US5916576A - Method of scavenging free radicals using orange extract - Google Patents

Method of scavenging free radicals using orange extract Download PDF

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Publication number
US5916576A
US5916576A US08/865,913 US86591397A US5916576A US 5916576 A US5916576 A US 5916576A US 86591397 A US86591397 A US 86591397A US 5916576 A US5916576 A US 5916576A
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United States
Prior art keywords
composition
orange
orange extract
extract
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US08/865,913
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English (en)
Inventor
Jeffrey M. Dornoff
Michael B. Davies
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Access Business Group International LLC
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Amway Corp
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Assigned to AMWAY CORPORATION reassignment AMWAY CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DAVIES, MICHAEL B., DORNOFF, JEFFREY M.
Priority to US08/865,913 priority Critical patent/US5916576A/en
Application filed by Amway Corp filed Critical Amway Corp
Priority to KR10-1998-0017074A priority patent/KR100358210B1/ko
Priority to MYPI98002342A priority patent/MY117323A/en
Priority to JP10145307A priority patent/JP3012594B2/ja
Priority to CNB981093396A priority patent/CN1195488C/zh
Priority to IDP980789A priority patent/ID20353A/id
Priority to TW087108408A priority patent/TW565460B/zh
Priority to HK99102387A priority patent/HK1017259A1/xx
Publication of US5916576A publication Critical patent/US5916576A/en
Application granted granted Critical
Assigned to ACCESS BUSINESS GROUP INTERNATIONAL LLC reassignment ACCESS BUSINESS GROUP INTERNATIONAL LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: AMWAY CORPORATION N/K/A ALTICOR INC.
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Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/346—Finished or semi-finished products in the form of powders, paste or liquids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
    • A23G2200/14—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing fruits, nuts, e.g. almonds, seeds, plants, plant extracts or essential oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • the present invention relates to a method of scavenging free radicals by incorporating orange extract into a composition.
  • the deleterious effects of free radicals are, in many cases, known but are continually being investigated. For example, it is believed that one of the causes of the deterioration of skin over time is the formation of free radicals within the elements forming the skin such as the fibers, cells and enzymes.
  • the formation of free radicals may be caused, in part, by the action of external radiation of sunlight.
  • the free radicals thus formed may attack the skin elements through a chain reaction that continues as long as the free radical exists, i.e., as long as the free radical does not combine with something (typically called a scavenger or inhibitor) that produces a stable molecule.
  • the adverse action of these free radicals at the cutaneous integument level may cause destruction of cell DNA and an erosion of the connective tissues (collagen and elastin). Thus, the skin looks more aged.
  • scavengers also referred to as inhibitors or antioxidants, and as used in the following specification and appended claims should be considered synonymous with scavenger
  • scavengers include phenols, aromatic amines, sulfur compounds, raw seed oils, wheat germ oil, tocopherols, and gums.
  • phosphoric acid, citric acid, and ascorbic acid have their own scavenging activity or enhance the activity of the known scavengers mentioned above.
  • French Demande 2,597,337-A2 describes a cosmetic to slow down the aging process by attacking free radicals.
  • the cosmetic includes a first water soluble active ingredient, which may include a source of vitamin C such as from acerola cherry extract, and a second fat soluble ingredient, which includes free radical scavengers such as vitamin E.
  • an orange extract which is substantially free of vitamin C, has free radical scavenging activity.
  • the present inventors have now found that an orange extract exhibits free radical scavenging activity and, as a result may find particular application in the preparation of pharmaceutical, food and agricultural compositions, and more particularly in cosmetics for external skin application.
  • the ability of the orange extract used in the present invention to scavenge free radicals is surprising and unexpected.
  • compositions that inhibit the formation of or scavenge the presence of free radicals can be enhanced by incorporating orange extract.
  • the present invention includes a composition of the type containing free radical scavengers wherein the improvement comprises adding orange extract.
  • the composition is a cosmetic composition suitable for use on human skin.
  • the orange extract may have application alone or in conjunction with skin whitening agents for use as a skin whitener.
  • the present invention also includes a method of providing free radical scavenging activity in a composition comprising admixing to the composition an effective amount of orange extract to increase the free radical scavenging activity of the composition.
  • the present invention is based on the anti-radical activity of orange extract towards the superoxide radical.
  • the compositions of the present invention incorporating the orange extract are particularly suitable for protecting the skin due in particular to the protection against phototoxic reactions and UV aggression.
  • the present invention also includes a method of scavenging free radicals in human skin comprising topically applying to the skin a composition comprising orange extract.
  • the composition further includes a pharmaceutically acceptable carrier.
  • the orange extract useful in the present invention is substantially free from ascorbic acid and contains only minor amounts of organic acids particularly carboxylic acids.
  • substantially free from ascorbic acid means that any ascorbic acid present in the orange extract is present in an amount no greater than about 1% by weight, preferably no greater than about 0.1%, and more preferably no greater than about 0.01% of the orange extract. Most preferably, the ascorbic acid, if present, is present in an amount no greater than about 0.005% of the orange extract.
  • minor amounts of organic acids and “minor amounts of carboxylic acids” as used in the specification and accompanying claims means that any organic acid and any carboxylic acid, which includes saturated and unsaturated carboxylic and dicarboxylic acids, hydroxymonocarboxylic acids, hydroxydicarboxylic acids, and hydroxytricarboxylic acids, is present in an amount no greater than about 5% by weight, preferably no greater than about 3%, and more preferably no greater than about 2% of the orange extract.
  • the amount of orange extract to be used can not be absolutely specified because it varies according to the form of preparation. However, it is generally used in an amount from about 0.01% to about 50%, preferably from about 0.01% to about 5%, desirably from about 0.05% to about 2%, more preferably from about 0.1% to about 1% based on the whole weight of the composition.
  • a free radical scavenger composition which comprises orange extract as an active ingredient.
  • the orange extract is substantially free from any substantial amount of vitamin C (ascorbic acid or its derivatives).
  • the orange extract does not contain more than about 1% by weight, preferably no greater than about 0.1%, and more preferably no greater than about 0.01% of the orange extract.
  • the ascorbic acid if present, is present in an amount no greater than about 0.005% of the orange extract.
  • the orange extract can be made in any suitable manner to achieve an extract that is substantially free of ascorbic acid.
  • the orange extract is obtained from orange peel, flowers, and/or leaves on an orange tree. It is believed that the orange extract is prepared by drying the material, pretreating it, cold extracting the the pretreated material by alternating maceration and percolation for 24 to 48 hours, filtrating, microfiltrating, and adding a suitable preservtive such as parabens or phenoxyethanol.
  • the orange extract is Bitter Orange Peel Extract HB from Centerchem, Inc. or Herbasol Orange Extract from Cosmetochem. It is believed that the Centerchem material is obtained from the orange peel while the Cosmetochem material is obtained from the orange flower.
  • the amount of orange extract to be used can not be absolutely specified because it varies according to the form of preparation. However, it is generally used in an amount from about 0.01% to about 50%, preferably from about 0.01% to about 5%, desirably from about 0.05% to about 2%, more preferably from about 0.1% to about 1% based on the whole weight of the whitener composition.
  • composition of the present invention may be prepared in various forms.
  • it may be in the form of a cosmetic preparation such as cream, cosmetic lotion, pack or powder, or as an emulsion, lotion, liniment or ointment.
  • various known conventional cosmetic ingredients may be incorporated.
  • cosmetic ingredients such as alcohols, fats and oils, surfactants, fatty acids, silicone oils, humectants, viscosity modifiers, emulsifiers, stabilizers, coloring agents, and perfumes.
  • an improved free radical scavenging composition wherein the improvement comprises adding orange extract, as fully defined above.
  • the orange extract may be desirable to incorporate the orange extract in, for example, a skin whitening composition.
  • the free radical scavenging activity of the orange extract can inhibit the conversion of dopaquinone with the result of inhibiting the production of eumelanin. Consequently, it is contemplated that the free radical scavenging activity of the orange extract can augment the known tyrosinase inhibitors and thus, provide enhanced skin whitening properties.
  • the present invention also contemplates a method of enhancing the free radical scavenging activity of known free radical scavengers that comprises adding orange extract to compositions containing known free radical scavengers.
  • the present invention also includes a method of providing free radical scavenging activity in a composition comprising admixing to the composition an effective amount of orange extract to increase the free radical scavenging activity of the composition.
  • a method of scavenging free radicals in human skin comprises topically applying to the skin orange extract. More preferably, the method comprises topically applying to the skin a composition comprising orange extract and a pharmaceutically acceptable carrier.
  • pharmaceutically acceptable means those drugs, medicaments, or inert ingredients which are suitable for use in contact with the tissues of humans and lower animals without undue toxicity, incompatibility, instability, irritation, and the like, commensurate with a reasonable benefit/risk ratio.
  • a control solution was prepared by measuring 39.43 mg of 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH), a known source of free radicals, and diluting it to 1000 ml with ethanol.
  • a control cuvette was charged with 1.75 ml of the control and 1.75 ml of ethanol.
  • a blank cuvette was charged with 3.5 ml of ethanol. The cuvettes were placed in an oven for 30 minutes at 37° C. The absorbency was measured at 516 nm using a UV/vis spectrophotometer by placing the blank cuvette into the reference slot and the control cuvette into the sample slot.
  • An orange extract was prepared according to the method described above.
  • a test cuvette was charged with 1.75 ml of the control solution and 1.75 ml of a 1% solution of orange extract.
  • a reference cuvette was charged with 1.75 ml of the orange extract and 1.75 ml of ethanol. The cuvettes were placed in an oven for 30 minutes at 37° C. The absorbency was measured in the manner described above with the test cuvette placed in the sample slot and the reference cuvette placed in the reference slot.
  • the free radical scavenging activity was calculated as a percentage of inhibition of the generation of the free radicals using the following formula:
  • DT is the measured absorbance of the test cuvette with respect to the reference cuvette and DR is the measured absorbance of the control cuvette with respect to the blank cuvette.
  • the orange extract exhibited 52% inhibition.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Birds (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
US08/865,913 1997-05-30 1997-05-30 Method of scavenging free radicals using orange extract Expired - Lifetime US5916576A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US08/865,913 US5916576A (en) 1997-05-30 1997-05-30 Method of scavenging free radicals using orange extract
KR10-1998-0017074A KR100358210B1 (ko) 1997-05-30 1998-05-13 항-라디칼활성을가지는오렌지추출물을포함하는미용조성물
MYPI98002342A MY117323A (en) 1997-05-30 1998-05-26 Method of scavenging free radicals using orange extract
JP10145307A JP3012594B2 (ja) 1997-05-30 1998-05-27 オレンジ抽出物を用いたフリーラジカルを捕捉する方法及びその組成物
CNB981093396A CN1195488C (zh) 1997-05-30 1998-05-28 用橙提取液清除自由基的方法
IDP980789A ID20353A (id) 1997-05-30 1998-05-28 Metoda membersihkan radikal bebas menggunakan ekstrat oranye
TW087108408A TW565460B (en) 1997-05-30 1998-05-29 Method of scavenging free radicals using orange extract
HK99102387A HK1017259A1 (en) 1997-05-30 1999-05-27 Method of scavenging free radicals using orange extract.

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Application Number Priority Date Filing Date Title
US08/865,913 US5916576A (en) 1997-05-30 1997-05-30 Method of scavenging free radicals using orange extract

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US5916576A true US5916576A (en) 1999-06-29

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Country Status (8)

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US (1) US5916576A (zh)
JP (1) JP3012594B2 (zh)
KR (1) KR100358210B1 (zh)
CN (1) CN1195488C (zh)
HK (1) HK1017259A1 (zh)
ID (1) ID20353A (zh)
MY (1) MY117323A (zh)
TW (1) TW565460B (zh)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020146469A1 (en) * 2000-12-20 2002-10-10 Benjamin Wiegand Methods for reducing chronic stress in mammals
US20020151527A1 (en) * 2000-12-20 2002-10-17 Benjamin Wiegand Method for reducing acne or improving skin tone
US20030147937A1 (en) * 2000-04-12 2003-08-07 Thomas Schwarz Use of compatible solutes as substances having free radical scavenging properties
US20030220550A1 (en) * 2002-01-29 2003-11-27 Mcculloch Laura Method of measuring the stress or relaxation level of a mammal
US20030225095A1 (en) * 2002-02-08 2003-12-04 Mcculloch Laura Method of affecting sleep and sleep-related behaviors
US20040028631A1 (en) * 2000-08-18 2004-02-12 Thomas Schwarz Cosmetic formulations
EP1398035A1 (fr) * 2002-09-12 2004-03-17 Jean Morelle Application locale cutanée d'émulsions caractérisées par leurs propriétés antiprostanoidiques
FR2844450A1 (fr) * 2002-09-12 2004-03-19 Jean Morelle Application locale cutanee d'emulsions, caracterisees par leurs proprietes antiprostanoidiques
US20040175438A1 (en) * 2003-03-03 2004-09-09 Benjamin Wiegand Methods for alleviating symptoms associated with menopause using sensory regimen
US6830755B2 (en) 1999-10-01 2004-12-14 Johnson & Johnson Consumer Companies, Inc. Method for relaxing human beings using personal care compositions
US20050226828A1 (en) * 2000-04-19 2005-10-13 Nof Corporation Method for whitening human skin
US20050249720A1 (en) * 2004-05-05 2005-11-10 Perez Mary R Cosmetic skin formulation

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001114634A (ja) * 1999-10-12 2001-04-24 Pola Chem Ind Inc カタラーゼ保護剤及びこれを含有する老化防止用化粧料。
JP2001122758A (ja) * 1999-10-22 2001-05-08 Pola Chem Ind Inc ＡＧＥｓ分解作用を有する老化肌防御、改善化粧料
JP5349719B2 (ja) * 2000-01-26 2013-11-20 株式会社コーセー 皮膚外用剤
KR20020040719A (ko) * 2002-04-18 2002-05-30 김대도 오랜지 팩
JP4669670B2 (ja) * 2004-06-04 2011-04-13 株式会社ロッテ 抗インフルエンザウイルス剤及びこれを吸着、含浸、添加させてなるインフルエンザ感染抑制用品
JP5748996B2 (ja) * 2010-12-24 2015-07-15 日本メナード化粧品株式会社 皮膚外用剤

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US2255341A (en) * 1939-04-13 1941-09-09 Fruit Growers Exchange Ca Composition of citrus fruit constituents and boric acid and method for making the same
US4460488A (en) * 1980-01-04 1984-07-17 Societe Anonyme Dite: L'oreal Plant extraction residue as a thickening or opacifying agent for a cosmetic composition
US5073545A (en) * 1987-06-09 1991-12-17 Lion Corporation Agent containing an ellagic acid series compound for external application and use thereof
US5167954A (en) * 1988-03-28 1992-12-01 Helga Frey Hair lotion containing cardomom and use thereof
US5152990A (en) * 1990-01-31 1992-10-06 Yutaka Miyauchi Hair grower
US5362494A (en) * 1990-11-14 1994-11-08 L'oreal Cosmetic, dermo-pharmaceutical or vesicle-containing composition including clycerol-derived compounds
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JPH0717846A (ja) * 1993-06-30 1995-01-20 Sansho Seiyaku Co Ltd 皮膚外用剤
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US5780086A (en) * 1994-08-08 1998-07-14 The Procter & Gamble Company Color and shelf stable beverage compositions containing tea extract
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US6830755B2 (en) 1999-10-01 2004-12-14 Johnson & Johnson Consumer Companies, Inc. Method for relaxing human beings using personal care compositions
US20030147937A1 (en) * 2000-04-12 2003-08-07 Thomas Schwarz Use of compatible solutes as substances having free radical scavenging properties
US20050226828A1 (en) * 2000-04-19 2005-10-13 Nof Corporation Method for whitening human skin
US20040028631A1 (en) * 2000-08-18 2004-02-12 Thomas Schwarz Cosmetic formulations
US20020151527A1 (en) * 2000-12-20 2002-10-17 Benjamin Wiegand Method for reducing acne or improving skin tone
US20020146469A1 (en) * 2000-12-20 2002-10-10 Benjamin Wiegand Methods for reducing chronic stress in mammals
US20030220550A1 (en) * 2002-01-29 2003-11-27 Mcculloch Laura Method of measuring the stress or relaxation level of a mammal
US6986747B2 (en) 2002-01-29 2006-01-17 Johnson & Johnson Consumer Companies Method of measuring the stress or relaxation level of a mammal
US20030225095A1 (en) * 2002-02-08 2003-12-04 Mcculloch Laura Method of affecting sleep and sleep-related behaviors
US20070275102A9 (en) * 2002-02-08 2007-11-29 Mcculloch Laura Method of affecting sleep and sleep-related behaviors
US20070149492A1 (en) * 2002-02-08 2007-06-28 Mcculloch Laura Method of affecting sleep and sleep-related behaviors
FR2844451A1 (fr) * 2002-09-12 2004-03-19 Jean Morelle Application locale cutanee, d'emulsions caracterisees par leurs proprietes antiprostanoidiques
FR2844450A1 (fr) * 2002-09-12 2004-03-19 Jean Morelle Application locale cutanee d'emulsions, caracterisees par leurs proprietes antiprostanoidiques
EP1398035A1 (fr) * 2002-09-12 2004-03-17 Jean Morelle Application locale cutanée d'émulsions caractérisées par leurs propriétés antiprostanoidiques
US20040175438A1 (en) * 2003-03-03 2004-09-09 Benjamin Wiegand Methods for alleviating symptoms associated with menopause using sensory regimen
US20050249720A1 (en) * 2004-05-05 2005-11-10 Perez Mary R Cosmetic skin formulation

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CN1195488C (zh) 2005-04-06
KR19980086982A (ko) 1998-12-05
HK1017259A1 (en) 1999-11-19
TW565460B (en) 2003-12-11
JP3012594B2 (ja) 2000-02-21
JPH1143444A (ja) 1999-02-16
MY117323A (en) 2004-06-30
CN1200922A (zh) 1998-12-09
ID20353A (id) 1998-12-03

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