08 | 1977-04-12 | The Procter & Gamble Company | Oral composition for calculus retardation |
FI48802C (fi) | 1965-12-08 | 1975-01-10 | Procter & Gamble | Hammaskiven muodostumista ehkäisevä hampaan- tai suunhoitoaine |
PH9776A (en) | 1967-12-11 | 1976-03-17 | M Francis | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue and method of use |
US4209487A (en) | 1975-06-02 | 1980-06-24 | Monsanto Company | Method for corrosion inhibition |
GB1569021A (en) | 1976-03-17 | 1980-06-11 | Kuraray Co | Adhesive cementing agents containing partial phosphonic orphosphonic acid esters |
DE2621605A1 (de) * | 1976-05-14 | 1977-12-01 | Bayer Ag | Organische derivate l-substituierter propan-1,3-diphosphonsaeuren und -phosphinsaeuren |
DE2732777C2 (de) * | 1977-07-20 | 1979-09-13 | Benckiser-Knapsack Gmbh, 6802 Ladenburg | N-Carboxyalkan-aminoalkan-polyphosphonsäuren und deren Alkalisalze sowie Verfahren zu ihrer Herstellung |
JPS5489027A (en) * | 1977-12-27 | 1979-07-14 | Nissan Chem Ind Ltd | Organo-phosphorus herbicide |
US4330530A (en) * | 1980-12-22 | 1982-05-18 | The Procter & Gamble Company | Anti-arthritic compositions and method using gold salts and organophosphonates |
DE3142517A1 (de) * | 1981-10-27 | 1983-05-05 | Chemische Fabrik Budenheim Rudolf A. Oetker, 6501 Budenheim | Verfahren zur herstellung eines phosphonsaeuregemisches |
DE3237573A1 (de) * | 1982-10-09 | 1984-04-12 | Hoechst Ag, 6230 Frankfurt | Technetium-99m-tri- und tetraphosphonate zur szintigraphischen dastellung res-haltiger organe und der lymphgefaesse und verfahren zu deren herstellung |
US4650609A (en) * | 1985-06-25 | 1987-03-17 | E. I. Du Pont De Nemours And Company | Tetraphosphinylquinodimethanes |
DE3805663A1 (de) * | 1988-02-24 | 1989-09-07 | Henkel Kgaa | Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen |
FR2636632B1 (fr) * | 1988-09-16 | 1996-02-02 | Oris Ind | Produits radiopharmaceutiques constitues par des complexes de tc, re ou y comportant des ligands tetraphosphonates et leur preparation |
US4981648A (en) * | 1988-11-09 | 1991-01-01 | W. R. Grace & Co.-Conn. | Inhibiting corrosion in aqueous systems |
EP0388575A1 (de) | 1989-03-23 | 1990-09-26 | Neomat Ag | Schneehalter |
JPH0449972A (ja) * | 1990-06-14 | 1992-02-19 | Tdk Corp | 生体硬組織代替体および複合成形体の製造方法 |
AU639468B2 (en) * | 1989-07-25 | 1993-07-29 | Smith & Nephew, Inc. | Prosthesis |
ZA9010217B (en) * | 1989-12-21 | 1991-10-30 | Smith & Nephew Richards Inc | Biocompatible low modulus titanium alloy for medical implants |
CA2049809C (en) * | 1990-11-05 | 2001-02-06 | H. Ravindranath Shetty | Method of surface hardening orthopaedic implant devices |
US5211663A (en) * | 1991-06-24 | 1993-05-18 | Smith & Nephew Richards, Inc. | Passivation methods for metallic medical implants |
GB9125115D0 (en) | 1991-11-23 | 1992-01-22 | Ciba Geigy Ag | Corrosion and/or scale inhibition |
AU4848193A (en) * | 1992-09-23 | 1994-04-26 | Upjohn Company, The | Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents |
ES2131684T3 (es) | 1993-05-10 | 1999-08-01 | Univ Montreal | Modificacion de la superficie de un implante con conjugados bioactivos para mejorar su integracion. |
US5642996A (en) * | 1993-10-20 | 1997-07-01 | Nikon Corporation | Endosseous implant |
WO1995029924A1 (en) * | 1994-05-02 | 1995-11-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Phosphonated polypyridyl compounds and their complexes |
US6173662B1 (en) | 1995-12-29 | 2001-01-16 | John L. Donovan | Method and apparatus for containing and suppressing explosive detonations |
JP3725935B2 (ja) * | 1996-03-21 | 2005-12-14 | 日本特殊陶業株式会社 | リン酸カルシウム系セラミックスの製造方法 |
US5962603A (en) * | 1996-07-23 | 1999-10-05 | Georgia-Pacific Resins, Inc. | Intumescent composition and method |
DK0852238T3 (da) | 1997-01-03 | 2002-10-28 | Therapol Sa | Polymerer med bakteriofobe og eventuelt celleproliferationsinhiberende egenskaber |
EP0893165A3 (de) | 1997-06-28 | 2000-09-20 | Degussa-Hüls Aktiengesellschaft | Bioaktive Beschichtung von Oberflächen unter Verwendung von Makroinitiatoren |
DE19731577A1 (de) * | 1997-07-23 | 1999-01-28 | Bayer Ag | Verwendung phosphonathaltiger Mischungen |
JP2002519010A (ja) | 1998-06-30 | 2002-07-02 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | Dna−pkの使用法 |
US6528603B1 (en) * | 1999-01-13 | 2003-03-04 | Board Of Trustees Operating Michigan State University | Phosphonate copolymer and methods of use |
-
2000
- 2000-11-20 AU AU2001221607A patent/AU2001221607A1/en not_active Abandoned
- 2000-11-20 WO PCT/EP2000/011510 patent/WO2002040073A1/en active Application Filing
-
2001
- 2001-11-19 NZ NZ526463A patent/NZ526463A/en not_active IP Right Cessation
- 2001-11-19 AU AU1912002A patent/AU1912002A/xx active Pending
- 2001-11-19 US US10/432,025 patent/US7090496B2/en not_active Expired - Lifetime
- 2001-11-19 WO PCT/EP2001/013364 patent/WO2002040074A1/en active IP Right Grant
- 2001-11-19 ES ES01996400.6T patent/ES2267862T5/es not_active Expired - Lifetime
- 2001-11-19 CA CA2429233A patent/CA2429233C/en not_active Expired - Fee Related
- 2001-11-19 AU AU3163002A patent/AU3163002A/xx active Pending
- 2001-11-19 EP EP01996400.6A patent/EP1351722B2/en not_active Expired - Lifetime
- 2001-11-19 US US10/432,026 patent/US7727540B2/en not_active Ceased
- 2001-11-19 NZ NZ526462A patent/NZ526462A/en not_active IP Right Cessation
- 2001-11-19 AT AT01991733T patent/ATE332153T1/de active
- 2001-11-19 WO PCT/EP2001/013365 patent/WO2002040075A1/en active IP Right Grant
- 2001-11-19 DK DK01991733.5T patent/DK1343545T4/da active
- 2001-11-19 JP JP2002542444A patent/JP5349727B2/ja not_active Expired - Fee Related
- 2001-11-19 AU AU2002231630A patent/AU2002231630B2/en not_active Ceased
- 2001-11-19 AT AT01996400T patent/ATE332154T2/de active
- 2001-11-19 US US13/213,472 patent/USRE43793E1/en active Active
- 2001-11-19 EP EP06111517.6A patent/EP1698357B1/en not_active Expired - Lifetime
- 2001-11-19 DK DK01996400.6T patent/DK1351722T4/en active
- 2001-11-19 JP JP2002542445A patent/JP5214084B2/ja not_active Expired - Fee Related
- 2001-11-19 CA CA2429230A patent/CA2429230C/en not_active Expired - Fee Related
- 2001-11-19 EP EP01991733A patent/EP1343545B2/en not_active Expired - Lifetime
- 2001-11-19 AU AU2002219120A patent/AU2002219120B2/en not_active Ceased
- 2001-11-19 DE DE60121365.3T patent/DE60121365T3/de not_active Expired - Lifetime
- 2001-11-19 ES ES01991733T patent/ES2267849T5/es not_active Expired - Lifetime
- 2001-11-19 DE DE60121361T patent/DE60121361T3/de not_active Expired - Lifetime
-
2008
- 2008-12-08 JP JP2008311703A patent/JP5363086B2/ja not_active Expired - Fee Related
-
2010
- 2010-03-17 JP JP2010061275A patent/JP2010162363A/ja active Pending
- 2010-05-27 US US12/788,815 patent/US8216601B2/en not_active Expired - Lifetime
-
2011
- 2011-04-21 JP JP2011094950A patent/JP5606383B2/ja not_active Expired - Fee Related
- 2011-04-25 JP JP2011097380A patent/JP2011172954A/ja active Pending
-
2012
- 2012-06-08 US US13/491,939 patent/US8802123B2/en not_active Expired - Fee Related
-
2014
- 2014-06-11 JP JP2014120412A patent/JP2014208256A/ja active Pending
- 2014-06-30 US US14/319,223 patent/US9730795B2/en not_active Expired - Lifetime
- 2014-07-30 JP JP2014154738A patent/JP5957044B2/ja not_active Expired - Fee Related
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4330537A (en) | 1977-12-07 | 1982-05-18 | The Procter & Gamble Company | Compositions for inhibiting mobilization of calcium phosphate in animal tissue |
US4712681A (en) | 1984-12-27 | 1987-12-15 | Branemark Per Ingvar | Method of packaging artificial implants in sterile and contamination-free manner and a package therefor |
US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
WO1992009697A1 (en) | 1990-11-30 | 1992-06-11 | Celtrix Laboratories, Inc. | USE OF A BONE MORPHOGENETIC PROTEIN IN SYNERGISTIC COMBINATION WITH TGF-β FOR BONE REPAIR |
US5733564A (en) | 1993-04-14 | 1998-03-31 | Leiras Oy | Method of treating endo-osteal materials with a bisphosphonate solution |
US5824651A (en) | 1993-05-10 | 1998-10-20 | Universite De Montreal | Process for modification of implant surface with bioactive conjugates for improved integration |
US5646134A (en) | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
WO1997014716A1 (de) | 1995-10-18 | 1997-04-24 | MERCK Patent Gesellschaft mit beschränkter Haftung | Cyclopeptidderivate |
EP0860213A2 (de) | 1997-01-03 | 1998-08-26 | Hüls Aktiengesellschaft | Bioaktive Beschichtung von Oberflächen |
WO1998052619A2 (de) | 1997-05-22 | 1998-11-26 | Merck Patent Gmbh | Peptid-beschichtete implantate und verfahren zu ihrer herstellung |
WO1999011202A1 (en) | 1997-09-05 | 1999-03-11 | Icet, Inc. | Biomimetic calcium phosphate implant coatings and methods for making the same |
WO1999031126A1 (de) | 1997-12-16 | 1999-06-24 | Merck Patent Gmbh | Cyclopeptidderivate mit integrin-inhibitor-eigenschaften |
WO2002013872A1 (de) | 2000-08-17 | 2002-02-21 | Merck Patent Gmbh | Peptid- und peptidmimetikakonjugate mit integrin-inhibitor-eigenschaften |
WO2002014350A2 (de) | 2000-08-17 | 2002-02-21 | Merck Patent Gmbh | Peptid- und peptidmimetika-derivate mit integrin-inhibitor-eigenschaften ii |
US7090496B2 (en) | 2000-11-20 | 2006-08-15 | Universite De Geneve | Endosseous implant |
Non-Patent Citations (5)
Title |
---|
Abstract of A. Sewing et al., "Cell Culture Study on Biomimetic Coatings and Adhesion Peptides as Functionalized Coating for Dental Implants", Conference at 16th European Conference on Biomaterials, Sep. 12-14, 2001, London, UK. |
Abstract of S. Röbetaler et al., "Biomimetic Coatings Functionalized with Adhesion Peptides for Dental Implants", Conference at 16th European Conference on Biomaterials, Sep. 12-14, 2001, London, UK. |
Abstract of S. Röβler et al., "Biomimetic Coatings Functionalized with Adhesion Peptides for Dental Implants", Conference at 16th European Conference on Biomaterials, Sep. 12-14, 2001, London, UK. |
Carine Viornery, "Surface functionalization of titanium with phosphonated ligands to improve bone bonding", Thése No. 2309, Lausanne, EPFL, 2000. |
Thesis of Martin Kantlehner, Techincal University of Munich, 2000. |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10342642B2 (en) | 2012-09-26 | 2019-07-09 | Straumann Holding Ag | Dental implant or abutment comprising a ceramic body covered with a monomolecular phosphate layer |
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