US6503198B1 - Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods - Google Patents

Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods Download PDF

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Publication number
US6503198B1
US6503198B1 US08/929,262 US92926297A US6503198B1 US 6503198 B1 US6503198 B1 US 6503198B1 US 92926297 A US92926297 A US 92926297A US 6503198 B1 US6503198 B1 US 6503198B1
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US
United States
Prior art keywords
noninvasive transdermal
analyte
skin
transdermal patch
chemistry component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US08/929,262
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English (en)
Inventor
Jack L. Aronowtiz
Joel R. Mitchen
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Technical Chemicals & Products Inc
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Technical Chemicals & Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Technical Chemicals & Products Inc filed Critical Technical Chemicals & Products Inc
Priority to US08/929,262 priority Critical patent/US6503198B1/en
Assigned to TECHNICAL CHEMICALS & PRODUCTS, INC. reassignment TECHNICAL CHEMICALS & PRODUCTS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ARONOWITZ, JACK L., MITCHEN, JOEL R.
Priority to CA002303129A priority patent/CA2303129A1/en
Priority to AT98948233T priority patent/ATE478340T1/de
Priority to EP98948233A priority patent/EP1015887B1/en
Priority to BRPI9815657-8A priority patent/BR9815657B1/pt
Priority to CNB988109824A priority patent/CN1144049C/zh
Priority to JP2000511068A priority patent/JP2001516056A/ja
Priority to PCT/US1998/019190 priority patent/WO1999013336A1/en
Priority to IL13499298A priority patent/IL134992A0/xx
Priority to AU94850/98A priority patent/AU9485098A/en
Priority to DE69841848T priority patent/DE69841848D1/de
Priority to KR1020007002559A priority patent/KR100666967B1/ko
Priority to MXPA00002489A priority patent/MXPA00002489A/es
Priority to ES98948233T priority patent/ES2348693T3/es
Priority to TW087118131A priority patent/TWI231862B/zh
Priority to NO20001126A priority patent/NO20001126L/no
Publication of US6503198B1 publication Critical patent/US6503198B1/en
Application granted granted Critical
Assigned to ARONOWITZ, JACK L. reassignment ARONOWITZ, JACK L. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FELTMAN, JAMES S.
Priority to JP2009037281A priority patent/JP4584338B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0035—Vaccination diagnosis other than by injuring the skin, e.g. allergy test patches
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
US08/929,262 1997-09-11 1997-09-11 Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods Expired - Fee Related US6503198B1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
US08/929,262 US6503198B1 (en) 1997-09-11 1997-09-11 Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods
DE69841848T DE69841848D1 (de) 1997-09-11 1998-09-11 Nicht-invasives transdermales system zum nachweiss analyten
MXPA00002489A MXPA00002489A (es) 1997-09-11 1998-09-11 Sistema transdermico no invasivo para detectar analitos..
EP98948233A EP1015887B1 (en) 1997-09-11 1998-09-11 Noninvasive transdermal systems for detecting analytes
BRPI9815657-8A BR9815657B1 (pt) 1997-09-11 1998-09-11 sistema transdermal não-invasivo para detectar um analisado.
CNB988109824A CN1144049C (zh) 1997-09-11 1998-09-11 用于检测分析物的非侵入性透皮系统
JP2000511068A JP2001516056A (ja) 1997-09-11 1998-09-11 分析対象物を検出する非侵襲性経皮システム
PCT/US1998/019190 WO1999013336A1 (en) 1997-09-11 1998-09-11 Noninvasive transdermal systems for detecting analytes
IL13499298A IL134992A0 (en) 1997-09-11 1998-09-11 Noninvasive transdermal systems for detecting analytes
AU94850/98A AU9485098A (en) 1997-09-11 1998-09-11 Noninvasive transdermal systems for detecting analytes
CA002303129A CA2303129A1 (en) 1997-09-11 1998-09-11 Noninvasive transdermal systems for detecting analytes
KR1020007002559A KR100666967B1 (ko) 1997-09-11 1998-09-11 분석물을 검출하기 위한 비침습성 경피 패취
AT98948233T ATE478340T1 (de) 1997-09-11 1998-09-11 Nicht-invasives transdermales system zum nachweiss analyten
ES98948233T ES2348693T3 (es) 1997-09-11 1998-09-11 Sistemas transdã‰rmicos no agresivos para detectar analitos.
TW087118131A TWI231862B (en) 1997-09-11 1998-10-31 Noninvasive transdermal systems for detecting an analyte in a biological fluid and methods
NO20001126A NO20001126L (no) 1997-09-11 2000-03-06 Et ikke-angripende transdermalt system for õ detektere analytter
JP2009037281A JP4584338B2 (ja) 1997-09-11 2009-02-20 分析対象物を検出する非侵襲性経皮システム

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/929,262 US6503198B1 (en) 1997-09-11 1997-09-11 Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods

Publications (1)

Publication Number Publication Date
US6503198B1 true US6503198B1 (en) 2003-01-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
US08/929,262 Expired - Fee Related US6503198B1 (en) 1997-09-11 1997-09-11 Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods

Country Status (16)

Country Link
US (1) US6503198B1 (pt)
EP (1) EP1015887B1 (pt)
JP (2) JP2001516056A (pt)
KR (1) KR100666967B1 (pt)
CN (1) CN1144049C (pt)
AT (1) ATE478340T1 (pt)
AU (1) AU9485098A (pt)
BR (1) BR9815657B1 (pt)
CA (1) CA2303129A1 (pt)
DE (1) DE69841848D1 (pt)
ES (1) ES2348693T3 (pt)
IL (1) IL134992A0 (pt)
MX (1) MXPA00002489A (pt)
NO (1) NO20001126L (pt)
TW (1) TWI231862B (pt)
WO (1) WO1999013336A1 (pt)

Cited By (41)

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US20030069482A1 (en) * 2001-10-09 2003-04-10 Workman Jerome James Sampling article for determining quantitative and qualitative drug transfer to skin
US20030100846A1 (en) * 1998-01-08 2003-05-29 Linda Custer System, method, and device for non-invasive body fluid sampling and analysis
US20030105391A1 (en) * 2000-10-19 2003-06-05 Berman Herbert L. Glucose measurement utilizing non-invasive assessment methods
US20040225206A1 (en) * 2003-05-09 2004-11-11 Kouchnir Mikhail A. Non-invasive analyte measurement device having increased signal to noise ratios
WO2004091376A3 (en) * 2003-04-15 2005-06-30 Metgen Inc Medical device for monitoring blood phenylalanine levels
US20050171413A1 (en) * 2004-02-04 2005-08-04 Medoptix, Inc. Integrated device for non-invasive analyte measurement
US20050177037A1 (en) * 2004-01-09 2005-08-11 Seiki Okada Extracting kit, extracting device, and extracting method
US20060004271A1 (en) * 2004-07-01 2006-01-05 Peyser Thomas A Devices, methods, and kits for non-invasive glucose measurement
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US20060024722A1 (en) * 2004-07-30 2006-02-02 Mark Fischer-Colbrie Samples for detection of oncofetal fibronectin and uses thereof
US20060036138A1 (en) * 2004-08-06 2006-02-16 Adam Heller Devices and methods of screening for neoplastic and inflammatory disease
US20060094944A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
US20060160244A1 (en) * 2005-01-19 2006-07-20 Sysmex Corporation Analyte extracting cartridge set and analyzing method
US20070027383A1 (en) * 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
US20070128681A1 (en) * 2005-12-05 2007-06-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
DE102006026173A1 (de) * 2006-06-06 2007-12-20 Fachhochschule Südwestfalen Verfahren zur nichtinvasiven Diagnose von Diabetes
US20080089993A1 (en) * 2004-08-23 2008-04-17 Remote Clinical Solutions, Inc. System and method for modifying a fluid for oral administration
US20080275468A1 (en) * 2007-04-27 2008-11-06 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
US20080281178A1 (en) * 2007-03-07 2008-11-13 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
US20090147026A1 (en) * 2007-12-07 2009-06-11 Roche Diagnostics Operations, Inc. Graphic zoom functionality for a custom report
US20090259301A1 (en) * 2008-04-10 2009-10-15 Daniel Gelbart Detector for abnormal conditions inside body
US20090312614A1 (en) * 2005-12-16 2009-12-17 Brenneman Allen J Transdermal Analyte Sensor Assembly and Methods of Using the Same
FR2953717A1 (fr) * 2009-12-15 2011-06-17 Oreal Lingette avec emulsion comprenant un polymere epaississant et un ester d'acide laurique ou d'alcool laurylique
US20110230453A1 (en) * 2008-03-11 2011-09-22 Urobiologics Llc Use of Female Mammal's Urine for Determination of Fetal Gender Related Characteristics
WO2012006617A3 (en) * 2010-07-09 2012-04-05 Methode Electronics, Inc. Optical analyte measurement
US8287483B2 (en) 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
WO2013008239A1 (en) * 2011-07-14 2013-01-17 Mor Gideon Noninvasive detection of meconium in amniotic fluid
WO2013186628A1 (en) 2012-06-15 2013-12-19 Delta Instruments S.R.L. Transdemal device for the fluorometric detection of an analyte in a biological fluid and analysis apparatus associated with said transdermal device
WO2014026113A1 (en) * 2012-08-10 2014-02-13 The Research Foundation For The State University Of New York Near-infrared spectroscopy and optical reporter
US8870810B2 (en) 1998-12-18 2014-10-28 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US20150011852A1 (en) * 2012-03-01 2015-01-08 Koninklijke Philips N.V. Sensor for determining concentration of gas
US9442065B2 (en) 2014-09-29 2016-09-13 Zyomed Corp. Systems and methods for synthesis of zyotons for use in collision computing for noninvasive blood glucose and other measurements
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
US20170248524A1 (en) * 2016-02-26 2017-08-31 DermaTec LLC Methods and Apparatuses Relating to Dermal Biochemical Sensors
WO2018165180A1 (en) 2017-03-06 2018-09-13 Medtronic Minimed, Inc. Colorometric sensor for the non-invasive screening of glucose in sweat in pre and type 2 diabetes
WO2019089746A1 (en) * 2017-11-01 2019-05-09 The Board Of Trustees Of The Leland Stanford Junior University Analyte detection method
WO2020113183A1 (en) * 2018-11-29 2020-06-04 In Diagnostics, Inc. Single-use clinical spectrophotometer
US10996218B2 (en) 2008-03-11 2021-05-04 Ournextbaby Llc Methods for chemotaxis / redox driven separation of X and Y chromosome bearing sperm and their insemination in gender specific menstrual cycles
EP2773266B1 (en) * 2011-10-31 2022-11-30 Sentec Ag A device for application of a sensor to a measurement site, a kit of an application device and sensor and use of an application device for optical measurements of physiological parameters
US11553861B1 (en) 2018-05-29 2023-01-17 My Salt and Sugar, LLC Apparatus to detect salt concentrations and glucose in bodily fluids
EP4361631A2 (en) 2017-03-06 2024-05-01 Medtronic MiniMed, Inc. Colorometric sensor for the non-invasive screening of glucose in sweat in pre and type 2 diabetes

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ATE221665T1 (de) 1998-06-24 2002-08-15 Transderm Technologies Llc Nichtinvasiven transdermal detektion von analyten
IL138788A0 (en) 2000-09-29 2001-10-31 Falk Fish Method and kit for the transdermal determination of analyte concentration in blood
EP1262559A1 (en) * 2001-06-01 2002-12-04 SIRS-Lab GmbH Dermal patch for detecting lactate
US6721586B2 (en) 2001-06-12 2004-04-13 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US6837988B2 (en) 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
US6875613B2 (en) 2001-06-12 2005-04-05 Lifescan, Inc. Biological fluid constituent sampling and measurement devices and methods
US6793632B2 (en) 2001-06-12 2004-09-21 Lifescan, Inc. Percutaneous biological fluid constituent sampling and measurement devices and methods
US6501976B1 (en) 2001-06-12 2002-12-31 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
GB2400037A (en) * 2003-03-31 2004-10-06 Psimedica Ltd Device made of silicon and method for collecting mammary fluid
DE102004039570B4 (de) * 2004-08-14 2007-03-01 Lts Lohmann Therapie-Systeme Ag Überwachungssystem zum Sammeln und zur transdermalen Weiterdiffusion von Umweltkontaminantien enthaltender Luft und Verfahren hierzu
JP5688829B2 (ja) * 2005-11-11 2015-03-25 敏一 吉川 示差的な糖尿病の予知・診断方法および糖尿病予知・診断用キット
JP4643768B2 (ja) * 2009-02-27 2011-03-02 シスメックス株式会社 生体内成分測定システム、組織液収集装置および生体内成分測定方法
JP5406646B2 (ja) * 2009-09-16 2014-02-05 シスメックス株式会社 組織液収集方法に用いる組織液収集キット及び組織液収集シート
JP5419771B2 (ja) * 2010-03-26 2014-02-19 シスメックス株式会社 診断支援方法、診断支援システム及び診断支援装置
JP5792517B2 (ja) * 2011-06-02 2015-10-14 国立大学法人長岡技術科学大学 ストレスの評価方法
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Cited By (75)

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US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US20030100846A1 (en) * 1998-01-08 2003-05-29 Linda Custer System, method, and device for non-invasive body fluid sampling and analysis
US8287483B2 (en) 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US8870810B2 (en) 1998-12-18 2014-10-28 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US20030105391A1 (en) * 2000-10-19 2003-06-05 Berman Herbert L. Glucose measurement utilizing non-invasive assessment methods
US7039447B2 (en) * 2000-10-19 2006-05-02 Vivomedical, Inc. Glucose measurement utilizing non-invasive assessment methods
US20030069482A1 (en) * 2001-10-09 2003-04-10 Workman Jerome James Sampling article for determining quantitative and qualitative drug transfer to skin
US20070122867A1 (en) * 2003-04-15 2007-05-31 Shunnarah Richard D Medical device for monitoring blood phenylalanine levels
EP1618207A2 (en) * 2003-04-15 2006-01-25 Metgen Inc. Medical device for monitoring blood phenylalanine levels
WO2004091376A3 (en) * 2003-04-15 2005-06-30 Metgen Inc Medical device for monitoring blood phenylalanine levels
EP1618207A4 (en) * 2003-04-15 2006-06-28 Metgen Inc MEDICAL DEVICE FOR MONITORING LEVELS IN PHENYLALANINE BLOOD
US20040225206A1 (en) * 2003-05-09 2004-11-11 Kouchnir Mikhail A. Non-invasive analyte measurement device having increased signal to noise ratios
US20110040166A1 (en) * 2004-01-09 2011-02-17 Sysmex Corporation Extracting kit, extracting device, and extracting method
US20050177037A1 (en) * 2004-01-09 2005-08-11 Seiki Okada Extracting kit, extracting device, and extracting method
US20050171413A1 (en) * 2004-02-04 2005-08-04 Medoptix, Inc. Integrated device for non-invasive analyte measurement
US20060004271A1 (en) * 2004-07-01 2006-01-05 Peyser Thomas A Devices, methods, and kits for non-invasive glucose measurement
US20070179371A1 (en) * 2004-07-01 2007-08-02 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
US7725149B2 (en) 2004-07-01 2010-05-25 Peyser Thomas A Devices, methods, and kits for non-invasive glucose measurement
US20070027383A1 (en) * 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
WO2006026020A2 (en) 2004-07-30 2006-03-09 Adeza Biomedical Corporation Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin
US7943294B2 (en) 2004-07-30 2011-05-17 Hologic, Inc. Methods for detecting oncofetal fibronectin
US9513298B2 (en) 2004-07-30 2016-12-06 Hologic, Inc. Methods for detecting oncofetal fibronectin
EP2299275A2 (en) 2004-07-30 2011-03-23 Adeza Biomedical Corporation Classification of the oncofetal fibronection level for the indication of diseases and other conditions
US8372581B2 (en) 2004-07-30 2013-02-12 Cytyc Corporation Methods for detecting oncofetal fibronectin
US20060024724A1 (en) * 2004-07-30 2006-02-02 Robert Hussa Oncofetal fibronectin as a marker for health and disease
US20060024722A1 (en) * 2004-07-30 2006-02-02 Mark Fischer-Colbrie Samples for detection of oncofetal fibronectin and uses thereof
US20060036138A1 (en) * 2004-08-06 2006-02-16 Adam Heller Devices and methods of screening for neoplastic and inflammatory disease
US20080089993A1 (en) * 2004-08-23 2008-04-17 Remote Clinical Solutions, Inc. System and method for modifying a fluid for oral administration
US8224414B2 (en) 2004-10-28 2012-07-17 Echo Therapeutics, Inc. System and method for analyte sampling and analysis with hydrogel
US20060094946A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with hydrogel
US20060094944A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
US20060160244A1 (en) * 2005-01-19 2006-07-20 Sysmex Corporation Analyte extracting cartridge set and analyzing method
EP1683476A1 (en) * 2005-01-19 2006-07-26 Sysmex Corporation Analyte extracting cartridge set
US20070128681A1 (en) * 2005-12-05 2007-06-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US20090312614A1 (en) * 2005-12-16 2009-12-17 Brenneman Allen J Transdermal Analyte Sensor Assembly and Methods of Using the Same
US8504131B2 (en) 2005-12-16 2013-08-06 Bayer Healthcare Llc Transdermal analyte sensor assembly and methods of using the same
US8271064B2 (en) * 2005-12-16 2012-09-18 Bayer Healthcare Llc Transdermal analyte sensor assembly and methods of using the same
DE102006026173A1 (de) * 2006-06-06 2007-12-20 Fachhochschule Südwestfalen Verfahren zur nichtinvasiven Diagnose von Diabetes
US20080281178A1 (en) * 2007-03-07 2008-11-13 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
US8812071B2 (en) 2007-03-07 2014-08-19 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
US9572527B2 (en) 2007-04-27 2017-02-21 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
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JP2001516056A (ja) 2001-09-25
CN1144049C (zh) 2004-03-31
CN1301347A (zh) 2001-06-27
KR20010023876A (ko) 2001-03-26
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NO20001126L (no) 2000-04-27
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WO1999013336A1 (en) 1999-03-18
AU9485098A (en) 1999-03-29

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