US7074216B2 - Sliding reconstitution device for a diluent container - Google Patents

Sliding reconstitution device for a diluent container Download PDF

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Publication number
US7074216B2
US7074216B2 US10/106,716 US10671602A US7074216B2 US 7074216 B2 US7074216 B2 US 7074216B2 US 10671602 A US10671602 A US 10671602A US 7074216 B2 US7074216 B2 US 7074216B2
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US
United States
Prior art keywords
sleeve
container
vial
connector
piercing member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related, expires
Application number
US10/106,716
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English (en)
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US20020123736A1 (en
Inventor
Thomas A. Fowles
Robert J. Weinberg
Thomas J. Progar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/153,816 external-priority patent/US6113583A/en
Priority claimed from US09/561,666 external-priority patent/US6582415B1/en
Application filed by Baxter International Inc filed Critical Baxter International Inc
Priority to US10/106,716 priority Critical patent/US7074216B2/en
Assigned to BAXTER INTERNATIONAL INC. reassignment BAXTER INTERNATIONAL INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FOWLES, THOMAS A., PROGAR, THOMAS J., WEINBERG, ROBERT J.
Publication of US20020123736A1 publication Critical patent/US20020123736A1/en
Priority to TW92105874A priority patent/TWI260233B/zh
Priority to PE2003000291A priority patent/PE20030939A1/es
Priority to ARP030101029 priority patent/AR039128A1/es
Priority to DE60328171T priority patent/DE60328171D1/de
Priority to EP20030745610 priority patent/EP1487533B1/en
Priority to NZ535308A priority patent/NZ535308A/en
Priority to PL374760A priority patent/PL205227B1/pl
Priority to PCT/US2003/009190 priority patent/WO2003082398A2/en
Priority to EP09075247A priority patent/EP2095805A3/en
Priority to CA 2478387 priority patent/CA2478387C/en
Priority to MXPA04009341A priority patent/MXPA04009341A/es
Priority to AU2003226002A priority patent/AU2003226002B2/en
Priority to KR10-2004-7015068A priority patent/KR20040111430A/ko
Priority to AT03745610T priority patent/ATE435048T1/de
Priority to DK03745610T priority patent/DK1487533T3/da
Priority to JP2003579928A priority patent/JP4454315B2/ja
Priority to CNB038067862A priority patent/CN100509081C/zh
Priority to ES03745610T priority patent/ES2328919T3/es
Priority to BR0308714A priority patent/BR0308714A/pt
Priority to US10/744,946 priority patent/US7358505B2/en
Priority to US10/744,953 priority patent/US7425209B2/en
Priority to ZA200407529A priority patent/ZA200407529B/en
Publication of US7074216B2 publication Critical patent/US7074216B2/en
Application granted granted Critical
Priority to AU2008203002A priority patent/AU2008203002A1/en
Priority to US12/189,966 priority patent/US8226627B2/en
Priority to JP2009178363A priority patent/JP2009240835A/ja
Adjusted expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means

Definitions

  • the present invention relates generally to the delivery of a beneficial agent to a patient. More specifically, the present invention relates to an improved device for reconstituting a beneficial agent to be delivered to a patient.
  • drugs are unstable even for a short period of time in a dissolved state and therefore are packaged, stored, and shipped in a powdered or lyophilized state to increase their shelf life.
  • the drugs In order for powdered drugs to be given intravenously to a patient, the drugs must first be placed in liquid form. To this end, these drugs are mixed or reconstituted with a diluent before being delivered intravenously to a patient.
  • the diluents may be, for example, a dextrose solution, a saline solution, or even water.
  • the drugs are stored in powdered form in glass vials or ampules.
  • reconstitution means to place the powdered drug in a liquid state, as well as, the dilution of a liquid drug.
  • the reconstitution procedure should be performed under sterile conditions. In some procedures for reconstituting, maintaining sterile conditions is difficult. Moreover, some drugs, such as chemotherapy drugs, are toxic and exposure to the medical personnel during the reconstitution procedure can be dangerous.
  • One way of reconstituting a powdered drug is to inject the liquid diluent directly into the drug vial. This can be performed by use of a combination-syringe and syringe needle having diluent therein.
  • drug vials typically include a pierceable rubber stopper. The rubber stopper of the drug vial is pierced by the needle, and liquid in the syringe is then injected into the vial.
  • the vial is shaken to mix the powdered drug with the liquid. After the liquid and drug are mixed, a measured amount of the reconstituted drug is then drawn into the syringe. The syringe is then withdrawn from the vial and the drug can then be injected into the patient.
  • Another method of drug administration is to inject the reconstituted drug, contained in the syringe, into a parenteral solution container. Examples of such containers include a MINI-BAGTM flexible parenteral solution container or VIAFLEX® flexible parenteral solution container sold by Baxter Healthcare Corporation of Deerfield, Ill. These parenteral solution containers may already have therein dextrose or saline solutions.
  • the reconstituted drug is injected into the container, mixed with the solution in the parenteral solution container and delivered through an intravenous solution administration set to a vein access site of the patient.
  • a reconstitution device sold by Baxter Healthcare Corporation, product code No. 2B8064. That device includes a double pointed needle and guide tubes mounted around both ends of the needle. This reconstitution device is utilized to place the drug vial in fluid communication with a flexible-walled parenteral solution container. Once the connection is made by piercing a port of the flexible container with one end of the needle and the vial stopper with the other end of the needle, liquid in the solution container may be forced through the needle into the drug vial by squeezing the sidewalls of the solution container. The vial is then shaken to mix the liquid and drug. The liquid in the vial is withdrawn by squeezing air from the solution container into the vial. When compression of the flexible walled solution container is stopped, the pressurized air in the vial acts as a pump to force the liquid in the vial back into the solution container.
  • U.S. Pat. No. 4,759,756 discloses a reconstitution device which, in an embodiment, includes an improved vial adaptor and bag adaptor that permit the permanent coupling of a vial and liquid container.
  • the bag adaptor is rotatable relative to the vial adaptor to either block fluid communication in a first position or effect fluid communication in a second position.
  • the '209 Patent discloses a first sleeve member that is mounted concentrically about a second sleeve member.
  • the sleeve members can be moved axially with respect to each other to cause a needle or cannula to pierce a drug container and a diluent container to place the containers in fluid communication with each other.
  • the process for using the '209 connector required three distinct steps.
  • the sleeves had to be rotated with respect to one another to move the device into an unlocked position.
  • the sleeves were then moved axially with respect to one another to an activated position to pierce closures of the containers.
  • the sleeves had to be rotated again to lock the sleeves in the activated position.
  • the device of the '209 Patent it is possible for the device of the '209 Patent to be easily and inadvertently disassembled when being moved to the activated position.
  • the second sleeve is capable of sliding entirely though the first sleeve member and becoming disassociated into separate parts. This would require the medical personnel to either reassemble the device or dispose of it due to contamination.
  • the device of the '209 Patent did not provide for a visual indication that the device was in the activated position. It was also possible for the device to be inadvertently moved to the inactivated position, by rotating the first and second sleeve members in a direction opposite of the third step described above.
  • the second container which is frequently a vial, to rotate within the device. This could cause coring of the vial stopper which could lead to leakage of the vial stopper. Additionally it was possible for a vial to be misaligned while being attached to the device causing the attachment process to be difficult for medical personnel.
  • the connector only releasably attached to the vial. Removal of the vial could remove all tamper evident indications that the reconstitution step has occurred and could lead to a second unintended dosage of medicine to be administered.
  • the seal had a sleeve that covered only a portion of the cannula. The sleeve of the seal was relatively resilient and had the tendency of pushing the connector away from the drug container when docked thereto.
  • the '020 patent discloses a connector having an end that docks to a drug vial and an opposite end that connects to the solution container. A shoulder and an end surface of the vial are held between first and second jaws of the vial end of the connector. The second jaws 71 terminate in a relatively sharp point that digs into and deforms the outermost end surface 94 of the vial sufficiently to accommodate dimensional variations between the shoulder and the outermost end surface of the vial.
  • the marks that are left in the deformable end surface of the vial are intended to provide a tamper evident feature. However, tamper evident marks will not be left in vials that have a cap that is too short to impinge upon the sharp points.
  • the connector has a spike 25 that penetrates stoppers on the vial and on the solution container to place these containers in fluid communication.
  • the connector of the '020 patent cannot be preattached to the fluid container or the drug container without piercing the stoppers of each.
  • the '020 patent states that the connector may be preassembled onto a drug vial, but there is no explanation of the structure of such a device. (Col. 6, lines 40–49)). This is undesirable as it initiates the time period in which the drug must be used, and typically this is a short period relative to the normal shelf-life of the product.
  • the connector of the '020 patent does not provide a structure for preventing a docked vial from rotating.
  • a closure of the vial can become damaged or cored upon rotation, which in turn, can lead to particles from the closure from entering the fluid that eventually passes to a patient. It can also lead to leakage of the closure of the vial.
  • the connector has a communicating portion having a communicating passage disposed at a top portion of the flexible container wherein one end of the communicating portion extends into the flexible container.
  • the drug vial is fitted partially or wholly into an opposite end of the communicating portion.
  • a membrane is disposed in the communicating passage for closing the passage.
  • the connector also includes a puncturing needle unit mounted in the communicating passage for enabling the drug vial and flexible container to communicate with each other. When the puncturing needle unit is pressed externally through the flexible container, the needle breaks the membrane and opening of the drug vial to enable the drug vial and container to communicate with each other.
  • U.S. Pat. No. 5,380,315 and EP 0843992 disclose another connector for attaching a drug vial to a flexible solution container. Similar to the '191 patent, this patent and patent application have a communication device in the form of spike that is mounted within the flexible container. The communication device is externally pressed towards a drug vial to puncture the drug vial and communicate the drug vial with the flexible container.
  • U.S. Pat. No. 5,478,337 discloses a device for connecting a vial to a flexible container. This patent requires the vial to be shipped pre-assembled to the connector, and, therefore, does not allow for medical personnel to selectively attach a vial to the connector.
  • U.S. Pat. No. 5,364,386 discloses a device for connecting a vial to a medical fluid container.
  • the device includes a screw cap 32 that must be removed before inserting the vial. Removing the screw cap, however, potentially exposes the piercing member 48 to contaminants as the piercing member is not hermetically sealed.
  • the present invention is provided to solve these and other problems.
  • the present invention provides a fluid reconstitution device for placing a first container, such as a diluent or liquid container (e.g. flexible container or syringe), in fluid communication with a second container, such as a drug vial.
  • a connector device for establishing fluid communication between the liquid container and the drug vial.
  • the connector has a piercing member having a first end and a second end and a central fluid pathway.
  • the piercing member is mounted to the liquid container and has fluid accessing portions hermetically sealed from an outside environment.
  • a vial receiving chamber is associated with the piercing member and is dimensioned to connect to the vial.
  • the vial may be selectively attached to the device without piercing the closure of the vial and without breaching the hermetic seal of the fluid accessing portions of the piercing member.
  • Means are provided for connecting the vial receiving chamber to the liquid container.
  • the device is movable from an inactivated position, where the piercing member is outside the sidewalls and no fluid flows between the liquid container and the drug vial, to an activated position, where fluid flows through the fluid pathway between the liquid container and the drug vial.
  • the device is movable from the inactivated position to the activated position by a force applied to the device outside the liquid container.
  • a hub mounting the piercing member within the means for connecting the vial receiving chamber to the liquid container and a protuberance attached to the means for connecting the vial receiving chamber to the liquid container and dimensioned for allowing movement of the hub from a first position to a second position wherein the hub moves past the protuberance.
  • the protuberance prevents the hub from returning to the first position.
  • a tamper evident strip associated with the device for indicating when the device has been moved from the inactivated position to the activated position.
  • the device has a first attaching member in the form of a port connector having a port snap connected to a port sleeve.
  • the port snap has a flange extending from an outer surface and is connected to a first sleeve member wherein the flange engages a protrusion on the first sleeve member.
  • the port sleeve is adapted to attach to the liquid container.
  • the port sleeve preferably has a membrane at one end.
  • the device includes a gripper assembly attached to the second end of the second sleeve.
  • the gripper assembly has a base and an annular wall portion extending from the base and a plurality of fingers circumjacent the wall portion.
  • the fingers are circumferentially spaced defining a vial receiving chamber adapted to receive the vial, wherein one finger has a tab adapted to engage an underside of the neck and one finger has a standing rib adapted to engage a side portion of the vial closure.
  • a first annular rim extends from the base and a second annular rim extends collectively from the fingers and in spaced relation to the first annular rim.
  • the gripper assembly has a disk-shaped panel extending to bottom portions of the fingers.
  • the panel has a center opening therethrough and supports an annular rim extending from the panel.
  • the annular rim is adapted to form a fluid tight seal against a target site of a closure of a container.
  • a sealing member preferably in the form of a septum having a disk having opposing first and second surfaces.
  • the disk has a center hub having a generally thickened cross-section.
  • the first surface has a first annular groove receiving the first annular rim.
  • the second surface has a second annular groove receiving the second annular rim.
  • the second surface further has an annular ridge having a sidewall tapering axially-outwardly, so that the annular ridge is capable of forming a fluid tight seal with the vial when the vial is received by the fingers of the gripper assembly.
  • the thickened center hub substantially blocks the central fluid passageway of the piercing member as the center hub is penetrated by the piercing member but before the piercing member completely penetrates the piercing center hub.
  • a septum is provided that includes a cap positioned within the annular ridge.
  • the cap is adapted to provide a fluid tight seal against a target site of a closure of a container.
  • the septum could include structure to provide a dual seal against the closure of the container.
  • the septum can take various forms and have rigid or flexible portions.
  • FIG. 1 is a cross-sectional elevation view of a connector device of the present invention
  • FIG. 2 is a cross-sectional perspective view of the connector device of the present invention.
  • FIG. 3 is an enlarged partial cross-sectional view of a port connector assembly of the connector device of FIG. 1 ;
  • FIG. 4 is a cross-sectional view of the connector device of the present invention attached to a flexible container
  • FIG. 5 is a cross-sectional view of the connector device of the present invention having a drug vial fixedly secured to the connector device, the connector device being in an inactivated position;
  • FIG. 6 is a cross-sectional view of the connector device shown in FIG. 5 wherein the connector device is in the initial stages of an activation process;
  • FIG. 7 is a cross-sectional view of the connector device in an activated position
  • FIG. 8 is a cross-sectional view of the connector device in a deactivated position
  • FIG. 9 is a cross-sectional elevation view of the connector device of the present invention having an alternative vial connecting device and sealing member;
  • FIG. 10 is a cross-sectional view of the connector device shown in FIG. 9 having a drug vial fixedly secured to the connector device, the connector device being in an inactivated position;
  • FIG. 11 is a cross-sectional view of an alternative embodiment of the sealing member used in the connector device.
  • FIG. 12 is a cross-sectional view of the connector device of the present invention utilizing the sealing member of FIG. 11 and having a drug vial fixedly secured to the connector device, the connector device being in an inactivated position;
  • FIG. 13 is a front elevation view of another embodiment of the sealing member used in the connector device of the present invention.
  • FIG. 14 is a top view of the sealing member of FIG. 13 ;
  • FIG. 15 is a cross-sectional view of the sealing member taken along lines 15 — 15 in FIG. 13 ;
  • FIG. 16 is a partial cross sectional view of the sealing member shown in FIG. 15 ;
  • FIG. 17 is a cross-sectional view of the connector device of the present invention utilizing the sealing member of FIG. 13 ;
  • FIG. 18 is an enlarged partial cross-section view showing the sealing member of FIG. 13 sealing a drug vial.
  • FIG. 19 is a plan view of another embodiment of the sealing member used in the connector device of the present invention.
  • FIG. 20 is a cross-sectional view of the sealing member taken along lines 20 — 20 in FIG. 19 ;
  • FIG. 21A is a cross-sectional view of the connector device of the present invention utilizing the sealing member of FIG. 19 , and having a drug vial fixedly secured to the connector device, the connector device being in an inactivated position;
  • FIG. 21B is a cross-sectional view of the connector device shown in FIG. 21A wherein the connector device is in the initial stages of an activation process;
  • FIG. 21C is a cross-sectional view of the connector device of FIG. 21A in an activated position
  • FIG. 21D is a cross-sectional view of the connector device of FIG. 21A in a deactivated position
  • FIG. 22 is a plan view of another embodiment of the sealing member used in the connector device of the present invention.
  • FIG. 23 is a cross-sectional view of the sealing member taken along lines 23 — 23 in FIG. 22 ;
  • FIG. 24 is cross-sectional view of the connector device of the present invention utilizing the sealing member of FIG. 20 .
  • the present invention provides a connector device that is used to mix two substances within separate containers. More particularly, the invention provides a device to reconstitute a drug with a diluent. To accomplish the reconstitution of the drug, the invention provides an improved connecting device for attaching to a first container, commonly a flexible bag or a syringe, containing a diluent, to a second container, commonly a vial containing a drug to be reconstituted.
  • the connector provides fluid communication between the two containers through a hermetically sealed piercing member so that the drug may be reconstituted, and delivered to a patient. What is meant by hermetically sealed is that the portions of the piercing member that contact the fluid and that pierce the closures of the two containers are sealed from the outside environment.
  • the beneficial agent may be either a powder or a lyophilized drug to be dissolved or a liquid drug to be reduced in concentration.
  • the devices of the present invention provide the benefit of allowing medical personnel to selectively attach a vial of their choice to the connector. Thus, hospitals and pharmacies do not have to stock prepackaged drug vial and connector assemblies.
  • the connectors of the present invention allow for docking a vial to the connector without breaching the hermetic seal of a piercing member associated with the connector and without piercing the closure of the vial.
  • a vial may be pre-docked to the device of the present invention for essentially the full period the drug is active.
  • the device of the present invention can be activated by applying a force directly to the connector without necessarily contacting sidewalls of the first and second containers.
  • a connector device is disclosed and generally referred to with the reference numeral 10 .
  • the device 10 is adapted to place a first container 12 , containing a liquid to be used as a diluent, in fluid communication with a second container 14 , containing a drug to be diluted or reconstituted.
  • the first container 12 is typically a flexible bag and is used to contain solutions for a patient to be received intravenously.
  • Flexible containers are typically constructed from two sheets of a polymeric material forming sidewalls that are attached at their outer periphery to define a fluid tight chamber therebetween.
  • the fluid container is a coextruded layered structure having a skin layer of a polypropylene and a radio frequency susceptible layer of a polymer blend of 40% by weight polypropylene, 40% by weight of an ultra-low density polyethylene, 10% by weight of a dimer fatty acid polyamide and 10% by weight of a styrene-ethylene-butene-styrene block copolymer.
  • layered structures are more thoroughly set forth in commonly assigned U.S. Pat. No. 5,686,527 which is incorporated herein by reference and made a part hereof.
  • a tubular port 16 is inserted between the sidewalls to provide access to the fluid chamber.
  • a second port 18 is shown for allowing access by a fluid administration set to deliver the reconstituted drug to a patient.
  • the first container 12 can be any type of container, including, for example, a syringe barrel, suitable for containing a liquid to be used to reconstitute a drug.
  • the second container 14 ( FIG. 5 ), which contains a drug to be reconstituted, is a vial.
  • the vial 14 is typically a glass container with a closure member.
  • the closure member may include a rubber stopper 20 and may also have a crimp ring 22 .
  • the rubber stopper 20 is inserted in an opening of the vial 14 .
  • the rubber stopper 20 is held in place by the crimp ring 22 ( FIG. 3 ), typically made of soft metal such as aluminum, that is crimped around the stopper 20 and the neck of the vial 14 to fixedly attach the stopper 20 to the vial 14 .
  • the crimp ring 22 has an aperture to define a target site on the rubber stopper 20 .
  • the device 10 can be adapted to accept vials of any size, particularly 20 mm and 13 mm vials.
  • the second container 14 can be any container that is adapted to accommodate drugs that require reconstitution.
  • the connector 10 is adapted to connect to both the flexible bag 12 and the vial 14 and place the contents of the flexible bag 12 and the vial 14 into fluid communication with one another.
  • the connector 10 generally comprises a sleeve assembly 24 , a piercing assembly 26 , a gripper assembly 28 and a port connector assembly 30 .
  • the gripper assembly 28 and one portion of the sleeve assembly 24 are collectively adapted for axial movement with respect to another portion of the sleeve assembly 24 from an inactivated position (e.g., FIG. 5 ) to an activated position ( FIG. 7 ).
  • the inactivated position is that the containers 12 , 14 are not in fluid communication with each other wherein the connector 10 has not been activated.
  • the activated position is that the containers 12 , 14 are placed in fluid communication with each other.
  • the deactivated position, or post reconstitution position is the first container 12 and the second container 14 are not in fluid communication and have been moved from the activated position to the deactivated position ( FIG. 8 ).
  • the sleeve assembly 24 generally comprises a first sleeve 32 and a second sleeve 34 .
  • the first sleeve 32 and second sleeve 34 are mounted for translational motion with respect to one another from the inactivated position to the activated position.
  • the first sleeve 32 is slidably mounted within the second sleeve 34 .
  • Each sleeve 32 , 34 has generally cylindrical walls and, collectively, the sleeves 32 , 34 define a central passageway 35 through the connector 10 .
  • the first sleeve 32 has a first end 36 and a second end 38 .
  • the first end 36 is adapted to receive and be connected to the port connector 30 as described in greater detail below.
  • the second end 38 of the first sleeve 32 has a partial annular groove 40 .
  • the annular groove 40 receives a sealing member 42 , preferably in the form of an O-ring.
  • the sealing member 42 provides a seal between the first sleeve 32 and the second sleeve 34 and in a preferred form of the invention is disposed between the first sleeve 32 and the second sleeve 34 .
  • the first sleeve 32 further has a guide 44 at an inner surface of the sleeve 32 , intermediate of the first end 36 and the second end 38 .
  • the guide 44 has an opening 46 adapted to receive a portion of the piercing assembly 26 during activation.
  • a projection 47 extends from the guide 44 .
  • An inner surface of the first sleeve 32 has a ramped protrusion 49 extending preferably around a full periphery of the inner surface. The protrusion 49 will cooperate with the port connector 30 as described below.
  • the first sleeve 32 has a stop surface 51 that cooperates with a stop surface in the form of the second ledge 64 on the second sleeve 34 to prevent the first sleeve 32 from sliding out of the second sleeve 34 .
  • the first sleeve 32 also has a stop surface 74 that interfaces with the piercing assembly 26 , as will be described in greater detail below.
  • the first sleeve has a detent 39 on its outer surface. The detent 39 cooperates with an end of the second sleeve 34 which maintains the device in the inactivated position.
  • the second sleeve 34 also has a first end 48 and a second end 50 .
  • the second end 50 of the second sleeve 34 is connected to the gripper assembly 28 .
  • the gripper assembly 28 is an integral portion of the second sleeve 34 although it could be separately attached.
  • the second sleeve 34 accommodates the piercing assembly 26 within the central passageway 35 .
  • the piercing assembly 26 is slidable within the central passageway 35 along an inner surface of the second sleeve 34 .
  • the second sleeve 34 has a first section 56 , a second section 58 , and a third section 60 .
  • the third section 60 has a larger diameter than the second section 58
  • the second section 58 has a larger diameter than the first section 56
  • a first ledge 62 is formed
  • a second ledge 64 is formed.
  • the second sleeve 34 has a ramped protuberance 66 on an inner surface of the second sleeve 34 . As shown in FIG. 2 , the ramped protuberance 66 may begin proximate the ledge 62 and advance towards the second end 50 of the second sleeve 34 wherein it forms a flange 67 .
  • the ramped protuberance 66 may also have a shorter construction as shown in FIG. 1 .
  • a plurality of ramped protuberances 66 are utilized and in a most preferred embodiment, four ramped protuberances 66 are spaced around the inner surface of the second sleeve 34 .
  • the third section 60 of the second sleeve 34 further has a hub stop surface 69 that maintains the piercing assembly 26 at an initial first position before the device 10 is placed in the activated position.
  • the second sleeve 34 has a plurality of projections 73 .
  • the projections 73 are tapered and designed to abut against the hub of the piercing assembly 26 when the device 10 is in the inactivated position. This prevents the piercing assembly from rattling during shipment and maintains the piercing assembly 26 and sealing member 84 in spaced relation in the inactivated position. As explained in greater detail below, the piercing assembly 26 will move past the projections 73 when the device is moved from the inactivated position to the activated position.
  • the piercing assembly 26 generally comprises the hub 70 which supports a piercing member 76 .
  • the piercing member 76 has a first end 78 that is positioned to pass through the opening 46 of the guide 44 of the first sleeve 32 upon activation.
  • a second end 80 of the piercing member 76 is positioned adjacent the gripper assembly 28 when in the inactivated position.
  • the piercing member 76 such as a cannula or needle, is a rigid, elongate, spiked member at each end 78 , 80 having a central fluid passage 82 for establishing a fluid flow passage between the first container 12 and the second container 14 .
  • the piercing member is positioned outside the sidewalls of the first container 12 .
  • Each end 78 , 80 of the piercing member 76 terminates in a sharp point or an oblique angle or bevel adapted to pierce through closures as will be described below.
  • the piercing member 76 can have other end configurations known in the art.
  • the piercing member 76 comprises a plastic spike 81 at the end 78 and a metal cannula 83 at the end 80 .
  • the spike 81 can be integrally molded with the hub 70 .
  • the metal cannula 83 preferably fits within the spike 81 .
  • the plastic spike 81 is positioned to pierce into the port 16 of the flexible container 12 .
  • the metal cannula 83 is positioned to pierce the vial 14 .
  • the piercing assembly 26 further has a plurality of wings 75 that extend along the piercing member 76 .
  • the wings 75 act as guides to assure the plastic spike 81 is properly aligned to pass through the opening 46 of the guide 44 on the first sleeve 32 .
  • four wings 75 are spaced around the piercing member 76 .
  • the hub 70 further has a top surface 71 .
  • the hub 70 connected to the piercing member 76 , is slideable within the central passageway 35 along an inner surface of the second sleeve 34 .
  • the hub 70 is generally round or disk-shaped.
  • the hub 70 has a greater diameter than the diameter of the second section 58 of the central passageway 35 but a slightly smaller diameter than the third section 60 .
  • the hub 70 has a stop surface 86 that cooperates with the stop surface 74 of the first sleeve 32 .
  • the stop surface 86 cooperates with the ledge 62 ( FIGS. 2 and 4 ) on the second sleeve 34
  • the top surface 71 of the hub 70 cooperates with the hub stop surface 69 , which keeps the piercing assembly 26 in a first position.
  • the hub 70 further has an annular outer surface 88 that slides along the inner surface of the second sleeve 34 and specifically along the ramped protrusions 66 .
  • FIGS. 1 and 2 further show the gripper assembly 28 attached to the second sleeve 34 .
  • the gripper assembly 28 is integrally attached to the second end 50 of the second sleeve 34 .
  • the gripper assembly 28 generally includes a wall portion 90 , a base 91 , a finger assembly 92 and a sealing member 84 .
  • the gripper assembly 28 serves as an attaching member that is adapted to attach the device 10 to the second container or drug vial 14 .
  • the gripper assembly 28 has a central opening 96 .
  • the wall portion 90 is preferably annular and forms a cup-like shape in cooperation with the base 91 .
  • the wall portion 90 is preferably continuous and solid.
  • the wall portion 90 supports means for fixedly attaching the second container or drug vial 14 to the gripper assembly 28 .
  • the means shown are a plurality of segmented fingers that cooperatively form the finger assembly 92 .
  • the finger assembly 92 comprises a plurality of alternating segmented fingers 98 a , 98 b that are connected at their bottom portions.
  • the wall portion 90 has a ledge 97 .
  • the bottom portions of the fingers 98 have corresponding structure to the ledge 97 .
  • the finger assembly 92 is bonded to the wall portion 90 proximal this area.
  • the fingers 98 a are spaced inwardly from the wall portion 90 to allow the fingers 98 a to flex when a drug vial 14 is inserted into the gripper assembly 28 .
  • the fingers 98 b have a rear portion contacting the wall portion 90 and generally do not flex as will be described in greater detail below.
  • the fingers 98 a , 98 b are generally trapezoidal in shape and are separated by gaps to define a vial receiving chamber that corresponds to the central opening 96 of the gripper assembly 28 for receiving a top of the vial 14 .
  • the present device utilizes six fingers 98 a , 98 b , it can be appreciated by one of ordinary skill in the art that more or fewer fingers could be utilized without departing from the scope of the present invention. For example, eight fingers could be used.
  • three of the fingers 98 a include radially inwardly tapering resilient tabs 104 , from a distal end to a proximal end, past which the medical professional must urge a neck of the drug vial 14 in order to connect it to the gripper assembly 28 .
  • the tabs 104 are configured such that a space 105 is maintained between the tab 104 and the finger 98 a . It is appreciated that the tabs 104 are capable of flexing to accommodate varying diameter vial closures.
  • the distal end of the fingers 98 have a radiused end that is smooth to avoid cutting the medical personnel handling the connector 10 .
  • the tabs 104 could also be formed, however, as solid bumps without departing from the invention.
  • the remaining fingers 98 b have axially extending, standing ribs 106 extending along an inner surface of the fingers 98 b .
  • the standing ribs 106 extend proximate a bottom portion of the finger but do not contact the base 91 of the gripper assembly 28 .
  • the ribs 106 are spaced from the base by the sealing member 84 .
  • the standing ribs 106 assist in aligning the vial 14 with the vial receiving chamber during insertion.
  • the standing ribs 106 are capable of indenting one or more sidewall portions of the metal crimp ring 22 of the vial 14 in order to inhibit the vial 14 from rotating.
  • each finger 98 b While one standing rib 106 is shown on each finger 98 b , a pair of standing ribs 106 on each finger 98 b could also be utilized to enhance the prevention of rotation of the vial 14 .
  • the fingers 98 b have a post 107 on a rear portion that contacts the wall portion 90 .
  • the fingers 98 b flex very little, if any, while the fingers 98 a do flex as the fingers 98 a are spaced inward from the wall portion 90 . It is desirable for the fingers 98 b not to flex in order to maximize the ability of the standing ribs 106 to indent the side of the crimp ring 22 and prevent rotation of the vial 14 .
  • the fingers 98 b having the standing ribs 106 are slightly taller than the fingers 98 a with the tabs 104 .
  • the fingers 98 b have a flat lead-in section 99 .
  • the flat lead-in section 99 helps to properly align the vial 14 as it is inserted into the gripper assembly 28 . Because the fingers 98 b are taller than the fingers 98 a , the vial 14 is aligned by the lead-in sections 99 and then contacts the tabs 104 as the vial 14 is further inserted into the gripper assembly 28 .
  • a flexible restraining member such as shrink wrap or the like
  • the wall portion 90 further has a first annular rim 108 extending from the base 91 .
  • the finger assembly 92 has a bottom portion 93 having a second annular rim 110 extending therefrom and towards the first annular rim 108 .
  • the second annular rim 110 is coradial with the first annular rim 103 and is longitudinally displaced therefrom.
  • the rims 108 , 110 cooperate with the sealing member 84 to be described in greater detail below.
  • the finger assembly 92 is ultrasonically welded to the inner surface of the wall portion 90 .
  • the sealing member 84 is positioned between the base 91 of the wall portion 90 and the bottom portion 93 of the finger assembly 92 wherein the sealing member 84 hermetically seals the central passageway 35 and the piercing member 26 disposed therein.
  • the sealing member 84 is positioned within the gripper assembly 28 .
  • the sealing member 84 has a base 111 and an annular ridge 112 .
  • the base has first and second surfaces.
  • the base is preferably disk-shaped.
  • the annular ridge 112 extends axially from the disk and towards the top of the vial 14 .
  • the annular ridge 112 is dimensioned to tightly and sealingly fit over the rubber stopper 20 of the vial 14 to prevent leakage from the vial 14 .
  • the annular ridge 112 tapers axially-outwardly.
  • the annular ridge 112 of the sealing member 84 is capable of deforming to accommodate dimensional variations in a height of a closure of the second container.
  • the sealing member 84 can be pre-slit at a central location corresponding to the end 80 of the piercing member 76 .
  • the sealing member 84 has a center hub 114 having a thickened cross-section as shown in FIG. 1 .
  • the center hub 114 is positioned to be pierced by the piercing member 76 during activation of the device 10 .
  • the piercing member 76 is buried into the thickened center hub 114 , without passing through the hub 114 , as the plastic spike 83 pierces into the container 12 .
  • FIG. 5 shows the sealing member 84 having a thickened center hub 114 a that is slightly thinner than the center hub 114 shown in FIG. 1 .
  • the disk-shaped sealing member 84 has a web 85 of thinner cross-section than the center hub 114 .
  • the web 85 assists the hub 114 in flexing to accommodate dimensional variations in the vial 14 .
  • the annular ridge 112 is positioned circumjacent the center hub 114 and the web 85 .
  • a first annular groove 113 is positioned at an outer periphery of the sealing member 84 on a first side of the sealing member 84 .
  • a second annular groove 115 is positioned on a second side of the sealing member 84 generally opposite annular groove 115 .
  • the first annular groove 113 receives the first annular rim 108 and the second annular groove 115 receives the second annular rim 110 wherein the sealing member 84 is sandwiched between the base 91 and the bottom portion 93 of the finger assembly 92 .
  • the sealing member 84 hermetically seals the passageway 35 and sealing member 76 at the second end 50 of the second sleeve 34 .
  • the sealing member 84 can be sized slightly larger such that when the annular grooves 113 , 115 receive the annular rims 108 , 110 , the sealing member 84 is subjected to a radial compressive force.
  • sealing member 84 is accounting for dimensional variations of vials 14 that are inserted into the gripper assembly 28 .
  • the sealing member 84 can be lubricated, which lubricates the piercing member 76 allowing it to enter the drug vial 14 more easily.
  • the sealing member 84 is preferably made from silicone rubber.
  • the sealing member 84 could have a central opening.
  • the central opening receives the piercing member 76 when the connector 10 is moved from its inactivated position to the activated position.
  • the central opening would also allow for steam sterilization past the sealing member 84 .
  • the wall portion 90 has a lip 122 at its outer periphery.
  • An end cap, or flip cap 124 is dimensioned to snap over the lip 122 to seal the gripper assembly 28 before a vial 14 is inserted into the gripper assembly 28 .
  • No orientation of the end cap 124 is required.
  • the lip 122 is preferably integrally molded with the wall portion 90 .
  • the end cap 124 is preferably made from plastic or other suitable material.
  • the end cap 124 provides a hermetic seal between the exterior of the device 10 and the central opening 96 .
  • a tape strip (not shown) could be stretched across the end cap 124 and attached to outer surfaces of the wall portion 90 as a tamper evident feature.
  • a seal material can be releasably secured to the wall portion 90 such as by heat sealing wherein the material can be peeled away by pulling a tab formed on the seal material.
  • the wall portion 90 provides for a solid surface to mount the seal material therefore hermetically sealing the connector 10 .
  • the seal material can be made of aluminum foil, or of polymeric based material such as TYVEK®, and more preferably TYVEK® grade 1073B, or spun paper or other material that is capable of being peelably attached to the wall portion 90 and capable of providing a barrier to the ingress of contaminants. It is also contemplated that sealing can be accomplished through induction welding or other sealing techniques.
  • FIGS. 1–3 show the port connector 30 of the device 10 .
  • the port connector 30 serves as a first attaching member to connect the first container 12 to the device 10 .
  • the port connector 30 includes a first attaching element 124 generally in the form of a port snap 124 and a second attaching element 126 generally in the form of a container sleeve 126 .
  • the container sleeve 126 is generally cylindrical and has one end closed by a membrane 128 .
  • the port snap 124 is also generally cylindrical and dimensioned to receive the container sleeve 126 .
  • the port snap 124 has a flange 130 extending around its outer surface.
  • a distal end of the port snap 124 has a generally circular, tapered finger 132 extending therefrom.
  • the container sleeve 126 is inserted into the port snap 124 and connected thereto preferably by solvent bonding an outer surface of the sleeve 126 to an inner surface of the port snap 124 , thus forming the port connector assembly 30 .
  • the membrane 128 of the sleeve 126 is positioned at the flange end of the port snap 124 .
  • a second sealing member 136 preferably in the form of a rubber septum, is inserted into the second end 36 of the first sleeve 32 before connecting the port connector assembly 30 to the second end 36 of the first sleeve 32 .
  • the second sealing member 136 is positioned adjacent the guide 44 wherein the projection 47 indents the second sealing member 136 . If desired, the second sealing member 136 could be pre-slit. The second sealing member 136 prevents “drip-back” after the deactivation procedure as will be described in greater detail below.
  • the port snap 124 is then inserted and urged into the first sleeve 32 wherein the flange 130 passes by the protrusion 49 of the first sleeve 32 .
  • the resiliency of the materials allow the flange 130 to snap back after passing by the protrusion 49 wherein a tight interference fit is formed between the port connector 30 and the first sleeve 32 .
  • the tapered finger 132 indents the second sealing member 136 , thus sandwiching the second sealing member 136 between the guide 44 and the port snap 124 .
  • the port connector assembly 30 is also connected to the first container 12 wherein the outer surface of the container sleeve 126 is connected to an inside surface of the container port 16 .
  • this connection is performed using an electron-beam process as disclosed in commonly-assigned U.S. patent application Ser. No. 09/294,964 entitled “Method and Apparatus For Manipulating Pre-Sterilized Components In An Active Sterile Field,” which is expressly incorporated herein by reference.
  • Other methods of connection are also possible such as solvent bonding.
  • the protrusion 49 and flange 130 are formed around a full periphery of the first sleeve 32 and port snap 124 respectively.
  • These structures can also be in the form of an interrupted annular ridge, a plurality of bumps or even a single bump.
  • the connector 10 is connected to the flexible bag 12 prior to shipping. It will be appreciated by one of ordinary skill in the art, however, that the connector 10 could be connected to the first container 12 at different times.
  • the device 10 can optionally include a tamper-evident strip 150 , which is preferably made from adhesive material.
  • the tamper-evident strip 150 can be attached at a juncture between the first sleeve 32 and the second sleeve 34 and over the detent 39 . Medical personnel must remove the strip 150 in order for the first sleeve 32 and the second sleeve 34 to be capable of relative axial movement.
  • the tamper evident strip 150 could be capable of indicating the first and second sleeves 32 , 34 have been moved axially with respect to one another, rather than preventing such movement, by becoming damaged upon such movement.
  • the tamper-evident strip 150 can also include a flap 152 for removing the tamper evident strip 150 .
  • the tamper evident strip 150 can indicate to a medical professional that someone has used or tampered with the device 10 by the fact that the tamper evident strip 150 is missing or damaged.
  • the tamper evident strip 150 can take alternative forms as shown in FIG. 21 .
  • FIGS. 1 , 2 and 4 show the connector 10 in its inactivated position where the connector 10 is in its most elongated state. In this inactivated position, the stop surface 51 of the first sleeve 32 abuts the stop surface 64 of the second sleeve 34 . The hub 70 is maintained between the hub stop surface 69 and the ledge 62 .
  • FIGS. 4–7 disclose the activation process for the connector 10 .
  • FIG. 4 shows the device 10 connected to the flexible container 12 . As shown in FIG. 5 , the end cap 124 is first flipped off the gripper assembly 28 .
  • the vial 14 is then inserted into the gripper assembly 28 wherein the fingers 98 a flex towards the wall portion 90 until the vial 14 passes by the tabs 104 wherein the neck of the vial 14 is positioned between the tabs 104 and the sealing member 84 .
  • the standing ribs 106 on the fingers 98 b indent a side portion of the crimp ring 22 on the vial 14 .
  • the vial 14 is fixedly attached to the connector 10 .
  • the annular ridge 112 of the sealing member 84 forms a fluid tight seal over the top of the vial 14 .
  • a vial 14 can be selectively docked to the connector 10 without piercing the stopper 20 of the vial 14 .
  • the second end 80 of the piercing member 76 is positioned close to the center hub 114 of the sealing member 84 . This reduces the stroke length or distance the piercing member 76 must travel to pierce the sealing member 84 and the stopper 20 of the drug vial 14 .
  • FIG. 6 shows the connector device 10 as the activation process commences.
  • the tamper-evident strip 150 is first peeled away from the sleeves 32 , 34 .
  • the vial 14 in the gripper assembly 28 along with the second sleeve 34 , are moved axially towards the flexible container 12 .
  • Adequate force must be applied so that the first end 48 of the second sleeve 34 moves past the detent 39 on the first sleeve 32 .
  • the plastic spike 81 will engage the second sealing member 136 . Because of the materials used, the plastic spike 81 will not yet pierce through the second sealing member 136 .
  • the sleeves 32 , 34 translate axially wherein the hub 70 advances to against the sealing member 84 ; also, the first end 48 of the second sleeve 34 proceeds to the first end 36 of the first sleeve 32 .
  • This position ( FIG. 7 ) represents the activated position.
  • the metal cannula 83 at the second end 80 of the piercing member 76 is pierced through the stopper 20 of the vial 14
  • the plastic spike 81 at the first end 78 of the piercing member 76 is pierced through the second sealing member 136 .
  • fluid communication is established between the flexible bag 12 and the vial 14 through the central fluid passageway 82 of the piercing member 76 .
  • the central passageway 35 is sealed in a substantially air-tight fashion at one end by the sealing member 84 , at an opposite end by the second sealing member 136 and at the interface between the sleeves 32 , 34 by the sealing member 42 .
  • the volume of the central passageway 35 necessarily decreases thus pressurizing the air located in the central passageway 35 . This pressurized air must be relieved before the connector 10 reaches the final activated position.
  • the sealing member 42 no longer contacts the inner surface of the second sleeve 34 ( FIG. 6 ) thus allowing the pressurized air to be relieved through the junction of the sleeves 32 , 34 .
  • the diluent contained in the flexible container 12 can pass through the piercing member 76 to reconstitute the drug contained in the vial 14 .
  • the drug vial 14 and second sleeve 34 can be pulled back away from the flexible container 12 .
  • FIG. 8 when the second sleeve 34 is pulled back, the piercing assembly 26 is retained in position by the flange 67 of the ramped protuberance 66 .
  • the stop surface 74 of the first sleeve 32 does not contact the ramped protuberance 66 and can be retracted.
  • the metal cannula 83 of the piercing member 76 remains in the closure of the vial 14 and the plastic spike 81 of the piercing member 76 is pulled past the membrane 128 and the second sealing member 136 ( FIG. 8 ). This position is referred to as the deactivated position, or post reconstitution position.
  • the second sealing member 136 is resilient and forms a seal once the plastic spike 81 passes by, thus preventing any of the resulting mixture from dripping back into the drug vial 14 or passing into the passageway 35 of the sleeve assembly 24 .
  • the resulting mixture can then be delivered to a patient through appropriate tubing sets (not shown) attached to the second port 18 on the flexible container 12 .
  • FIGS. 9 and 10 disclose another embodiment of the connector device 10 having an alternative vial connecting structure. Similar elements will be designated with the same reference numerals.
  • the connector device 10 utilizes an alternative finger assembly 92 , generally designated with the reference numeral 200 , as well as an alternative sealing member 84 , or septum, generally designated with the reference numeral 202 .
  • the finger assembly 200 has a disk-shaped base or panel 204 at a bottom portion of the fingers 98 .
  • the panel 204 has a first side 206 and a second side 208 .
  • the panel 204 further has a center opening 210 extending through the panel 204 from the first side 206 to the second side 208 .
  • the panel 204 also has an annular ring 212 extending from the second side 208 of the disk.
  • the annular ring 212 has a rounded end surface 214 that is generally blunt.
  • the annular ring 212 further has an inner lip 216 .
  • the panel 204 and annular ring 212 are preferably integrally molded with the finger assembly 92 of a rigid material.
  • the annular ring 212 is made from PVC material.
  • the septum 202 is similar to the septum 84 but has a conical-shaped central portion 218 that supports a center plug 220 .
  • the septum 202 is supported in the connector device 10 similar the previously-described septum 84 .
  • the septum 202 is positioned between the base 91 and a bottom portion of the finger assembly 92 wherein the panel 204 extends over the septum 202 .
  • the center plug 220 fits into the center opening 210 and abuts against the inner lip 216 .
  • FIG. 10 shows the connector device 10 having the vial 14 fixedly secured to the gripper assembly 28 .
  • the vial 14 has a crimp ring 22 that has an aperture or circular opening on the rubber stopper 20 that plugs the opening of the vial 14 .
  • the opening defines a target site of the rubber stopper 20 .
  • the annular ring 212 is sized such that it fits within the opening of the crimp ring 22 .
  • the annular ring 212 does not contact the crimp ring 22 .
  • the annular ring 212 is rigid and has a hardness greater than the rubber stopper 20 .
  • the annular ring 212 deforms the rubber stopper 20 but does not cut or pierce into the stopper 20 .
  • the annular ring 212 sealingly engages the rubber stopper 20 to form a fluid tight seal against the closure member or stopper 20 .
  • the metal cannula 83 pierces through the center plug 220 passing through the annular ring 212 and stopper 20 and into the vial 14 .
  • the annular ring 212 is integrally connected to the panel 204 and finger assembly 92 .
  • the septum 202 could be modified to support the rigid annular ring 212 .
  • FIGS. 11 and 12 disclose another embodiment of the sealing member 84 , used with the connector device 10 , generally designated by the reference numeral 250 . Similar elements will be referred to with identical reference numerals. Similar to the sealing member 84 discussed above, the sealing member 250 has a disk-shaped base having a first surface 251 and a second surface 253 . The annular ridge 112 extends axially from the second surface 253 of the disk and towards the top of the vial 14 . The sealing member 250 further has a cap 252 concentrically disposed within the annular ridge 112 and that also extends from the second surface 253 of the disk. The cap 252 is generally in the form of a conical frustum.
  • the cap 252 has a frustoconical sidewall 254 connected to a top wall 256 .
  • the top wall 256 has a slight concave shape.
  • the frustoconical sidewall 254 extends from the disk towards the vial 14 further than the annular ridge 112 .
  • the sealing member 250 has a recessed portion 258 on an underside surface adjacent to a bottom portion of the sidewall 254 .
  • FIG. 12 discloses the sealing member 250 connected in the connector device 10 similar to the sealing member 84 as well as a vial 14 connected to the gripper assembly 28 .
  • the top wall 256 of the cap 252 deflects into a generally planar position to tightly and sealingly fit against the rubber stopper 20 of the vial 14 .
  • the rubber stopper 20 could be molded with a depression to accommodate the top wall 256 .
  • the frustoconical sidewall 254 bows outwardly.
  • the annular ridge 112 tightly and sealingly fits over the crimp ring 22 of the vial 14 .
  • the recessed portion 258 accommodates the deflection of the cap 252 against the vial 14 .
  • the sealing member 250 provides a dual fluid tight seal against the closure member of the vial 14 .
  • the cap 252 sealingly fits against the target site of the rubber stopper 20 and the annular ridge 112 sealingly fits against an outer portion of the rubber stopper 20 .
  • the sealing member 250 provides even greater sealing capabilities by providing a dual-seal structure.
  • the sealing member 250 can also be preferably made from Silicone PL-S146.
  • a seal is provided directly against the rubber stopper 20 .
  • the annular ring 212 and cap 252 provide a seal against the target site of the rubber stopper 20 .
  • sterility would not be comprised since the annular ring 212 and cap 252 directly seal against the rubber stopper 20 .
  • FIGS. 13–18 disclose another embodiment of the sealing member 84 , used with the connector device 10 , generally designated by the reference numeral 300 .
  • the sealing member 300 generally includes a base 302 , a diaphragm 304 , and an annular ridge 306 .
  • the base 302 is generally disk-shaped.
  • the disk or base 302 has a first surface 308 and a second surface 310 .
  • the first surface 308 faces into the connector 10 and the second surface 310 faces the container to be attached to the connector 10 .
  • the base 302 has the identical grooved structure at its periphery to attach the sealing member 300 to the connector 10 as described above.
  • the diaphragm member 304 is generally a flexible member that extends from the second surface 310 of the base 302 .
  • the diaphragm member 304 extends from a generally central portion of the base 302 .
  • the diaphragm member 304 may be considered to be frustoconical in shape.
  • the diaphragm member 304 has a frustoconical or annular sidewall 312 and a membrane 316 extending across and connected to the annular sidewall 312 .
  • the membrane 316 of the diaphragm member 304 is adapted to confront the closure member of the vial 14 . As shown in FIG. 16 , the membrane 316 has an outer surface 317 that is preferably slightly convex.
  • the annular wall 312 has a lip 313 extending therefrom.
  • the lip 313 is also annular.
  • the lip 313 has a rounded protrusion 314 .
  • the diaphragm member 304 is capable of forming a first fluid tight seal with the closure of the container.
  • the annular ridge 306 extends from the second surface 310 of the disk 302 .
  • the annular ridge 306 is circumjacent the diaphragm 304 and is positioned outwardly of the diaphragm member 304 .
  • the annular ridge 306 tapers axially-outwardly from a proximal end to a distal end.
  • the annular ridge 306 is capable of forming a second fluid tight seal with the closure of the container.
  • the diaphragm member 304 extends from the second surface 310 at a first length.
  • the annular ridge 306 extends from the second surface 310 at a second length. The second length is less than the first length, thus, the diaphragm member 304 extends from the second surface 310 a greater distance than the annular ridge 306 .
  • FIGS. 17–18 show the sealing member 300 connected to the connector 10 .
  • the sealing member 300 is connected similarly as described above.
  • FIGS. 17–18 also show the vial 14 connected to the connector 10 .
  • the vial 14 has a closure member that includes a rubber stopper 20 and a crimp ring 22 .
  • the crimp ring 22 has a central opening defining a target sight 23 ( FIG. 18 ) on the rubber stopper 20 .
  • the vial 14 may be connected to the connector 10 and then have a shrink wrap member 350 applied over the vial 14 and connected to the gripper assembly 28 .
  • the vial 14 , connector 10 (inactivated) and container 12 may be shipped in this fashion if desired.
  • the sealing member 300 provides a dual seal on the vial 14 .
  • the diaphragm member 304 abuts the closure to provide a first fluid tight seal with the closure of the vial 14
  • the annular ridge 306 abuts the closure to provide a second fluid tight seal with the closure of the vial 14 .
  • the rounded protrusion 314 of the diaphragm member 304 indents the rubber stopper 20 at the target site 23 to form the first seal.
  • a space 330 is maintained between the crimp ring 22 and the annular wall 312 and membrane 316 of the diaphragm member 304 .
  • the membrane 316 confronts the rubber stopper 20 .
  • the annular ridge 306 deflects outwardly against the crimp ring 22 to form the second seal. It is understood that other variations are possible to form a dual-seal such as with an o-ring.
  • the diaphragm member 304 when the vial 14 is connected to the connector 10 , the diaphragm member 304 initially contacts the rubber stopper 20 of the vial 14 . As the vial 14 further advances into the gripper assembly 28 , the diaphragm member 304 initially is displaced towards the piercing member 76 . Upon further advancement, the annular wall 316 folds upon itself while the lip 312 forms a fluid tight seal on the rubber stopper 20 . This action also moves the membrane 316 into a second position wherein the surface 317 moves from the slightly convex surface to a generally planar surface.
  • the respective heights and flexibility of the diaphragm member 304 and annular ridge 306 allow these components to account for dimensional differences in heights of different closures.
  • FIGS. 19–21 disclose another embodiment of the sealing member 84 , used with the connector device 10 , generally designated by the reference numeral 400 .
  • the sealing member 400 or septum 400 , generally has a base 402 and an annular ring 406 .
  • the septum 400 is a single integral component made from a generally rigid material. As such, the septum 400 is preferably injection-molded in a single process. In one preferred embodiment, the septum 400 is made from polyethylene. PVC material may also be used.
  • the base 402 is generally disk-shaped.
  • the disk or base 402 has a first surface 408 and a second surface 410 .
  • the first surface 408 faces into the connector 10 and the second surface 410 faces the container to be attached to the connector 10 .
  • the base 402 has the identical grooved structure at its periphery to attach the sealing member 400 to the connector 10 as described above.
  • the base 402 also has a plurality of spokes 405 extending from the annular ring 406 along the base 402 .
  • the annular ring 406 is a rigid member.
  • the annular ring 406 extends from the second surface 410 of the base 402 .
  • the annular ring 406 is positioned at generally a central portion of the base 402 .
  • the ring 406 defines an opening 412 , preferably a center opening 412 , in the base 402 .
  • a membrane 414 is positioned in the center opening 412 .
  • the membrane 414 maybe considered a portion of the base 402 and integrally molded with the base 402 .
  • the membrane 414 is axially spaced from the base 402 .
  • the membrane 414 is also designed to be spaced from the closure 20 of the vial 14 when the vial s 14 is connected to the connector 10 .
  • the rigid annular ring 406 has a protrusion 416 at a distal end.
  • the protrusion 416 is tapered to a rounded end 418 .
  • the rigid annular ring 406 is capable of forming a fluid tight seal with the closure 20 of the vial 14 .
  • FIG. 21A shows the septum 400 connected to the connector 10 .
  • the septum 400 is cooperates similarly with the gripper assembly 28 to be mounted in the connector 10 as described above.
  • FIG. 21 also shows the vial 14 connected to the connector 10 .
  • the vial 14 has the rubber stopper 20 positioned in the opening of the vial 14 and the crimp ring 22 positioned over the stopper 20 .
  • the crimp ring has an aperture that defines the target site 23 on the rubber stopper 20 .
  • the rounded protrusion 418 indents the rubber stopper 20 sufficiently to provide the fluid tight seal.
  • the height of the annular ring 406 is set such that a sufficient interference fit is achieved between the annular ring 406 and the rubber stopper 20 .
  • the rounded end of the annular ring 406 assures that the rubber stopper 20 is indented but not cut by the ring 406 .
  • the annular ring 406 indents the rubber stopper 20 at the target site 23 .
  • the annular ring 406 is spaced inwardly from the crimp ring 22 wherein a space 420 is maintained between the annular ring 406 and the crimp ring 22 .
  • the membrane 414 is spaced from the rubber stopper 20 .
  • the connector 10 can be activated as shown in FIGS. 21B and 21C wherein the piercing member 76 pierces through the membrane 414 and rubber stopper 20 and into the vial 14 .
  • the connector 10 can also be positioned in the deactivated position shown in FIG. 21D .
  • the rubber stoppers 20 used may have imperfections across a top surface of the stoppers 20
  • the stoppers 20 may have bumps at locations that would correspond to the target site on the stopper.
  • the stoppers 20 may also have identification markings. These imperfections or markings can vary the height of the stopper 20 .
  • the rigidity of the septum 400 sufficiently deforms the stopper 20 without piercing the stopper 20 and helps provide a sufficient fluid tight seal regardless of such imperfections or markings across the rubber stopper 20 .
  • FIGS. 22–24 disclose yet another embodiment of the sealing member 84 , used with the connector device 10 , generally designated by the reference numeral 500 .
  • the sealing member 500 or septum 500 , has one portion made of rigid material and a pierceable portion made of a rubber material.
  • the portions of the septum 500 are formed simultaneously together in a two-shot injection molded process. It is understood, however, that other processes can be used to connect the separate portions including an insert molding process. Adhesives or an interference fit could also be used.
  • the septum 500 generally has a base 502 and a membrane 504 .
  • the base 502 is generally disk-shaped.
  • the disk or base 502 has a first surface 508 and a second surface 510 .
  • the first surface 508 faces into the connector 10 and the second surface 510 faces the container to be attached to the connector 10 .
  • the base 502 has an opening 512 therethrough, preferably in a center of the base 502 .
  • the opening 512 defines an inner surface 513 on the base 502 .
  • the base further has an annular ring 514 extending from the second surface of the base 502 and around the center opening 512 .
  • the annular ring 514 is tapered wherein a distal end has rounded protrusion 516 .
  • the annular ring 512 is capable of forming a fluid tight seal with the closure 20 of the vial 14 as described below.
  • the first side 508 has a recessed portion 507 .
  • the membrane 504 is positioned in the center opening 512 and closes the opening 512 .
  • the membrane has a generally planar section 518 with a depending leg 520 .
  • the leg 520 is connected to the inner surface 513 of the base 502 .
  • the base 502 has the similar grooved structure as described above for connecting the septum 500 to the gripper assembly 28 .
  • the base 502 may have a collar 522 .
  • the base 502 has an outer peripheral edge 524 .
  • the collar 522 is connected to the outer peripheral edge.
  • the base 502 has a tongue 526 and the collar has an inner peripheral groove 528 .
  • the tongue 526 is received by the groove 528 .
  • the collar 522 has the grooved structure as described above.
  • the collar 522 is formed of the rubber material like the membrane 504 .
  • the septum 500 is formed sin one preferred embodiment by a two-shot injection molded process.
  • the base 502 of the septum 500 is a rigid plastic material.
  • the membrane 504 and collar 522 of the septum 500 are a softer rubber material.
  • the components are molded together simultaneously in a two-shot injection molded process as is known in the art.
  • the septum 500 possesses the rigidity from the plastic material that provides a fluid tight seal with the closure while also possessing a soft material in the membrane for the piercing member to easily pierce through.
  • FIG. 24 shows the septum 500 connected to the connector 10 .
  • the septum 500 is cooperates similarly with the gripper assembly 28 to be mounted in the connector 10 as described above.
  • FIG. 24 also shows the vial 14 connected to the connector 10 .
  • the vial 14 has the rubber stopper 20 positioned in the opening of the vial 14 and the crimp ring 22 positioned over the stopper 20 .
  • the crimp ring has an aperture that defines the target site 23 on the rubber stopper 20 .
  • the septum 500 provides a fluid tight seal on the vial 14 .
  • the annular ring 514 abuts the rubber stopper 20 to provide the seal.
  • the rounded protrusion 516 indents the rubber stopper 20 sufficiently to provide the fluid tight seal.
  • the height of the annular ring 514 is set such that a sufficient interference fit is achieved between the annular ring 514 and the rubber stopper 20 .
  • the rounded end of the annular ring 516 assures that the rubber stopper 20 is indented but not cut by the ring 406 .
  • the annular ring 514 indents the rubber stopper 20 at the target site 23 .
  • the annular ring 514 is spaced inwardly from the crimp ring 22 wherein a space 530 is maintained between the annular ring 514 and the crimp ring 22 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
US10/106,716 1998-09-15 2002-03-26 Sliding reconstitution device for a diluent container Expired - Fee Related US7074216B2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
US10/106,716 US7074216B2 (en) 1998-09-15 2002-03-26 Sliding reconstitution device for a diluent container
TW92105874A TWI260233B (en) 2002-03-26 2003-03-18 Sliding reconstitution device for a diluent container
PE2003000291A PE20030939A1 (es) 2002-03-26 2003-03-24 Dispositivo de reconstitucion deslizable para un contenedor diluyente
ARP030101029 AR039128A1 (es) 2002-03-26 2003-03-25 Dispositivo de reconstitucion deslizable para un contenedor diluyente
CNB038067862A CN100509081C (zh) 2002-03-26 2003-03-26 用于稀释剂容器的滑动重组装置
ES03745610T ES2328919T3 (es) 2002-03-26 2003-03-26 Dispositivo de reconstitucion deslizante para un recipiente de diluyente.
EP20030745610 EP1487533B1 (en) 2002-03-26 2003-03-26 Sliding reconstitution device for a diluent container
MXPA04009341A MXPA04009341A (es) 2002-03-26 2003-03-26 Dispositivo de reconstitucion deslizable para un contenedor diluyente.
BR0308714A BR0308714A (pt) 2002-03-26 2003-03-26 Dispositivo de reconstituição deslizante para um recipiente de diluente
NZ535308A NZ535308A (en) 2002-03-26 2003-03-26 Sliding reconstitution device for a diluent container
PL374760A PL205227B1 (pl) 2002-03-26 2003-03-26 Urządzenie łączące dla ustalenia połączenia płynowego pomiędzy pierwszym pojemnikiem i drugim pojemnikiem
PCT/US2003/009190 WO2003082398A2 (en) 2002-03-26 2003-03-26 Sliding reconstitution device for a diluent container
EP09075247A EP2095805A3 (en) 2002-03-26 2003-03-26 A septum for a medical connector
CA 2478387 CA2478387C (en) 2002-03-26 2003-03-26 Sliding reconstitution device for a diluent container
DE60328171T DE60328171D1 (de) 2002-03-26 2003-03-26 Gleitende rekonstitutionsvorrichtung für einen behälter mit verdünnungsmittel
AU2003226002A AU2003226002B2 (en) 2002-03-26 2003-03-26 Sliding reconstitution device for a diluent container
KR10-2004-7015068A KR20040111430A (ko) 2002-03-26 2003-03-26 희석제 용기용 활주식 재구성 장치
AT03745610T ATE435048T1 (de) 2002-03-26 2003-03-26 Gleitende rekonstitutionsvorrichtung für einen behälter mit verdünnungsmittel
DK03745610T DK1487533T3 (da) 2002-03-26 2003-03-26 Glidende genfortyndingsindretning til en beholder med fortyndingsmiddel
JP2003579928A JP4454315B2 (ja) 2002-03-26 2003-03-26 希釈剤容器用のスライド式再構成装置
US10/744,953 US7425209B2 (en) 1998-09-15 2003-12-23 Sliding reconstitution device for a diluent container
US10/744,946 US7358505B2 (en) 1998-09-15 2003-12-23 Apparatus for fabricating a reconstitution assembly
ZA200407529A ZA200407529B (en) 2002-03-26 2004-09-20 Sliding reconstitution device for a diluent container.
AU2008203002A AU2008203002A1 (en) 2002-03-26 2008-07-08 A septum for a medical connector
US12/189,966 US8226627B2 (en) 1998-09-15 2008-08-12 Reconstitution assembly, locking device and method for a diluent container
JP2009178363A JP2009240835A (ja) 2002-03-26 2009-07-30 希釈剤容器用のスライド式再構成装置

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/153,816 US6113583A (en) 1998-09-15 1998-09-15 Vial connecting device for a sliding reconstitution device for a diluent container
US09/561,666 US6582415B1 (en) 1998-09-15 2000-05-02 Sliding reconstitution device for a diluent container
US10/106,716 US7074216B2 (en) 1998-09-15 2002-03-26 Sliding reconstitution device for a diluent container

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/561,666 Continuation-In-Part US6582415B1 (en) 1998-09-15 2000-05-02 Sliding reconstitution device for a diluent container

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/744,946 Continuation-In-Part US7358505B2 (en) 1998-09-15 2003-12-23 Apparatus for fabricating a reconstitution assembly
US10/744,953 Continuation-In-Part US7425209B2 (en) 1998-09-15 2003-12-23 Sliding reconstitution device for a diluent container

Publications (2)

Publication Number Publication Date
US20020123736A1 US20020123736A1 (en) 2002-09-05
US7074216B2 true US7074216B2 (en) 2006-07-11

Family

ID=28673551

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/106,716 Expired - Fee Related US7074216B2 (en) 1998-09-15 2002-03-26 Sliding reconstitution device for a diluent container

Country Status (20)

Country Link
US (1) US7074216B2 (pt)
EP (2) EP2095805A3 (pt)
JP (2) JP4454315B2 (pt)
KR (1) KR20040111430A (pt)
CN (1) CN100509081C (pt)
AR (1) AR039128A1 (pt)
AT (1) ATE435048T1 (pt)
AU (2) AU2003226002B2 (pt)
BR (1) BR0308714A (pt)
CA (1) CA2478387C (pt)
DE (1) DE60328171D1 (pt)
DK (1) DK1487533T3 (pt)
ES (1) ES2328919T3 (pt)
MX (1) MXPA04009341A (pt)
NZ (1) NZ535308A (pt)
PE (1) PE20030939A1 (pt)
PL (1) PL205227B1 (pt)
TW (1) TWI260233B (pt)
WO (1) WO2003082398A2 (pt)
ZA (1) ZA200407529B (pt)

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JP2005521487A (ja) 2005-07-21
ZA200407529B (en) 2005-06-30
NZ535308A (en) 2006-11-30
KR20040111430A (ko) 2004-12-31
AU2003226002B2 (en) 2008-10-30
WO2003082398A2 (en) 2003-10-09
PL205227B1 (pl) 2010-03-31
EP2095805A3 (en) 2009-10-14
ES2328919T3 (es) 2009-11-19
US20020123736A1 (en) 2002-09-05
AU2008203002A1 (en) 2008-07-31
CN1700935A (zh) 2005-11-23
JP2009240835A (ja) 2009-10-22
CN100509081C (zh) 2009-07-08
CA2478387A1 (en) 2003-10-09
JP4454315B2 (ja) 2010-04-21
MXPA04009341A (es) 2005-01-25
PL374760A1 (en) 2005-10-31
AR039128A1 (es) 2005-02-09
DE60328171D1 (de) 2009-08-13
BR0308714A (pt) 2005-01-04
TW200304387A (en) 2003-10-01
EP1487533B1 (en) 2009-07-01
DK1487533T3 (da) 2009-10-05
EP2095805A2 (en) 2009-09-02
CA2478387C (en) 2011-01-04
TWI260233B (en) 2006-08-21
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ATE435048T1 (de) 2009-07-15
AU2003226002A1 (en) 2003-10-13

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